Araştırma Makalesi
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Significant HbA1c Reduction with Target-Focused Glucose Education and Patient-Led Follow-Up in Uncontrolled Type 2 Diabetes Mellitus

Yıl 2025, Cilt: 9 Sayı: 3, 326 - 333, 31.12.2025

Öz

Aim: Although most patients with diabetes (DM) own a glucose monitoring device, inadequate knowledge of fasting and postprandial
target values often prevents correct interpretation of results and effective use of this technology. This study aimed to evaluate the effect
of target-oriented education and a patient-responsibility-based follow-up system, combined with medical therapy, on HbA1c levels.
Material and Methods: This single-arm, prospective interventional study included 84 adults with type 2 diabetes mellitus (T2DM) and
HbA1c ≥8.0%. At baseline, a questionnaire assessed participants’ knowledge of fasting and postprandial glucose targets and educational
level. Participants then received standardized written and verbal education on these targets. A patient-led follow-up model was
implemented, instructing patients to attend the outpatient clinic when self-measured glucose values exceeded target levels. Statistical
analyses included Friedman, Wilcoxon signed-rank, and Kruskal-Wallis tests.
Results: The mean age was 57.8 ± 8.4 years; 42.9% (n=36) were male. At baseline, only 10.7% correctly identified fasting and 1.2%
postprandial glucose targets. Median HbA1c decreased from 9.7% (IQR 8.6-11.5) to 8.1% (IQR 7.63-9.0) at 3 months and 7.1% (IQR
6.9-7.57) at 6 months (all p<0.001). Clinic visit frequency increased significantly during the first 3 months and declined as glycemic
targets were approached (p<0.001).Conclusion: Awareness of fasting and postprandial glucose targets was critically low among patients with T2DM. A minimalist, targetfocused
educational strategy combined with a patient-led monitoring model achieved a clinically meaningful reduction in HbA1c levels.

Etik Beyan

The study was conducted in accordance with the Declaration of Helsinki. Administrative permission was obtained from Mehmet Akif İnan Training and Research Hospital, and ethical approval was granted by the Harran University Ethics Committee (Date: October 21, 2024; No: HRÜ/24.16.53). Written informed consent was obtained from all participants.

Destekleyen Kurum

None

Teşekkür

None

Kaynakça

  • 1. Sartore G, Ragazzi E, Caprino R, Lapolla A. Long-term HbA1c variability and macro-/micro-vascular complications in type 2 diabetes mellitus: a meta-analysis update. Acta Diabetol2023; 60:721-38. https://doi.org/10.1007/s00592-023- 02037-8.
  • 2. American Diabetes Association Professional Practice Committee. 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes-2025. Diabetes Care. 2025 Jan 1;48(1 Suppl 1):S27-S49. doi: 10.2337/dc25-S002. PMID: 39651986; PMCID: PMC11635041. n.d.
  • 3. American Diabetes Association Professional Practice Committee. 6. Glycemic Goals and Hypoglycemia: Standards of Care in Diabetes-2025. Diabetes Care. 2025 Jan 1;48(1 Suppl 1):S128-S145. doi: 10.2337/dc25-S006.
  • 4. Bekele BB, Negash S, Bogale B, Tesfaye M, Getachew D, Weldekidan F, Balcha B. Effect of diabetes self-management education (DSME) on glycated hemoglobin (HbA1c) level among patients with T2DM: Systematic review and meta-analysis of randomized controlled trials. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 2021;15:177-85. https:// doi.org/10.1016/j.dsx.2020.12.030.
  • 5. Mikhael EM, Hassali MA, Hussain SA. <p>Effectiveness of Diabetes Self-Management Educational Programs For Type 2 Diabetes Mellitus Patients In Middle East Countries: A Systematic Review</p>. Diabetes MetabSyndrObes2020;Volume 13:117-38. https://doi.org/10.2147/DMSO.S232958.
  • 6. Beck J, Greenwood DA, Blanton L, Bollinger ST, Butcher MK, Condon JE, et al. 2017 National Standards for Diabetes Self-Management Education and Support. Diabetes Educ 2017;43:449-64. https://doi.org/10.1177/0145721717722968.
  • 7. Ozcelik F, Yiginer O, Arslan E, Serdar MA, Uz O, Kardesoglu E, Kurt I. Association between glycemic control and the level of knowledge and disease awareness in type 2 diabetic patients. Pol Arch Med Wewn2010;120:399-406.
  • 8. Rusdiana, Savira M, Amelia R. The Effect of Diabetes Self-Management Education on Hba1c Level and Fasting Blood Sugar in Type 2 Diabetes Mellitus Patients in Primary Health Care in Binjai City of North Sumatera, Indonesia. Open Access Maced J Med Sci 2018;6:715-8. https://doi.org/10.3889/oamjms. 2018.169.
  • 9. Parsons SN, Luzio SD, Harvey JN, Bain SC, Cheung WY, Watkins A, et al. Effect of structured self‐monitoring of blood glucose, with and without additional TeleCare support, on overall glycaemic control in non‐insulin treated Type 2 diabetes: the SMBG Study, a 12‐month randomized controlled trial. Diabetic Medicine 2019;36:578-90. https://doi.org/10.1111/ dme.13899.
  • 10. American Diabetes Association Professional Practice Committee. 5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes: Standards of Care in Diabetes- 2025. Diabetes Care. 2025 Jan 1;48(1 Suppl 1):S86-S127. doi: 10.2337/dc25-S005. Erratum in: Diabetes Care. 2025 Apr 1;48(4):665. doi: 10.2337/dc25-er04a. PMID: 39651983; PMCID: PMC11635047. n.d.
  • 11. Kessels RP. Patients' memory for medical information. J R Soc Med. 2003;96(5):219-22. https://doi. org/10.1177/014107680309600504.
  • 12. Çetinkaya Özdemir S, Semerci Çakmak V, Sert H, Demirci T. Effect of Perceived Food Literacy on Eating Behavior Pattern, Glycemic Parameters, and Lipid Profile in Patients with Type 2 Diabetes: Structural Equation Modeling. Turkish Journal of Diabetes and Obesity. 2025 Apr 30;9(1):70-80. https://doi. org/10.25048/tudod.1639291
  • 13. Küçük S, Uludasdemir D, Karşıgil P, Güven İ. Tip 2 Diyabet Hastalarında Sağlıklı Yaşam Biçimi Davranışlarının Belirlenmesi ve Diyabet Öz Yeterliliği. Turkish Journal of Diabetes and Obesity. 2023 Aug 31;7(2):112-21. https://doi.org/10.25048/ tudod.1299744
  • 14. Sun X, Zhou X, Li S, Ji L. Association between frequency of self-monitoring of blood glucose and glycemic control in patients with type 2 diabetes. Diabetes Res Clin Pract 2024;209:111027. https://doi.org/10.1016/j.diabres. 2023.111027.
  • 15. Ugwu E, Gezawa I, Adeleye O. Glycemic impact of intensified self monitoring of blood glucose in insulin treated subjects with type 2 diabetes mellitus. Journal of Social Health and Diabetes 2018;06:027-33. https://doi.org/10.1055/s-0038-1676194.
  • 16. Kleefstra N, Hortensius J, Logtenberg SJJ, Slingerland RJ, Groenier KH, Houweling ST, Gans ROB, van Ballegooie E, Bilo HJG. Self-monitoring of blood glucose in tablet-treated type 2 diabetic patients (ZODIAC). Neth J Med 2010;68:311-6.
  • 17. Holt TA. Improving the effectiveness of self-monitoring of blood glucose in type 2 diabetes. British Journal of General Practice 2015;65:e211-2. https://doi.org/10.3399/bjgp15X684277.

Kontrolsüz Tip 2 Diabetes Mellitus'ta Hedef Odaklı Glukoz Eğitimi ve Hasta Önderliğinde Takip ile HbA1c'de Anlamlı Düşüş

Yıl 2025, Cilt: 9 Sayı: 3, 326 - 333, 31.12.2025

Öz

Amaç: Diyabetli (DM) hastaların çoğunda glukoz ölçüm cihazı bulunmasına rağmen, açlık ve yemek sonrası hedef değerlerine ilişkin
yetersiz bilgi, sonuçların doğru yorumlanmasını ve bu teknolojinin etkili kullanımını sıklıkla engellemektedir. Bu çalışma, hedef odaklı
eğitim ve hasta sorumluluğuna dayalı bir takip sisteminin, tıbbi tedavi ile birlikte, HbA1c düzeyleri üzerindeki etkisini değerlendirmeyi
amaçlamıştır.
Gereç ve Yöntemler: Bu tek kollu, prospektif müdahale çalışmasına, HbA1c ≥%8,0 olan tip 2 diyabetli (T2DM) 84 yetişkin dahil edilmiştir.
Başlangıçta, katılımcıların açlık ve yemek sonrası glukoz hedeflerine ilişkin bilgileri ve eğitim düzeyleri bir anketle değerlendirilmiştir.
Daha sonra katılımcılara bu hedefler hakkında standartlaştırılmış yazılı ve sözlü eğitim verilmiştir. Hasta sorumluluğuna dayalı
bir takip modeli uygulanmış ve hastalara kendi ölçtükleri glukoz değerleri hedef düzeyleri aştığında polikliniğe başvurmaları talimatı
verilmiştir. İstatistiksel analizler Friedman, Wilcoxon işaretli sıralama ve Kruskal-Wallis testlerini içermiştir.
Bulgular: Ortalama yaş 57,8 ± 8,4 yıldı; %42,9'u (n=36) erkekti. Başlangıçta, sadece %10,7'si açlık ve %1,2'si yemek sonrası glukoz
hedeflerini doğru bir şekilde belirleyebildi. Medyan HbA1c, 3 ayda %9,7'den (IQR 8,6-11,5) %8,1'e (IQR 7,63-9,0) ve 6 ayda %7,1'e
(IQR 6,9-7,57) düştü (tüm p<0,001). Klinik ziyaret sıklığı ilk 3 ay boyunca önemli ölçüde arttı ve glisemik hedeflere yaklaşıldıkça azaldı
(p<0,001).
Sonuç: T2DM’li hastalarda açlık ve yemek sonrası glukoz hedeflerine ilişkin farkındalık kritik derecede düşüktü. Sade ve hedef odaklı
bir eğitim stratejisinin, hasta sorumluluğuna dayalı bir izleme modeliyle birleştirildiğinde, HbA1c düzeylerinde klinik olarak anlamlı
bir azalma sağlanmıştır.

Etik Beyan

Çalışma, Helsinki Bildirgesi ilkelerine uygun olarak yürütülmüştür. İdari izin Mehmet Akif İnan Eğitim ve Araştırma Hastanesi'nden alınmış olup, etik kurul onayı Harran Üniversitesi Etik Kurulu tarafından sağlanmıştır (Tarih: 21 Ekim 2024; Sayı: HRÜ/24.16.53). Tüm katılımcılardan yazılı bilgilendirilmiş onam alınmıştır.

Destekleyen Kurum

Yok

Teşekkür

Yok

Kaynakça

  • 1. Sartore G, Ragazzi E, Caprino R, Lapolla A. Long-term HbA1c variability and macro-/micro-vascular complications in type 2 diabetes mellitus: a meta-analysis update. Acta Diabetol2023; 60:721-38. https://doi.org/10.1007/s00592-023- 02037-8.
  • 2. American Diabetes Association Professional Practice Committee. 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes-2025. Diabetes Care. 2025 Jan 1;48(1 Suppl 1):S27-S49. doi: 10.2337/dc25-S002. PMID: 39651986; PMCID: PMC11635041. n.d.
  • 3. American Diabetes Association Professional Practice Committee. 6. Glycemic Goals and Hypoglycemia: Standards of Care in Diabetes-2025. Diabetes Care. 2025 Jan 1;48(1 Suppl 1):S128-S145. doi: 10.2337/dc25-S006.
  • 4. Bekele BB, Negash S, Bogale B, Tesfaye M, Getachew D, Weldekidan F, Balcha B. Effect of diabetes self-management education (DSME) on glycated hemoglobin (HbA1c) level among patients with T2DM: Systematic review and meta-analysis of randomized controlled trials. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 2021;15:177-85. https:// doi.org/10.1016/j.dsx.2020.12.030.
  • 5. Mikhael EM, Hassali MA, Hussain SA. <p>Effectiveness of Diabetes Self-Management Educational Programs For Type 2 Diabetes Mellitus Patients In Middle East Countries: A Systematic Review</p>. Diabetes MetabSyndrObes2020;Volume 13:117-38. https://doi.org/10.2147/DMSO.S232958.
  • 6. Beck J, Greenwood DA, Blanton L, Bollinger ST, Butcher MK, Condon JE, et al. 2017 National Standards for Diabetes Self-Management Education and Support. Diabetes Educ 2017;43:449-64. https://doi.org/10.1177/0145721717722968.
  • 7. Ozcelik F, Yiginer O, Arslan E, Serdar MA, Uz O, Kardesoglu E, Kurt I. Association between glycemic control and the level of knowledge and disease awareness in type 2 diabetic patients. Pol Arch Med Wewn2010;120:399-406.
  • 8. Rusdiana, Savira M, Amelia R. The Effect of Diabetes Self-Management Education on Hba1c Level and Fasting Blood Sugar in Type 2 Diabetes Mellitus Patients in Primary Health Care in Binjai City of North Sumatera, Indonesia. Open Access Maced J Med Sci 2018;6:715-8. https://doi.org/10.3889/oamjms. 2018.169.
  • 9. Parsons SN, Luzio SD, Harvey JN, Bain SC, Cheung WY, Watkins A, et al. Effect of structured self‐monitoring of blood glucose, with and without additional TeleCare support, on overall glycaemic control in non‐insulin treated Type 2 diabetes: the SMBG Study, a 12‐month randomized controlled trial. Diabetic Medicine 2019;36:578-90. https://doi.org/10.1111/ dme.13899.
  • 10. American Diabetes Association Professional Practice Committee. 5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes: Standards of Care in Diabetes- 2025. Diabetes Care. 2025 Jan 1;48(1 Suppl 1):S86-S127. doi: 10.2337/dc25-S005. Erratum in: Diabetes Care. 2025 Apr 1;48(4):665. doi: 10.2337/dc25-er04a. PMID: 39651983; PMCID: PMC11635047. n.d.
  • 11. Kessels RP. Patients' memory for medical information. J R Soc Med. 2003;96(5):219-22. https://doi. org/10.1177/014107680309600504.
  • 12. Çetinkaya Özdemir S, Semerci Çakmak V, Sert H, Demirci T. Effect of Perceived Food Literacy on Eating Behavior Pattern, Glycemic Parameters, and Lipid Profile in Patients with Type 2 Diabetes: Structural Equation Modeling. Turkish Journal of Diabetes and Obesity. 2025 Apr 30;9(1):70-80. https://doi. org/10.25048/tudod.1639291
  • 13. Küçük S, Uludasdemir D, Karşıgil P, Güven İ. Tip 2 Diyabet Hastalarında Sağlıklı Yaşam Biçimi Davranışlarının Belirlenmesi ve Diyabet Öz Yeterliliği. Turkish Journal of Diabetes and Obesity. 2023 Aug 31;7(2):112-21. https://doi.org/10.25048/ tudod.1299744
  • 14. Sun X, Zhou X, Li S, Ji L. Association between frequency of self-monitoring of blood glucose and glycemic control in patients with type 2 diabetes. Diabetes Res Clin Pract 2024;209:111027. https://doi.org/10.1016/j.diabres. 2023.111027.
  • 15. Ugwu E, Gezawa I, Adeleye O. Glycemic impact of intensified self monitoring of blood glucose in insulin treated subjects with type 2 diabetes mellitus. Journal of Social Health and Diabetes 2018;06:027-33. https://doi.org/10.1055/s-0038-1676194.
  • 16. Kleefstra N, Hortensius J, Logtenberg SJJ, Slingerland RJ, Groenier KH, Houweling ST, Gans ROB, van Ballegooie E, Bilo HJG. Self-monitoring of blood glucose in tablet-treated type 2 diabetic patients (ZODIAC). Neth J Med 2010;68:311-6.
  • 17. Holt TA. Improving the effectiveness of self-monitoring of blood glucose in type 2 diabetes. British Journal of General Practice 2015;65:e211-2. https://doi.org/10.3399/bjgp15X684277.
Toplam 17 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Endokrinoloji, İç Hastalıkları
Bölüm Araştırma Makalesi
Yazarlar

Rıza Altunbaş 0000-0002-6588-0016

Adnan Türkel 0000-0002-2854-3416

Gönderilme Tarihi 30 Ekim 2025
Kabul Tarihi 22 Aralık 2025
Yayımlanma Tarihi 31 Aralık 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 9 Sayı: 3

Kaynak Göster

APA Altunbaş, R., & Türkel, A. (2025). Significant HbA1c Reduction with Target-Focused Glucose Education and Patient-Led Follow-Up in Uncontrolled Type 2 Diabetes Mellitus. Turkish Journal of Diabetes and Obesity, 9(3), 326-333.
AMA Altunbaş R, Türkel A. Significant HbA1c Reduction with Target-Focused Glucose Education and Patient-Led Follow-Up in Uncontrolled Type 2 Diabetes Mellitus. Turk J Diab Obes. Aralık 2025;9(3):326-333.
Chicago Altunbaş, Rıza, ve Adnan Türkel. “Significant HbA1c Reduction with Target-Focused Glucose Education and Patient-Led Follow-Up in Uncontrolled Type 2 Diabetes Mellitus”. Turkish Journal of Diabetes and Obesity 9, sy. 3 (Aralık 2025): 326-33.
EndNote Altunbaş R, Türkel A (01 Aralık 2025) Significant HbA1c Reduction with Target-Focused Glucose Education and Patient-Led Follow-Up in Uncontrolled Type 2 Diabetes Mellitus. Turkish Journal of Diabetes and Obesity 9 3 326–333.
IEEE R. Altunbaş ve A. Türkel, “Significant HbA1c Reduction with Target-Focused Glucose Education and Patient-Led Follow-Up in Uncontrolled Type 2 Diabetes Mellitus”, Turk J Diab Obes, c. 9, sy. 3, ss. 326–333, 2025.
ISNAD Altunbaş, Rıza - Türkel, Adnan. “Significant HbA1c Reduction with Target-Focused Glucose Education and Patient-Led Follow-Up in Uncontrolled Type 2 Diabetes Mellitus”. Turkish Journal of Diabetes and Obesity 9/3 (Aralık2025), 326-333.
JAMA Altunbaş R, Türkel A. Significant HbA1c Reduction with Target-Focused Glucose Education and Patient-Led Follow-Up in Uncontrolled Type 2 Diabetes Mellitus. Turk J Diab Obes. 2025;9:326–333.
MLA Altunbaş, Rıza ve Adnan Türkel. “Significant HbA1c Reduction with Target-Focused Glucose Education and Patient-Led Follow-Up in Uncontrolled Type 2 Diabetes Mellitus”. Turkish Journal of Diabetes and Obesity, c. 9, sy. 3, 2025, ss. 326-33.
Vancouver Altunbaş R, Türkel A. Significant HbA1c Reduction with Target-Focused Glucose Education and Patient-Led Follow-Up in Uncontrolled Type 2 Diabetes Mellitus. Turk J Diab Obes. 2025;9(3):326-33.

Zonguldak Bülent Ecevit Üniversitesi Obezite ve Diyabet Uygulama ve Araştırma Merkezi’nin bilimsel yayım organıdır.

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