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Yangısal hastalıklarda hiperbarik oksijen tedavisi

Yıl 2024, , 11 - 21, 31.01.2024
https://doi.org/10.55665/troiamedj.1326387

Öz

Hiperbarik Oksijen Tedavisi, basınç odası adı verilen kapalı bir sızdırmaz kabin içerisinde, artırılmış atmosferik basınç altında, %100 oranında oksijenin, hastalara maske, başlık ya da entübasyon tüpü vasıtasıyla solutulması prensibine dayanan bir tedavi yöntemidir. Hiperbarik Oksijen Tedavisi’nin uygulandığı kabinler, tek kişilik olabildiği gibi, aynı anda birden fazla hastanın tedavi edilebildiği çok kişilik basınç odaları da bulunmaktadır. Tedavi edici oksijen basıncının, çevre basıncının üzerinde bir basınçta uygulanması gerekmektedir. Tedavi süreleri de, her seans için ortalama 90 dakika veya vakanın tıbbi durumuna göre daha uzundur. 1955 yılından beri tıp pratiğinde aktif olarak kullanılmakta olan Hiperbarik Oksijen Tedavisi, temelde iki fizyolojik mekanizma ile etki göstermektedir. Bunlar, yüksek basıncın doğrudan fiziksel etkisi ve parsiyel oksijen basıncının yükselmesi ile oluşan fizyolojik etkilerdir. Bu temel etki mekanizmaları aracılığıyla, dolaşım sisteminde ve dokularda patolojik olarak oluşan gaz kabarcıklarının hacmini azaltır, doku oksijenasyonunu artırır, yara iyileşmesini hızlandırır, iyileşmeyen yaralarda bakteriyel enfeksiyon riskini azaltır, anjiogenezi uyarır ve immün yanıtı düzenler. Hiperbarik oksijen tedavisi bu etkileri sayesinde, dekompresyon hastalığı, karbon monoksit zehirlenmesi, hava ve gaz embolisi, gazlı gangren, crush yaralanması, kompartman sendromu, retinal arter oklüzyonu, diabetik ayak gibi iyileşmeyen yaralar, yumuşak dokunun nekrotizan enfeksiyonları, ani işitme kaybı ve kronik osteomiyelit gibi birçok tıbbi durumda endikedir. Bunlara ek olarak, son yıllarda yapılan deneysel ve klinik çalışmalarda, yangısal ve sistemik hastalıklar, maligniteler, COVID-19 enfeksiyonu, erektil disfonksiyon, yaşlanma, iskemik kalp ve beyin hastalıkları gibi durumlarda da etkinliği araştırılmaktadır. Bu derlemenin amacı, Hiperbarik Oksijen Tedavisi’nin etki mekanizmalarını, yangı üzerine etkilerini ve son yıllarda yapılan birçok yeni çalışmaya konu olan yangısal hastalıklar üzerindeki etkinliğini gözden geçirmektir.

Kaynakça

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Hyperbaric oxygen therapy in inflammatory diseases

Yıl 2024, , 11 - 21, 31.01.2024
https://doi.org/10.55665/troiamedj.1326387

Öz

Hyperbaric Oxygen Therapy is a treatment method based on the principle of inhaling 100% oxygen under increa-sed atmospheric pressure in a closed sealed cabin called a pressure chamber, through a mask, hood or intubation tube. Hyperbaric Oxygen Therapy cabins can be monoplace or multiplace chambers where more than one patient can be treated at the same time. The therapeutic oxygen pressure must be applied at a pressure above the ambient pressure. Treatment times average 90 minutes per session, or longer depending on the medical condition of the case. Hyperbaric Oxygen Therapy, which has been actively used in medical practice since 1955, works mainly through two physiological mechanisms. These are the direct physical effects of high pressure and the physiologi-cal effects caused by the increase in partial oxygen pressure. Through these basic mechanisms of action, it redu-ces the volume of pathologically formed gas bubbles in the circulatory system and tissues, increases tissue oxy-genation, accelerates wound healing, reduces the risk of bacterial infection in non-healing wounds, stimulates angiogenesis and regulates the immune response. Thanks to these effects, hyperbaric oxygen therapy is indicated in many medical conditions such as decompression sickness, carbon monoxide poisoning, air and gas embolism, gas gangrene, crush injury, compartment syndrome, retinal artery occlusion, non-healing wounds such as diabetic foot, necrotizing infections of soft tissue, sudden hearing loss and chronic osteomyelitis. In addition, recent experimental and clinical trials are investigating its efficacy in inflammatory and systemic diseases, malignancies, COVID-19 infection, erectile dysfunction, aging, ischemic heart and brain diseases. The aim of this review is to review the mechanisms of action of Hyperbaric Oxygen Therapy, its effects on inflammation and its efficacy on inflammatory diseases, which have been the subject of many new studies in recent years.

Kaynakça

  • 1. Savage S. New medical therapy: hyperba-rics. Tenn Med. 2010;103(3):39-40.
  • 2. Bert P. La pression barométrique: recherches de physiologie expérimentale. G. Masson, 1878.
  • 3. Çimsit M. Basınç odaları. Çimsit M (Editör) Hiperbarik Tıp Teori ve Uygulama. Eflatun Ya-yınevi, 1. Baskı, Ankara, 2009: 13-22
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  • 77. Rello J, Valenzuela-Sánchez F, Ruiz-Rodriguez M, Moyano S. Sepsis: A Review of Advances in Management. Adv Ther. 2017;34(11):2393-2411. doi:10.1007/s12325-017-0622-8
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  • 80. Edremitlioğlu M, Kiliç D, Oter S, et al. The ef-fect of hyperbaric oxygen treatment on the renal functions in septic rats: relation to oxidative damage. Surg Today. 2005;35(8):653-661. doi:10.1007/s00595-004-3000-5
  • 81. Bærnthsen NF, Hansen MB, Wahl AM, Simon-sen U, Hyldegaard O. Treatment with 24 h-delayed normo- and hyperbaric oxygenation in severe sepsis induced by cecal ligation and puncture in rats. J Inflamm (Lond). 2017;14:27. Published 2017 Nov 25. doi:10.1186/s12950-017-0173-4
  • 82. Oter S, Edremitlioglu M, Korkmaz A, et al. Ef-fects of hyperbaric oxygen treatment on liver functions, oxidative status and histology in septic rats. Intensive Care Med. 2005;31(9):1262-1268. doi:10.1007/s00134-005-2701-6
  • 83. Bajek S, Nikolić M, Soić-Vranić T, Bajek G, Cvijanović O, Starcević-Klasan G. Influence of hyperbaric oxygen treatment on myogenic transcriptional factors of denervated rat muscle. Coll Antropol. 2012 Mar;36(1):167-72. PMID: 22816216.
  • 84. Yamamoto N, Oyaizu T, Yagishita K, Enomoto M, Horie M, Okawa A. Multiple and early hy-perbaric oxygen treatments enhance muscle hea-ling after muscle contusion injury: a pilot study. Undersea Hyperb Med. 2021 Third-Quarter;48(3):227-238. PMID: 34390627.
  • 85. Oyaizu T, Enomoto M, Yamamoto N, Tsuji K, Horie M, Muneta T, Sekiya I, Okawa A, Yagishi-ta K. Hyperbaric oxygen reduces inflammation, oxygenates injured muscle, and regenerates ske-letal muscle via macrophage and satellite cell activation. Sci Rep. 2018 Jan 22;8(1):1288. doi: 10.1038/s41598-018-19670-x. PMID: 29358697; PMCID: PMC5778072.
  • 86. Horie M, Enomoto M, Shimoda M, Okawa A, Miyakawa S, Yagishita K. Enhancement of sa-tellite cell differentiation and functional reco-very in injured skeletal muscle by hyperbaric oxygen treatment. J Appl Physiol (1985). 2014;116(2):149-155. doi:10.1152/japplphysiol.00235.2013
  • 87. Woo J, Min JH, Lee YH, Roh HT. Effects of Hyperbaric Oxygen Therapy on Inflammation, Oxidative/Antioxidant Balance, and Muscle Damage after Acute Exercise in Normobaric, Normoxic and Hypobaric, Hypoxic Environ-ments: A Pilot Study. Int J Environ Res Public Health. 2020;17(20):7377. Published 2020 Oct 10. doi:10.3390/ijerph17207377 .
Toplam 87 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri (Diğer)
Bölüm Makaleler
Yazarlar

Serdar Yalçın 0009-0006-4701-2190

Mustafa Edremitlioğlu 0000-0002-0510-9852

Yayımlanma Tarihi 31 Ocak 2024
Gönderilme Tarihi 12 Temmuz 2023
Yayımlandığı Sayı Yıl 2024

Kaynak Göster

APA Yalçın, S., & Edremitlioğlu, M. (2024). Yangısal hastalıklarda hiperbarik oksijen tedavisi. Troia Medical Journal, 5(1), 11-21. https://doi.org/10.55665/troiamedj.1326387
AMA Yalçın S, Edremitlioğlu M. Yangısal hastalıklarda hiperbarik oksijen tedavisi. Troia Med J. Ocak 2024;5(1):11-21. doi:10.55665/troiamedj.1326387
Chicago Yalçın, Serdar, ve Mustafa Edremitlioğlu. “Yangısal hastalıklarda Hiperbarik Oksijen Tedavisi”. Troia Medical Journal 5, sy. 1 (Ocak 2024): 11-21. https://doi.org/10.55665/troiamedj.1326387.
EndNote Yalçın S, Edremitlioğlu M (01 Ocak 2024) Yangısal hastalıklarda hiperbarik oksijen tedavisi. Troia Medical Journal 5 1 11–21.
IEEE S. Yalçın ve M. Edremitlioğlu, “Yangısal hastalıklarda hiperbarik oksijen tedavisi”, Troia Med J, c. 5, sy. 1, ss. 11–21, 2024, doi: 10.55665/troiamedj.1326387.
ISNAD Yalçın, Serdar - Edremitlioğlu, Mustafa. “Yangısal hastalıklarda Hiperbarik Oksijen Tedavisi”. Troia Medical Journal 5/1 (Ocak 2024), 11-21. https://doi.org/10.55665/troiamedj.1326387.
JAMA Yalçın S, Edremitlioğlu M. Yangısal hastalıklarda hiperbarik oksijen tedavisi. Troia Med J. 2024;5:11–21.
MLA Yalçın, Serdar ve Mustafa Edremitlioğlu. “Yangısal hastalıklarda Hiperbarik Oksijen Tedavisi”. Troia Medical Journal, c. 5, sy. 1, 2024, ss. 11-21, doi:10.55665/troiamedj.1326387.
Vancouver Yalçın S, Edremitlioğlu M. Yangısal hastalıklarda hiperbarik oksijen tedavisi. Troia Med J. 2024;5(1):11-2.