Epitelyal Over Kanserlerinde Genetik Testler

Tevfik Güvenal; Fuat Demirkıran; İlkkan Dünder

Epitelyal Over Kanserlerinde Genetik Testler

Öz

Epitalyal over kanserleri için en bilinen risk faktörü aile öyküsü ve genetik mutasyonların varlığıdır. Genetik mutasyonların en bilineni BRCA1 ve 2 gen mutasyonları olup bunlar homolog rekombinasyon onarım gen ailesindendir. Ayrıca BRCA1-2 dışında homolog rekombinasyon onarımında görevli diğer gen mutasyonları da risk faktörü oluşturmaktadır. Gen mutasyonları germ line ve/veya somatik mutasyonlar şeklinde olmaktadır. Günümüzde epitelyal over kanserlerinde, özellikle yüksek dereceli seröz tümörlerde bu mutasyonların bilinmesi, hem hastanın tedavasinin yönlendirilmesinde hem de aile bireylerinde risk olup olmadığının belirlenmesinde önemlidir. Bu derlemede bu testlerin saptanma yöntemleri, tedavi seçminde etkinliği ve riskli kadınlardaki yönetim tartışılacaktır.

Anahtar Kelimeler

Destekleyen Kurum

Türk Jinekolojik Onkoloji Derneği

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Jinekolojik Onkoloji Cerrahisi

Bölüm

Derleme

Yazarlar

Tevfik Güvenal ^*
Türkiye

Fuat Demirkıran
Türkiye

İlkkan Dünder
Türkiye

Erken Görünüm Tarihi

12 Eylül 2025

Yayımlanma Tarihi

11 Eylül 2025

Gönderilme Tarihi

11 Temmuz 2023

Kabul Tarihi

2 Eylül 2025

Yayımlandığı Sayı

Yıl 2025 Cilt: 25 Sayı: 2

IZ

https://izlik.org/JA64UA44SG

Kaynak Göster

RIS / Bibtex

APA

Güvenal, T., Demirkıran, F., & Dünder, İ. (2025). Epitelyal Over Kanserlerinde Genetik Testler. Türk Jinekolojik Onkoloji Dergisi, 25(2), 66-75. https://izlik.org/JA64UA44SG

AMA

1.Güvenal T, Demirkıran F, Dünder İ. Epitelyal Over Kanserlerinde Genetik Testler. TRSGO Dergisi. 2025;25(2):66-75. https://izlik.org/JA64UA44SG

Chicago

Güvenal, Tevfik, Fuat Demirkıran, ve İlkkan Dünder. 2025. “Epitelyal Over Kanserlerinde Genetik Testler”. Türk Jinekolojik Onkoloji Dergisi 25 (2): 66-75. https://izlik.org/JA64UA44SG.

EndNote

Güvenal T, Demirkıran F, Dünder İ (01 Eylül 2025) Epitelyal Over Kanserlerinde Genetik Testler. Türk Jinekolojik Onkoloji Dergisi 25 2 66–75.

IEEE

[1]T. Güvenal, F. Demirkıran, ve İ. Dünder, “Epitelyal Over Kanserlerinde Genetik Testler”, TRSGO Dergisi, c. 25, sy 2, ss. 66–75, Eyl. 2025, [çevrimiçi]. Erişim adresi: https://izlik.org/JA64UA44SG

ISNAD

Güvenal, Tevfik - Demirkıran, Fuat - Dünder, İlkkan. “Epitelyal Over Kanserlerinde Genetik Testler”. Türk Jinekolojik Onkoloji Dergisi 25/2 (01 Eylül 2025): 66-75. https://izlik.org/JA64UA44SG.

JAMA

1.Güvenal T, Demirkıran F, Dünder İ. Epitelyal Over Kanserlerinde Genetik Testler. TRSGO Dergisi. 2025;25:66–75.

MLA

Güvenal, Tevfik, vd. “Epitelyal Over Kanserlerinde Genetik Testler”. Türk Jinekolojik Onkoloji Dergisi, c. 25, sy 2, Eylül 2025, ss. 66-75, https://izlik.org/JA64UA44SG.

Vancouver

1.Tevfik Güvenal, Fuat Demirkıran, İlkkan Dünder. Epitelyal Over Kanserlerinde Genetik Testler. TRSGO Dergisi [Internet]. 01 Eylül 2025;25(2):66-75. Erişim adresi: https://izlik.org/JA64UA44SG