Landau Kleffner syndrome: two cases report Case Report

Yıl 2008, Cilt: 43 Sayı: 2, 65 - 68, 01.06.2008

Faruk İncecik M. Özlem Hergüner Şakir Altunbaşak

Öz

Landau Kleffner syndrome LKS or acquired epileptic aphasia is an acquired aphasia in children showing normal language and motor development Although its treatment is not standardized till now valproic acid VPA high dose methyl prednisolone adrenocorticotropic hormone intravenous immunoglobulin IVIG clobazam sulthiam levatiracetam and surgical treatment multiple subpial transections were used and successful results were reported We just administered high doses of methyl prednisolone to our five and eight years old two cases of Landau Kleffner syndrome as we couldn’t recieve response to valproic acid in addition to intravenous immungloubulın treatment However of the cases who received high dose methyl prednisolone showed clinical and elektroencephalographical improvement Turk Arch Ped 2008; 43: 65 8 Key words: Epilepsy Landau Kleffner syndrome treatment

Anahtar Kelimeler

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Landau Kleffner sendromu: İki olgu sunumu Olgu Sunumu

Öz

Landau Kleffner sendromu veya edinsel epileptik konuşamama afazi normal dil ve motor gelişimi gösteren çocuklarda ortaya çıkan kazanılmış bir konuşamama halidir Henüz bilinen bir tedavisi olmamasına rağmen şimdiye kadar valproik asit yüksek doz metil prednizolon adrenokortikotropin hormon damar içi immünglobülin klobazam sultiyam levatirasetam ve cerrahi tedavi mutiple subpial transection kullanılmış ve başarılı sonuçlar bildirilmiştir Biz de beş ve sekiz yaşında Landau Kleffner sendromu tanısı konulan iki olgumuza valproik asit ile birlikte önce damar içi immünglobülin yanıt alamadığımız için sonra yüksek doz metil prednizolon uyguladık Damar içi immünglobülin tedavisine iki olgumuzda da yanıt alamadık Ancak yüksek doz metil prednizolon uyguladığımız olgularımızdan birisinde hem klinik hem de elektroansefalogram bulgularında düzelme saptadık Türk Ped Arş 2008; 43: 65 8 Anahtar kelimeler: Epilepsi Landau Kleffner sendromu tedavi

Anahtar Kelimeler

Epilepsi, Landau-Kleffner sendromu, tedavi

Kaynakça

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