Genotoxic Effects of Obesity

Öz

Obesity is considered as a disease, which affects the whole world. Recent years, epidemiological studies linking obesity with increased risk of cancer is steadily increasing. Studies suggest that obesity might be a risk for genotoxic damage. Obesity-associated genotoxic damage can initiator, promote cancer growth by favoring cancer cell proliferation and migration, and blocking to apoptosis. Obesity can change the repair mechanism of DNA chain breaks. In addition, the increase in oxidative stress and inflammation associated with obesity could increase DNA damage and prevent DNA functioning mechanisms, resulting in DNA damage transformation into a cancerous cell. Studies over the past few years have shown that obesity can affect genome stability. In this review article, the genotoxic effects of obesity are explained in detail.

Anahtar Kelimeler

• Cancer, DNA Damage, Genotoxicity, Obesity, Obesogens

Obezitenin Genotoksik Etkileri

Öz

Obezite; tüm dünyayı etkisi altına alan, önemli bir sağlık sorunudur. Son yıllarda, obeziteyi artan kanser riski ile ilişkilendiren epidemiyolojik çalışmalar giderek artmaktadır. Bilimsel çalışmalar obezitenin genotoksik hasar için risk teşkil edebileceğini göstermektedir. Obezite ile ilişkili genotoksik hasar kanser hücresi çoğalmasını ve göçünü destekleyerek ve apoptozu bloke ederek kanser büyümesini teşvik edebilir. Obezitenin DNA zincir kırıklarının onarım mekanizmasını değiştirdiği ortaya çıkartılmıştır. Ayrıca, obeziteyle birlikte ortaya çıkan oksidatif stres ve enflamasyonda artış DNA hasarını artırabilmekte ve DNA tamir mekanizmalarının işlevini engelleyerek DNA hasarı birikmiş hücrenin kanserli bir hücreye dönüşümü sonucu doğabilmektedir. Geçtiğimiz birkaç yılda yapılmış olan çalışmalar obezitenin genom kararlılığını etkileyebileceğini göstermiştir. Sunulan derlemede obezitenin genotoksik etkilerine yönelik bilgiler ayrıntılı şekilde anlatılmıştır.

Anahtar Kelimeler

• Kanser,
• DNA hasarı,
• Genotoksisite,
• Obezite,
• , Obezojenler

Kaynakça

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