Yıl 2016, Cilt 19 , Sayı 3, Sayfalar 107 - 112 2018-05-21

HUMAN PAPİLLOMA VİRÜS POZİTİF KADINLARDA KONVANSİYONEL VE SIVI BAZLI SMEAR TEKNİKLERİNİN KARŞILAŞTIRMASI
COMPARISON OF CONVENTIONAL AND LIQUID BASED SMEAR TECHNIQUES IN HUMAN PAPİLLOMA VIRUS POSITIVE WOMEN

Ümit Görkem [1] , Cihan Toğrul [2] , Dilek Yılmaz [3] , Cansu Nergizli [4] , Emine Arslan [5] , Tayfun Güngör [6]


Amaç: Human Papilloma Virus (HPV) test sonuçlarına göre kategorize edilmiş kadınlarda konvansiyonel smear (KS) ve sıvı bazlı smear (SBS) tekniklerinin karşılaştırılması amaçlanmıştır. Materyal ve Metodlar: Bu prospektif kesitsel çalışmaya Hitit Üniversitesi Hastanesi başvuran 140 kadın dahil edildi. HPV test sonuçlarına göre katılımcılar ikiye ayrıldı: 1)HPV-negatif (n=51) ve 2)HPV-pozitif (n=89). KS ve SBS tekniklerine göre alınan örnekler Bethesta 2001sistemine göre şu şekilde yorumlandı. 1- Normal, 2- Önemi belirsiz atipik skuamöz hücre (ASC-US), 3- Yüksek dereceli skuamöz intraepitelyal lezyonun ekarte edilemediği atipik skuamöz hücreler (ASC-H), 4- Düşük dereceli skuamöz intraepitelyal lezyon (L-SIL), 5- Yüksek dereceli skuamöz intraepitelyal lezyon (H-SIL), 6- Sınıflandırılamayan atipik glandüler hücreler (AGC-NOS) ve 7- Yetersiz materyal. Bulgular: HPV pozitif katılımcıların daha çok kırsal bölgede yaşadığı (p=0.005), daha çok kötü ekonomik düzeyine (p=0.010) ve daha dü- şük eğitim düzeyine sahip oldukları (p=0.002) belirlendi. Her iki grup sigara içme, oral kontraseptif kullanımı, smear testi yaptırma durumu, genital enfeksiyon öyküsü istatistiksel olarak benzer idiler (p=0.315, p=0.498, p=0.329, p=0.086 ve p=0.773). Ancak geçirilmiş genital siğil öyküsü HPV pozitif grupta daha sık idi (p<0.000). L-SIL tanısı istatistiksel anlamlılıkla SBS tekniğinde daha sık rapor edilmişti (p<0.001). Diğer tüm tanıların sıklığının ise HPV pozitif ve negatif gruplarda istatistiksel anlamda benzer olduğu saptandı (p>0.05). Her iki smear tekniğinde rapor edilen aynı sitolojik sonuçların çıkma uyumluluğu açısından anlamlı bir fark gözlenmedi (p=0.099). Sonuç: Çalışmamızda SBS tekniğinin L-SIL lezyonlarının saptanmasında daha avantajlı olduğunu ve diğer sitolojik tanılar için smear teknikleri arasında bir fark olmadığı gösterilmiştir. Ayrıca KS, maliyet artışı konusu da dikkate alındığında SBS tekniğine iyi bir alternatif olabilir. 

Aim: It was aimed to compare conventional (CS) and liquid-based smear (LBS) techniques in women cathegorized according to Human Papilloma Virus (HPV) test results. Material and methods: 140 participant women admitted to Hitit University Hospital was included into this prospective cross-sectional study. According to HPV test results, the participants were divided into two groups; 1) HPV-negative (n=51) and 2) HPV-positive (n=89) groups.The specimens collected by CS and LBS techniques were reported according to Bethesta 2001 system; 1- Normal, 2- Atypical squamous cells of undetermined significance (ASC-US), 3- Atypical squamous cells- cannot exclude HSIL (ASC-H), 4- Low-grade squamous intraepithelial lesion (L-SIL), 5- High-grade squamous intraepithelial lesion (H-SIL), 6- Atypical Glandular Cells not otherwise specified (AGC-NOS) and 7- Inadequate specimen. Results: HPV-positive women were living at rural area (p=0.005), had lower economical level (p=0.010) and lower educational level (p=0.002). Both groups were statistically similar at the aspects of smoking, oral contraceptives, performing servical smear, medical history of genital infections (p=0.315, p=0.498, p=0.329, p=0.086 and p=0.773). Past genital warts were more frequent in HPV-positive group (p<0.001). L-SIL was more frequently reported in LBS technique (p<0.001). Other cytologically results were found to be similar in HPV groups (p>0.05, for all). The compatibility of the same results in both groups was not statistically different ((p=0.099). Conclusion: In our study, LBS technique has an advantage for detecting L-SIL, and it is demonstrated that there is no difference for cytological diagnosis. Furthermore, CS technique may be a preferable option to LBS technique due to increased costs. 

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Birincil Dil tr
Konular Cerrahi
Bölüm Araştırma Makalesi
Yazarlar

Yazar: Ümit Görkem (Sorumlu Yazar)

Yazar: Cihan Toğrul

Yazar: Dilek Yılmaz

Yazar: Cansu Nergizli

Yazar: Emine Arslan

Yazar: Tayfun Güngör

Tarihler

Yayımlanma Tarihi : 21 Mayıs 2018

Bibtex @araştırma makalesi { trsgo425406, journal = {Türk Jinekolojik Onkoloji Dergisi}, issn = {2148-5372}, address = {trsgo.dergisi@yahoo.com}, publisher = {Türk Jinekolojik Onkoloji Derneği}, year = {2018}, volume = {19}, pages = {107 - 112}, doi = {}, title = {HUMAN PAPİLLOMA VİRÜS POZİTİF KADINLARDA KONVANSİYONEL VE SIVI BAZLI SMEAR TEKNİKLERİNİN KARŞILAŞTIRMASI}, key = {cite}, author = {Görkem, Ümit and Toğrul, Cihan and Yılmaz, Dilek and Nergizli, Cansu and Arslan, Emine and Güngör, Tayfun} }
APA Görkem, Ü , Toğrul, C , Yılmaz, D , Nergizli, C , Arslan, E , Güngör, T . (2018). HUMAN PAPİLLOMA VİRÜS POZİTİF KADINLARDA KONVANSİYONEL VE SIVI BAZLI SMEAR TEKNİKLERİNİN KARŞILAŞTIRMASI. Türk Jinekolojik Onkoloji Dergisi , 19 (3) , 107-112 . Retrieved from https://dergipark.org.tr/tr/pub/trsgo/issue/37060/425406
MLA Görkem, Ü , Toğrul, C , Yılmaz, D , Nergizli, C , Arslan, E , Güngör, T . "HUMAN PAPİLLOMA VİRÜS POZİTİF KADINLARDA KONVANSİYONEL VE SIVI BAZLI SMEAR TEKNİKLERİNİN KARŞILAŞTIRMASI". Türk Jinekolojik Onkoloji Dergisi 19 (2018 ): 107-112 <https://dergipark.org.tr/tr/pub/trsgo/issue/37060/425406>
Chicago Görkem, Ü , Toğrul, C , Yılmaz, D , Nergizli, C , Arslan, E , Güngör, T . "HUMAN PAPİLLOMA VİRÜS POZİTİF KADINLARDA KONVANSİYONEL VE SIVI BAZLI SMEAR TEKNİKLERİNİN KARŞILAŞTIRMASI". Türk Jinekolojik Onkoloji Dergisi 19 (2018 ): 107-112
RIS TY - JOUR T1 - HUMAN PAPİLLOMA VİRÜS POZİTİF KADINLARDA KONVANSİYONEL VE SIVI BAZLI SMEAR TEKNİKLERİNİN KARŞILAŞTIRMASI AU - Ümit Görkem , Cihan Toğrul , Dilek Yılmaz , Cansu Nergizli , Emine Arslan , Tayfun Güngör Y1 - 2018 PY - 2018 N1 - DO - T2 - Türk Jinekolojik Onkoloji Dergisi JF - Journal JO - JOR SP - 107 EP - 112 VL - 19 IS - 3 SN - 2148-5372- M3 - UR - Y2 - 2019 ER -
EndNote %0 Türk Jinekolojik Onkoloji Dergisi HUMAN PAPİLLOMA VİRÜS POZİTİF KADINLARDA KONVANSİYONEL VE SIVI BAZLI SMEAR TEKNİKLERİNİN KARŞILAŞTIRMASI %A Ümit Görkem , Cihan Toğrul , Dilek Yılmaz , Cansu Nergizli , Emine Arslan , Tayfun Güngör %T HUMAN PAPİLLOMA VİRÜS POZİTİF KADINLARDA KONVANSİYONEL VE SIVI BAZLI SMEAR TEKNİKLERİNİN KARŞILAŞTIRMASI %D 2018 %J Türk Jinekolojik Onkoloji Dergisi %P 2148-5372- %V 19 %N 3 %R %U
ISNAD Görkem, Ümit , Toğrul, Cihan , Yılmaz, Dilek , Nergizli, Cansu , Arslan, Emine , Güngör, Tayfun . "HUMAN PAPİLLOMA VİRÜS POZİTİF KADINLARDA KONVANSİYONEL VE SIVI BAZLI SMEAR TEKNİKLERİNİN KARŞILAŞTIRMASI". Türk Jinekolojik Onkoloji Dergisi 19 / 3 (Mayıs 2018): 107-112 .
AMA Görkem Ü , Toğrul C , Yılmaz D , Nergizli C , Arslan E , Güngör T . HUMAN PAPİLLOMA VİRÜS POZİTİF KADINLARDA KONVANSİYONEL VE SIVI BAZLI SMEAR TEKNİKLERİNİN KARŞILAŞTIRMASI. TRSGO Dergisi. 2018; 19(3): 107-112.
Vancouver Görkem Ü , Toğrul C , Yılmaz D , Nergizli C , Arslan E , Güngör T . HUMAN PAPİLLOMA VİRÜS POZİTİF KADINLARDA KONVANSİYONEL VE SIVI BAZLI SMEAR TEKNİKLERİNİN KARŞILAŞTIRMASI. Türk Jinekolojik Onkoloji Dergisi. 2018; 19(3): 112-107.