Evaluation of Insulin Resistance Measurement Methods in Patients with Polycystic Ovary Syndrome

Öz

Aim: This study aims to compare insulin resistance (IR) measurement methods in women with and without polycystic ovary syndrome (PCOS) who have the same body mass index. Material and Methods: There were 84 women with PCOS and non-PCOS (n=18 normal weight and n=24 overweight/obese in both groups). Triglyceride glucose index (TyG), assessment of insulin resistance with homeostasis model (HOMA-IR), visceral adiposity index (VAI) were calculated using lipid level, glucose level and anthropometric measurements. Mann-Whitney U or Student's t-test was used to compare measurements between the groups. The relationship between HOMA-IR and age was calculated with the Pearson correlation test, and the relationship between HOMA-IR and TyG was calculated with the Spearman correlation test. p<0.05 was considered significant. Results: Triglyceride levels, insulin, TyG, and HOMA-IR were higher in the PCOS group than in the non-PCOS group (p=0.003, p=0.001, p=0.006, p=0.001, respectively). In the PCOS group, there was a negative correlation between HOMA-IR and age (r=-0.399, p=0.024), and a positive correlation between HOMA-IR and TyG index (r=0.776, p<0.001). TyG index and HOMA-IR were higher in normal weight PCOS women than non-PCOS (p=0.002, p=0.003, respectively), however there was no difference in overweight/obese PCOS women and non-PCOS. In PCOS patients, a TyG index >3.91 (89.5% sensitivity, 76.9% specificity) predicted insulin resistance (IR). Conclusion: TyG and HOMA-IR levels are higher in women with PCOS than non-PCOS. The TyG index can be used as an alternative method in evaluating insulin resistance among these patients.

Anahtar Kelimeler

• Polycystic ovary syndrome
• Insulin resistance
• TyG
• VAI
• HOMA-IR

Polikistik Over Sendromlu Hastalarda İnsülin Direnci Ölçüm Metodlarının Değerlendirilmesi

Öz

Amaç: Bu çalışmada polikistik over sendromlu (PKOS) kadınlarda insülin direnci (IR) ölçüm metodlarının, aynı beden kütle indeksine sahip PKOS olmayan kadınlarla karşılaştırılması hedeflenmiştir. Gereç ve Yöntemler: Çalışmamıza PKOS (n=18 normal kilolu ve n=24 hafif kilolu/obez) ve PKOS olmayan (n=18 normal kilolu ve n=24 hafif kilolu/obez) toplam 84 kadın dahil edildi. Lipit düzeyi, glukoz düzeyi ve antropometrik ölçümler kullanılarak trigliserid glukoz indeksi (TyG), insülin direncinin homeostaz modeliyle değerlendirmesi (HOMA-IR), visseral adipozite indeksi (VAI) hesaplandı. PKOS olan ve olmayan gruplar arasında ölçüm değerlerinin karşılaştırılmasında Mann-Whitney U test ya da Student t-test kullanıldı. HOMAIR ile yaş arasındaki ilişki Pearson korelasyon testi, HOMA-IR ile TyG arasındaki ilişki Spearman korelasyon testi ile hesaplandı. p<0.05 anlamlı kabul edildi. Bulgular: PKOS grubunda PKOS olmayan gruba göre trigliserid düzeyi, insülin, TyG ve HOMA-IR yüksek bulundu (sırasıyla; p= 0.003, p=0.001, p=0.006, p=0.001). PKOS grubunda HOMA-IR ile yaş arasında negatif korelasyon (r=-0.399, p=0.024), HOMA-IR ile TyG indeksi arasında pozitif korelasyon (r=0.776, p< 0.001) tespit edildi. Normal kilolu PKOS’lu kadınlarda PKOS olmayanlara göre TyG indeksi ve HOMA-IR yüksek bulundu. (sırasıyla p=0.002, p=0.003). Ancak hafif kilolu/obez PKOS’lu kadınlarda PKOS olmayanlara göre fark görülmedi. PKOS hastalarında TyG indeksinin >3.91 olması (%89.5 sensivite, %76.9 spesifite) insulin rezistansını (IR) predikte etti. Sonuç: PKOS’lu kadınlarda PKOS olmayanlara göre TyG ve HOMA-IR düzeyleri yüksektir. Bu hastalarda insulin rezistansı değerlendirilmesinde TyG indeksi alternatif bir metod olarak kullanılabilir

Anahtar Kelimeler

• Polikistik over sendromu
• İnsülin direnci
• TyG
• HOMA-IR
• VAİ

Kaynakça

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