Lokal İleri Evre Serviks Kanseri Yönetimi: Güncel Derleme

Yıl 2021, Cilt: 22 Sayı: 1, 9 - 14, 22.03.2021

Pinar Solmaz Hasdemir , Tevfik Güvenal

Öz

Servikal kanser sıklığı dünyada kadın kanserleri ve kadın kansere bağlı ölümleri arasında dördüncü sıradadır. Erken evre ve ileri evre servikal kanserlerde tedavi yaklaşımı göreceli olarak net olmakla birlikte lokal ileri servikal kanserlerdeki tedavi yaklaşımı tartışmalı bir konudur. Klasik literatür radyoterapi ve cerrahi tedavinin karşılaştırılması şeklinde iken son yıllarda eş zamanlı radyokemoterapi de etkin bir yöntem olarak değerlendirilmektedir. Bu derlemede lokal ileri servikal kanserlerde tedavi yaklaşımları tarihsel olarak değerlendirilecek ve güncel yaklaşımlar literatür eşliğinde özetlenecektir.

Anahtar Kelimeler

Serviks kanseri, lokal ileri evre, cerrahi tedavi, kemoterapi, radyoterapi

Management of Locally Advanced Cervical Cancer: A Contemporary Review

Öz

Cervical cancer is the fourth most frequently diagnosed cancer and the fourth leading cause of cancer death in women. Treatment strategy is quite certain in early and advanced stages, but there are controversies in the treatment of locally advanced cervical cancers. While clasical literature compares raditherapy and surgical therapy in the management of locally advanced cervical cancer, concominant chemoradiotherapy is considering as a novel therapeutic option. In this review article, treatment options in locally advanced cervical cancer will be discussed in chronological order in light of literature.

Anahtar Kelimeler

cervical cancer, locally advanced stage, surgical treatment, chemotherapy, radiotherapy

Kaynakça

• 1- Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 Nov;68(6):394-424. Erratum in: CA Cancer J Clin. 2020; 70: 313
• 2- Pecorelli S. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet 2009; 105: 103–4.
• 3- Bhatla N, Aoki D, Sharma DN, Sankaranarayanan R. Cancer of the cervix uteri. Int J Gynaecol Obstet 2018; 143: 22–36.
• 4- Falcetta FS, Medeiros LR, Edelweiss MI, Pohlmann PR, Stein AT, Rosa DD. Adjuvant platinum-based chemotherapy for early stage cervical cancer. Cochrane Database Syst Rev. 2016;11:CD005342.
• 5- Cibula D, Pötter R, Chiva L, Planchamp F, Avall-Lundqvist E, Raspollini MR. The European Society of Gynaecological Oncology / European Society for Radiotherapy and Oncology /European Society of Pathology Guidelines for the Management of Patients With Cervical Cancer. International Journal of Gynaecological Cancer 2018; 28: 641-655.
• 6- Newton M, Hickman B, Bolten A. Radical hysterectomy versus radiotherapy in stage I cervical cancer: preliminary results. Obstet Gynecol. 1964; 24: 563–568.
• 7- Newton M. Radical hysterectomy or radiotherapy for stage I cervical cancer. Am J Obstet Gynecol. 1975; 123: 535–542.
• 8- Morley GW, Seski JC. Radical pelvic surgery versus radiation therapy for stage I carcinoma of the cervix (exclusive of microinvasion). Am J Obstet Gynecol. 1976; 126: 785–798.
• 9- Brewster WR, Monk BJ, Ziogas A, Anton-Culver H, Yamada SD, Berman ML. Intent-to-treat analysis of stage Ib and IIa cervical cancer in the United States: radiotherapy or surgery 1988-1995. Obstet Gynecol. 2001;97(2):248-254.
• 10- Bansal N, Herzog TJ, Shaw RE, Burke WM, Deutsch I, Wright JD. Primary therapy for early-stage cervical cancer: radical hysterectomy vs radiation. Am J Obstet Gynecol. 2009; 201: 485.e1-485.e4859.
• 11- Doll KM, Donnelly E, Helenowski I, Rosenbloom LBS, Small W, Schink JC, Lurain JR. Radical Hysterectomy Compared With Primary Radiation for Treatment of Stage IB1 Cervix Cancer, American Journal of Clinical Oncology. 2014; 37: 30-34.
• 12- Landoni F, Maneo A, Colombo A, et al. Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer. Lancet. 1997; 350: 535-540.
• 13- Landoni F, Colombo A, Milani R, Placa F, Zanagnolo V, Mangioni C. Randomized study between radical surgery and radiotherapy for the treatment of stage IB-IIA cervical cancer: 20-year update. J Gynecol Oncol. 2017; 28: 34.
• 14- Benedetti-Panici P, Greggi S, Colombo A, et al. Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicenter randomized study. J Clin Oncol. 2002; 20: 179-188.
• 15- Colombo A, Landoni F, Maneo A, Zanetta G, Nava S, Tancini G. Neoadjuvant chemotherapy to radiation and concurrent chemoradiation for locally advanced squamous cell carcinoma of the cervix: a review of the recent literature. Tumori. 1998; 84: 229-237.
• 16- Maneo A, Colombo A, Landoni F, Colombo A, Villa A, Mangioni C. Trattamento del carcinoma della cervice uterina stadio IIIB. Confronto tra radioterapia, chemio-radioterapia concomitante e chemioterapia neoadiuvante [Treatment of stage IIIB cervical carcinoma. A comparison between radiotherapy, concurrent chemo-radiotherapy and neoadjuvant chemotherapy]. Minerva Ginecol. 2005; 57: 141-152.
• 17- Zhu Y, Yang J, Zhang X, Chen D, Zhang S. Acquired treatment response from neoadjuvant chemotherapy predicts a favorable prognosis for local advanced cervical cancer: A meta-analysis. Medicine (Baltimore). 2018; 97: 530.
• 18- Pötter R, Dimopoulos J, Georg P, et al. Clinical impact of MRI assisted dose volume adaptation and dose escalation in brachytherapy of locally advanced cervix cancer. Radiother Oncol. 2007; 83: 148-155.
• 19- Min LA, Ackermans LL, Nowee ME, et al. Pre-treatment prediction of early response to chemoradiotherapy by quantitative analysis of baseline staging FDG-PET/CT and MRI in locally advanced cervical cancer [published online ahead of print, 2020 Jul 28]. Acta Radiol. 2020; 284185120943046.
• 20- Tangjitgamol S, Katanyoo K, Laopaiboon M, Lumbiganon P, Manusirivithaya S, Supawattanabodee B. Adjuvant chemotherapy after concurrent chemoradiation for locally advanced cervical cancer. Cochrane Database Syst Rev. 2014; 12: CD010401.
• 21- Windschall A, Ott OJ, Sauer R, Strnad V. Radiation therapy and simultaneous chemotherapy for recurrent cervical carcinoma. Strahlenther Onkol. 2005; 181: 545-550.
• 22- Smith ES, Moon AS, OʼHanlon R, et al. Radical Trachelectomy for the Treatment of Early-Stage Cervical Cancer: A Systematic Review [published online ahead of print, 2020 Aug 6]. Obstet Gynecol. 2020;10.1097/AOG.0000000000003952.
• 23_https://en.wikibooks.org/wiki/Radiation_Oncology/Cervix/Early_Stage_Nonbulky#:~:text=Sedlis%20criteria%20often%20simplified%20to%20needing%202%20or,%5Bi.e%20%3E1%2F3%20stromal%20invasion%5D%20Size%20%3E%204%20cm
• 24- Tucker K, Staley A, Wang M, Rossi EC, Gehrig PA, Clark LH. Can preoperative cervical excision pathology predict the need for adjuvant radiation in early-stage cervix cancer? Abstracts / Gynecologic Oncology 2019; 154: 2–288.
• 25- Penson RT, Huang HQ, Wenzel LB, et al. Bevacizumab for advanced cervical cancer: patient-reported outcomes of a randomised, phase 3 trial (NRG Oncology-Gynecologic Oncology Group protocol 240) [published correction appears in Lancet Oncol. 2016 Jan;17(1):e6]. Lancet Oncol. 2015; 16: 301-311.
• 26- Chase D, Huang HQ, Monk BJ, et al. Patient-reported outcomes at discontinuation of anti-angiogenesis therapy in the randomized trial of chemotherapy with bevacizumab for advanced cervical cancer: an NRG Oncology Group study [published correction appears in Int J Gynecol Cancer. 2020 Aug;30(8):1267]. Int J Gynecol Cancer. 2020; 30: 596-601.