Effects of Irisin Hormone on Health and Energy Homeostasis

Yıl 2024, Cilt: 8 Sayı: 3, 294 - 303, 30.12.2024

Muhammed Enes Kartal , Özlem Baran

Öz

Obesity is a significant public health issue with a growing prevalence linked to cardiovascular disease, type 2 diabetes mellitus, an
increased incidence of certain types of cancer, and respiratory complications. Adipose tissue and muscle tissue play important roles in
the management of obesity. Irisin, a myokine released from muscles, adipose tissue, and various tissues and organs, is a hormone that is
stimulated by exercise. In the literature search, PubMed, Science Direct and Google Scholar databases were searched and the structure,
release, role in energy metabolism and effects on obesity of irisin hormone were analysed comprehensively. Irisin is incorporated into
the circulatory system following the proteolysis of the C-terminal part of FNDC5, a cell membrane protein, by a protease that is yet to
be discovered. Released by myocytes, irisin is 12 kDa in size and consists of 112 amino acids. Irisin has a significant effect on energy
metabolism by increasing mitochondrial biogenesis and uncoupling protein-1 expression, thereby enhancing the conversion of white
adipose tissue to brown adipose tissue and promoting thermogenesis. As a result, energy expenditure increases significantly. Due to this
effect, it is thought that irisin may be beneficial for the treatment of obesity. However, the functions of the irisin hormone in various
tissues and organs, the receptors involved in these functions, and its effects on diseases have not yet been fully elucidated. Therefore,
further research on irisin, a promising hormone for regulating energy metabolism and preventing obesity, is warranted.

Anahtar Kelimeler

Energy homeostasis, Irisin, Obesity

İrisin Hormonunun Sağlık ve Enerji Homeostazı Üzerine Etkileri

Öz

Obezite; kardiyovasküler hastalık, tip-2 diyabetes mellitus, belirli kanser türlerinin görülme sıklığında artış ve solunum komplikasyonlarıyla
ilişkili, prevelansı günden güne artan önemli bir halk sağlığı sorunudur. Obezitenin yönetiminde adipoz doku ve kas dokusu
önemli bir rol oynamaktadır. Kaslardan, adipoz dokudan ve çeşitli doku ve organlardan salınan bir miyokin olan irisin, egzersizle
stimüle edilen bir hormondur. Literatür incelemesinde, PubMed, Science Direct ve Google Akademik veri tabanları taranarak, irisin
hormonunun yapısı, salınımı, enerji metabolizmasındaki rolü ve obezite üzerindeki etkileri kapsamlı bir şekilde analiz edilmiştir. İrisin,
henüz tam olarak keşfedilmeyen bir proteaz tarafından, bir hücre zarı proteini olan FNDC5’in C-terminal kısmının proteolizinin ardından
meydana gelerek sirkülatuar sisteme dahil olur. Miyositler tarafından salınan irisin, 12 kDa büyüklüğünde ve 112 aminoasitten
oluşmaktadır. İrisin, mitokondri biyogenezini ve uncoupling protein-1 ekspresyonunu artırarak enerji metabolizması üzerinde önemli
bir etkiye sahiptir, böylece beyaz adipoz dokunun kahverengi adipoz dokuya dönüşümünü ve termojenezi artırmaktadır. Bunun sonucu
olarak da enerji harcaması önemli ölçüde artar. Bu etkisiyle irisinin, obezitenin tedavisi açısından faydalı olabileceği düşünülmektedir.
Ancak irisin hormonunun çeşitli doku ve organlardaki işlevleri, bu işlevlerdeki görevli reseptörler ve hastalıklar üzerindeki etkileri
henüz bulunamamıştır. Bu sebeple enerji metabolizmasının regülasyonu ve obezitenin önlenmesi için umut vaat eden bir hormon olan
irisin hakkında daha fazla araştırmanın yapılması gerekmektedir.

Anahtar Kelimeler

Enerji homeostazı, İrisin, Obezite

Etik Beyan

Derleme türünde bir çalışma olduğu için etik kurul oluru gerekmemiştir.

Destekleyen Kurum

Bulunmamaktadır.

Teşekkür

Bulunmamaktadır.

Kaynakça

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