Yıl 2016, Cilt 19 , Sayı 3, Sayfalar 99 - 106 2018-05-21

SURGICAL MANAGEMENT OF RECURRENT EPITHELIAL OVARIAN CANCER
REKÜRREN EPİTELYAL OVER KANSERİNİN CERRAHİ YÖNETİMİ

Murat Öz [1] , İlker Selçuk [2] , Zeliha Fırat Cüylan [3] , Hüseyin Akıllı [4] , Ali Ayhan [5]


Primary cytoreductive surgery followed by platinum based intravenous chemotherapy is the mainstay of the treatment in epithelial ovarian cancer (EOC). Most of the patients Show complete remission after the initial therapy. However, patients with advanced stage disease will eventually recur. There is not a standardized management for recurrent EOC. The management and therapeutic options should be highly individualized for recurrent EOC patients. There are two majör options fort he patients with recurrent EOC: first option is intravenous chemotherapy, which should be established according to the platinum sensitivity of the tumor. Second option is adjuvant intravenous chemotherapy followed by secondary cytoreductive surgery (SCR). Due to lack of high quality evidence, there is not a standard approach for recurrent EOC. In the review article, we evaluated the rationale in the management of recurrent EOC and tried to establish a current approach for individualizing the management and patient selection for SCR in EOC.

Epitelyal over kanseri’nin (EOK) standart yönetim şekli primer sitoredüktif cerrahi ve ardından verilen intravenöz platin tabanlı kemoterapidir. İlk tedavi sonrası hastaların büyük bölümünde remisyon görülmesine rağmen ileri evre hastalıkta nihayetinde hastaların tamamına yakını nüksetmektedir. Rekürren EOK’de henüz standartlaşmış bir yönetim şekli yoktur. Nüks hastaların değerlendirilmesi ve tedavi şekli mutlaka bireyselleştirilmelidir. Nüks tanısı alan hastanın önünde iki seçenek vardır. Birincisi platin duyarlılığına göre belirlenecek kemoterapi rejiminin alınması, ikincisi ise sekonder sitoredüksiyon (SSR) girişiminin ardından verilecek adjuvan kemoterapi. Henüz iki yöntem de standart yönetime girmiş değildir, çünkü bu konuya açıklık getirecek kanıtlar henüz olgunlaşmamıştır. Bu derlemede son literatür ışığında rekürren EOK hastalarında SSR girişiminin rasyoneli ve şimdiye dek yapılmış çalışmalar irdelenerek tedavinin bireyselleştirilmesi ve hasta seçimi konusunda güncel yaklaşım oluşturulmaya çalışılacaktır. 

  • 1. Bristow RE, Tomacruz RS, Armstrong DK, Trimble EL, Montz FJ. Survival eff ect of maximal cytoreductive surgery for advanced ovarian carcinoma during the platinum era: a meta-analysis. Journal of clinical oncology : off icial journal of the American Society of Clinical Oncology. 2002;20(5):1248-59.
  • 2. Parmar MK, Ledermann JA, Colombo N,, et al. Paclitaxel plus platinum-based chemotherapy versus conventional platinum-based chemotherapy in women with relapsed ovarian cancer: the ICON4/AGO-OVAR-2.2 trial. Lancet. 2003;361(9375):2099-106.
  • 3. Aghajanian C, Blank SV, Goff BA, et al. OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer. Journal of clinical oncology : off icial journal of the American Society of Clinical Oncology. 2012;30(17):2039-45.
  • 4. Morris M, Gershenson DM, Wharton JT. Secondary cytoreductive surgery in epithelial ovarian cancer: nonresponders to first-line therapy. Gynecologic oncology. 1989;33(1):1-5.
  • 5. Petrillo M, Pedone Anchora L, Tortorella L, et al. Secondary cytoreductive surgery in patients with isolated platinum-resistant recurrent ovarian cancer: a retrospective analysis. Gynecologic oncology. 2014;134(2):257-61.
  • 6. Al Rawahi T, Lopes AD, Bristow RE, et al. Surgical cytoreduction for recurrent epithelial ovarian cancer. Th e Cochrane database of systematic reviews. 2013;2:CD008765.
  • 7. Berek JS, Hacker NF, Lagasse LD, Nieberg RK, Elashoff RM. Survival of patients following secondary cytoreductive surgery in ovarian cancer. Obstetrics and gynecology. 1983;61(2):189-93.
  • 8. Bristow RE, Puri I, Chi DS. Cytoreductive surgery for recurrent ovarian cancer: a meta-analysis. Gynecologic oncology. 2009;112(1):265-74.
  • 9. Lee CK, Lord S, Grunewald T, Gebski V, et al. Impact of secondary cytoreductive surgery on survival in patients with platinum sensitive recurrent ovarian cancer: analysis of the CALYPSO trial. Gynecologic oncology. 2015;136(1):18-24.
  • 10. Harter P, du Bois A, Hahmann M, et al. Surgery in recurrent ovarian cancer: the Arbeitsgemeinschaft Gynaekologische Onkologie (AGO) DESKTOP OVAR trial. Annals of surgical oncology. 2006;13(12):1702-10.
  • 11. Zang RY, Zhang ZY, Li ZT,, et al. Eff ect of cytoreductive surgery on survival of patients with recurrent epithelial ovarian cancer. Journal of surgical oncology. 2000;75(1):24-30.
  • 12. Chi DS, McCaughty K, Diaz JP, et al. Guidelines and selection criteria for secondary cytoreductive surgery in patients with recurrent, platinum-sensitive epithelial ovarian carcinoma. Cancer. 2006;106(9):1933-9.
  • 13. Gadducci A, Cosio S, Zola P, et al. Th e clinical outcome of epithelial ovarian cancer patients with apparently isolated lymph node recurrence: a multicenter retrospective Italian study. Gynecologic oncology. 2010;116(3):358-63.
  • 14. Ferrero A, Ditto A, Giorda G, et al. Secondary cytoreductive surgery for isolated lymph node recurrence of epithelial ovarian cancer: a multicenter study. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 2014;40(7):891-8.
  • 15. Petrillo M, Fagotti A, Ferrandina G, Fanfani F, et al. Ovarian cancer patients with localized relapse: clinical outcome and prognostic factors. Gynecologic oncology. 2013;131(1):36-41.
  • 16. Gershenson DM, Sun CC, Bodurka D, Coleman RL, et al. Recurrent low-grade serous ovarian carcinoma is relatively chemoresistant. Gynecologic oncology. 2009;114(1):48-52.
  • 17. Crane EK, Sun CC, Ramirez PT, Schmeler KM, Malpica A, Gershenson DM. Th e role of secondary cytoreduction in low-grade serous ovarian cancer or peritoneal cancer. Gynecologic oncology. 2015;136(1):25-9.
  • 18. van de Laar R, Kruitwagen RF, IntHout J, Zusterzeel PL, Van Gorp T, Massuger LF. Surgery for Recurrent Epithelial Ovarian Cancer in the Netherlands: A Population-Based Cohort Study. International journal of gynecological cancer : off icial journal of the International Gynecological Cancer Society. 2015.
  • 19. Goldie JH, Coldman AJ. A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate. Cancer Treat Rep. 1979;63(11-12):1727-33.
  • 20. Covens AL. A critique of surgical cytoreduction in advanced ovarian cancer. Gynecologic oncology. 2000;78(3 Pt 1):269-74.
  • 21. Hoskins WJ, McGuire WP, Brady MF, et al. Th e eff ect of diameter of largest residual disease on survival aft er primary cytoreductive surgery in patients with suboptimal residual epithelial ovarian carcinoma. American journal of obstetrics and gynecology. 1994;170(4):974-9; discussion 9-80.
  • 22. Minaguchi T, Satoh T, Matsumoto K, et al. Proposal for selection criteria of secondary cytoreductive surgery in recurrent epithelial ovarian, tubal, and peritoneal cancers. Int J Clin Oncol. 2015.
  • 23. Tian WJ, Chi DS, Sehouli J, et al. A risk model for secondary cytoreductive surgery in recurrent ovarian cancer: an evidence-based proposal for patient selection. Annals of surgical oncology. 2012;19(2):597-604.
  • 24. Ayhan A, Gultekin M, Taskiran C, et al. Th e role of secondary cytoreduction in the treatment of ovarian cancer: Hacettepe University experience. American journal of obstetrics and gynecology. 2006;194(1):49-56.
  • 25. Harter P, Sehouli J, Reuss A, et al. Prospective validation study of a predictive score for operability of recurrent ovarian cancer: the Multicenter Intergroup Study DESKTOP II. A project of the AGO Kommission OVAR, AGO Study Group, NOGGO, AGO-Austria, and MITO. International journal of gynecological cancer : off icial journal of the International Gynecological Cancer Society. 2011;21(2):289-95.
  • 26. Benedetti Panici P, Perniola G, Angioli R, et al. Bulky lymph node resection in patients with recurrent epithelial ovarian cancer: impact of surgery. International journal of gynecological cancer : off icial journal of the International Gynecological Cancer Society. 2007;17(6):1245-51.
  • 27. Janicke F, Holscher M, Kuhn W, et al. Radical surgical procedure improves survival time in patients with recurrent ovarian cancer. Cancer. 1992;70(8):2129-36.
  • 28. Vaccarello L, Rubin SC, Vlamis V, et al. Cytoreductive surgery in ovarian carcinoma patients with a documented previously complete surgical response. Gynecologic oncology. 1995;57(1):61-5.
  • 29. Cormio G, di Vagno G, Cazzolla A, et al. Surgical treatment of recurrent ovarian cancer: report of 21 cases and a review of the literature. European journal of obstetrics, gynecology, and reproductive biology. 1999;86(2):185-8.
  • 30. Gadducci A, Iacconi P, Cosio S, Fanucchi A, Cristofani R, Riccardo Genazzani A. Complete salvage surgical cytoreduction improves further survival of patients with late recurrent ovarian cancer. Gynecologic oncology. 2000;79(3):344-9.
  • 31. Onda T, Yoshikawa H, Yasugi T, Yamada M, Matsumoto K, Taketani Y. Secondary cytoreductive surgery for recurrent epithelial ovarian carcinoma: proposal for patients selection. British journal of cancer. 2005;92(6):1026-32.
  • 32. Benedetti Panici P, De Vivo A, Bellati F, et al. Secondary cytoreductive surgery in patients with platinum-sensitive recurrent ovarian cancer. Annals of surgical oncology. 2007;14(3):1136-42.
  • 33. van de Laar R, Massuger LF, Van Gorp T, IntHout J, Zusterzeel PL, Kruitwagen RF. External validation of two prediction models of complete secondary cytoreductive surgery in patients with recurrent epithelial ovarian cancer. Gynecologic oncology. 2015;137(2):210-5.
  • 34. Rutten MJ, Leefl ang MM, Kenter GG, Mol BW, Buist M. Laparoscopy for diagnosing resectability of disease in patients with advanced ovarian cancer. Th e Cochrane database of systematic reviews. 2014;2:CD009786.
  • 35. Jansen FW, Kapiteyn K, Trimbos-Kemper T, Hermans J, Trimbos JB. Complications of laparoscopy: a prospective multicentre observational study. Br J Obstet Gynaecol. 1997;104(5):595-600.
  • 36. Chi DS, Abu-Rustum NR, Sonoda Y, et al. Ten-year experience with laparoscopy on a gynecologic oncology service: analysis of risk factors for complications and conversion to laparotomy. American journal of obstetrics and gynecology. 2004;191(4):1138-45.
  • 37. Vergote I, Marquette S, Amant F, Berteloot P, Neven P. Port-site metastases aft er open laparoscopy: a study in 173 patients with advanced ovarian carcinoma. International journal of gynecological cancer : off icial journal of the International Gynecological Cancer Society. 2005;15(5):776-9.
  • 38. Tanner EJ, Chi DS, Eisenhauer EL, Diaz-Montes TP, Santillan A, Bristow RE. Surveillance for the detection of recurrent ovarian cancer: survival impact or lead-time bias? Gynecologic oncology. 2010;117(2):336-40.
  • 39. Rustin GJ, Nelstrop AE, Tuxen MK, Lambert HE. Defining progression of ovarian carcinoma during followup according to CA 125: a North Th ames Ovary Group Study. Annals of oncology : off icial journal of the European Society for Medical Oncology / ESMO. 1996;7(4):361-4.
  • 40. Rustin GJ, Marples M, Nelstrop AE, Mahmoudi M, Meyer T. Use of CA-125 to define progression of ovarian cancer in patients with persistently elevated levels. Journal of clinical oncology : off icial journal of the American Society of Clinical Oncology. 2001;19(20):4054-7.
  • 41. Parker PA, Kudelka A, Basen-Engquist K, Kavanagh J, de Moor J, Cohen L. Th e associations between knowledge, CA125 preoccupation, and distress in women with epithelial ovarian cancer. Gynecologic oncology. 2006;100(3):495-500.
  • 42. Angioli R, Plotti F, Capriglione S, et al. Can the preoperative HE4 level predict optimal cytoreduction in patients with advanced ovarian carcinoma? Gynecologic oncology. 2013;128(3):579-83.
  • 43. Angioli R, Capriglione S, Aloisi A, et al. A Predictive Score for Secondary Cytoreductive Surgery in Recurrent Ovarian Cancer (SeC-Score): A Single-Centre, Controlled Study for Preoperative Patient Selection. Annals of surgical oncology. 2015;22(13):4217-23.
  • 44. Chung HH, Kwon HW, Kang KW, et al. Prognostic value of preoperative metabolic tumor volume and total lesion glycolysis in patients with epithelial ovarian cancer. Annals of surgical oncology. 2012;19(6):1966-72.
  • 45. Lee JW, Cho A, Lee JH, et al. Th e role of metabolic tumor volume and total lesion glycolysis on (1)(8)F-FDG PET/ CT in the prognosis of epithelial ovarian cancer. European journal of nuclear medicine and molecular imaging. 2014;41(10):1898-906.
  • 46. Kim CY, Jeong SY, Chong GO, et al. Quantitative metabolic parameters measured on F-18 FDG PET/CT predict survival aft er relapse in patients with relapsed epithelial ovarian cancer. Gynecologic oncology. 2015;136(3):498- 504.
  • 47. Munkarah AR, Coleman RL. Critical evaluation of secondary cytoreduction in recurrent ovarian cancer. Gynecologic oncology. 2004;95(2):273-80.
  • 48. Plotti F, Scaletta G, Aloisi A, et al. Quality of Life in Platinum-Sensitive Recurrent Ovarian Cancer: Chemotherapy Versus Surgery Plus Chemotherapy. Annals of surgical oncology. 2015;22(7):2387-94.
  • 49. Wenzel L, Huang HQ, Monk BJ, Rose PG, Cella D. Quality-of-life comparisons in a randomized trial of interval secondary cytoreduction in advanced ovarian carcinoma: a Gynecologic Oncology Group study. Journal of clinical oncology : off icial journal of the American Society of Clinical Oncology. 2005;23(24):5605-12.
  • 50. Spiliotis J, Halkia E, Lianos E, et al. Cytoreductive surgery and HIPEC in recurrent epithelial ovarian cancer: a prospective randomized phase III study. Annals of surgical oncology. 2015;22(5):1570-5.
  • 51. Bakrin N, Cotte E, Golfier F, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for persistent and recurrent advanced ovarian carcinoma: a multicenter, prospective study of 246 patients. Annals of surgical oncology. 2012;19(13):4052-8.
  • 52. Bakrin N, Bereder JM, Decullier E, et al. Peritoneal carcinomatosis treated with cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for advanced ovarian carcinoma: a French multicentre retrospective cohort study of 566 patients. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 2013;39(12):1435-43.
  • 53. Woelber L, Jung S, Eulenburg C,, et al. Perioperative morbidity and outcome of secondary cytoreduction for recurrent epithelial ovarian cancer. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 2010;36(6):583-8.
  • 54. Salani R, Santillan A, Zahurak ML, et al. Secondary cytoreductive surgery for localized, recurrent epithelial ovarian cancer: analysis of prognostic factors and survival outcome. Cancer. 2007;109(4):685-91.
  • 55. Fotopoulou C, Richter R, Braicu IE, et al. Clinical outcome of tertiary surgical cytoreduction in patients with recurrent epithelial ovarian cancer. Annals of surgical oncology. 2011;18(1):49-57.
  • 56. Leitao MM, Jr., Kardos S, Barakat RR, Chi DS. Tertiary cytoreduction in patients with recurrent ovarian carcinoma. Gynecologic oncology. 2004;95(1):181-8.
  • 57. Karam AK, Santillan A, Bristow RE, et al. Tertiary cytoreductive surgery in recurrent ovarian cancer: selection criteria and survival outcome. Gynecologic oncology. 2007;104(2):377-80.
  • 58. Fotopoulou C, Zang R, Gultekin M, et al. Value of tertiary cytoreductive surgery in epithelial ovarian cancer: an international multicenter evaluation. Annals of surgical oncology. 2013;20(4):1348-54.
  • 59. Shih KK, Chi DS, Barakat RR, Leitao MM, Jr. Beyond tertiary cytoreduction in patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer. Gynecologic oncology. 2010;116(3):364-9.
  • 60. Fotopoulou C, Savvatis K, Kosian P, et al. Quaternary cytoreductive surgery in ovarian cancer: does surgical effort still matter? British journal of cancer. 2013;108(1):32-8.
  • 61. Galaal K, Naik R, Bristow RE, Patel A, Bryant A, Dickinson HO. Cytoreductive surgery plus chemotherapy versus chemotherapy alone for recurrent epithelial ovarian cancer. Th e Cochrane database of systematic reviews. 2010(6):CD007822.
  • 62. Friedlander M, Trimble E, Tinker A, et al. Clinical trials in recurrent ovarian cancer. International journal of gynecological cancer : off icial journal of the International Gynecological Cancer Society. 2011;21(4):771-5.
  • 63. van de Laar R, Zusterzeel PL, Van Gorp T, et al. Cytoreductive surgery followed by chemotherapy versus chemotherapy alone for recurrent platinum-sensitive epithelial ovarian cancer (SOCceR trial): a multicenter randomised controlled study. BMC Cancer. 2014;14:22.
Birincil Dil tr
Bölüm Derleme
Yazarlar

Yazar: Murat Öz (Sorumlu Yazar)

Yazar: İlker Selçuk

Yazar: Zeliha Fırat Cüylan

Yazar: Hüseyin Akıllı

Yazar: Ali Ayhan

Tarihler

Yayımlanma Tarihi : 21 Mayıs 2018

Bibtex @derleme { trsgo425402, journal = {Türk Jinekolojik Onkoloji Dergisi}, issn = {2148-5372}, address = {trsgo.dergisi@yahoo.com}, publisher = {Türk Jinekolojik Onkoloji Derneği}, year = {2018}, volume = {19}, pages = {99 - 106}, doi = {}, title = {REKÜRREN EPİTELYAL OVER KANSERİNİN CERRAHİ YÖNETİMİ}, key = {cite}, author = {Öz, Murat and Selçuk, İlker and Cüylan, Zeliha Fırat and Akıllı, Hüseyin and Ayhan, Ali} }
APA Öz, M , Selçuk, İ , Cüylan, Z , Akıllı, H , Ayhan, A . (2018). REKÜRREN EPİTELYAL OVER KANSERİNİN CERRAHİ YÖNETİMİ. Türk Jinekolojik Onkoloji Dergisi , 19 (3) , 99-106 . Retrieved from https://dergipark.org.tr/tr/pub/trsgo/issue/37060/425402
MLA Öz, M , Selçuk, İ , Cüylan, Z , Akıllı, H , Ayhan, A . "REKÜRREN EPİTELYAL OVER KANSERİNİN CERRAHİ YÖNETİMİ". Türk Jinekolojik Onkoloji Dergisi 19 (2018 ): 99-106 <https://dergipark.org.tr/tr/pub/trsgo/issue/37060/425402>
Chicago Öz, M , Selçuk, İ , Cüylan, Z , Akıllı, H , Ayhan, A . "REKÜRREN EPİTELYAL OVER KANSERİNİN CERRAHİ YÖNETİMİ". Türk Jinekolojik Onkoloji Dergisi 19 (2018 ): 99-106
RIS TY - JOUR T1 - REKÜRREN EPİTELYAL OVER KANSERİNİN CERRAHİ YÖNETİMİ AU - Murat Öz , İlker Selçuk , Zeliha Fırat Cüylan , Hüseyin Akıllı , Ali Ayhan Y1 - 2018 PY - 2018 N1 - DO - T2 - Türk Jinekolojik Onkoloji Dergisi JF - Journal JO - JOR SP - 99 EP - 106 VL - 19 IS - 3 SN - 2148-5372- M3 - UR - Y2 - 2019 ER -
EndNote %0 Türk Jinekolojik Onkoloji Dergisi REKÜRREN EPİTELYAL OVER KANSERİNİN CERRAHİ YÖNETİMİ %A Murat Öz , İlker Selçuk , Zeliha Fırat Cüylan , Hüseyin Akıllı , Ali Ayhan %T REKÜRREN EPİTELYAL OVER KANSERİNİN CERRAHİ YÖNETİMİ %D 2018 %J Türk Jinekolojik Onkoloji Dergisi %P 2148-5372- %V 19 %N 3 %R %U
ISNAD Öz, Murat , Selçuk, İlker , Cüylan, Zeliha Fırat , Akıllı, Hüseyin , Ayhan, Ali . "REKÜRREN EPİTELYAL OVER KANSERİNİN CERRAHİ YÖNETİMİ". Türk Jinekolojik Onkoloji Dergisi 19 / 3 (Mayıs 2018): 99-106 .
AMA Öz M , Selçuk İ , Cüylan Z , Akıllı H , Ayhan A . REKÜRREN EPİTELYAL OVER KANSERİNİN CERRAHİ YÖNETİMİ. TRSGO Dergisi. 2018; 19(3): 99-106.
Vancouver Öz M , Selçuk İ , Cüylan Z , Akıllı H , Ayhan A . REKÜRREN EPİTELYAL OVER KANSERİNİN CERRAHİ YÖNETİMİ. Türk Jinekolojik Onkoloji Dergisi. 2018; 19(3): 106-99.