Homeobox (HOX) genleri ve jinekolojik kanserler

Yıl 2022, Cilt: 22 Sayı: 2, 1 - 6, 05.06.2022

Dilek Yüksel , Yunus Terzi Feride Şahin

Öz

Homeobox (HOX) genleri bir transkripsiyon faktörü olarak, embriyonik gelişim ve kanser ilerlemesinde önemli bir rol oynar. Ayrıca dişi üreme yolunun uygun şekilde bölünmesini sağlar ve yetişkin kimliğine yol açan konumsal kimliği verir. HOX genlerinin jinekolojik kanserlerde farklı ekspresyon paterni sergilediği, diyagnostic belirteç olmanın yanı sıra prognostik belirteç olarak kullanılabileceği öngörülmektedir. HOX genlerinin jinekolojik kanserlerin onkogenezindeki rolüne ilişkin bilgilerimiz gelişmektedir. Burada HOX genlerinin insan gelişimi ve jinekolojik kanser onkogenezindeki rollerini gözden geçiriyoruz.

Anahtar Kelimeler

Homebox genleri, Jinekolojik Kanserler, Onkogenez, Embriyogenezis

Homeobox (HOX) genes and gynecological cancers

Öz

Homeobox (HOX) genes play a significant role as a transcription factor in embryonic development and cancer progression. In addition, it ensures appropriate division of the female reproductive tract and determines spatial identity that leads to adult identity. It has been predicted that HOX genes exhibit a different expression pattern in gynecological cancers and can be used as a prognostic marker as well as a diagnostic marker. Our scientific knowledge has broadened regarding the role of HOX genes in the oncogenesis of gynecological cancers. Here, we review the role of HOX genes in human development and oncogenesis of gynecological cancers.

Anahtar Kelimeler

Homebox genes, Gynecological Cancers, Oncogenesis, Embryogenesis

Kaynakça

• Referans1 Shah N, Sukumar S. The Hox genes and their roles in oncogenesis. Nat. Rev. Cancer 2010; 10:361–371.
• Referans2 Pando SM, Taylor HS. Homeobox gene expression in ovarian cancer. Cancer Treat Res 2002;107:231-245.
• Referans3 Daftary GS, Taylor HS. Endocrine regulation of HOX genes, Endocr Rev.2006; 27: 331–355.
• Referans4 Alexander T, Nolte C, Krumlauf R. Hox genes and segmentaTion of the hindbrain and axial skeleton. Annu Rev Cell Dev Biol 2009;25:431–456.
• Referans5 Du H, Taylor HS. The Role of Hox Genes in Female Reproductive Tract Development, Adult Function, and Fertility. Cold Spring Harb Perspect Med 2015;9;6(1):a023002.
• Referans6 Cheng W, Liu J, Yoshida H, Rosen D, Naora H. Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract. Nat Med 2005;11:531–537.
• Referans7 Yılmaz N, Ozaksit G, Terzi YK, et al. HOXA11 and MMP2 gene expression in uterosacral ligaments of women with pelvic organ prolapse. J Turk Ger Gynecol Assoc 2014;15:104-108.
• Referans8 Taylor HS. The role of HOX genes in the development and function of the female reproductive tract. Semin Reprod Med 2000;18: 81–89.
• Referans9 Taylor HS. Endocrine disruptors affect developmental programming of HOX gene expression. Fertil Steril 2008; 89 :e57 – e58.
• Referans10 Ota T, Choi KB, Gilks CB, Leung PC, Auersperg N. Cell type and stage-specific changes in HOXA7 protein expression in human ovarian folliculogenesis: Possible role of GDF-9. Differentiation 2006; 74: 1–10.
• Referans11 Ota T, Asahina H, Park SH, et al. HOX cofactors expression and regulation in the human ovary. Reprod Biol Endocrinol 2008;6: 49
• Referans12 Hennessy BT, Mills GB. Ovarian cancer: homeobox genes, autocrine/paracrine growth, and kinase signaling. Int J Biochem Cell Biol 2006;38:1450-1456.
• Referans13 Hong JH, Lee JK, Park JJ, Lee NW, Lee KW, Na JY. Expression pattern of the class I homeobox genes in ovarian carcinoma. J Gynecol Oncol 2010;21: 29–37.
• Referans14 Miller KR, Patel JN, Ganapathi MK, Tait DL, Ganapathi RN. Biological role and clinical implications of homeobox genes in serous epithelial ovarian cancer. Gynecol Oncol 2016;141(3):608-615.
• Referans15 Abate-Shen C. Deregulated homeobox gene expression in cancer: Cause or consequence? Nat. Rev. Cancer 2002;2:777–785.
• Referans16 Ozer O, Bilezikci B, Aktas S, Sahin FI. Methylation profile analysis of DNA repair genes in hepatocellular carcinoma with MS-MLPA. Diagn Mol Pathol 2013;22:222-227.
• Referans17 Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature 2011;474:609-615.
• Referans18 Kelly ZL, Michael A, Butler-Manuel S, Pandha HS, Morgan Richard GL.HOX genes in ovarian cancer. J Ovarian Res 2011; 4:16.
• Referans19 Kelly Z, Moller-Levet C, McGrath S, et al. The prognostic significance of specific HOX gene expression patterns in ovarian cancer. Int J Cancer 2016;139:1608-1617.
• Referans20 Tait DL, Bahrani-Mostafavi Z, Vestal CG, Richardson C, Mostafavi MT. Downregulation of HOXC6 in Serous Ovarian Cancer. Cancer Invest 2015;33:303-311.
• Referans21 Sahin I, Yilmaz Z, Sahin FI. Cytogenetic abnormalities in serous papillary adenocarcinoma of the ovary. Eur J Gynecol Oncol 2004;25:585-586.
• Referans22 Idaikkadar P, Morgan R, Michael A. HOX Genes in High Grade Ovarian Cancer. Cancers (Basel) 2019;11:1107.
• Referans23 Miao J, Wang Z, Provencher H , et al. HOXB13 promotes ovarian cancer progression. Proc Natl Acad Sci USA 2007;104:17093–17098.
• Referans24 Rubin E, Wu X, Zhu T, et al. A role for the HOXB7 homeodomain protein in DNA repair. Cancer Res 2007;67:1527-1535.
• Referans25 Morgan R, El-Tanani M, Hunter KD, Harrington KJ, Pandha HS. Targeting HOX/PBX dimers in cancer. Oncotarget 2017;8:32322–32331.
• Referans26 Lane DB, Rutherford TJ, Taylor HS. HOXA10 expression in endometrial adenocarcinoma. Tumour Biol 2004;25:264-269.
• Referans27 Akbas GE, Taylor HS. HOXC and HOXD gene expression in human endometrium: Lack of redundancy with HOXA paralogs. Biol Reprod 2004;70:39–45.
• Referans28 Wan J, Liu H, Feng Q, Liu J, Ming L. HOXB9 promotes endometrial cancer progression by targeting E2F3. Cell Death Dis 2018;9:509.
• Referans29 Jin Eoh K, Jung Kim H, Lee J, et al. Upregulation of homeobox gene is correlated with poor survival outcomes in cervical cancer. Oncotarget 2017; 8: 84396-84402.
• Referans30 Sharma Saha S, Roy Chowdhury R, Ranjan Mondal N, Roy S, Sengupta S. Expression signatures of HOX cluster genes in cervical cancer pathogenesis: Impact of human papillomavirus type 16 oncoprotein E7. Oncotarget 2017; 8: 36591-36602.