Enflamatuar Belirteç Olarak Nötrofil Lenfosit Oranı, Platelet Lenfosit Oranı gibi Hematolojik Parametrelerin Tıkayıcı Uyku Apne Sendromunun Şiddeti ile İlişkisinin Değerlendirilmesi

Yıl 2017, Cilt: 1 Sayı: 3, 125 - 131, 03.12.2017

Oğuz Dikbaş Nilgün Erten Fatma Küçüker Özge Yılmaz Akşehirli

Öz

Amaç: Bu çalışmanın amacı tıkayıcı uyku apnesi (OSAS) olan hastalarda hematolojik parametrelerin değerlendirilmesidir.

Gereç ve Yöntemler: Bu araştırmada uyku laboratuvarında Polisomnografi testi yapılan hastalar geriye dönük olarak değerlendirilmiştir. Kanser, kardiyovasküler hastalık, hematolojik bozukluk, enfeksiyon hastalıkları, romatolojik hastalıklar, renal ve hepatik yetmezlik olan hastalar çalışmaya alınmamıştır. Çalışmaya apne-hipopne endeksi 5 olaydan fazla olan 210 hasta ve 57 AHI 5 den az olan kontrol olarak alınmıştır. Araştırma grubu polisomnografideki AHI skorlarına göre 4 gruba ayrılmıştır: hafif OSAS (AHI= 5-15), orta OSAS (AHI=15- 30), ciddi OSAS (AHI> 30), ve kontrol (AHI<5). Hematolojik parametreler değerlendirilmiş ve karşılaştırılmıştır.

Bulgular: Trombosit lenfosit oranı OSAS hastalarında kontrol grubuna göre anlamlı düşük saptanmıştır. (p = 0.050). OSAS ve kontrol grupları arasında nötrofil lenfosit oranı yönünden istatistiksel olarak anlamlı farklılık izlenmemiştir (p = 0.947). Serum trigliserid ve ortalama trombosit hacmi OSAS hastalarında anlamlı yüksek izlenmiştir (p < 0.0001; p = 0.043). Trombosit dağılım hacmi ciddi OSAS grubunda kontrol grubuna ve diğer OSAS alt gruplarına göre anlamlı yüksek saptanmıştır. (p = 0.014).

Sonuç: OSAS ve NLR arasında herhangi bir ilişki izlenmemiştir. NLR, PLR, ve OSAS arasındaki olası ilişki üzerine hâlâ araştırmaların sonuçları tartışmalıdır.

Anahtar Kelimeler

Tıkayıcı uyku apne sendromu, OSAS, Nötrofil lenfosit oranı, Platelet lenfosit oranı

Relationship of Potential Inflammatory Markers Namely Neutrophile Lymphocyte Ratio and Platelet Lymphocyte Ratio With the Severity of Obstructive Sleep Apnea

Öz

Aim: The aim of the present study is to evaluate hematological parameters in patients with obstructive sleep apnea syndrome (OSAS).

Material and Methods: Patients underwent a polysomnographic (PSG) test at our sleep laboratory was retrospectively reviewed. Patients with cancer, cardiovascular disease, hematologic disorders, infectious diseases and rheumatologically disorders, renal or hepatic insufficiency were excluded from the study. Two hundred and ten OSAS patients with an apnea-hypopnea index (AHI) of more than five events and 57 controls with an AHI of less than four events were included. Study population was divided into four groups depending on the AHI as: mild OSAS (AHI= 5-15), moderate OSAS (AHI=15-30), severe OSAS (AHI>30), and the control (AHI<5). Hematologic parameters were measured and compared.

Results: Platelet lymphocyte ratio was significantly lower in patients with OSAS compared to the control (p = 0.050). Neutrophil lymphocyte ratio between OSAS and the control was not different (p = 0.947). Serum triglyceride level and mean platelet volume were significantly higher in patients with OSAS (p < 0.0001; p = 0.043). Platelet distribution width was significantly higher in severe OSAS group compared to control, mild and moderate OSAS subgroups (0.014).

Conclusion: No relationship was found between OSAS and NLR. There is a debate over putative relationship between NLR, PLR, and OSAS.

Anahtar Kelimeler

Obstructive sleep apnea syndrome, OSAS, Neutrophil lymphocyte ratio, Platelet lymphocyte ratio

Kaynakça

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