The significance of leptin and homocysteine levels in the pediatric patients with portal hypertension and their relation with antropometric parameters Original Investigation

Yıl 2007, Cilt: 42 Sayı: 1, 17 - 23, 01.03.2007

Mesut Aydoğdu Tülay Erkan Hafize Uzun Seval Aydın Yaşar Doğan Fügen Çokuğraş Tufan Kutlu E. Mahir Gülcan Ethem Erginöz Osman Şenyüz

Öz

Aim: To measure leptin and homocysteine levels in serum of pediatric patients with portal hypertension in order to assess their role in the development of hemodynamic and nutritional changes Material and Method: Twenth four patients with intrahepatic portal hypertension IHPH ten patients with extrahepatic portal hypertension EHPH and twenty healthy children as control group were evaluated by anthropometric measurements; height height Z score weight weight Z score weight to height weight to age body mass index BMI mid arm circumference MAC and triceps skinfold thickness TSF Serum levels of leptin homocystein B12 vitamin and folic acid in all cases and serum levels of homocysteine in patients after methionin loading were measured B12 and folic acid levels were measured by RIA homocystein and leptin levels were measured by ELISA Results: No statistically significant difference was found between the three groups according to sex folic acid and nbsp; B12 nbsp; nbsp; vitamin levels but there was statistically significant difference in measurements of height height Z score weight weight Z score weight to height weight to age BMI MAC TSF leptin and fasting homocysteine levels between the control and the IHPH groups Between the control and the EHPH groups there was only significant difference in measurements of leptin and fasting homocysteine levels No statistically significant difference was found between IHPH and EHPH according to levels of parameters Conclusions: As a result we observed malnutrition very frequently in both EHPH and IHPH groups and IHPH group was more severely affected according to nutritional values Serum homocysteine and leptin levels didn t significantly differ in between IHPH and EHPH groups These results suggest that homocysteine which plays an important role in the etiology of atherosclerosis doesn t play the same role in the etiology of portal hypertension Turk Arch Ped 2007; 42: 17 23 Key words: Homocysteine leptin malnutrition portal hypertension

Anahtar Kelimeler

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Portal hipertansiyonda serum leptin ve homosistein düzeylerinin anlamı ve antropometrik değişkenler ile ilişkisi Orijinal Araştırma

Öz

Amaç: Portal hipertansiyonlu PH hastalarda serum homosistein düzeyleri ile PH tipi ve serum leptin homosistein düzeyleri ile antropometrik ölçümleri arasında ilişkinin araştırılması Gereç ve Yöntem: Çalışmaya 10 u ekstrahepatik portal hipertansiyon EHPH 24 ü intrahepatik portal hipertansiyon İHPH tanılı 34 hasta ve 20 sağlıklı çocuk alındı Antropometrik ölçüm olarak boy boy Z skoru kilo kilo Z skoru boya göre kilo BGK yaşa göre kilo YGK vücut kitle indeksi VKİ kol çevresi KÇ triseps deri kıvrımı kalınlığına TDK bakıldı Tüm olgulardan leptin homosistein B12 ve folik asit düzeyleri ile hasta grubunda ayrıca metiyonin nbsp; yükleme sonrası homosistein düzeyi araştırıldı B12 nbsp; ve folik asit RIA kit homosistein ve leptin düzeyleri ELISA nbsp; kiti nbsp; ile çalışıldı Bulgular: Üç nbsp; grup arasında yaş cinsiyet folik asit ve B12 vitamini nbsp; düzeyi açısından istatistiksel olarak anlamlı fark saptanmadı Ancak kontrol ve İHPH grupları arasında boy boy Z skoru kilo kilo Z skoru BGK YGK VKİ KÇ TDK kalınlığı açlık homosistein düzeyi ve leptin değişkenleri açısından anlamlı fark vardı Bu anlamlılık kontrol grubu ile EHPH grubu arasında sadece leptin ve açlık homosistein düzeyinde idi EHPH ve İHPH arasında ise nbsp; değişkenlerin düzeyleri açısından anlamlı bir fark yoktu Çıkarımlar: Çalışmamızda hem EHPH hem de İHPH li hastalarda beslenme yetersizliği olmakla beraber İHPH li hastalar daha fazla etkilenmişti Leptin ve homosistein düzeyleri ise PH nin intrahepatik veya ekstrahepatik olmasına göre nbsp; farklılık göstermiyordu Dolayısıyla arteriyel tıkaç oluşumunda önemli bir etmen olan homosisteinin EHPH etiolojisinde aynı rolü oynamadığı görüşüne varıldı Türk Ped Arş 2007; 42: 17 23 Anahtar kelimeler: Beslenme bozukluğu homosistein leptin portal hipertansiyon

Anahtar Kelimeler

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Kaynakça

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