Obezite, Diabetes Mellitus ve Hiperlipideminin Lipom Gelişimi Üzerinde Etkisinin Değerlendirilmesi. Obezite Lipom Boyutunu Etkiler mi?

Öz

Amaç: Bu çalışmada obez, diabetes mellitus (DM), hiperlipidemisi olan hastalardaki lipomlar ile normal vücut kütle indeksine (VKİ) sahip, normal seviyelerde kan lipid düzeyleri bulunan ve DM bulunmayan bireylerdeki lipomlar arasındaki klinikopatolojik özellikleri incelemeyi amaçladık. Gereç ve Yöntemler: Bölümümüzde 2017- 2021 yılları arasında tanı alan lipom olgularına ait klinikopatolojik veriler retrospektif olarak hasta dosyaları taranarak incelenmiştir. DM, hiperlipidemi ve obez olan bireyler ayrı ayrı belirlenmiştir. Her bir lipoma ait tümör çapı, tümör sayısı (tek ya da multiple (çok sayıda)) ve tümör histolojik alt tipi (sıradan veya varyant lipom) arşiv patoloji raporları taranarak belirlenmiştir. Obezite, DM ve hiperlipidemisi olan ve olmayan bireylerdeki lipomlar bu histolojik özellikler açısından karşılaştırılmıştır. Bulgular: Çalışmamızda DM ve hiperlipidemisi bulunan veya bulunmayan bireyler arasında lipom boyutu, lipom sayısı ve tümör histolojik alt tipi bakımından anlamlı farklılık bulunmamıştır. Obezite olan bireylerde tümör çapları olmayanlara göre daha yüksek bulunmasına rağmen bu farklılık istatistiksel olarak anlamlı değildir (p=0,825). Çalışmamızda dikkat çekici bir nokta VKİ en yüksek olan bireyde en büyük tümör çapının bulunmasıdır. Tümör çapları bizim serimizde 40 yaş üstü bireylerde anlamlı olarak daha büyük saptanmıştır (p=0,03). Sonuç: Sonuç olarak obezitenin lipom gelişimi yanı sıra lipom boyutu üzerinde de etkili olabileceğini ve hatta eşlik eden DM, hiperlipideminin tümör boyutunu daha da artırabileceğini düşünüyoruz.

Anahtar Kelimeler

• Obezite
• diabetes mellitus
• lipom
• tümör boyutu

Evaluation of the Effect of Obesity, Diabetes Mellitus and Hyperlipidemia on the Development of Lipoma. Does Obesity Affect Lipoma Size?

Öz

Aim: In this study, we aimed to examine the clinicopathological features of lipomas between patients with obesity, diabetes mellitus (DM), hyperlipidemia and individuals with normal body mass index, normal blood lipid levels and without DM. Material and Methods: Lipomas that were diagnosed between 2017 and 2021 in our department were retrospectively reviewed for clinicopathological datas. Individuals with DM, hyperlipidemia and obesity were determined. Diameter, number (single or multiple) and histological subtype (ordinary or variant lipoma) of each lipoma were determined by scanning archival pathology reports. Lipomas in individuals with and without obesity, DM, and hyperlipidemia were compared for these histological features. Results: In our study, no significant difference was found between individuals with or without DM and hyperlipidemia in terms of lipoma size, number and histological subtype. Although tumor diameters were found to be higher in obese individuals than in nonobeses, this difference was not statistically significant (p=0.825). A remarkable point in our study was that the largest tumor diameter was found in the individual with the highest body mass index. Also tumor diameters were found to be significantly larger in individuals over 40 years of age in our series (p=0.03). Conclusion: In conclusion, we think that obesity may have an effect on lipoma size as well as lipoma development, and even concomitant DM and hyperlipidemia may increase tumor size even more.

Anahtar Kelimeler

• obesity
• diabetes mellitus
• lipoma
• tumor size

Kaynakça

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