Değişik hastalık gruplarında trombosit hacim değişkenleri Orijinal Araştırma

Öz

Amaç: Değişik hastalıklarda trombosit hacim değişkenlerinin ortalama trombosit hacimi [MPV] trombosit dağılım aralığı [PDW] değerlerini belirlemek istedik Bu şekilde doğrudan kemik iliğinden kaynaklanan hastalıkların; tanı sırasında birbirleriyle ayırıcı tanısının sağlanması ve sistemik hastalıkların trombositler üzerine etkileri belirlenmek istenildi Gereç ve Yöntem: Üç yıllık sürede kliniğimizde takip edilen 452 akut veya kronik olgunun kayıtları geriye dönük olarak incelendi Olgular kan hastalıkları sistemik hastalıklar ve entoksikasyonlar olarak üç gruba ayrıldı Bulgular: Çalışmaya alınan 452 hastanın 245 i 54 erkek 207 si 46 kız idi Hastaların yaş ortalaması 87 1±58 2 1 216 ay idi MPV değeri kan hastalıklarında 7 6±1 4 fl sistemik hastalıklardan kalp hastalıklarında 7 8±1 1 fl böbrek hastalıklarında 7 2±1 0 fl endokrin hastalıklarda 8 2±1 4 fl alerjik hastalıklarda 6 7±0 4 fl ve entoksikasyonda 7 8±1 5 fl olarak saptandı MPV açısından gruplar arasında istatistiksel anlamlı fark yoktu p gt;0 05 PDW değeri kan hastalıklarında 14 6±3 1 fl sistemik hastalıklardan kalp hastalıklarında 17 6±4 0 fl böbrek hastalıklarında 17 8±5 7 fl endokrin hastalıklarda 16 4±1 8 fl alerjik hastalıklarda 15 9±0 5 fl ve entoksikasyonda 16 9±0 6 fl olarak saptandı PDW değerleri açısından kan hastalıkları ve sistemik hastalıklar arasında kan hastalıkları ve entoksikasyonlar arasında nbsp; istatistiksel anlamlı fark vardı p lt;0 05 Çıkarımlar: Özellikle kan hastalıklarında hasta sayısının daha fazla olduğu gruplarda trombosit hacim değişkenlerinin değerlendirileceği ilave çalışmalara ihtiyaç vardır Trombositlere ait PDW değerinin ayırıcı tanıda daha önemli olduğu dikkati çekmektedir nbsp; Anahtar kelimeler: klinik hastalıklar ortalama trombosit hacmi trombosit dağılım aralığı trombosit hacim değişkenleri

Anahtar Kelimeler

• klinik hastalıklar, ortalama trombosit hacmi, trombosit dağılım aralığı, trombosit hacim değişkenleri

Thrombocyte volume parameters in different disease groups Original Article

Öz

Aim: We aimed to determine the values of thrombocyte volume parameters mean platelet volume MPV platelet distribution width PDW in different diseases In this way we aimed to ensure differential diagnosis in the diseases directly caused by bone marrow during the diagnosis process and to determine the effects of the systemic diseases on thrombocytes Material and Method: The records of 452 acute or chronic cases who have been followed in our clinic for three years were reviewed retrospectively The cases were divided into three groups as hematological diseases systemic diseases and intoxications Results: Of the 452 patients taken into this study 245 54 were boys 207 46 were girls The medium nbsp; age of the patients was 87 1±58 2 1 216 months The MPV values were determined to be as 7 6±1 4 7 8±1 1 7 2±1 0 8 2±1 4 6 7±0 4 and 7 8±1 5 fl in hematological cardiac nephrological endocrinological allergic diseases and intoxications respectively There was not a significant difference among the groups for MPV p 0 05 PDW value was determined to be as 14 6±3 1 17 6±4 0 17 8±5 7 16 4±1 8 15 9±0 5 and 16 9±0 6 fl in hematological cardiac nephrological endocrinological allergic diseases and nbsp; intoxications respectively There were significant statistical differences for PDW values between hematological and systemic diseases nbsp; or intoxications p 0 05 Conclusions: Additional studies those include higher number of patients and those evaluate PDW values especially in hematological diseases might require It is a remarkable fact that PDW values of thrombocytes is very important in differential diagnosis Key words: clinical disorders mean platelet volume platelet distribution width platelet volume parameters

Anahtar Kelimeler

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Kaynakça

1. Tong M, Seth P, Penington DG. Proplatelets and stress platelets. Blood 1987; 69: 522- 8.
2. Thompson CB, Jakubowski JA. The pathophysiology and clinical relevance of platelet heterogenity. Blood 1988; 72: 1- 8.
3. Holme S, Simmonds M, Ballek R, Murphy S. Comparative measurements of platelet size by coulter counter microscopy of blood smears, and light transmission studies. Relationship between platelet size and shape. J Lab Clin Med 1981; 97: 610- 22.
4. Disorders of platelet size. In: Philip Lanzkowsky (ed). Manual of Pediatric Hematology and Oncology. Third Edition. Boston: Acedemic Press 2000; 233- 85.
5. Nelson RB, Kehl D. Electronically determined platelet indices in trombocytopenic patients. Cancer 1981; 48: 954- 6.
6. Tomita E, Akatsuka J, Kokubun Y. Differential diagnosis of various thrombocytopenias in childhood by analysis of platelet volume. Pediatr Res 1980; 14: 133- 7. 1.
7. Wilson DB. Acquired platelet defects. In: Nathan DG, Orkin
8. SH, Ginsburg D, Look AT (eds). Nathan and Oski's Hematology

9. of Infancy and Childhood. Philadelphia: WB Saunders Company, 2003; 1599- 600. 2.
10. Dow RB. The clinical and laboratory utility of platelet volume
11. parameters. Aust J Med Sci 1994; 15: 12- 5. 3.
12. Rowan RM. Platelet size distribution analysis: principles
13. techniques and potential clinical utility. Hematology Reviews 1986; 1: 109- 44. 4.
14. Kim KY, Kim KE, Kim KH. Mean platelet volume in the normal
15. state and in various clinical disorders. Yonsei Med J 1986; 27: 219- 26. 5.
16. Graham S, Traub B, Mink IB. Automated platelet-sizing parameters
17. on a normal population. Am J Clin Pathol 1987; 87: 365- 9. 6.
18. Bessman JD, Gilmer PR, Gardner FH. Use of mean platelet
19. volume improves detection of platelet disorders. Blood Cells 1985; 11: 127- 35. 7.
20. Trowbridge EA, Reardon DM, Hutchinson D, Pickering C.
21. The routine measurement of platelet volume: a comparison
22. of light-scattering and aperture-impedance technologies. Clin
23. Phys Physiol Meas 1985; 6:221- 38. 8.
24. Odell TT, Murphy JR, Jackson CW. Stimulation of megakar
25. yocytopoiesis by acute thrombocytopenia in rats. Blood 1976; 48: 765- 75. 9.
26. Gewirtz AM, Poncz M. Megakaryocytopoiesis and platelet
27. production. In: Hoffman R, Benz EJ, Shattil SJ, Bruce Furie,
28. Cohen HJ (eds). Hematology Basic Principles and Practice.
29. New York: Churchill Livingstone, 1991; 1148- 57.
30. Tong M, Seth P, Penington DG. Proplatelets and stress platelets. Blood 1987; 69: 522- 8.
31. Thompson CB, Jakubowski JA. The pathophysiology and clinical relevance of platelet heterogenity. Blood 1988; 72: 1- 8.
32. Holme S, Simmonds M, Ballek R, Murphy S. Comparative measurements of platelet size by coulter counter microscopy of blood smears, and light transmission studies. Relationship between platelet size and shape. J Lab Clin Med 1981; 97: 610- 22.
33. Disorders of platelet size. In: Philip Lanzkowsky (ed). Manual of Pediatric Hematology and Oncology. Third Edition. Boston: Acedemic Press 2000; 233- 85.
34. Nelson RB, Kehl D. Electronically determined platelet indices in trombocytopenic patients. Cancer 1981; 48: 954- 6.
35. Tomita E, Akatsuka J, Kokubun Y. Differential diagnosis of various thrombocytopenias in childhood by analysis of platelet volume. Pediatr Res 1980; 14: 133- 7. 1.
36. Wilson DB. Acquired platelet defects. In: Nathan DG, Orkin
37. SH, Ginsburg D, Look AT (eds). Nathan and Oski's Hematology
38. of Infancy and Childhood. Philadelphia: WB Saunders Company, 2003; 1599- 600. 2.
39. Dow RB. The clinical and laboratory utility of platelet volume
40. parameters. Aust J Med Sci 1994; 15: 12- 5. 3.
41. Rowan RM. Platelet size distribution analysis: principles
42. techniques and potential clinical utility. Hematology Reviews 1986; 1: 109- 44. 4.
43. Kim KY, Kim KE, Kim KH. Mean platelet volume in the normal
44. state and in various clinical disorders. Yonsei Med J 1986; 27: 219- 26. 5.
45. Graham S, Traub B, Mink IB. Automated platelet-sizing parameters
46. on a normal population. Am J Clin Pathol 1987; 87: 365- 9. 6.
47. Bessman JD, Gilmer PR, Gardner FH. Use of mean platelet
48. volume improves detection of platelet disorders. Blood Cells 1985; 11: 127- 35. 7.
49. Trowbridge EA, Reardon DM, Hutchinson D, Pickering C.
50. The routine measurement of platelet volume: a comparison
51. of light-scattering and aperture-impedance technologies. Clin
52. Phys Physiol Meas 1985; 6:221- 38. 8.
53. Odell TT, Murphy JR, Jackson CW. Stimulation of megakar
54. yocytopoiesis by acute thrombocytopenia in rats. Blood 1976; 48: 765- 75. 9.
55. Gewirtz AM, Poncz M. Megakaryocytopoiesis and platelet
56. production. In: Hoffman R, Benz EJ, Shattil SJ, Bruce Furie,
57. Cohen HJ (eds). Hematology Basic Principles and Practice.
58. New York: Churchill Livingstone, 1991; 1148- 57.
59. Tong M, Seth P, Penington DG. Proplatelets and stress platelets. Blood 1987; 69: 522- 8.
60. Thompson CB, Jakubowski JA. The pathophysiology and clinical relevance of platelet heterogenity. Blood 1988; 72: 1- 8.
61. Holme S, Simmonds M, Ballek R, Murphy S. Comparative measurements of platelet size by coulter counter microscopy of blood smears, and light transmission studies. Relationship between platelet size and shape. J Lab Clin Med 1981; 97: 610- 22.
62. Disorders of platelet size. In: Philip Lanzkowsky (ed). Manual of Pediatric Hematology and Oncology. Third Edition. Boston: Acedemic Press 2000; 233- 85.
63. Nelson RB, Kehl D. Electronically determined platelet indices in trombocytopenic patients. Cancer 1981; 48: 954- 6.
64. Tomita E, Akatsuka J, Kokubun Y. Differential diagnosis of various thrombocytopenias in childhood by analysis of platelet volume. Pediatr Res 1980; 14: 133- 7.