Obez Prediyabetiklerde α-klotho, FGF-23 ve İnsülin Direncinin Değerlendirilmesi

Öz

Amaç: Prediyabet, hiperglisemi ve tip 2 diabetes mellitus (T2DM) gelişme riski olan bir durumdur. Bu çalışmanın amacı, kan basıncı, serum lipoproteinleri, glikoz ve insülin düzeylerinin yanı sıra α-klotho ve FGF-23 parametrelerinin konsantrasyonlarını belirlemektir. Ayrıca obez prediyabetiklerde ve obez normoglisemilerde tüm bu parametreler arasındaki korelasyonu belirlemeyi hedefliyoruz. Gereç yöntemler: Toplam 26 obez normoglisemik (kontrol grubu) ve 25 obez prediyabetik birey bu çalışmaya dahil edildi. Hastanemizin biyokimya laboratuvarlarında rutin prosedür kapsamında glukoz, hemoglobin A1c (HbA1c) ve kolesterol seviyeleri otoanalizör kullanılarak analiz edildi. α-klotho ve fibroblast büyüme faktörü-23 (FGF-23) düzeylerini belirlemek için ELISA yöntemi kullanıldı. Bulgular: Bulgulara göre obez prediyabetik grupta serum LDL-C, TC, HbA1c, glikoz, insülin ve HOMA-IR seviyelerinde kontrol grubuna göre anlamlı artış tespit edildi (p <0.05). Ancak obez prediyabetik grupta serum α-klotho ve FGF-23 düzeyleri kontrol grubuna göre anlamlı olarak düşük bulundu (p <0.05). α-klotho ve FGF-23 değerleri, HOMA-IR değerleri ile ayrı ayrı karşılaştırıldığında güçlü negatif korelasyon gösterdi (p <0.01). Sonuç: Bu bulgular, α-klotho ve / veya FGF-23 parametrelerinin prediyabet için bir belirteç olabileceğini düşündürmektedir. Çalışmamızın sonuçları, ileride yapılacak çalışmalarla birlikte, diyabet polikliniklerinde prediyabet tanı kriterleri olarak literatüre önemli katkı sağlayacaktır.

Anahtar Kelimeler

• prediyabet
• insülin direnci
• α-klotho
• fibroblast büyüme faktörü-23 (FGF-23)

Evaluation of α-klotho, FGF-23 and Insulin Resistance in Obese Prediabetics

Öz

Aim: Prediabetes is a condition with hyperglycemia and risk of development type 2 diabetes mellitus (T2DM). The aim of this study is to determine the concentrations of blood pressure, serum lipoproteins, glucose and insulin levels as well as the concentrations of α-klotho and FGF-23 parameters. We also aim at the correlation between all these parameters in obese prediabetics and obese normoglycemics. Material methods: A total of 26 obese normoglycemic (control group) and 25 obese prediabetic individuals were included in this study. Glucose, haemoglobin A1c (HbA1c) and cholesterols levels were analyzed as part of a routine procedure in the biochemistry laboratories of our hospital using an autoanalyzer. In order to determine α-klotho and fibroblast growth factor-23 (FGF-23) levels, ELISA method was used. Result: According to the findings, a significant increase was detected in serum LDL-C, TC, HbA1c, glucose, insulin and HOMA-IR levels in the obese prediabetic group compared to the control group (p <0.05). However, serum α-klotho and FGF-23 levels were found to be significantly lower in the obese prediabetic group compared to the control group (p <0.05). α-klotho and FGF-23 values showed strong negative correlation when compared with HOMA-IR values separately (p <0.01). Conclusion: These findings suggest that α-klotho and / or FGF-23 parameters may be a marker for prediabetes. The results of our study, together with the future studies, will make a significant contribution to the literature, as prediabetes diagnostic criteria in the diabetes outpatient clinics.

Anahtar Kelimeler

• Prediabetes
• insulin resistance
• α-klotho
• fibroblast growth factor-23 (FGF-23)

Kaynakça

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