Comparison of Cognitive Reserve, Depression and Anxiety in Patients with Diabetes Mellitus

Yıl 2024, , 1 - 5, 29.04.2024

Serap Tuna , Fatih Özden , Neşe Yeniçeri , Cem Şahin

https://doi.org/10.25048/tudod.1334220

Cited By: 1

Öz

Aim: Few studies have comprehensively examined the cognitive reserve in patients with Diabetes Mellitus (DM). The purpose of this
study was to compare cognitive reserve, depression, and anxiety in patients with DM..
Material and Methods: A prospective cross-sectional study was conducted with a total of 80 participants (40 with DM and 40 with
healthy controls). Patients with DM diagnosed at a hospital's internal medicine outpatient clinic were included. Patients’ cognitive
reserve was evaluated with Cognitive Reserve Index Questionnaire (CRI). Depression and anxiety of the individuals were assessed with
Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI), respectively. The difference between the groups was analyzed by
independent sample t-test. In addition, Pearson's correlation coefficient was used to assess the relationship between the parameters.
Results: Individuals with DM had significantly lower CRI-total (p=0.009) and CRI-education (p=0.011) scores. In addition, BDI
(p=0.001) and BAI (p=0.019) scores were higher in individuals with DM. Correlational analyses showed a statistically significant weak
negative correlation between BDI and CRI-total (r=-0.373, p=0.001), CRI-education (r=-0.294, p=0.008) and CRI-work (r=-0.386,
p=0.001) scores in individuals with DM.
Conclusion: The results of the present study revealed a lower cognitive reserve (particularly education-related component) in patients
with DM. Besides, depression and anxiety were higher in individuals with DM than in healthy controls. In participants with DM,
depression was associated with cognitive reserve (except leisure time).

Anahtar Kelimeler

Anxiety and Depression, Cognition, Psychological Status, Type 2 Diabetes

Proje Numarası

Yok

Diabetes Mellituslu Hastalarda Bilişsel Rezerv, Depresyon ve Anksiyetenin Karşılaştırılması

Öz

Amaç: Diabetes Mellitus (DM) hastalarında bilişsel rezervi kapsamlı bir şekilde araştıran bir çalışma bulunmamaktadır. Bu çalışmanın
amacı DM’li hastalarda bilişsel rezerv, depresyon ve anksiyetenin karşılaştırılmasıdır.
Gereç ve Yöntemler: Toplam 80 katılımcı (40 DM'li ve 40 sağlıklı kontrol) ile prospektif kesitsel bir çalışma yürütülmüştür. Çalışmaya
bir eğitim ve araştırma hastanesinin dahiliye polikliniğine DM tanısıyla başvuran hastalar dahil edilmiştir. Hastaların bilişsel rezervi
Bilişsel Rezerv İndeksi Anketi (KRİ) ile değerlendirilmiştir. Bireylerin depresyon ve anksiyeteleri sırasıyla Beck Depresyon Envanteri
(BDE) ve Beck Anksiyete Envanteri (BAE) ile değerlendirilmiştir. Gruplar arasındaki fark bağımsız örneklem t-testi ile analiz edilmiştir.
Ayrıca, parametreler arasındaki ilişki için Pearson korelasyon katsayısı kullanılmıştır.
Bulgular: DM'li bireylerin KRİ-toplam (p=0,009) ve KRİ-eğitim (p=0,011) skorları anlamlı derecede düşüktü. Ayrıca, BDE (p=0,001) ve
BAE (p=0,019) puanları DM'li bireylerde daha yüksekti. Korelasyon analizleri DM'li bireylerde BDI ile KRİ-toplam (r=-0,373, p=0,001), KRİ-eğitim (r=-0,294, p=0,008) ve KRİ-iş (r=-0,386, p=0,001) puanları arasında istatistiksel olarak anlamlı negatif düşük düzeyli
korelasyon olduğunu göstermiştir.
Sonuç: Bu çalışmanın sonuçları, DM'li hastalarda bilişsel rezervin (özellikle eğitimle ilgili bileşen) daha düşük olduğunu ortaya
koymuştur. Ayrıca, DM'li bireylerde depresyon ve anksiyete sağlıklı kontrollere göre daha yüksekti. Depresyon, DM'li katılımcılarda
bilişsel rezerv (boş zaman hariç) ile ilişkiliydi.

Anahtar Kelimeler

Anksiyete ve Depresyon, Biliş, Psikolojik Durum, Tip 2 Diyabet

Destekleyen Kurum

Yok

Proje Numarası

Yok

Teşekkür

Yok

Kaynakça

• 1. Mukhtar Y, Galalain A, Yunusa U. A modern overview on diabetes mellitus: a chronic endocrine disorder. European Journal of Biology. 2020;5(2):1-14.
• 2. Balaji R, Duraisamy R, Kumar M. Complications of diabetes mellitus: A review. Drug Invention Today. 2019;12(1): 98-103.
• 3. Robert AA, Al Dawish MA, Braham R, Musallam MA, Al Hayek AA, Al Kahtany NH. Type 2 Diabetes Mellitus in Saudi Arabia: Major Challenges and Possible Solutions. Curr Diabetes Rev. 2017;13(1):59-64.
• 4. Atlas D. International Diabetes Federation. IDF Diabetes Atlas, 7th edn. Brussels, Belgium: International Diabetes Federation, 2015. European Respiratory Journal. 2006;27:188-207.
• 5. Palta P, Carlson MC, Crum RM, Colantuoni E, Sharrett AR, Yasar S, Nahin RL, DeKosky ST, Snitz B, Lopez O, Williamson JD, Furberg CD, Rapp SR, Golden SH. Diabetes and Cognitive Decline in Older Adults: The Ginkgo Evaluation of Memory Study. J Gerontol A Biol Sci Med Sci. 2017;73(1):123-130.
• 6. Moheet A, Mangia S, Seaquist ER. Impact of diabetes on cognitive function and brain structure. Ann N Y Acad Sci. 2015;1353:60-71.
• 7. Peña-González P, Mondragón-Maya A, Silva-Pereyra J, Roa-Rojas P. Cognitive Reserve and Executive Functions in Adults with Type 2 Diabetes. J Diabetes Res. 2020;2020:7941543.
• 8. Woon LS, Sidi HB, Ravindran A, Gosse PJ, Mainland RL, Kaunismaa ES, Hatta NH, Arnawati P, Zulkifli AY, Mustafa N, Leong Bin Abdullah MFI. Depression, anxiety, and associated factors in patients with diabetes: evidence from the anxiety, depression, and personality traits in diabetes mellitus (ADAPT-DM) study. BMC Psychiatry. 2020;20(1):227.
• 9. Khan P, Qayyum N, Malik F, Khan T, Khan M, Tahir A. Incidence of Anxiety and Depression Among Patients with Type 2 Diabetes and the Predicting Factors. Cureus. 2019;11(3):e4254.
• 10. Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods. 2009;41(4):1149-1160.
• 11. Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39(2):175- 191.
• 12. Gignac GE, Szodorai ET. Effect size guidelines for individual differences researchers. Personality and Individual Differences. 2016;102:74-78.
• 13. Ozakbas S, Yigit P, Akyuz Z, Sagici O, Abasiyanik Z, Ozdogar AT, Kahraman T, Bozan HR, Hosgel I; Multiple Sclerosis Research Group. Validity and reliability of "Cognitive Reserve Index Questionnaire" for the Turkish Population. Mult Scler Relat Disord. 2021;50:102817.
• 14. Çebi M, Kulce SN. The Turkish translation study of the Cognitive Reserve Index Questionnaire (CRIq). Appl Neuropsychol Adult. 2022;29(6):1536-1542.
• 15. Hisli N. Beck Depresyon Envanterinin gecerliligi uzerine bit calisma (A study on the validity of Beck Depression Inventory.). Psikoloji Dergisi. 1988;6:118-22.
• 16. Ulusoy M, Sahin NH, Erkmen H. Turkish version of the Beck Anxiety Inventory: psychometric properties. Journal of Cognitive Psychotherapy. 1998;12(2):163-172.
• 17. Zhang X, Jiang X, Han S, Liu Q, Zhou J. Type 2 Diabetes Mellitus Is Associated with the Risk of Cognitive Impairment: a Meta-Analysis. J Mol Neurosci. 2019;68(2):251-260.
• 18. You Y, Liu Z, Chen Y, Xu Y, Qin J, Guo S, Huang J, Tao J. The prevalence of mild cognitive impairment in type 2 diabetes mellitus patients: a systematic review and meta-analysis. Acta Diabetol. 2021;58(6):671-685.
• 19. Xue M, Xu W, Ou YN, Cao XP, Tan MS, Tan L, Yu JT. Diabetes mellitus and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 144 prospective studies. Ageing Res Rev. 2019;55:100944.
• 20. Chow YY, Verdonschot M, McEvoy CT, Peeters G. Associations between depression and cognition, mild cognitive impairment and dementia in persons with diabetes mellitus: A systematic review and meta-analysis. Diabetes Res Clin Pract. 2022;185:109227.
• 21. Yang X, Li Z, Sun J. Effects of cognitive behavioral therapy- based intervention on improving glycaemic, psychological, and physiological outcomes in adult patients with diabetes mellitus: a meta-analysis of randomized controlled trials. Front Psychiatry. 2020;11:711.
• 22. Duda B, Puente AN, Miller LS. Cognitive reserve moderates relation between global cognition and functional status in older adults. J Clin Exp Neuropsychol. 2014;36(4):368-378.
• 23. Pelimanni E, Jehkonen M. Type 2 Diabetes and Cognitive Functions in Middle Age: A Meta-Analysis. J Int Neuropsychol Soc. 2019;25(2):215-229.
• 24. Philippou E, Constantinou M. The influence of glycemic index on cognitive functioning: a systematic review of the evidence. Adv Nutr. 2014;5(2):119-30.
• 25. Fiqri AM, Sjattar EL, Irwan AM. Cognitive Behavioral Therapy for self-care behaviors with type 2 diabetes mellitus patients: A systematic review. Diabetes Metab Syndr. 2022;16(7):102538.
• 26. Cockrell JR, Folstein MF. Mini-Mental State Examination. In: Abou-Saleh MT, Katona CLE, Anand KA, eds., Principles and Practice of Geriatric Psychiatry, 2002 Edition, John Wiley & Sons, Chichester, 2002;140-141.