Effect of Low Fat and Low Cholesterol Diet Intervention on LDL Subgroups in Dyslipidemic Patients: Epidemiological Observational Study

Öz

Aim: According to studies, the individual cardiovascular disease (CVD) risk is predicted and low density lipoprotein cholesterol (LDL cholesterol) sub-group concentration better than LDL cholesterol. High fat and cholesterol intakes are generally considered to pose a risk on CVD. The purpose of this study is to analogize LDL sub-group concentration pre and post a diet with LowFat and LowCholesterol written a prescription to dyslipidemic sicks along 3 months. Material and Methods: Diagnosticated dyslipidemia sicks (n=47) on the part of the endocrinologist were pursued along 3 months via a LowFat, LowCholesterol diet upon a lasting a month basis, on condition that they were proper for each. Before and after dietary intervention periods, biochemical parameters and anthropometric measurements were compared. Results: A sum of 47 participants (15 men and 32 women) with an average age of 48.51±9.86 years were involved. 13 women were at premenopausal and 19 women were at postmenopausal stages of 32 women involved. Small dense LDL (Sd-LDL) decreased from 11.0 (0.0-37.0) mg/dL at the beginning to 7.0 (0.0-68.1) mg/dL after the dietary intervention, but this decline was unimportant (p=0.686). Midbands (MiDC, MidB, MidA) subgroups of intermediate density lipoprotein cholesterol (IDL-cholesterol) declined considerably after dietary interference (p<0.001, p=0.008, p=0.045, respectively). Conclusion: A LowFat and LowCholesterol diet prescribed to dyslipidemic sicks (without using medicimes influencing lipid profile) along 3 months, had a positive impact on decreasing the sub-groups of IDL-cholesterol and LDL-cholesterol. Also, this dietary intervention induced beneficial impacts on anthropometric indications, tension and blood lipid profiles of the patients. Trial Registration: ClinicalTrials.gov ID: NCT04894318. Release Date: May 15, 2021

Anahtar Kelimeler

• Dyslipidemia
• LDL Sub-groups
• IDL Sub-groups
• LowFat LowCholesterol Diet

Proje Numarası

TYL-2018-8497

Dislipidemik Hastalarda Az Yağlı ve Az Kolesterollü Diyet Müdahalesinin LDL Alt Grupları Üzerine Etkisi: Epidemiyolojik Gözlemsel Çalışma

Öz

Amaç: Çalışmalara göre, düşük yoğunluklu lipoprotein kolesterol (LDL kolesterol) alt grup konsantrasyonları bireysel kardiyovasküler hastalık (KVH) riskini, LDL kolesterolden daha iyi tahmin etmektedir. Yağ ve kolesterolün fazla alımları genellikle kardiyovasküler hastalık (KVH) için bir risk olarak kabul edilir. Bu çalışmanın amacı, dislipidemik hastalara 3 ay süreyle az yağlı ve az kolesterollü bir diyetin öncesi ve sonrası LDL alt grup konsantrasyonunu karşılaştırmaktır. Gereç ve Yöntemler: Endokrinolog tarafından dislipidemi tanısı konulan hastalar (n=47) aylık olarak her birine özel olmak kaydıyla az yağlı, az kolesterollü diyetle 3 ay izlendi. Diyet müdahale dönemleri öncesi ve sonrası, biyokimyasal parametreler ve antropometrik ölçümler karşılaştırıldı. Bulgular: Yaş ortalaması 48,51±9,86 olan toplam 47 katılımcı (15 erkek ve 32 kadın) çalışmaya dahil edildi. Dahil edilen 32 kadından 13'ü menopoz öncesi, 19'u menopoz sonrası dönemdeydi. Çalışmanın başında 11,0 (0,0-37,0) mg/dL olan Small dense LDL (Sd-LDL), diyet müdahalesinden sonra 7,0 (0,0-68,1) mg/dL'ye düştü, ancak anlamlı değildi (p=0,686). Orta yoğunluklu lipoprotein kolesterolün (IDL-kolesterol) alt grupları MiDA, MidB, MidC diyet sonrası önemli ölçüde azaldı (sırasıyla, p=0,045, p=0,008, p<0,001). Sonuç: Dislipidemik hastalara (lipit profilini etkileyen ilaç kullanmayan) 3 ay boyunca verilen az yağlı ve az kolesterollü diyet, LDLkolesterol ve IDL-kolesterol alt gruplarını düşürmede olumlu etki göstermiştir. Ayrıca bu diyet, hastaların antropometrik ölçümleri, kan basıncı ve kan lipid profilleri üzerinde yararlı etkilere neden olmuştur.

Anahtar Kelimeler

• Dislipidemi
• LDL Alt Grupları
• IDL Alt Grupları
• Düşük Yağlı Düşük Kolesterollü Diyet

Destekleyen Kurum

Erciyes Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü

Proje Numarası

TYL-2018-8497

Kaynakça

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