Tip 2 Diabetes Mellituslu Hastalarda ABO ve Rh Kan Grupları ile Diyabetin Mikrovasküler Komplikasyonları Arasındaki İlişki

Öz

Amaç: Bu çalışma tip 2 diyabetes mellitus (DM) hastalarında ABO ve Rh kan grupları ile diyabetin mikrovasküler komplikasyonları arasındaki olası ilişkiyi araştırmayı amaçlamıştır. Gereç ve Yöntemler: Çalışmaya Şubat 2019-Nisan 2022 tarihleri arasında tip 2 DM nedeniyle yatırılan hastalar dahil edildi. Hastaların demografik özellikleri, kullanmış oldukları antidiyabetik ilaçlar, komorbid hastalıkları, açlık glukoz, HbA1c değerleri, ABO/Rh kan grupları ile mikrovasküler komplikasyon durumu (nefropati, retinopati ve nöropati) her bir hasta için retrospektif olarak kayıt edildi. Bulgular: Çalışmaya toplam 348 hasta dahil edildi. Hastaların 142’si erkek (%40,9), 206’sı kadındı (%59,1). Ortalama yaş 59,3 ± 12,8’di. Hastalarda diyabetik nefropati, retinopati ve nöropati sırasıyla %31,3, %35,20 ve %52,0 olarak saptandı. Hastaların 151’i (%43,4) A kan grubu, 14 hasta (%14,7) B kan grubu, 127 (%36,7 ) hasta 0 kan grubu ve 19 hasta (%5,5) AB kan grubuna sahipti. Rh kan grubu 318 hastada pozitif, 30 hastada negatifti. Kan grupları ile mikrovasküler komplikasyon arasında anlamlı bir ilişki saptanmadı. Rh kan gurubu negative olan hastalarda nefropati ve retinopati anlamlı daha az saptandı (sırasıyla p=0.044 ve p=0.041). Sonuç: Kan grupları ile mikrovasküler komplikasyon arasında anlamlı bir ilişki saptanmadı ancak Rh pozitifliği diyabetik nefropati ve retinopati gelişimi için risk faktörü olabilir

Anahtar Kelimeler

• Tip 2 diyabetes melitus
• ABO ve Rh kan grupları
• diyabetin mikrovasküler komplikasyonları

The Relationship Between ABO and Rh Blood Groups and Microvascular Complications of Diabetes in Patients with Type 2 Diabetes Mellitus

Öz

Aim: This study aimed to investigate the possible relationships between ABO and Rh blood groups and microvascular complications of diabetes in type 2 diabetes mellitus (DM) patients. Material and Methods: This study included Type 2 DM patients who were hospitalized and followed in our clinic between February 2019 and April 2022. The patients’ data files were retrospectively reviewed in order to record demographic characteristics, antidiabetic medications, comorbid diseases, fasting plasma glucose, HbA1c values, ABO/Rh blood groups, and microvascular complication status (nephropathy, retinopathy, and neuropathy). Results: A total of 348 patients were included in the study. In the sample group, male patients constituted 40.9% (142) and female patients 59.1% (206) of the sample, and the mean age was 59.3±12.8 years. Diabetic nephropathy, retinopathy, and neuropathy rates were 31.3%, 41.0%, and 52.0%, respectively. The blood group was A in 151 (43.4%), B in 51 (14.6%), 0 in 127 (36.5%), and AB in 19 (5.5%) patients. Patients with different blood types did not show any significant differences in the microvascular complications of diabetes. The frequency of nephropathy and retinopathy were lower in Rh-negative patients than in Rh-positive patients (p=0.044 and p=0.041, respectively). Conclusion: ABO blood groups are not correlated with the microvascular complications of diabetes in patients with type 2 DM. However, Rh positivity may pose certain risks for nephropathy and retinopathy.

Anahtar Kelimeler

• ABO and Rh blood groups
• type 2 diabetes mellitus
• microvascular complications of diabetes

Kaynakça

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