The role of sacubitril valsartan in experimental animal models

Öz

The benefits of sacubutril/valsartan (S/V), a new molecule in the treatment of heart failure, have been demonstrated in large and comprehensive studies and have been put into use in daily practice. This drug combination was developed to counteract the detrimental effects of renin-angiotensin-aldosterone system (RAAS) activation while increasing levels of potentially beneficial endogenous vasoactive peptides degraded by neprilysin. In the last 2022 European Society of Cardiology Heart Failure Guidelines, there is a class 1 indication with ACE-Is and beta blockers, which had a treat-ment class 1 indication previously published in heart failure. In addition, the effects of S/V were examined in different experimental animal models, so etiological differences were also evaluated and continue to be evaluated. In this review, we aimed to summarize experimental animal studies with S/V.

Anahtar Kelimeler

• Sacubutril/Valsartan
• Heart Failure
• Animal
• Experimental

Sakubitril valsartan’ın deneysel havyan modellerindeki yeri

Öz

Kalp yetersizliği tedavisinde yeni bir molekül olan sakubutril/valsartan’ın (S/V) büyük ve kapsamlı çalışmalarda faydaları ortaya koyulmuş ve günlük pratikte kullanıma sunulmuştur. Bu ilaç kombinasyonu, neprilisin tarafından bozulan potansiyel olarak faydalı endojen vazoaktif peptitlerin seviyelerini arttırırken, renin anjiyotensin aldosteron sistemi (RAAS) aktivasyonunun zararlı etkilerini engellemek için geliştirilmiştir. Son yayınlanan 2022 Avrupa Kardiyoloji Derneği Kalp Yetersizliği Kılavuzu’nda da daha önce kalp yetersizliği tedavisinde sınıf 1 endikasyona sahip olan ACE-İ ve beta blokerler ile birlikte sınıf 1 endikasyonu almıştır. Bunun yanında farklı deneysel hayvan modellerinde de S/V’ın etkileri incelenmiş, böylece etiyolojik farklılıklar da değerlendirilmiş ve incelenmeye, değerlendirilmeye devam etmektedir. Bu derlemede S/V ile yapılmış deneysel hayvan çalışmalarını özetlemeyi amaçladık.

Anahtar Kelimeler

• Sacubutril/Valsartan
• Kalp yetersizliği
• Hayvan
• Deneysel

Kaynakça

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