Polikistik Over Sendromlu Hastalarda Yeni Antropometrik Ölçümlerin Kardiyometabolik Risk ve İnsülin Rezistansını Belirlemedeki Önemi

Öz

Amaç: Polikistik Over Sendromunda (PKOS) abdominal obezite sıklıkla görülmektedir. Abdominal obezitenin değerlendirilmesi PKOS’lu hastalarda metabolik ve kardiyovasküler disfonksiyon açısından önemlidir. Bu çalışmada PKOS’lu hastalarda yeni antropometrik ölçümleri ve kardiyovasküler risk ve insülin rezistansı ile ilişkisini araştırmayı amaçladık. Gereç ve Yöntemler: Çalışmaya 62 PKOS’lu hasta ve 38 sağlıklı kontrol dahil edildi. Hastaların klinik bulguları, serum hormon düzeyleri ve overlerin ultrasonik bulguları değerlendirildi. Antropometrik ölçümler, HOMA-IR düzeyleri ve karotis intima media kalınlıkları (KIMK) değerlendirildi. Bulgular: Abdominal obezite belirteci olan bel çevresi, LAP, BAI, BRI, VAI, AVI ve WHtR PKOS’lu hastalarda anlamlı olarak yüksekti (p<0,01). HOMA-IR ve KIMK PKOS’lu hastalarda anlamlı olarak yüksek tespit edildi (p<0,01). Antropometrik ölçümler ile KIMK ve insülin rezistansı arasında istatistiksel olarak anlamlı korelasyon tespit edildi. Antropometrik öçlümler PKOS belirteci olarak da anlamlı bulundu. Sonuçlar: BKI ve Bel/Boy oranı gibi antropometrik ölçümler bazı kısıtlılıklara sahip olsa da obezite değerlendirmesinde kullanışlıdır. PKOS’lu hastalarda bel çevresi gibi yeni antropomterik ölçümler abdominal obezite ve metabolik/kardiyovasküler risklerin belirlenmesinde daha kullanışlıdır.

Anahtar Kelimeler

• Polikistik Over Sendromu
• Ateroskleroz
• Antropometri
• Karotis İntima Media Kalınlığı
• Abdominal Obezite

The Importance of New Anthropometric Measurements in Detecting Cardio Metabolic Risk and Insulin Resistance in Patients with Polycystic Ovary Syndrome: Single Center Experience

Öz

Objective: Abdominal obesity is frequently seen in Polycystic Ovary Syndrome (PCOS). The evaluation of abdominal obesity might be important according to metabolic and cardiovascular dysfunctions in patients with PCOS. We aimed to evaluate the new anthropometric measurements in patients with polycystic ovary syndrome (PCOS) and their relationship with cardiovascular risk and insulin resistance. Methods: We included 62 patients with PCOS and 38 healthy individuals as control. The clinical examinations, serum hormone levels and ultrasonographic findings of overs were evaluated. Anthropometric Measurements, HOMA-IR values and Carotid intima-media thickness (CIMT) measurements were evaluated. Results: The predictors of abdominal obesity as waist circumference, LAP, BAI, BRI, VAI, AVI, WHtR were significantly higher in patient with PCOS (p<0.01). HOMA-IR and CIMT were also significantly higher in patients with PCOS compared with controls (p<0.01). We found significant correlations between anthropometric measurements and CIMT and insulin resistance. Anthropometric measurements were also valuable in prediction of PCOS. Conclusion: Some of the measurements as BMI and waist/height ratio are used in evaluation of obesity. However, they had some limitations in prediction of obesity. We believe that recently used anthropometric measurements as waist circumference might be more useful predictors in evaluation of abdominal obesity and metabolic/cardiovascular risks in patients with PCOS.

Anahtar Kelimeler

• Polycystic ovary syndrome
• Atherosclerosis
• Anthropometry
• Carotid intima-media thickness
• Abdominal obesity

Kaynakça

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