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The relationship between tumor necrosis factor α-308 G/A poly-morphism and serum tumor necrosis factor α levels in patients with migraine without aura

Yıl 2021, Cilt: 2 Sayı: 3, 73 - 78, 29.09.2021

Öz

Objective: The aim of this study is to investigate the association of tumor necrosis factor (TNF) α-308 G/A genotype with migraine risk and the effect on serum TNF-α levels in patients with migraine without aura.
Methods: A total number of 70 patients with the diag-nosis of migraine without aura and 65 control subjects were included in this study. TNF-α level was studied from two separate blood samples taken from the pa-tient group during an attack and attack-free period separately and TNF-α-308 G/A genotype was studied once while one blood sample was taken for studying the TNF-α-308 G/A and TNF-α level genotype from the control group.
Results: The mean TNF-α level during an attack and attack-free periods were 13.58±2.84 pg/mL and 12.91±3.39 pg/mL, respectively in patients with mi-graine (n=70). This difference was statistically signifi-cant (p=0.033). The mean serum TNF-α level during an attack was 14.37±3.4 pg/mL in the migraine patients with G/A genotype (n= 38) and 12.79±1.54 pg/mL in those with A/A genotype (n=30); the difference be-tween the two groups was statistically significant (p=0.034). The effect of genotype distribution on mi-graine development was statistically significant (p=0.003).
Conclusion: TNF-α-308 G/A polymorphism is related to migraine in Turkish patients and TNF-α level in-creases during an attack compared with attack-free periods in patients with migraine without aura. Further studies are required for determining the relationship between TNF-α308 G/A polymorphism and TNF-α levels in the serum.

Kaynakça

  • 1. Ertas M, Baykan B, Orhan EK, et al. One-year preva-lence and the impact of migraine and tension-type headache in Turkey: A nationwide home-based study in adults. J Headache Pain 2012;13(2):147-57.
  • 2. Puledda F, Messina R, Goadsby PJ. An update on migraine: Current understanding and future directions. J Neurol 2017;264(9):2031-39.
  • 3. Goadsby PJ, Holland PR, Martins-Oliveira M, et al. Pathophysiology of migraine: A disorder of sensory processing. Physiol Rev 2017;97(2):553-622.
  • 4. Horasanli B, Atac FB, Coven I, et al. Angiotensin I-converting enzyme gene (I/D) polymorphism in pati-ents with migraine. Headache 2013;53(1):161-64.
  • 5. Martami F, Razeghi Jahromi S, Togha M, et al. The serum level of inflammatory markers in chronic and episodic migraine: A case-control study. Neurol Sci 2018;39(10):1741-49.
  • 6. Erdener SE, Dalkara T. Modelling headache and migraine and its pharmacological manipulation. Br J Pharmacol 2014;171(20):4575-94.
  • 7. Gu L, Yan Y, Long J, et al. The TNF-α-308G/A polymorphism is associated with migraine risk: A meta-analysis. Exp Ther Med 2012;3(6):1082-86.
  • 8. Oliveira AB, Bachi ALL, Ribeiro RT, et al. Unbalan-ced plasma TNF-α and IL-12/IL-10 profile in women with migraine is associated with psychological and physiological outcomes. J Neuroimmunol 2017;313:138-44.
  • 9. Yazici AC, Atac FB, Verdi H, et al. Comparison of IL10 and IL2 genotypes of Turkish population with other populations. Int J Immunogenet 2009;36(2):97-101.
  • 10. Stuart S, Maher BH, Sutherland H, et al. Genetic variation in cytokine-related genes and migraine sus-ceptibility. Twin Res Hum Genet 2013;16(6):1079-86.
  • 11. Rainero I, Grimaldi LM, Salani G, et al. Associa-tion between the tumor necrosis factor-alpha -308 G/A gene polymorphism and migraine. Neurology 2004;62(1):141-3.
  • 12.Peng Y, Liu Y, Huang D, et al. Association of TNF-α-308(G/A) and -238(G/A) polymorphisms with non-traumatic osteonecrosis of the femoral head risks: A meta-analysis. Int Orthop 2018;42(7):1711-21.
  • 13.Niu YM, Weng H, Zhang C, et al. Systematic review by multivariate meta-analyses on the possible role of tumor necrosis factor-α gene polymorphisms in asso-ciation with ischemic stroke. Neuromolecular Med 2015;17(4):373-84.
  • 14. Liu J, Lian Z, Chen H, et al. Associations between tumor necrosis factor-α gene polymorphisms and the risk of Guillain-Barré syndrome and its subtypes: A systematic review and meta-analysis. J Neuroimmunol 2011;313:25-33.
  • 15. El-Tahan RR, Ghoneim AM, El-Mashad N. TNF-α gene polymorphisms and expression. Springerplus 2016;5(1):1508.
  • 16.Pinho-Ribeiro FA, Verri WA Jr, Chiu IM. Nocicep-tor sensory neuron-immune interactions in pain and inflammation. Trends Immunol 2017;38(1):5-19.
  • 17. Yilmaz IA, Ozge A, Erdal ME, et al. Cytokine polymorphism in patients with migraine: Some sugges-tive clues of migraine and inflammation. Pain Med 2010;11(4):492-97.
  • 18. Fawzi MS, El-Shal AS, Rashad NM, et al. Influence of tumor necrosis factor alpha gene promoter poly-morphisms and its serum level on migraine susceptibi-lity in Egyptian patients. J Neurol Sci 2015;348(1-2):74-80.
  • 19. Mason BN, Russo AF. Vascular contributions to migraine: Time to revisit? Front Cell Neurosci 2018;12:233.
  • 20. Rodriguez-Acevedo AJ, Smith RA, Roy B, et al. Genetic association and gene expression studies sug-gest that genetic variants in the SYNE1 and TNF genes are related to menstrual migraine. J Headache Pain 2014;15(1):62.
  • 21. Chen M, Tang W, Hou L, et al. Tumor necrosis fac-tor (TNF) -308G>A, nitric oxide synthase 3 (NOS3)+894G>T polymorphisms and migraine risk: A Meta-Analysis. PLoS One 2015;10(6):e0129372.
  • 22. Ghosh J, Joshi G, Pradhan S, Mittal B. Investiga-tion of TNFA 308G > A and TNFB 252G > A poly-morphisms in genetic susceptibility to migraine. J Neurol 2010;257(6):898-904.
  • 23. Headache Classification Subcommittee of the In-ternational Headache Society. The International Classi-fication of Headache Disorders: 2nd edition. Cephalal-gia. 2004;24 Suppl 1:9-160.
  • 24. Yılmaz Y, Verdi H, Taneri A, et al. Maternal-fetal proinflammatory cytokine gene polymorphism and preterm birth. DNA Cell Biol 2012;31(1):92-107.
  • 25. Schürks M, Rist PM, Zee RY, et al. Tumour necrosis factor gene polymorphisms and migraine: A systematic review and meta-analysis. Cephalalgia 2011;31(13):1381-404.
  • 26. Mazaheri S, Hajilooi M, Rafiei A. The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with migraine without aura. J Neurol 2006;253(12):1589-93.
  • 27. Perini F, D'Andrea G, Galloni E, et al. Plasma cyto-kine levels in migraineurs and controls. Headache 2005;45(7):926-31.
  • 28. Gallai V SP, Floridi A, Franceschini M, et al. Mo-nocyte function in migraine patients with and without aura. Headache Q 1994;214-27.
  • 29. Sarchielli P, Alberti A, Baldi A, et al. Proinflamma-tory cytokines, adhesion molecules, and lymphocyte integrin expression in the internal jugular blood of migraine patients without aura assessed ictally. Hea-dache 2006;46(2):200-7.
  • 30. Pappa S, Hatzistilianou M, Kouvatsi A, et al. Tumour necrosis factor gene polymorphisms and migra-ine in Greek children. Arch Med Sci 2010;6(3):430-7.
  • 31.Uzar E, Evliyaoglu O, Yucel Y, et al. Serum cytoki-ne and pro-brain natriuretic peptide (BNP) levels in patients with migraine. Eur Rev Med Pharmacol Sci 2011;15(10):1111-16.

Aurasız migrenlilerde tümör nekroz faktörü α-308 G/A polimorfizmi ve serum tümör nekroz faktörü α düzeyleri arasındaki ilişki

Yıl 2021, Cilt: 2 Sayı: 3, 73 - 78, 29.09.2021

Öz

Amaç: Bu çalışmanın amacı, tümör nekroz faktör (TNF)-α 308 G/A genotipinin migren ile ilişkisini ve aurasız migrenlilerde serum TNF- α düzeyi üzerine etkisini araştırmaktır.
Yöntem: Bu çalışmaya aurasız migren tanılı 70 hasta ile migreni olmayan 65 kişiden oluşan kontrol grubu dahil edildi. Hasta grubunda TNF-α seviyesi biri atak biri ataksız dönemde olmak üzere alınan iki ayrı kan örneğinden ayrı ayrı çalışılmış, TNF-α 308 G/A geno-tipi ise bir kez çalışılmıştır. Kontrol grubunda da TNF-α seviyesi ve TNF-α 308 G/A genotipi birer kez çalı-şılmıştır.
Bulgular: Migren (n=70) grubunda ataklı ve ataksız dönemde TNF-α seviyesi sırasıyla 13.58±2.84 pg/mL ve 12.91±3.39 pg/mL idi. Bu fark istatistiksel olarak anlamlıydı (p=0.033). G/A genotipi olan migren hasta-larında (n=38) atak sırasında ortalama serum TNF-a seviyesi, 14.37±3.4 pg/mL ve A/A genotipi olanlarda (n=30) ise 12.79±1.54 pg/mL idi. İki grup arasındaki fark (p=0.034) istatiksel olarak anlamlıydı. Ayrıca genotip dağılımının migren gelişimi üzerindeki etkisi istatistiksel olarak anlamlı olarak bulundu (p=0.003).
Sonuç: TNF-α 308 G/A polimorfizmi, Türkiye’deki migren hastaları ile ilişkilidir ve aurasız migrenli has-talarda TNF- α seviyesi ataklı dönem ile ataksız dö-nemle karşılaştırıldığında artmaktadır. TNF-α 308 G/A polimorfizmi ile serumdaki TNF-α seviyeleri arasın-daki ilişkinin belirlenmesi için daha fazla çalışmalar gerekir.

Kaynakça

  • 1. Ertas M, Baykan B, Orhan EK, et al. One-year preva-lence and the impact of migraine and tension-type headache in Turkey: A nationwide home-based study in adults. J Headache Pain 2012;13(2):147-57.
  • 2. Puledda F, Messina R, Goadsby PJ. An update on migraine: Current understanding and future directions. J Neurol 2017;264(9):2031-39.
  • 3. Goadsby PJ, Holland PR, Martins-Oliveira M, et al. Pathophysiology of migraine: A disorder of sensory processing. Physiol Rev 2017;97(2):553-622.
  • 4. Horasanli B, Atac FB, Coven I, et al. Angiotensin I-converting enzyme gene (I/D) polymorphism in pati-ents with migraine. Headache 2013;53(1):161-64.
  • 5. Martami F, Razeghi Jahromi S, Togha M, et al. The serum level of inflammatory markers in chronic and episodic migraine: A case-control study. Neurol Sci 2018;39(10):1741-49.
  • 6. Erdener SE, Dalkara T. Modelling headache and migraine and its pharmacological manipulation. Br J Pharmacol 2014;171(20):4575-94.
  • 7. Gu L, Yan Y, Long J, et al. The TNF-α-308G/A polymorphism is associated with migraine risk: A meta-analysis. Exp Ther Med 2012;3(6):1082-86.
  • 8. Oliveira AB, Bachi ALL, Ribeiro RT, et al. Unbalan-ced plasma TNF-α and IL-12/IL-10 profile in women with migraine is associated with psychological and physiological outcomes. J Neuroimmunol 2017;313:138-44.
  • 9. Yazici AC, Atac FB, Verdi H, et al. Comparison of IL10 and IL2 genotypes of Turkish population with other populations. Int J Immunogenet 2009;36(2):97-101.
  • 10. Stuart S, Maher BH, Sutherland H, et al. Genetic variation in cytokine-related genes and migraine sus-ceptibility. Twin Res Hum Genet 2013;16(6):1079-86.
  • 11. Rainero I, Grimaldi LM, Salani G, et al. Associa-tion between the tumor necrosis factor-alpha -308 G/A gene polymorphism and migraine. Neurology 2004;62(1):141-3.
  • 12.Peng Y, Liu Y, Huang D, et al. Association of TNF-α-308(G/A) and -238(G/A) polymorphisms with non-traumatic osteonecrosis of the femoral head risks: A meta-analysis. Int Orthop 2018;42(7):1711-21.
  • 13.Niu YM, Weng H, Zhang C, et al. Systematic review by multivariate meta-analyses on the possible role of tumor necrosis factor-α gene polymorphisms in asso-ciation with ischemic stroke. Neuromolecular Med 2015;17(4):373-84.
  • 14. Liu J, Lian Z, Chen H, et al. Associations between tumor necrosis factor-α gene polymorphisms and the risk of Guillain-Barré syndrome and its subtypes: A systematic review and meta-analysis. J Neuroimmunol 2011;313:25-33.
  • 15. El-Tahan RR, Ghoneim AM, El-Mashad N. TNF-α gene polymorphisms and expression. Springerplus 2016;5(1):1508.
  • 16.Pinho-Ribeiro FA, Verri WA Jr, Chiu IM. Nocicep-tor sensory neuron-immune interactions in pain and inflammation. Trends Immunol 2017;38(1):5-19.
  • 17. Yilmaz IA, Ozge A, Erdal ME, et al. Cytokine polymorphism in patients with migraine: Some sugges-tive clues of migraine and inflammation. Pain Med 2010;11(4):492-97.
  • 18. Fawzi MS, El-Shal AS, Rashad NM, et al. Influence of tumor necrosis factor alpha gene promoter poly-morphisms and its serum level on migraine susceptibi-lity in Egyptian patients. J Neurol Sci 2015;348(1-2):74-80.
  • 19. Mason BN, Russo AF. Vascular contributions to migraine: Time to revisit? Front Cell Neurosci 2018;12:233.
  • 20. Rodriguez-Acevedo AJ, Smith RA, Roy B, et al. Genetic association and gene expression studies sug-gest that genetic variants in the SYNE1 and TNF genes are related to menstrual migraine. J Headache Pain 2014;15(1):62.
  • 21. Chen M, Tang W, Hou L, et al. Tumor necrosis fac-tor (TNF) -308G>A, nitric oxide synthase 3 (NOS3)+894G>T polymorphisms and migraine risk: A Meta-Analysis. PLoS One 2015;10(6):e0129372.
  • 22. Ghosh J, Joshi G, Pradhan S, Mittal B. Investiga-tion of TNFA 308G > A and TNFB 252G > A poly-morphisms in genetic susceptibility to migraine. J Neurol 2010;257(6):898-904.
  • 23. Headache Classification Subcommittee of the In-ternational Headache Society. The International Classi-fication of Headache Disorders: 2nd edition. Cephalal-gia. 2004;24 Suppl 1:9-160.
  • 24. Yılmaz Y, Verdi H, Taneri A, et al. Maternal-fetal proinflammatory cytokine gene polymorphism and preterm birth. DNA Cell Biol 2012;31(1):92-107.
  • 25. Schürks M, Rist PM, Zee RY, et al. Tumour necrosis factor gene polymorphisms and migraine: A systematic review and meta-analysis. Cephalalgia 2011;31(13):1381-404.
  • 26. Mazaheri S, Hajilooi M, Rafiei A. The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with migraine without aura. J Neurol 2006;253(12):1589-93.
  • 27. Perini F, D'Andrea G, Galloni E, et al. Plasma cyto-kine levels in migraineurs and controls. Headache 2005;45(7):926-31.
  • 28. Gallai V SP, Floridi A, Franceschini M, et al. Mo-nocyte function in migraine patients with and without aura. Headache Q 1994;214-27.
  • 29. Sarchielli P, Alberti A, Baldi A, et al. Proinflamma-tory cytokines, adhesion molecules, and lymphocyte integrin expression in the internal jugular blood of migraine patients without aura assessed ictally. Hea-dache 2006;46(2):200-7.
  • 30. Pappa S, Hatzistilianou M, Kouvatsi A, et al. Tumour necrosis factor gene polymorphisms and migra-ine in Greek children. Arch Med Sci 2010;6(3):430-7.
  • 31.Uzar E, Evliyaoglu O, Yucel Y, et al. Serum cytoki-ne and pro-brain natriuretic peptide (BNP) levels in patients with migraine. Eur Rev Med Pharmacol Sci 2011;15(10):1111-16.
Toplam 31 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Makaleler
Yazarlar

Derya Tatlısuluoğlu

Eda Derle

Ruhsen Ocal

Seda Kibaroglu

Fatma Belgin Ataç

Ufuk Can

Yayımlanma Tarihi 29 Eylül 2021
Gönderilme Tarihi 1 Temmuz 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 2 Sayı: 3

Kaynak Göster

APA Tatlısuluoğlu, D., Derle, E., Ocal, R., Kibaroglu, S., vd. (2021). The relationship between tumor necrosis factor α-308 G/A poly-morphism and serum tumor necrosis factor α levels in patients with migraine without aura. Troia Medical Journal, 2(3), 73-78.
AMA Tatlısuluoğlu D, Derle E, Ocal R, Kibaroglu S, Ataç FB, Can U. The relationship between tumor necrosis factor α-308 G/A poly-morphism and serum tumor necrosis factor α levels in patients with migraine without aura. Troia Med J. Eylül 2021;2(3):73-78.
Chicago Tatlısuluoğlu, Derya, Eda Derle, Ruhsen Ocal, Seda Kibaroglu, Fatma Belgin Ataç, ve Ufuk Can. “The Relationship Between Tumor Necrosis Factor α-308 G/A Poly-Morphism and Serum Tumor Necrosis Factor α Levels in Patients With Migraine Without Aura”. Troia Medical Journal 2, sy. 3 (Eylül 2021): 73-78.
EndNote Tatlısuluoğlu D, Derle E, Ocal R, Kibaroglu S, Ataç FB, Can U (01 Eylül 2021) The relationship between tumor necrosis factor α-308 G/A poly-morphism and serum tumor necrosis factor α levels in patients with migraine without aura. Troia Medical Journal 2 3 73–78.
IEEE D. Tatlısuluoğlu, E. Derle, R. Ocal, S. Kibaroglu, F. B. Ataç, ve U. Can, “The relationship between tumor necrosis factor α-308 G/A poly-morphism and serum tumor necrosis factor α levels in patients with migraine without aura”, Troia Med J, c. 2, sy. 3, ss. 73–78, 2021.
ISNAD Tatlısuluoğlu, Derya vd. “The Relationship Between Tumor Necrosis Factor α-308 G/A Poly-Morphism and Serum Tumor Necrosis Factor α Levels in Patients With Migraine Without Aura”. Troia Medical Journal 2/3 (Eylül 2021), 73-78.
JAMA Tatlısuluoğlu D, Derle E, Ocal R, Kibaroglu S, Ataç FB, Can U. The relationship between tumor necrosis factor α-308 G/A poly-morphism and serum tumor necrosis factor α levels in patients with migraine without aura. Troia Med J. 2021;2:73–78.
MLA Tatlısuluoğlu, Derya vd. “The Relationship Between Tumor Necrosis Factor α-308 G/A Poly-Morphism and Serum Tumor Necrosis Factor α Levels in Patients With Migraine Without Aura”. Troia Medical Journal, c. 2, sy. 3, 2021, ss. 73-78.
Vancouver Tatlısuluoğlu D, Derle E, Ocal R, Kibaroglu S, Ataç FB, Can U. The relationship between tumor necrosis factor α-308 G/A poly-morphism and serum tumor necrosis factor α levels in patients with migraine without aura. Troia Med J. 2021;2(3):73-8.