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Abstract

Malpractice has gained an alarming dimension especially along with the introduction of compulsory professional liability insurance On the other hand it is quite difficult to say that malpractice is discussed by considering all responsible determinants According to individual focused approach the error is caused by single individual so the solution can be achieved by punishing the individual It is known that this approach does not reduce errors and adversely affect services due to high compensations and increased insurance premiums In Turkey malpractice is simply considered in the customer seller relationship context and individual focused approach is adopted However it is well established that this ldquo;blame culture rdquo; has negative effects on service provided social perception of the profession and job satisfaction Beside recognizing individual professional responsibilities basically it should be stressed that declaring healthcare workers as mainly responsible would not be fair In addition it violates right to health because of increasing the preventable errors and harms Turk Arch Ped 2011; 46: 6 11

Keywords

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Hipoksik iskemik beyin hasarı oluşturulan yenidoğan sıçanlarda ABT 491 uygulamasının görsel uyarılma potansiyelleri üzerine etkileri Özgün Araştırma

Öz

Özet Amaç: Bu çalışmada hipoksik iskemik beyin hasarı HİBH oluşturulan sıçanlara ABT 491 uygulanmasının görsel uyarılma potansiyelleri GUP üzerine olan etkilerinin araştırılması amaçlandı Gereç ve Yöntem: Çalışmada 57 tane Wistar cinsi yenidoğan erkek sıçan kullanıldı Sıçanlar rastgele olarak üç gruba ayrıldıktan sonra 1 n=18 ve 2 grupta n=20 doğum sonrası yedinci günde değiştirilmiş Levine Rice örneğine göre HİBH oluşturuldu Üçüncü grup n=19 sham grubu olarak ayrıldı Hipoksik iskemik beyin hasarı sonrasında 1 gruptaki sıçanlara periton içine ABT 491 2 gruptakilere ise serum fizyolojik SF uygulandı Sıçanlar 16 haftalık olduklarında oksipital bölgeye yerleştirilen Ag AgCl disk elektrot aracılığıyla GUP rsquo;ları kaydedildi Bulgular: ABT grubunda P3 dalga süreleri SF grubuna göre daha kısa bulundu p lt;0 05 Sham grubu ile karşılaştırıldığında ABT ve SF gruplarında tepeden tepeye P2 N2 ve N2 P3 dalga genlikleri daha küçüktü tüm ikili karşılaştırmalar için p lt;0 001 Çıkarımlar: Hipoksik iskemik beyin hasarının GUP yanıtlarının genliklerinde azalmaya neden olduğu ve bu azalmanın ABT 491 ile düzeltilemediği; buna karşılık HİBH sonrası ABT 491 uygulamasının P3 dalga sürelerindeki kısalmayı düzelttiği söylenebilir Türk Ped Arş 2010; 45: 319 23 Anahtar sözcükler: ABT 491 apopitoz hipoksik iskemik beyin hasarı görsel uyarılma potansiyeli PAF

Anahtar Kelimeler

• ABT-491, apopitoz, hipoksik iskemik beyin hasarı, görsel uyarılma potansiyeli, PAF

Kaynakça

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