Endometrial endometrioid adenokarsinomda mikrokistik, elonge ve fragmente (MELF) i̇nvazyon paterninin prognostik faktörlerle i̇lişkisi

Yıl 2024, Cilt: 24 Sayı: 3, 101 - 110

Metehan Uzundal , Taylan Şenol , Enis Özkaya

Öz

Amaç: Mikrokistik, Elonge ve Fragmente(MELF) myoinvazyon paterninin diğer histopatolojik faktörlerle ilişkili olup olmadığını ve böylece lenf nodu metastazının artmış bir görülme sıklığı ile ilişkili olup olmadığını araştırmaktı, dolayısıyla ileri evre hastalık için ek bir risk faktörü olarak değerlendirilebilir mi?
Yöntem: Mart 2015 ile Ekim 2020 tarihleri arasında Sağlık Bilimleri Üniversitesi Bağcılar Eğitim ve Araştırma Hastanesi Kadın Hastalıkları ve Doğum Kliniği’nde endometrial kanser için ameliyat edilen 105 hasta bu çalışmaya dahil edildi. MELF pozitif ve negatif gruplar arasında sağkalım ve nüks oranları değerlendirildi.
Bulgular: Hastalıksız sağkalım eğrileri MELF(+) ve MELF(-) gruplar arasında karşılaştırıldı. Gruplar arasında hastalıksız sağkalım açısından istatistiksel olarak anlamlı bir fark bulunamadı (P=0,310). 5 yıllık hastalıksız sağkalım MELF(+) grubunda %88,1 iken, MELF(-) grubunda %93,2 idi. Genel sağkalım eğrileri arasında anlamlı bir fark bulunmadı (P=0,894). 5 yıllık genel sağkalım MELF(+) grubunda %90,8 iken, MELF(-) grubunda %93,1 idi.
Sonuç: Endometrioid tip endometrial kanserde MELF invazyon paterninin hastalıksız sağkalım ve genel sağkalım üzerinde anlamlı bir etkisi gözlenmedi. MELF pozitif grupta anlamlı derecede daha yüksek bir LVSI insidansı bulduk. MELF paterninin varlığı, LVSI’da artışla dolaylı olarak prognozu olumsuz etkileyebilir.

Anahtar Kelimeler

Endometrium karsinomu, MELF, lenfovasküler invazyon

The relationship of MELF (microcystic, elongated and fragmented) invasion pattern with prognostic factors in endometrial endometrioid adenocarcinoma

Öz

Introduction: The aim of the present study was to investigate whether the Microcystic, Elongated And Fragmented (MELF) pattern of myometrial invasion is related to an increased occurrence of lymph node metastasis and could be considered as an additional risk factor for advanced stage disease.
Methods: One hundred and five patients who were operated for endometrial cancer between March 2015 and October 2020 in the Department of Obstetrics and Gynecology, Health Sciences University Bağcılar Training and Research Hospital, were included in this study. Survival and recurrence rates were evaluated between MELF positive and negative groups.
Results: Disease-free survival (DFS) curves were compared between the MELF(+) and MELF(-) groups. No statistically significant difference was found between groups in terms of disease-free survival. (P=0.310). The 5-year DFS was 88.1% in the MELF(+) group, while the 5-year DFS was 93.2% in the MELF(-) group. There was no significant difference between the overall survival (OS) curves (P=0.894). While the 5-year OS was 90.8% in the MELF(+) group, the 5-year OS was 93.1% in the MELF(-) group.
Conclusion: No significant effect of MELF invasion pattern was observed on disease-free survival and overall survival in endometrioid type endometrial cancer. We found a significantly higher incidence of lymphovascular space invasion (LVSI) in the MELF positive group. The presence of MELF pattern may indirectly affect the prognosis negatively with the increase in LVSI.

Anahtar Kelimeler

Endometrial carcinoma, MELF, lenfovascular invasion

Kaynakça

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