Gestasyonel Diyabetli ve Gestasyonel Diyabet Olmayan Gebelerde Tiroid Fonksiyon Testlerinin Karşılaştırılması

Yıl 2021, Cilt: 5 Sayı: 3, 285 - 290, 30.12.2021

Hatice Özışık Şevki Çetinkalp Aslı Suner İsmet Hortu Ahmet Mete Ergenoğlu Mehmet Erdoğan

https://doi.org/10.25048/tudod.974721

Öz

Amaç: Bu çalışmanın amacı, gestasyonel diyabeti olan ve olmayan gebelerde tiroid hormon düzeylerinde ve anti-tiroid peroksidaz
antikorlarında farklılık olup olmadığını belirlemektir.
Gereç ve Yöntemler: 107 gebe kadının tıbbi kayıtlarını incelendi. Anne yaşı, gebelik haftası, vücut kütle indeksi, tiroid fonksiyon testleri
ve antitiroid peroksidaz antikorları, açlık kan şekeri testleri ve HbA1c düzeyleri ile ilgili klinik veriler elde edildi. Pearson ki-kare testi,
Mann-Whitney U testi ve bağımsız örnekler t testi, Spearman korelasyon katsayısı ve lojistik regresyon modeli uygulandı Bulgular: Gestasyonel diyabet grubu anlamlı olarak daha yaşlıydı (p=0,001). Vücut kütle indeksi iki grup arasında istatistiksel olarak
farklıydı (p=0,002). İki grup arasında açlık kan şekeri ve HbA1c açısından istatistiksel olarak anlamlı farklılıklar vardı (sırasıyla p<0,001
ve p=0,004). Gestasyonel diyabetli gebelerde anti-tiroid peroksidaz antikorları sıklığı daha yüksekti, ancak istatistiksel olarak anlamlı
farklılık yoktu (p=0,716). Ötiroidizm (%57,9) tüm hastalarda daha yaygındı. Subklinik hipotiroidi olguları GDM’li olan ve olmayan
gruplar arasında istatistiksel olarak anlamlı farklılık gösterirken (p<0,001), ötiroidizm ve izole hipotiroksinemi arasında anlamlı fark
bulunmadı (sırasıyla p=0,093 ve p=0,220). Sonuçlarımız subklinik hipotiroidizmi olan gebelerin gestasyonel diyabet olma olasılığının
5,5 kat daha fazla olduğunu göstermektedir.
Sonuç: Gestasyonel diyabetli kadınlarda gebelikteki subklinik hipotiroidizm gestasyonel diyabetli olmayan kadınlardan daha sık
saptanmıştır. Gestasyonel diyabetli kadınlara rutin olarak tiroid testleri yapılmalı ve anti-tiroid peroksidaz antikorlarına bakılmalıdır

Anahtar Kelimeler

gestasyonel diyabet, hipotiroidizm, anti tiroid peroksidaz antikorları

Destekleyen Kurum

yok

Proje Numarası

yok

Teşekkür

Ahmet Topaçoğlu'na dil kontrolü için teşekkür ederiz

Comparison of Thyroid Function Tests in Pregnant Women with and without Gestational Diabetes

Öz

Aim: The aim of this study was to determine whether there were abnormalities in thyroid hormone levels and anti-thyroid peroxidase
antibodies in pregnant women with and without gestational diabetes mellitus.
Material and Methods: We analyzed the medical records of 107 pregnant women. Clinical data related to maternal age, gestational
week, body mass index, thyroid function tests, and anti-thyroid peroxidase antibodies, fasting blood glucose tests and HbA1c levels were
obtained. The Pearson chi-square test, the Mann-Whitney U test, independent samples t-test, the Spearman correlation coefficient and
Logistic regression model were performed.
Results: Gestational diabetes mellitus group was significantly older (p=0.001). Body mass index was statistically different between
the two groups (p=0.002). There were statistically significant differences in fasting blood glucose and HbA1c between the two groups
(p<0.001 and p=0.004, respectively). The frequency of anti-thyroid peroxidase antibodies was higher in pregnant women with gestational
diabetes mellitus, but the result was not statistically significant (p=0.716). Euthyroidism (57.9%) was more prevalent in all patients. While
cases of subclinical hypothyroidism were statistically significantly different between gestational diabetes mellitus and non-gestational
diabetes mellitus groups (p<0.001), euthyroidism and isolated hypothyroxinemia had no significant differences (p=0.093 and p=0.220,
respectively). Our results suggest that pregnant women with subclinical hypothyroidism are 5.5 times more likely to be gestational
diabetes mellitus.
Conclusion: Subclinical hypothyroidism during pregnancy was detected more frequently in women with gestational diabetes mellitus
than in women without gestational diabetes mellitus. Taken together, women with GDM should be performed thyroid tests and anti
TPO routinely.

Anahtar Kelimeler

Gestational diabetes mellitus, Hypothyroidism, Anti-thyroid peroxidase antibodies

Proje Numarası

yok

Kaynakça

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