Investigation of favipravir side effects in the treatment of SARS COV2

Öz

The frightening speed at which the COVID-19 pandemic is spreading around the world has shown us how few antiviral drug options we have available. Currently, the COVID-19 pandemic is almost in its second year, and favipiravir is an important antiviral agent still used in the first line of treatment. It is thought that there is a need for more advanced studies on the use of SARS COV2, as this drug, which has recently had disagreements about its use, day by day. However, the literature information on the side effects of this drug is limited, and the frequency of side effects and the mechanism of action have not been fully explained. A study conducted in Japan found that approximately 20% of patients receiving low-dose favipiravir experienced side effects. Although with low frequency, hyperuricemia, diarrhea and neutropenia, and psychiatric symptoms and teratogenicity are mostly mentioned. The effect of favipiravir on corrected QT interval prolongation is still unclear. Overall, in fact, favipiravir has a good safety profile, as confirmed by a large systematic review. We aimed to contribute to this study by reviewing the side effects of favipiravir in the light of the literature due to a lot of information that is still unclear.

Anahtar Kelimeler

• SARS COV 2
• favipiravir
• COVID 19

SARS COV2 tedavisinde favipiravir yan etkilerinin araştırılması

Öz

COVID-19 pandemisinin dünyaya yayılma hızındaki korkutucu hız, bize mevcut antiviral ilaç seçeneklerimizin ne kadar az olduğunu gösterdi. Şu an COVID-19 pandemisi neredeyse ikinci yılını doldurmak üzeredir ve favipiravir tedavide ilk basamakta halen kullanılan önemli bir antiviral ajandır. Son dönemde, özellikle kullanımı konusunda fikir ayrılıkları yaşanan bu ilacın, gün geçtikçe, SARS CoV2 tedavisinde kullanımı hakkında daha çok çalışmaya ihtiyaç olduğu düşünülmektedir. Ancak literatürde, bu ilaç ile ilgili yan etki bilgileri sınırlı olup yan etki sıklığı ve etki mekanizması tam olarak açıklanamamıştır. Japonya’da yapılan bir çalışmada, düşük doz favipiravir alan hastaların yaklaşık %20'sinde yan etkilerin görüldüğü bulunmuştur. Seyrek olmakla birlikte en çok hiperürisemi, diyare, nötropeni ve psikiyatrik semptomlar ile teratojeniteden bahsedilmektedir. Favipiravirin düzeltilmiş QT mesafesi uzamasındaki etkisi ise hala belirsizdir. Genel olarak, aslında favipiravir, geniş bir sistematik incelemeyle onaylandığı gibi iyi bir güvenlik profiline sahiptir. Hala net olmayan birçok bilgi sebebi ile favipiravirin yan etkilerini literatür ışığında gözden geçirerek bu çalışmaya katkı sağlamayı amaçladık.

Anahtar Kelimeler

• SARS COV2
• Favipiravir
• COVID-19

Kaynakça

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