Anticardiolipin antibodies in children with portal vein thrombosis Original Article

Yıl 2009, Cilt: 44 Sayı: 4, - , 01.12.2009

E. Mahir Gülcan Tufan Kutlu Tülay Erkan Fügen Çokuğraş

https://izlik.org/JA38WP82FF

Öz

Aim: The aim of this study was to evaluate the frequency of anticardiolipin antibodies in children with portal vein thrombosis and nbsp; whether anticardiolipin antibodies have effect on thrombosis in the portal vein Material and Method: IgG and IgM anticardiolipin levels were measured in 20 patients with portal vein thrombosis and in 20 healthy controls using an ELISA method nbsp; nbsp; Results: IgG anticardiolipin nbsp; levels GPL unit were found as 13 9±4 8 in the portal vein thrombosis patients and 4 4±1 9 in the control group p lt;0 05 and IgM anticardiolipin levels MPL unit were found as 10 4±5 9 in the portal vein thrombosis patients and in 10 4±0 8 in the nbsp; control group p gt;0 05 In seven 35 portal vein thrombosis patients and in one 5 in the control group anticardiolipin IgG p lt;0 05 and in two portal vein thrombosis patients 10 and in two in the control group 10 anticardiolipin IgM p gt;0 05 levels were high gt;10 GPL and MPL unit Conclusions: IgG anticardiolipin antibodies are significantly associated with portal vein thrombosis in children Turk Arch Ped 2009; 44: 124 6 Key words: Anticardiolipin antibodies child portal vein thrombosis

Anahtar Kelimeler

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Portal ven trombozlu çocuklarda antikardiyolipin antikorları Orijinal Araştırma

https://izlik.org/JA38WP82FF

Öz

Amaç: Portal ven trombozlu çocuklarda antikardiyolipin antikorlarının sıklığının ve portal vendeki tromboz üzerine etkisinin olup olmadığının araştırılması nbsp; Gereç ve Yöntem: Bu ileriye dönük çalışmaya portal ven trombozlu 20 ve kontrol grubu olarak sağlıklı 20 çocuk alındı Antikardiyolipin IgM ve IgG ölçümleri ELISA yöntemi kullanılarak yapıldı Bulgular: Portal ven trombozlu hastalarda antikardiyolipin IgG düzeyleri 13 9±4 8 GPL ünitesi kontrol grubunda 4 4±1 9 GPL ünitesi p lt;0 05 ; antikardiyolipin IgM düzeyleri portal ven trombozlu hastalarda 10 4±5 9 MPL ünitesi kontrol grubunda 10 4±0 8 MPL ünitesi nbsp; p gt;0 05 bulundu Portal ven trombozlu hastaların yedisinde 35 kontrol grubununun birinde 5 antikardiyolipin IgG p lt;0 05 ve portal ven trombozlu hastaların ikisinde 10 kontrol gurubunun ikisinde 10 antikardiyolipin IgM p gt;0 05 yüksekti gt;10 GPL ve MPL ünitesi nbsp;Çıkarımlar: Çocuklarda antikardiyolipin IgG portal ven trombozu ile anlamlı ilişkilidir nbsp; Türk Ped Arş 2009; 44: 124 6 Anahtar kelimeler: Antikardiyolipin antikorları çocuk portal ven trombozu nbsp;

Anahtar Kelimeler

Antikardiyolipin antikorları , çocuk , portal ven trombozu

Kaynakça

• Male C, Lechner K, Eichinger S, et al. Clinical significance of lupus anticoagulants in children. J Pediatr 1999; 134: 199-205. (Abstract) / (Full Text) / (PDF)
• Angelini L, Ravelli A, Caporali R, Rumi V, Nardocci N, Martini A. High prevalence of antibodies in children with idiopatic cerebral ischemia. Pediatrics 1994; 94: 500-3. (Abstract)
• Brady L, Magilavy D, Black D. Portal vein thrombosis associ- ated with antiphospholipid antibodies in a child. J Pediatr Gastroenterol Nutr 1996; 23: 470-3. (Abstract)
• Love PE, Santoro SA. Antiphospholipid antibodies: anticardi- olipin and the lupus anticoagulant in systemic lupus erythemato- sus (SLE) and in non-SLE disorders. Prevalence and clinical sig- nificance. Ann Intern Med 1990; 112: 682-98. (Abstract) / (PDF)
• Ravelli A, Caporali R, Di Fuccia G, Zonta L, Montecucco C, Martini A. Anticardiolipin antibodies in pediatric systemic lupus erythematosus. Arch Pediatr Adolesc Med 1994; 148: 398-402. (Abstract) / (PDF)
• Saca LF, Szer IS, Henar E, Nanjundiah P, Haddad ZH, Quismorio FP Jr. Budd-Chiari syndrome associated with antiphospholipid antibodies in a child: report of a case and review of the literature. J Rheumatol 1994; 21: 545-8. (Abstract)
• Bernstein ML, Salusinsky-Sternbach M, Bellefleur M, Esseltine DW. Thrombotic and hemorrhage complications in children with lupus anticoagulant. Am J Dis Child 1984; 138: 1132-5. (Abstract)
• Dubuisson C, Boyer-Neumann C, Wolf M, Meyer D, Bernard O. Protein C, protein S and antithrombin III in children with portal vein obstruction. J Hepatol 1997; 27: 132-5. (Abstract) / (PDF)
• Egesel T, Ünsal İ, Bayraktar Y. Antiphospholipid antibodies and lipoprotein (a) as etiologic or contributory factors in patients with idiopatic cavernous transformation of portal vein. Turk J Gastroenterol 2002; 13: 89-93. (Abstract) / (Full Text) / (PDF)
• Baran M, Yüksekkaya HA, Çakır M, et al. Çocuklarda poshepatik portal hipertansiyon. Çocuk Sağlığı Hast Derg 2008; 51: 75-80. (Abstract) / (Full Text) / (PDF)
• Abd El-Hamid N, Taylor RM, Marinello D, et al. Aetiology and management of extrahepatik portal vein obstruction in children: King’s Collage Hospital Experience. J Pediatr Gastroenterol Nutr 2008; 47: 630-4. (Abstract)
• Font J, Cervera R, Lopez-Soto A, et al. Anticardiolipin antibodies in patients with autoimmune diseases: isotype distribution and clinical associations. Clin Rheumatol 1989; 8: 475-83. (Abstract)
• Kushner M, Simonian N. Lupus anticoagulant, anticardiolipin antibodies, and serebral iskemi. Stroke 1989; 20: 225:9.
• Cronin ME, Biswas RM, Van der Straeton C, Fleisher TA, Klippel JH. IgG and IgM anticardiolipin antibodies in patients with lupus and anticardiolipin antibody associated clinical syn- dromes. J Rheumatol 1988; 15: 795-8. (Abstract)
• Lee HJ, Park JW, Chang JC. Mesenteric and portal venous obstruc- tion associated with primary antiphospholipid antibody syndrome. J Gastroenterol Hepatol 1997; 12: 822-6. (Abstract) / (PDF)
• Fourcade L, De Pina JJ, Debonne JM, et al. Mesenteric venous thrombosis and antiphospholipid syndrome. Apropos of a case. Ann Med Interne 1995; 146: 278-80.
• Pellettier S, Landi B, Piette JC, et al. The antiphospholipid syndrome as a second cause of non-malignant Budd-Chiari syndrome. Arthritis Rheum 1992; 35: 238.
• van Spronsen FJ, de Langen ZJ, van Elburg RM, Kimpen JL. Appendicitis in an eleven-year-old boy complicated by throm- bosis of the portal and superior mesenteric veins. Pediatr Infect Dis J 1996; 15: 910-2.
• Yachha SK, Aggarwal R, Sharma BC, Misra RN, Aggarwal A, Naik SR. Functional protein C and anti-cardiolipin antibody in children with portal vein thrombosis. Indian J Gastroenterol 2001; 20: 47-9. (Abstract)
• Pati HP, Srivastava A, Sahni P. Extra hepatic portal vein thrombosis in a child associated with lupus anticoagulant. J Trop Pediatr 2003; 49: 191-2. (Abstract) / (PDF)