Polikistik Over Sendromlu Hastalarda İnsülin Direnci Ölçüm Metodlarının Değerlendirilmesi

Yıl 2022, , 24 - 31, 30.04.2022

Muhammet Cüneyt Bilginer , Damla Tüfekçi , Yasemin Emür Günay , Oğuzer Usta , Hülya Coşkun , Ozge Üçüncü , İrfan Nuhoğlu , Mustafa Koçak

https://doi.org/10.25048/tudod.1041387

Cited By: 1

Öz

Amaç: Bu çalışmada polikistik over sendromlu (PKOS) kadınlarda insülin direnci (IR) ölçüm metodlarının, aynı beden kütle indeksine
sahip PKOS olmayan kadınlarla karşılaştırılması hedeflenmiştir.
Gereç ve Yöntemler: Çalışmamıza PKOS (n=18 normal kilolu ve n=24 hafif kilolu/obez) ve PKOS olmayan (n=18 normal kilolu ve n=24
hafif kilolu/obez) toplam 84 kadın dahil edildi. Lipit düzeyi, glukoz düzeyi ve antropometrik ölçümler kullanılarak trigliserid glukoz
indeksi (TyG), insülin direncinin homeostaz modeliyle değerlendirmesi (HOMA-IR), visseral adipozite indeksi (VAI) hesaplandı. PKOS
olan ve olmayan gruplar arasında ölçüm değerlerinin karşılaştırılmasında Mann-Whitney U test ya da Student t-test kullanıldı. HOMAIR
ile yaş arasındaki ilişki Pearson korelasyon testi, HOMA-IR ile TyG arasındaki ilişki Spearman korelasyon testi ile hesaplandı. p<0.05
anlamlı kabul edildi.
Bulgular: PKOS grubunda PKOS olmayan gruba göre trigliserid düzeyi, insülin, TyG ve HOMA-IR yüksek bulundu (sırasıyla; p= 0.003,
p=0.001, p=0.006, p=0.001). PKOS grubunda HOMA-IR ile yaş arasında negatif korelasyon (r=-0.399, p=0.024), HOMA-IR ile TyG
indeksi arasında pozitif korelasyon (r=0.776, p< 0.001) tespit edildi. Normal kilolu PKOS’lu kadınlarda PKOS olmayanlara göre TyG
indeksi ve HOMA-IR yüksek bulundu. (sırasıyla p=0.002, p=0.003). Ancak hafif kilolu/obez PKOS’lu kadınlarda PKOS olmayanlara göre
fark görülmedi. PKOS hastalarında TyG indeksinin >3.91 olması (%89.5 sensivite, %76.9 spesifite) insulin rezistansını (IR) predikte etti.
Sonuç: PKOS’lu kadınlarda PKOS olmayanlara göre TyG ve HOMA-IR düzeyleri yüksektir. Bu hastalarda insulin rezistansı
değerlendirilmesinde TyG indeksi alternatif bir metod olarak kullanılabilir

Anahtar Kelimeler

Polikistik over sendromu, İnsülin direnci, TyG, HOMA-IR, VAİ

Destekleyen Kurum

Yok

Evaluation of Insulin Resistance Measurement Methods in Patients with Polycystic Ovary Syndrome

Öz

Aim: This study aims to compare insulin resistance (IR) measurement methods in women with and without polycystic ovary syndrome
(PCOS) who have the same body mass index.
Material and Methods: There were 84 women with PCOS and non-PCOS (n=18 normal weight and n=24 overweight/obese in both
groups). Triglyceride glucose index (TyG), assessment of insulin resistance with homeostasis model (HOMA-IR), visceral adiposity
index (VAI) were calculated using lipid level, glucose level and anthropometric measurements. Mann-Whitney U or Student's t-test
was used to compare measurements between the groups. The relationship between HOMA-IR and age was calculated with the Pearson
correlation test, and the relationship between HOMA-IR and TyG was calculated with the Spearman correlation test. p<0.05 was
considered significant.
Results: Triglyceride levels, insulin, TyG, and HOMA-IR were higher in the PCOS group than in the non-PCOS group (p=0.003, p=0.001,
p=0.006, p=0.001, respectively). In the PCOS group, there was a negative correlation between HOMA-IR and age (r=-0.399, p=0.024),
and a positive correlation between HOMA-IR and TyG index (r=0.776, p<0.001). TyG index and HOMA-IR were higher in normal
weight PCOS women than non-PCOS (p=0.002, p=0.003, respectively), however there was no difference in overweight/obese PCOS
women and non-PCOS. In PCOS patients, a TyG index >3.91 (89.5% sensitivity, 76.9% specificity) predicted insulin resistance (IR).
Conclusion: TyG and HOMA-IR levels are higher in women with PCOS than non-PCOS. The TyG index can be used as an alternative
method in evaluating insulin resistance among these patients.

Anahtar Kelimeler

Polycystic ovary syndrome, Insulin resistance, TyG, VAI, HOMA-IR

Kaynakça

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