The relationship between the amount of edema and functional capacity and annexin V and ICAM 1 in patients with heart failure

Öz

Objective: Edema, one of the common findings of congestive heart failure, can be seen in the form of pretibial, scrotal or pulmonary edema and always undesired changes the quality of life of patients. Some studies have previously demonstrated the correlation of some cytokines and inflammation markers with heart failure. This study purposed to investigate the relevance of the amount of edema and functional capacity with ICAM 1 and annexin V in heart failure patients. Methods: The study included a total of 40 individuals, 20 of whom were diagnosed with heart failure and 20 of whom were enrolled as the control group. Edema grades and functional capacities were scored and noted. All patients underwent transthoracic echocardiography. ICAM 1 and annexin V levels were compared between the patient and control groups. The correlation between the grade of edema and functional capacity and ICAM 1 and annexin V levels was examined. ROC curve analysis was used to determine the cut-off point. Results: There was a significant difference in both ICAM 1 and annexin V levels in the patient group compared to the control group (ICAM 1 58.14±25.65 ng/mL, 36.04±14.14 ng/mL, p<0.05; annexin V 9.84±1.86 ng/mL, 8.39±0.61 ng/mL, p<0.05). Analyzes showed a correlation between increased degrees of edema and decreased functional capacity and levels of ICAM 1 and annexin V. Conclusion: The results of this study may contribute to the prediction that ICAM 1 can be a new goal for the treatment of heart failure and that annexin V can be an auxiliary test for the diagnosis. It is believed that this contribution can be expanded by studies with a larger sample size.

Anahtar Kelimeler

• ICAM 1
• annexin V
• heart failure
• edema
• functional capacity

Kalp yetmezliği hastalarında ödem miktarı ve fonksiyonel kapasite ile annexin V ve ICAM 1 arasındaki ilişki

Öz

Amaç: Konjestif kalp yetmezliğinin yaygın bulgularından biri olan ödem pretibial, skrotal ya da pulmoner ödem şeklinde görülebilmekte ve hastaların yaşam standartlarını daima olumsuz yönde etkilemektedir. Bazı sitokin ve inflamasyon markerlarının kalp yetmezliği ile korelasyonu daha önce kimi çalışmalarda gösterilmiştir. Amacımız; kalp yetmezliği hastalarında fonksiyonel kapasite ve ödem miktarı ile ICAM 1 ve annexin V arasında ilişkiyi incelemektir. Yöntem: Çalışmaya kalp yetmezliği tanısı almış 20 ve kontrol grubu olarak belirlenmiş 20 olmak üzere toplam 40 kişi alındı. Ödem dereceleri ve fonksiyonel kapasiteleri skorlanarak not edildi. Tüm hastalara transtorasik ekokardiografi yapıldı. Hasta ve kontrol grubu arasında ICAM 1 ve annexin V düzeyleri karşılaştırıldı. Ödem derecesi ve fonksiyonel kapasite ile ICAM 1 ve annexin V düzeyleri arasındaki korelasyona bakıldı. Kesim noktasının belirlenmesi için ROC Curve analizi kullanıldı. Bulgular: Hem ICAM 1 hem de annexin V düzeylerinde hasta grupta kontrol grubuna kıyasla anlamlı fark oluştu (ICAM 1 58.14±25.65 ng/mL, 36.04±14.14 ng/mL, p<0.05; annexin V 9.84±1.86 ng/mL, 8.39±0.61 ng/mL, p<0.05). Analizler ödem dereceleri artması ve fonksiyonel kapasitenin azalması ile ICAM 1 ve annexin V seviyeleri arasında bir korelasyon gösterdi. Sonuç: Bu çalışmanın sonuçları, ICAM 1'in kalp yetmezliği tedavisi için yeni bir hedef olabileceği ve annexin V'nin tanı için yardımcı bir test olabileceği öngörüsüne katkıda bulunabilir. Bu katkının daha geniş örneklemli çalışmalarla genişletilebileceği düşünülmektedir.

Anahtar Kelimeler

• ICAM 1
• annexin V
• kalp yetmezliği
• ödem
• fonksiyonel kapasite

Kaynakça

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