Araştırma Makalesi
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Bibliometric analysis of reference intervals in clinical laboratories research area

Yıl 2026, Cilt: 7 Sayı: 1, 1 - 9, 06.01.2026

Öz

Objective: This study conducts a bibliometric analysis of reference interval in clinical laboratory research to evaluate scholarly output.
Methods: Articles published since 2000 on the term “reference value” and “reference interval” in the field of the clinical laboratory were found in the Web of Science Core Collection SCIE index. VOS viewer and Mi-crosoft Excel were employed to perform bibliometric and visual analyses.
Results:The study analysed 664 articles on reference intervals in 85 countries, with the United States lead-ing with 120 publications. The top organizations contributing to the research were the Hospital for Sick Children and the University of Toronto, followed by Yamaguchi University, the University of Copenhagen, and the University of Southern Denmark. The data also showed a significant increase in research funding distribution, with the United States Department of Health and Human Services, National Institutes of Health, Japan Society for the Promotion of Science, Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan, and Canadian Institutes of Health Research holding notable records. The statis-tics indicated a notable rise in citations, with 2021 recording the highest number of citations. The study also highlighted the importance of keywords in the dataset, with "reference intervals" appearing 166 times and "reference interval" appearing 97 times.
Conclusion: This study provides a systematic and objective perspective for evaluating the characteristics of publications on reference intervals in clinical laboratory research and for generating evidence-based scienti-fic insights.

Etik Beyan

Ethical approval was not required for this study, as it is based on analysis of previously published literature and does not involve human participants or animal experiments.

Destekleyen Kurum

This study was not financially supported by any institution or organization.

Teşekkür

None.

Kaynakça

  • 1. Oguzman H, Dogan S. Determination of 25 hy-droxyvitamin D reference ranges in Hatay re-gion by indirect method. Interdiscip Med J 2023;14(49):140-4.
  • 2. Doyle K, Bunch DR. Reference intervals: past, present, and future. Crit Rev Clin Lab Sci 2023;60(6):466-82.
  • 3. Coleman RE. Normal ranges for laboratory find-ings. Can Med Assoc J 1928;19(3):349.
  • 4. Horn PS, Pesce AJ. Reference intervals: an up-date. Clin Chim Acta 2003;334(1-2):5-23.
  • 5. Jones G, Barker A. Reference intervals. Clin Bi-ochem Rev 2008;29(Suppl 1):S93-7.
  • 6. Ozarda Y. Reference intervals: current status, recent developments and future considera-tions. Biochem Med 2016;26(1):5-16.
  • 7. Siest G, Henny J, Gräsbeck R, et al. The theory of reference values: an unfinished symphony. Clin Chem Lab Med 2013;51(1):47-64.
  • 8. Gräsbeck R. The evolution of the reference val-ue concept. Clin Chem Lab Med 2004;42(7):692-7.
  • 9. International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Committee of Reference Intervals and Decision Limits. https://ifcc.org/ifcc-scientific-division/sd-committees/c-ridl/ Accessed:15.12.2023
  • 10. Kuyubaşı SN, Demirkıran ND, Kozlu S, et al. Global analysis of chronic osteomyelitis publi-cations with a bibliometric approach. Cyprus J Med Sci 2023;8(1):8-12.
  • 11. Lu A, Duan P, Xie J, et al. Recent progress and research trend of anti-cataract pharmacology therapy: A bibliometric analysis and literature review. Eur J Pharmacol 2022;934:175299.
  • 12. Gökçe ON, Alkan S. Contribution of Turkey in Liver Transplant Research: A Scopus Database Search. Exp Clin Transplant. 2023;21(5):415-21.
  • 13. van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for biblio-metric mapping. Scientometrics 2010;84(2):523-38.
  • 14. Arruda H, Silva ER, Lessa M, et al. VOSviewer and Bibliometrix. J Med Libr Assoc 2022;110(3):392-5.
  • 15. Kokol P, Blažun Vošner H, Završnik J. Applica-tion of bibliometrics in medicine: a historical bibliometrics analysis. Health Info Libr J 2021;38(2):125-38.
  • 16. Akar A. Bibliometric Analysis Study on Percu-taneous Diskectomy. Journal of Contemporary Medicine 2023;13(2):176-81.
  • 17. Verma A, Chitalia VC, Waikar SS, Kolachalama VB. Machine learning applications in nephrolo-gy: a bibliometric analysis comparing kidney studies to other medicine subspeciali-ties. Kidney Medicine 2021;3(5):762-7.
  • 18. Alkan S, Önder T, Oğuz Mızrakçı S. Biblio-metric analysis of global rabies research be-tween 1992-2022. Journal of Zoonotic Diseases 2023;7(1):217-28.
  • 19. Ekici A, Alkan S, Aydemir S, et al. Trends in Naegleria fowleri global research: A biblio-metric analysis study. Acta tropica 2022;234,106603.
  • 20. Adeli K, Higgins V, Trajcevski K, White-Al Habeeb N. The Canadian laboratory initiative on pediatric reference intervals: A CALIPER white paper. Crit Rev Clin Lab Sci 2017;54(6):358-413.
  • 21. Colantonio DA, Kyriakopoulou L, Chan MK, et al. Closing the gaps in pediatric laboratory ref-erence intervals: a CALIPER database of 40 bi-ochemical markers in a healthy and multiethnic population of children. Clin Chem 2012;58(5):854-68.
  • 22. Pediatric reference value distributions and co-variate-stratified reference intervals for 29 en-docrine and special chemistry biomarkers on the Beckman Coulter Immunoassay Systems: a CALIPER study of healthy community chil-dren. Clin Chem Lab Med 2016;54(4):643-57.
  • 23. Konforte D, Shea JL, Kyriakopoulou L, et al. Complex biological pattern of fertility hor-mones in children and adolescents: a study of healthy children from the CALIPER cohort and establishment of pediatric reference intervals. Clin Chem 2013;59(8):1215-27.
  • 24. Kyriakopoulou L, Yazdanpanah M, Colantonio DA, et al. A sensitive and rapid mass spectro-metric method for the simultaneous measure-ment of eight steroid hormones and CALIPER pediatric reference intervals. Clin Biochem 2013;46(7-8):642-51.
  • 25. Bevilacqua V, Chan MK, Chen Y, et al. Pediatric population reference value distributions for cancer biomarkers and covariate-stratified refer-ence intervals in the CALIPER cohort. Clin Chem 2014;60(12):1532-42.
  • 26. Raizman JE, Cohen AH, Teodoro-Morrison T, et al. Pediatric reference value distributions for vitamins A and E in the CALIPER cohort and establishment of age-stratified reference inter-vals. Clin Biochem 2014;47(9):812-5.
  • 27. Teodoro-Morrison T, Kyriakopoulou L, Chen YK, et al. Dynamic biological changes in meta-bolic disease biomarkers in childhood and ado-lescence: a CALIPER study of healthy commu-nity children. Clin Biochem 2015;48(13-14):828-36.
  • 28. Raizman JE, Quinn F, Armbruster DA, et al. Pe-diatric reference intervals for calculated free tes-tosterone, bioavailable testosterone and free androgen index in the CALIPER cohort. Clin Chem Lab Med 2015;53(10):e239-43.
  • 29. Kelly J, Raizman JE, Bevilacqua V, et al. Com-plex reference value distributions and parti-tioned reference intervals across the pediatric age range for 14 specialized biochemical mark-ers in the CALIPER cohort of healthy commu-nity children and adolescents. Clin Chim Acta 2015;450:196-202.
  • 30. The Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER). https://caliperproject.ca/ Accessed:15.12.2023

Klinik laboratuvar araştırma alanında referans aralıkların bibliyometrik analizi

Yıl 2026, Cilt: 7 Sayı: 1, 1 - 9, 06.01.2026

Öz

Amaç: Bu çalışma, akademik çıktıyı değerlendirmek amacıyla klinik laboratuvar araştırmalarında referans aralıklara ilişkin bibliyometrik bir analiz gerçekleştirmektedir.
Yöntem: Klinik laboratuvar alanında “referans değer” ve “referans aralık” terimi üzerine 2000 yılından itibaren yayımlanan makaleler Web of Science Core Collection SCIE indeksinde bulunmuştur. Bibliyome-trik ve görsel analizler VOSviewer ve Microsoft Excel kullanılarak yapılmıştır.
Bulgular: Çalışmada 85 ülkeden referans aralıklar üzerine 664 makale incelenmiş olup, en fazla yayına sahip ülke 120 yayın ile Amerika Birleşik Devletleri olmuştur. Araştırmaya en çok katkı sağlayan kurumlar arasında Sick Children Hastanesi ve Toronto Üniversitesi ilk sırada yer almış, bunları Yamaguchi Üniversi-tesi, Kopenhag Üniversitesi ve Güney Danimarka Üniversitesi izlemiştir. Veriler ayrıca, Amerika Birleşik Devletleri Sağlık ve İnsan Hizmetleri Bakanlığı, Ulusal Sağlık Enstitüleri, Japonya Bilimi Teşvik Derneği, Japonya Eğitim Kültür Spor Bilim ve Teknoloji Bakanlığı (MEXT) ve Kanada Sağlık Araştırmaları En-stitüleri’nin dikkat çekici kayıtlara sahip olduğu, araştırma fonlarının dağılımında önemli bir artış olduğunu göstermiştir. Veriler ayrıca, 2021 yılının en yüksek atıf sayısına sahip yıl olmasıyla, atıf eğiliminde belirgin bir artış olduğunu da ortaya koymuştur. Çalışma ayrıca veri setindeki anahtar kelimelerin önemini vurgulamış, “referans aralıkları” ifadesi 166 kez ve “referans aralığı” ifadesi 97 kez yer almıştır.
Sonuç: Klinik laboratuvarlarda referans aralıkları alanındaki yayınların niteliklerini değerlendirmek ve bilimsel cevaplar elde etmek için bu çalışma, sistematik ve objektif bir bakış açısı sunmaktadır.

Etik Beyan

Bu çalışma, daha önce yayımlanmış literatürün analizi üzerine kurulu olduğundan ve insan katılımcılar veya hayvan deneyleri içermediğinden etik onay gerektirmemektedir.

Destekleyen Kurum

Bu çalışma herhangi bir kurum veya kuruluş tarafından maddi olarak desteklenmemiştir

Teşekkür

Yok.

Kaynakça

  • 1. Oguzman H, Dogan S. Determination of 25 hy-droxyvitamin D reference ranges in Hatay re-gion by indirect method. Interdiscip Med J 2023;14(49):140-4.
  • 2. Doyle K, Bunch DR. Reference intervals: past, present, and future. Crit Rev Clin Lab Sci 2023;60(6):466-82.
  • 3. Coleman RE. Normal ranges for laboratory find-ings. Can Med Assoc J 1928;19(3):349.
  • 4. Horn PS, Pesce AJ. Reference intervals: an up-date. Clin Chim Acta 2003;334(1-2):5-23.
  • 5. Jones G, Barker A. Reference intervals. Clin Bi-ochem Rev 2008;29(Suppl 1):S93-7.
  • 6. Ozarda Y. Reference intervals: current status, recent developments and future considera-tions. Biochem Med 2016;26(1):5-16.
  • 7. Siest G, Henny J, Gräsbeck R, et al. The theory of reference values: an unfinished symphony. Clin Chem Lab Med 2013;51(1):47-64.
  • 8. Gräsbeck R. The evolution of the reference val-ue concept. Clin Chem Lab Med 2004;42(7):692-7.
  • 9. International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Committee of Reference Intervals and Decision Limits. https://ifcc.org/ifcc-scientific-division/sd-committees/c-ridl/ Accessed:15.12.2023
  • 10. Kuyubaşı SN, Demirkıran ND, Kozlu S, et al. Global analysis of chronic osteomyelitis publi-cations with a bibliometric approach. Cyprus J Med Sci 2023;8(1):8-12.
  • 11. Lu A, Duan P, Xie J, et al. Recent progress and research trend of anti-cataract pharmacology therapy: A bibliometric analysis and literature review. Eur J Pharmacol 2022;934:175299.
  • 12. Gökçe ON, Alkan S. Contribution of Turkey in Liver Transplant Research: A Scopus Database Search. Exp Clin Transplant. 2023;21(5):415-21.
  • 13. van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for biblio-metric mapping. Scientometrics 2010;84(2):523-38.
  • 14. Arruda H, Silva ER, Lessa M, et al. VOSviewer and Bibliometrix. J Med Libr Assoc 2022;110(3):392-5.
  • 15. Kokol P, Blažun Vošner H, Završnik J. Applica-tion of bibliometrics in medicine: a historical bibliometrics analysis. Health Info Libr J 2021;38(2):125-38.
  • 16. Akar A. Bibliometric Analysis Study on Percu-taneous Diskectomy. Journal of Contemporary Medicine 2023;13(2):176-81.
  • 17. Verma A, Chitalia VC, Waikar SS, Kolachalama VB. Machine learning applications in nephrolo-gy: a bibliometric analysis comparing kidney studies to other medicine subspeciali-ties. Kidney Medicine 2021;3(5):762-7.
  • 18. Alkan S, Önder T, Oğuz Mızrakçı S. Biblio-metric analysis of global rabies research be-tween 1992-2022. Journal of Zoonotic Diseases 2023;7(1):217-28.
  • 19. Ekici A, Alkan S, Aydemir S, et al. Trends in Naegleria fowleri global research: A biblio-metric analysis study. Acta tropica 2022;234,106603.
  • 20. Adeli K, Higgins V, Trajcevski K, White-Al Habeeb N. The Canadian laboratory initiative on pediatric reference intervals: A CALIPER white paper. Crit Rev Clin Lab Sci 2017;54(6):358-413.
  • 21. Colantonio DA, Kyriakopoulou L, Chan MK, et al. Closing the gaps in pediatric laboratory ref-erence intervals: a CALIPER database of 40 bi-ochemical markers in a healthy and multiethnic population of children. Clin Chem 2012;58(5):854-68.
  • 22. Pediatric reference value distributions and co-variate-stratified reference intervals for 29 en-docrine and special chemistry biomarkers on the Beckman Coulter Immunoassay Systems: a CALIPER study of healthy community chil-dren. Clin Chem Lab Med 2016;54(4):643-57.
  • 23. Konforte D, Shea JL, Kyriakopoulou L, et al. Complex biological pattern of fertility hor-mones in children and adolescents: a study of healthy children from the CALIPER cohort and establishment of pediatric reference intervals. Clin Chem 2013;59(8):1215-27.
  • 24. Kyriakopoulou L, Yazdanpanah M, Colantonio DA, et al. A sensitive and rapid mass spectro-metric method for the simultaneous measure-ment of eight steroid hormones and CALIPER pediatric reference intervals. Clin Biochem 2013;46(7-8):642-51.
  • 25. Bevilacqua V, Chan MK, Chen Y, et al. Pediatric population reference value distributions for cancer biomarkers and covariate-stratified refer-ence intervals in the CALIPER cohort. Clin Chem 2014;60(12):1532-42.
  • 26. Raizman JE, Cohen AH, Teodoro-Morrison T, et al. Pediatric reference value distributions for vitamins A and E in the CALIPER cohort and establishment of age-stratified reference inter-vals. Clin Biochem 2014;47(9):812-5.
  • 27. Teodoro-Morrison T, Kyriakopoulou L, Chen YK, et al. Dynamic biological changes in meta-bolic disease biomarkers in childhood and ado-lescence: a CALIPER study of healthy commu-nity children. Clin Biochem 2015;48(13-14):828-36.
  • 28. Raizman JE, Quinn F, Armbruster DA, et al. Pe-diatric reference intervals for calculated free tes-tosterone, bioavailable testosterone and free androgen index in the CALIPER cohort. Clin Chem Lab Med 2015;53(10):e239-43.
  • 29. Kelly J, Raizman JE, Bevilacqua V, et al. Com-plex reference value distributions and parti-tioned reference intervals across the pediatric age range for 14 specialized biochemical mark-ers in the CALIPER cohort of healthy commu-nity children and adolescents. Clin Chim Acta 2015;450:196-202.
  • 30. The Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER). https://caliperproject.ca/ Accessed:15.12.2023
Toplam 30 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Kimya
Bölüm Araştırma Makalesi
Yazarlar

Nihan Uşaklıgil Bu kişi benim 0009-0008-6581-2508

Havva Yasemin Çinpolat 0000-0002-7161-2907

Gönderilme Tarihi 29 Ağustos 2025
Kabul Tarihi 27 Kasım 2025
Yayımlanma Tarihi 6 Ocak 2026
Yayımlandığı Sayı Yıl 2026 Cilt: 7 Sayı: 1

Kaynak Göster

APA Uşaklıgil, N., & Çinpolat, H. Y. (2026). Bibliometric analysis of reference intervals in clinical laboratories research area. Troia Medical Journal, 7(1), 1-9. https://doi.org/10.55665/troiamedj.1774136
AMA Uşaklıgil N, Çinpolat HY. Bibliometric analysis of reference intervals in clinical laboratories research area. Troia Med J. Ocak 2026;7(1):1-9. doi:10.55665/troiamedj.1774136
Chicago Uşaklıgil, Nihan, ve Havva Yasemin Çinpolat. “Bibliometric analysis of reference intervals in clinical laboratories research area”. Troia Medical Journal 7, sy. 1 (Ocak 2026): 1-9. https://doi.org/10.55665/troiamedj.1774136.
EndNote Uşaklıgil N, Çinpolat HY (01 Ocak 2026) Bibliometric analysis of reference intervals in clinical laboratories research area. Troia Medical Journal 7 1 1–9.
IEEE N. Uşaklıgil ve H. Y. Çinpolat, “Bibliometric analysis of reference intervals in clinical laboratories research area”, Troia Med J, c. 7, sy. 1, ss. 1–9, 2026, doi: 10.55665/troiamedj.1774136.
ISNAD Uşaklıgil, Nihan - Çinpolat, Havva Yasemin. “Bibliometric analysis of reference intervals in clinical laboratories research area”. Troia Medical Journal 7/1 (Ocak2026), 1-9. https://doi.org/10.55665/troiamedj.1774136.
JAMA Uşaklıgil N, Çinpolat HY. Bibliometric analysis of reference intervals in clinical laboratories research area. Troia Med J. 2026;7:1–9.
MLA Uşaklıgil, Nihan ve Havva Yasemin Çinpolat. “Bibliometric analysis of reference intervals in clinical laboratories research area”. Troia Medical Journal, c. 7, sy. 1, 2026, ss. 1-9, doi:10.55665/troiamedj.1774136.
Vancouver Uşaklıgil N, Çinpolat HY. Bibliometric analysis of reference intervals in clinical laboratories research area. Troia Med J. 2026;7(1):1-9.