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The ratio of mortality and morbidity in very low birth weight infants in a public hospital

Yıl 2011, , 44 - 50, 01.06.2011

Yekta Canbak İbrahim Şilfeler Bayram Ali Dorum Hilal Kurnaz Sevil Dorum

https://doi.org/10.4274/tpa.46.62

Öz

Aim: The aim of this study was to evaluate the risk factors for term and pretem newborns etiological agents antibiotic susceptibility and rate of hospital acquired bloodstream infections in newborns hospitalized in our Neonatal Intensive Care Unit during 2008

Anahtar Kelimeler

-

Kaynakça

  • Lawn JE, Cousens, Bhutta ZA, et al. Why are 4 million newborn babies dying each year? Lancet 2004; 364: 399-401.
  • Dogramaci İ. yenidoğan ölümleri. Yurdakök M, Erdem G (edt) Türk Neonatoloji Derneği. Neonatoloji, 2003; 3-5.
  • Horbar JD, Badger GJ, Carpenter JH, et al. Trends in mortality and morbidity for very low birth weight infants, 1991- 1999. Pediatrics 2002; 110: 143-51.
  • Horbar JD, Wright EC, Onstad L. Decreasing mortality associated with the introduction of surfactant therapy: an observational study of neonates weighing 601-1300 grams at birth. Pediatrics 1993; 92: 191-6.
  • Jobe AH. Pulmonary surfactant therapy. N Engl J Med 1993; 328: 861-8.
  • Horbar JD, Wright LL, Soll RF, et al. A multicenter randomized trial comparing two surfactants for the treatment of neonatal respiratory distress syndrome. National Institute of Child Health and Human Development Neonatal Research Network. J Pediatr 1993; 123: 757-66.
  • NIH Consensus Development Panel on the Effect of Corticosteroids for Fetal Maturation on Perinatal Outcomes. Effect of corticosteroids for fetal maturation on perinatal outcomes. JAMA 1995; 273: 413-8.
  • Greenough A, Milner AD, Dimitriou G. Prendergast M. Synchronized mechanical ventilation for respiratory support in newborn infants. Cochrane Database Syst Rev 2001; 1: CD000456.
  • Cools F, Henderson-Smart DJ, Offringa M, Askie LM. Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants. Cochrane Database Syst Rev 2009; 8: CD000104.
  • Stewart AL, Reynolds EO, Lipscomb AP. Outcome for infants of very low birthweight: survey of world literature. Lancet 1981; 1: 1038-40.
  • Lagercrantz H, Katz-Salamon M, Forssberg H. The Stockholm neonatal project: Neonatal mortality and morbidity at the Children’s Centre, Karolinska Hospital. Acta Paediatr Suppl 1997; 419: 11-5.
  • Stoll BJ, Kliegman RM. The Fetus and the Neonatal Infant. In: Behrman RE, Kliegman RM, Jenson HB (eds). Nelson Textbook of Pediatrics. 17th ed. Philadelphia: W.B. Saunders Company 2003; 519-640.
  • Ballard JL, Novak KK, Driver M. A simplified score for assesment of fetal malnutrition of newly born infants. J Pediatr 1979; 95: 769-74.
  • Ballard JL, Khoury JC, Wedig K, Wang L, Eilers-Walsman BL, Lipp R. New Ballard Score, expanded to include extremely premature infants. J Pediatr 1991; 119: 417-23.
  • Lubchenco LO, Hansman C, Dressler M, Boyd H. Intrauterin growth as estimated from liveborn birtweight data at 24-42 weeks of gestation. Pediatrics 1963; 32: 793-800.
  • A national study of risk factors associated with mortality in very low birthweight infants in the Malaysian neonatal intensive care units. Malaysian Very Low Birth Weight Study Group. J Peaditr Child Health 1997; 33: 18-25.
  • Hack M, Horbar JD, Malloy MH, Tyson JE, Wright E, Wright L. Very low birth weight outcomes of the National Institute of Child Health and Human Developmental Neonatal Network. Pediatrics 1991; 87: 587-97.
  • Atasay B, Günlemez A, Ünal S, Arsan S. Outcomes of very low birth weight infants in a newborn tertiary center in Turkey, 1997-2000. Turk J Pediatr 2003; 45: 283-9.
  • Türkiye’de yenidoğan bakım ünitelerinde mortalite oranları 2007. Türk Neonatoloji Derneği Bülteni 2008; 17: 15-9.
  • Türkiye’de yenidoğan bakım ünitelerinde mortalite oranları 2004. Türk Neonatoloji Derneği Bülteni 2004; 10: 10-4.
  • Duman N, Kumral A, Gulcan H, Ozkan H. Outcome of very-low-birth-weight infants in a developing country: a prospective study from the western region of Turkey. J Matern Fetal Neonatal Med 2003; 13: 54-8.
  • Greenough A, Roberton NRC. Respiratory Distres Syndrome. In: Neonatal Respiratory Disorders. Greenough A, Milner AD, Roberton NRC (eds). 1st Ed. London: Arnold, The Hodder Headline Group, 1996; 238-79.
  • Rodriguez RJ, Martin RJ, Fanaroff AA. Respiratory Distres Syndrome and its Management. In: Fanaroff AA, Martin RJ (eds). Neonatal-Perinatal Medicine. 7th ed. St. Louis: Mosby 2002; 1001-11.
  • Davis MJ, Rosenfeld WN. Chronic Lung Disease. In: Avery GB, Fletcher AM, Macdonald MG (eds). Neonatology Pathophysiology and management of the Newborn. 5th ed. Philadelphia: Lippincott Williams and Wilkıns, 1999; 509-31.
  • Lemons JA, Bauer CR, Oh W, et al. Very low birth weight outcomes of the national instuitude of child health and human development, neonatal research network, January 1995 through December 1996. Pediatrics 2001; 107:1.
  • Köksal N, Baytan B, Bayram Y, Nacarküçük E. Risk factors for intraventricular hemorrage in very low birth weight infants. Indian J Pediatr 2002; 69: 561-4.
  • Wilson R, Kanto WP Jr, McCarthy BJ, et al. Epidemiologic characteristics of necrotizing enterocolitis: a population-based study. Am J Epidemiol 1981; 114: 880-7.
  • Lee SK, McMillan DD, Ohlsson A, et al. Variations in practice and outcomes in the Canadian NICU Network: 996–1997. Pediatrics 2000; 106: 1070-9.
  • Palmer EA, Flynn JT, Hardy RJ, et al. Incidence and early course of retinopathy of prematurity. The Cryotherapy for Retinopathy of Prematurity Cooperative Group. Ophthalmology 1991; 98: 1628-40.
  • Brown MS, Baron AE, France EK, Hamman RF. Association between higher cumulative doses of recombinant erythropoietin and risk for retinopathy of prematurity. J AAPOS 2006; 10: 143-9.
  • Blair BM, O’halloran HS, Pauly TH, Stevens JL. Decreased incidence of retinopathy of prematurity,1995-1997. J AAPOS 2001; 5: 118-22.
  • Mathew MR, Fern AI, Hill R. Retinopathy of prematurity: are we screening too many babies? Eye 2002; 16: 538-42.
  • Shah VA, Yeo CL, Ling YL, Ho LY. Incidence, risk factors of retinopathy of prematurity among very low irth weight infants in Singapore. Ann Acad Med Singapore 2005; 34: 169-78.
  • Phan MH, Nguyen PN, Reynolds JD. Incidence and severity of retinopathy of prematurity in Vietnam a developing middle-income country. J Pediatr Ophthalmol Strabismus 2003; 40: 208-12.
  • Parsson E, Carle-Petrelius B, Cernerud G, Ots L, Wallin A, Holmstrom G. Incidence of ROP in two consecutive Swedish population based studies. Br J Ophthalmol 2002; 86: 1122-6.
  • Mayet I, Cockinos C. Retinopathy of prematurity in South Africans at a tertiary hospital: a prospective study. Eye (Lond) 2006; 20: 29-31.
  • Delport SD, Swanepoel JC, Odendaal PJ, Roux P. Incidence of retinopathy of prematurity in very-lowbirth-weight infants born at Kalafong Hospital, Pretoria. S Afr Med J 2002; 92: 986-90.
  • Yanovitch TL, Siatkowski RM, McCaffree M, CorffKE. Retinopathy of prematurity in infants with birth weight>or=1250 grams-incidence, severity, and screening guideline cost-analysis. J AAPOS 2006; 10: 128-34.
  • Mutlu FM, Altınsoy Hİ, Mumcuoğlu T, et al. Frequency and risk factor analysis for retinopathy of prematurity: a multivariate statistical analysis. J Pediatr Ophthalmol Strabismus 2008; 45 (8).
  • United Nations Development Programme (UNDP). Human Development Report, 2004. http://hdr.undp.org/reports (last accessed November 22, 2006).
  • Early Treatment for Retinopathy of Prematurity Cooperative Group. Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthalmol 2003; 121: 1684-96.
  • Good WV, Hardy RJ, Dobson V, et al. The incidence and course of retinopathy of prematurity: findings from the early treatment for retinopathy of prematurity study. Pediatrics 2005; 116: 15-23.

Bir devlet hastanesinde çok düşük doğum ağırlıklı yenidoğanlarda hastalık ve ölüm oranları

Yıl 2011, , 44 - 50, 01.06.2011

Yekta Canbak İbrahim Şilfeler Bayram Ali Dorum Hilal Kurnaz Sevil Dorum

https://doi.org/10.4274/tpa.46.62

Öz

Amaç: Hastanemiz yenido¤an yo¤un bak›m birimindeki çok düflük do¤um a¤›rl›kl› hastalar›n hastal›k ve ölüm oranlar›n› belirlemek amac›yla hastalar geriye dönük olarak incelendi. Gereç ve

Yöntem: Hastanemiz yenido¤an yo¤un bak›m biriminde iki y›l içerisinde yatarak tedavi alan çok düflük do¤um a¤›rl›kl› erken do¤mufl bebekler aras›nda çal›flma ölçütlerine uyan 94 olgu çal›flmaya al›nd›. Bu olgular›n verileri (gebelik yafl›, do¤um tart›s›, perinatal risk etmenleri, hastanede yat›fl süreleri, sürfaktan tedavisi, mekanik ventilasyon uygulamalar›, s›k›nt›l› solunum sendromu (SSS), ventriküler içi kanama, periventriküler lökomalasi, nekrotizan enterokolit, kronik akci¤er hastal›¤› ve prematüre retinopatisi) kaydedilip istatistiksel incelemeleri yap›ld›.

Bulgular: Çal›flmam›zda çok düflük do¤um a¤›rl›kl› bebeklerde ölüm oran› %25,5 olarak bulundu. En s›k karfl›lafl›lan anneye ait risk etkenleri preeklampsi/eklampsi (%26,3) olup sonuçlar›m›z “NICHD Neonatal Network” grubunun verileri ile uyumluydu. Çal›flmam›zda grup1’de SSS oran› %100, grup 2’de %93,8, grup 3’te %78,3 ve grup 4’te ise %47,6 olup SSS (+) ve SSS (-) gruplar›n›n cinsiyet da¤›l›mlar› aras›nda istatistiksel olarak anlaml› farkl›l›k gözlenmedi (p=0,19). Ancak erkek bebeklerde SSS (+) olas›l›¤› k›z bebeklerden 1,81 (0,74-4,42) kat riskli bulundu.

Çıkarımlar: Birimimizde % 25,5 olarak belirledi¤imiz ölüm oran›n›n do¤um öncesi bak›m flartlar›n›n düzeltilmesi, steroid kullan›m›n›n artmas›, do¤um öncesi bak›m eksikli¤i nedeniyle s›k karfl›laflt›¤›m›z erken yenido¤an enfeksiyonlar›n azalmas› ve nakil koflullar›n›n düzeltilmesi ile daha iyiye gidece¤i kan›s›nday›z. 

Anahtar Kelimeler

Çok düşük doğum ağırlığı erken doğum hastalık ölüm oranı yenidoğan

Kaynakça

  • Lawn JE, Cousens, Bhutta ZA, et al. Why are 4 million newborn babies dying each year? Lancet 2004; 364: 399-401.
  • Dogramaci İ. yenidoğan ölümleri. Yurdakök M, Erdem G (edt) Türk Neonatoloji Derneği. Neonatoloji, 2003; 3-5.
  • Horbar JD, Badger GJ, Carpenter JH, et al. Trends in mortality and morbidity for very low birth weight infants, 1991- 1999. Pediatrics 2002; 110: 143-51.
  • Horbar JD, Wright EC, Onstad L. Decreasing mortality associated with the introduction of surfactant therapy: an observational study of neonates weighing 601-1300 grams at birth. Pediatrics 1993; 92: 191-6.
  • Jobe AH. Pulmonary surfactant therapy. N Engl J Med 1993; 328: 861-8.
  • Horbar JD, Wright LL, Soll RF, et al. A multicenter randomized trial comparing two surfactants for the treatment of neonatal respiratory distress syndrome. National Institute of Child Health and Human Development Neonatal Research Network. J Pediatr 1993; 123: 757-66.
  • NIH Consensus Development Panel on the Effect of Corticosteroids for Fetal Maturation on Perinatal Outcomes. Effect of corticosteroids for fetal maturation on perinatal outcomes. JAMA 1995; 273: 413-8.
  • Greenough A, Milner AD, Dimitriou G. Prendergast M. Synchronized mechanical ventilation for respiratory support in newborn infants. Cochrane Database Syst Rev 2001; 1: CD000456.
  • Cools F, Henderson-Smart DJ, Offringa M, Askie LM. Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants. Cochrane Database Syst Rev 2009; 8: CD000104.
  • Stewart AL, Reynolds EO, Lipscomb AP. Outcome for infants of very low birthweight: survey of world literature. Lancet 1981; 1: 1038-40.
  • Lagercrantz H, Katz-Salamon M, Forssberg H. The Stockholm neonatal project: Neonatal mortality and morbidity at the Children’s Centre, Karolinska Hospital. Acta Paediatr Suppl 1997; 419: 11-5.
  • Stoll BJ, Kliegman RM. The Fetus and the Neonatal Infant. In: Behrman RE, Kliegman RM, Jenson HB (eds). Nelson Textbook of Pediatrics. 17th ed. Philadelphia: W.B. Saunders Company 2003; 519-640.
  • Ballard JL, Novak KK, Driver M. A simplified score for assesment of fetal malnutrition of newly born infants. J Pediatr 1979; 95: 769-74.
  • Ballard JL, Khoury JC, Wedig K, Wang L, Eilers-Walsman BL, Lipp R. New Ballard Score, expanded to include extremely premature infants. J Pediatr 1991; 119: 417-23.
  • Lubchenco LO, Hansman C, Dressler M, Boyd H. Intrauterin growth as estimated from liveborn birtweight data at 24-42 weeks of gestation. Pediatrics 1963; 32: 793-800.
  • A national study of risk factors associated with mortality in very low birthweight infants in the Malaysian neonatal intensive care units. Malaysian Very Low Birth Weight Study Group. J Peaditr Child Health 1997; 33: 18-25.
  • Hack M, Horbar JD, Malloy MH, Tyson JE, Wright E, Wright L. Very low birth weight outcomes of the National Institute of Child Health and Human Developmental Neonatal Network. Pediatrics 1991; 87: 587-97.
  • Atasay B, Günlemez A, Ünal S, Arsan S. Outcomes of very low birth weight infants in a newborn tertiary center in Turkey, 1997-2000. Turk J Pediatr 2003; 45: 283-9.
  • Türkiye’de yenidoğan bakım ünitelerinde mortalite oranları 2007. Türk Neonatoloji Derneği Bülteni 2008; 17: 15-9.
  • Türkiye’de yenidoğan bakım ünitelerinde mortalite oranları 2004. Türk Neonatoloji Derneği Bülteni 2004; 10: 10-4.
  • Duman N, Kumral A, Gulcan H, Ozkan H. Outcome of very-low-birth-weight infants in a developing country: a prospective study from the western region of Turkey. J Matern Fetal Neonatal Med 2003; 13: 54-8.
  • Greenough A, Roberton NRC. Respiratory Distres Syndrome. In: Neonatal Respiratory Disorders. Greenough A, Milner AD, Roberton NRC (eds). 1st Ed. London: Arnold, The Hodder Headline Group, 1996; 238-79.
  • Rodriguez RJ, Martin RJ, Fanaroff AA. Respiratory Distres Syndrome and its Management. In: Fanaroff AA, Martin RJ (eds). Neonatal-Perinatal Medicine. 7th ed. St. Louis: Mosby 2002; 1001-11.
  • Davis MJ, Rosenfeld WN. Chronic Lung Disease. In: Avery GB, Fletcher AM, Macdonald MG (eds). Neonatology Pathophysiology and management of the Newborn. 5th ed. Philadelphia: Lippincott Williams and Wilkıns, 1999; 509-31.
  • Lemons JA, Bauer CR, Oh W, et al. Very low birth weight outcomes of the national instuitude of child health and human development, neonatal research network, January 1995 through December 1996. Pediatrics 2001; 107:1.
  • Köksal N, Baytan B, Bayram Y, Nacarküçük E. Risk factors for intraventricular hemorrage in very low birth weight infants. Indian J Pediatr 2002; 69: 561-4.
  • Wilson R, Kanto WP Jr, McCarthy BJ, et al. Epidemiologic characteristics of necrotizing enterocolitis: a population-based study. Am J Epidemiol 1981; 114: 880-7.
  • Lee SK, McMillan DD, Ohlsson A, et al. Variations in practice and outcomes in the Canadian NICU Network: 996–1997. Pediatrics 2000; 106: 1070-9.
  • Palmer EA, Flynn JT, Hardy RJ, et al. Incidence and early course of retinopathy of prematurity. The Cryotherapy for Retinopathy of Prematurity Cooperative Group. Ophthalmology 1991; 98: 1628-40.
  • Brown MS, Baron AE, France EK, Hamman RF. Association between higher cumulative doses of recombinant erythropoietin and risk for retinopathy of prematurity. J AAPOS 2006; 10: 143-9.
  • Blair BM, O’halloran HS, Pauly TH, Stevens JL. Decreased incidence of retinopathy of prematurity,1995-1997. J AAPOS 2001; 5: 118-22.
  • Mathew MR, Fern AI, Hill R. Retinopathy of prematurity: are we screening too many babies? Eye 2002; 16: 538-42.
  • Shah VA, Yeo CL, Ling YL, Ho LY. Incidence, risk factors of retinopathy of prematurity among very low irth weight infants in Singapore. Ann Acad Med Singapore 2005; 34: 169-78.
  • Phan MH, Nguyen PN, Reynolds JD. Incidence and severity of retinopathy of prematurity in Vietnam a developing middle-income country. J Pediatr Ophthalmol Strabismus 2003; 40: 208-12.
  • Parsson E, Carle-Petrelius B, Cernerud G, Ots L, Wallin A, Holmstrom G. Incidence of ROP in two consecutive Swedish population based studies. Br J Ophthalmol 2002; 86: 1122-6.
  • Mayet I, Cockinos C. Retinopathy of prematurity in South Africans at a tertiary hospital: a prospective study. Eye (Lond) 2006; 20: 29-31.
  • Delport SD, Swanepoel JC, Odendaal PJ, Roux P. Incidence of retinopathy of prematurity in very-lowbirth-weight infants born at Kalafong Hospital, Pretoria. S Afr Med J 2002; 92: 986-90.
  • Yanovitch TL, Siatkowski RM, McCaffree M, CorffKE. Retinopathy of prematurity in infants with birth weight>or=1250 grams-incidence, severity, and screening guideline cost-analysis. J AAPOS 2006; 10: 128-34.
  • Mutlu FM, Altınsoy Hİ, Mumcuoğlu T, et al. Frequency and risk factor analysis for retinopathy of prematurity: a multivariate statistical analysis. J Pediatr Ophthalmol Strabismus 2008; 45 (8).
  • United Nations Development Programme (UNDP). Human Development Report, 2004. http://hdr.undp.org/reports (last accessed November 22, 2006).
  • Early Treatment for Retinopathy of Prematurity Cooperative Group. Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthalmol 2003; 121: 1684-96.
  • Good WV, Hardy RJ, Dobson V, et al. The incidence and course of retinopathy of prematurity: findings from the early treatment for retinopathy of prematurity study. Pediatrics 2005; 116: 15-23.
Toplam 42 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Orijinal Makale
Yazarlar

Yekta Canbak Bu kişi benim

İbrahim Şilfeler Bu kişi benim

Bayram Ali Dorum Bu kişi benim

Hilal Kurnaz Bu kişi benim

Sevil Dorum Bu kişi benim

Yayımlanma Tarihi 1 Haziran 2011
Yayımlandığı Sayı Yıl 2011

Kaynak Göster

APA Canbak, Y., Şilfeler, İ., Dorum, B. A., Kurnaz, H., vd. (2011). Bir devlet hastanesinde çok düşük doğum ağırlıklı yenidoğanlarda hastalık ve ölüm oranları. Türk Pediatri Arşivi, 46(2), 44-50. https://doi.org/10.4274/tpa.46.62
AMA Canbak Y, Şilfeler İ, Dorum BA, Kurnaz H, Dorum S. Bir devlet hastanesinde çok düşük doğum ağırlıklı yenidoğanlarda hastalık ve ölüm oranları. Türk Pediatri Arşivi. Haziran 2011;46(2):44-50. doi:10.4274/tpa.46.62
Chicago Canbak, Yekta, İbrahim Şilfeler, Bayram Ali Dorum, Hilal Kurnaz, ve Sevil Dorum. “Bir Devlet Hastanesinde çok düşük doğum ağırlıklı yenidoğanlarda hastalık Ve ölüm Oranları”. Türk Pediatri Arşivi 46, sy. 2 (Haziran 2011): 44-50. https://doi.org/10.4274/tpa.46.62.
EndNote Canbak Y, Şilfeler İ, Dorum BA, Kurnaz H, Dorum S (01 Haziran 2011) Bir devlet hastanesinde çok düşük doğum ağırlıklı yenidoğanlarda hastalık ve ölüm oranları. Türk Pediatri Arşivi 46 2 44–50.
IEEE Y. Canbak, İ. Şilfeler, B. A. Dorum, H. Kurnaz, ve S. Dorum, “Bir devlet hastanesinde çok düşük doğum ağırlıklı yenidoğanlarda hastalık ve ölüm oranları”, Türk Pediatri Arşivi, c. 46, sy. 2, ss. 44–50, 2011, doi: 10.4274/tpa.46.62.
ISNAD Canbak, Yekta vd. “Bir Devlet Hastanesinde çok düşük doğum ağırlıklı yenidoğanlarda hastalık Ve ölüm Oranları”. Türk Pediatri Arşivi 46/2 (Haziran 2011), 44-50. https://doi.org/10.4274/tpa.46.62.
JAMA Canbak Y, Şilfeler İ, Dorum BA, Kurnaz H, Dorum S. Bir devlet hastanesinde çok düşük doğum ağırlıklı yenidoğanlarda hastalık ve ölüm oranları. Türk Pediatri Arşivi. 2011;46:44–50.
MLA Canbak, Yekta vd. “Bir Devlet Hastanesinde çok düşük doğum ağırlıklı yenidoğanlarda hastalık Ve ölüm Oranları”. Türk Pediatri Arşivi, c. 46, sy. 2, 2011, ss. 44-50, doi:10.4274/tpa.46.62.
Vancouver Canbak Y, Şilfeler İ, Dorum BA, Kurnaz H, Dorum S. Bir devlet hastanesinde çok düşük doğum ağırlıklı yenidoğanlarda hastalık ve ölüm oranları. Türk Pediatri Arşivi. 2011;46(2):44-50.