The Relationship Between ABO and Rh Blood Groups and Microvascular Complications of Diabetes in Patients with Type 2 Diabetes Mellitus

Yıl 2024, , 65 - 70, 29.04.2024

Sevgül Fakı , Nurcan İnce , Abbas Ali Tam , Feride Pınar Altay , Gülsüm Karaahmetli , Beril Turan Erdoğan , Neslihan Çuhacı Seyrek , Oya Topaloğlu , Reyhan Ersoy , Bekir Çakır

https://doi.org/10.25048/tudod.1359676

Öz

Aim: This study aimed to investigate the possible relationships between ABO and Rh blood groups and microvascular complications of
diabetes in type 2 diabetes mellitus (DM) patients.
Material and Methods: This study included Type 2 DM patients who were hospitalized and followed in our clinic between February
2019 and April 2022. The patients’ data files were retrospectively reviewed in order to record demographic characteristics, antidiabetic
medications, comorbid diseases, fasting plasma glucose, HbA1c values, ABO/Rh blood groups, and microvascular complication status
(nephropathy, retinopathy, and neuropathy).
Results: A total of 348 patients were included in the study. In the sample group, male patients constituted 40.9% (142) and female
patients 59.1% (206) of the sample, and the mean age was 59.3±12.8 years. Diabetic nephropathy, retinopathy, and neuropathy rates were
31.3%, 41.0%, and 52.0%, respectively. The blood group was A in 151 (43.4%), B in 51 (14.6%), 0 in 127 (36.5%), and AB in 19 (5.5%)
patients. Patients with different blood types did not show any significant differences in the microvascular complications of diabetes.
The frequency of nephropathy and retinopathy were lower in Rh-negative patients than in Rh-positive patients (p=0.044 and p=0.041,
respectively).
Conclusion: ABO blood groups are not correlated with the microvascular complications of diabetes in patients with type 2 DM.
However, Rh positivity may pose certain risks for nephropathy and retinopathy.

Anahtar Kelimeler

ABO and Rh blood groups, type 2 diabetes mellitus, microvascular complications of diabetes

Tip 2 Diabetes Mellituslu Hastalarda ABO ve Rh Kan Grupları ile Diyabetin Mikrovasküler Komplikasyonları Arasındaki İlişki

Öz

Amaç: Bu çalışma tip 2 diyabetes mellitus (DM) hastalarında ABO ve Rh kan grupları ile diyabetin mikrovasküler komplikasyonları
arasındaki olası ilişkiyi araştırmayı amaçlamıştır.
Gereç ve Yöntemler: Çalışmaya Şubat 2019-Nisan 2022 tarihleri arasında tip 2 DM nedeniyle yatırılan hastalar dahil edildi. Hastaların
demografik özellikleri, kullanmış oldukları antidiyabetik ilaçlar, komorbid hastalıkları, açlık glukoz, HbA1c değerleri, ABO/Rh kan
grupları ile mikrovasküler komplikasyon durumu (nefropati, retinopati ve nöropati) her bir hasta için retrospektif olarak kayıt edildi.
Bulgular: Çalışmaya toplam 348 hasta dahil edildi. Hastaların 142’si erkek (%40,9), 206’sı kadındı (%59,1). Ortalama yaş 59,3 ± 12,8’di.
Hastalarda diyabetik nefropati, retinopati ve nöropati sırasıyla %31,3, %35,20 ve %52,0 olarak saptandı. Hastaların 151’i (%43,4) A kan
grubu, 14 hasta (%14,7) B kan grubu, 127 (%36,7 ) hasta 0 kan grubu ve 19 hasta (%5,5) AB kan grubuna sahipti. Rh kan grubu 318
hastada pozitif, 30 hastada negatifti. Kan grupları ile mikrovasküler komplikasyon arasında anlamlı bir ilişki saptanmadı. Rh kan gurubu
negative olan hastalarda nefropati ve retinopati anlamlı daha az saptandı (sırasıyla p=0.044 ve p=0.041).
Sonuç: Kan grupları ile mikrovasküler komplikasyon arasında anlamlı bir ilişki saptanmadı ancak Rh pozitifliği diyabetik nefropati ve
retinopati gelişimi için risk faktörü olabilir

Anahtar Kelimeler

Tip 2 diyabetes melitus, ABO ve Rh kan grupları, diyabetin mikrovasküler komplikasyonları

Etik Beyan

Ethical Considerations: Local ethics committee approval was obtained for the study in accordance with the ethical standards of the Declaration of Helsinki. (Number: E.Kurul-E1-22-2681, Date: 15/06/2022)

Destekleyen Kurum

YOKTUR

Teşekkür

TEŞEKKÜRLER

Kaynakça

• 1. Seid MA, Akalu Y, Gela YY, Belsti Y, Diress M, Fekadu SA, Dagnew B, Getnet M. Microvascular complications and its predictors among type 2 diabetes mellitus patients at Dessie town hospitals, Ethiopia. Diabetol Metab Syndr. 2021;13(1):86.
• 2. Vithian K, Hurel S. Microvascular complications: pathophysiology and management. Clin Med (Lond). 2010;10(5):505-509.
• 3. Waseem AG, Iqbal M, Awwab O, Tahir KM. Association of diabetes mellitus with ABO and Rh blood groups. The Annals of Pakistan Institute of Medical Sciences. 2012;8(2):134-136.
• 4. Franchini M, Lippi G. The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer. BMC Med. 2015;13:7.
• 5. Legese B, Abebe M, Fasil A. Association of ABO and Rh Blood Group Phenotypes with Type 2 Diabetes Mellitus at Felege Hiwot Comprehensive Referral Hospital Bahir Dar, Northwest Ethiopia. Int J Chronic Dis. 2020;2020:2535843.
• 6. Umadevi B, Roopakala M.S, Silvia Cr WD, KM Kumar P. Role of von Willebrand factor in type 2 diabetes mellitus patients. Journal of Evolution of Medical and Dental Sciences. 2016;5(81):6075-6079.
• 7. Barbalic M, Dupuis J, Dehghan A, Bis JC, Hoogeveen RC, Schnabel RB, Nambi V, Bretler M, Smith NL, Peters A, Lu C, Tracy RP, Aleksic N, Heeriga J, Keaney JF Jr, Rice K, Lip GY, Vasan RS, Glazer NL, Larson MG, Uitterlinden AG, Yamamoto J, Durda P, Haritunians T, Psaty BM, Boerwinkle E, Hofman A, Koenig W, Jenny NS, Witteman JC, Ballantyne C, Benjamin EJ. Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels. Hum Mol Genet. 2010;19(9):1863-1872.
• 8. Aggarwal T, Singh D, Sharma B, Siddiqui SS, Agarwal S. Association of ABO and Rh blood groups with type 2 diabetes mellitus in Muzaffarnagar city. National Journal of Physiology, Pharmacy and Pharmacology. 2018;8(2): 167-170.
• 9. Azizi R, Manoochehry S, Razavi-Ratki SK, Seyed Hosseini SM, Vakili M, Namiranian N. Distribution of ABO and Rh blood groups among diabetes type 2 patients in Yazd Diabetes Research Center (2015-2016). IJDO 2016;8(4):191-195.
• 10. Navabi J, Navabi SM, Hemmati N, Shaahmadi Z, Aghaei A. Higher Odds of Type 2 Diabetes for Some Blood Groups. Public Health Genomics. 2020;23(1-2):37-41.
• 11. Meo SA, Rouq FA, Suraya F, Zaidi SZ. Association of ABO and Rh blood groups with type 2 diabetes mellitus. Eur Rev Med Pharmacol Sci. 2016;20(2):237-42.
• 12. Ünal A, Koçyiğit İ, Yılmaz S, Eser B, Elmalı F, Sipahioğlu MH, Tokgöz B, Oymak O. The Abo Blood Groups are Related to Diabetic Nephropathy. Turkish J Nephrol. 2015;24:266-269.
• 13. Gupta G, Langer B, Shah T, K Gupta A, Goni M. Association of microvascular complications of type 2 diabetes mellitus with ABO blood group. Int J Adv Med. 2019;6(3):738-743.
• 14. Mandal B, Shukla R, Basu A, Sinha A, Maiti A, Bhattacharjee K. Association of ABO blood groups with type-2 diabetes mellitus and its complications. J Diabetes Metab Disord Control. 2018;5(1):1‒7.
• 15. Fagherazzi G, Gusto G, Clavel-Chapelon F, Balkau B, Bonnet F. ABO and Rhesus blood groups and risk of type 2 diabetes: evidence from the large E3N cohort study. Diabetologia. 2015;58(3):519-522.
• 16. Jankowski JAZ. Inflammation and Gastrointestinal Cancers: Springer Science & Business Media, Berlin, Heidelberg: Springer, 2011.
• 17. Langari SH, Bahar A, Asadian L, Abediankenai S, Namazi SS, Kashi Z. Coronary Heart Disease and ABO Blood Group in Diabetic Women: A Case-Control Study. Sci Rep. 2019;9(1):7441.
• 18. Bruun-Rasmussen P, Hanefeld Dziegiel M, Banasik K, Johansson PI, Brunak S. Associations of ABO and Rhesus D blood groups with phenome-wide disease incidence: A 41-year retrospective cohort study of 482,914 patients. Elife. 2023;12:e83116.
• 19. Getawa S, Bayleyegn B, Aynalem M, Worku YB, Adane T. Relationships of ABO and Rhesus blood groups with type 2 diabetes mellitus: a systematic review and meta-analysis. J Int Med Res. 2022;50(10):3000605221129547