ASSESSMENT OF HEAVY METAL LEVELS IN FOLLICULAR FLUID OF WOMEN WITH UNEXPLAINED INFERTILITY

Yıl 2017, Cilt: Volume 2 Sayı: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 171 - 171, 16.02.2017

Eyüp Çırak Onur Erdem Serdar Çetınkaya Seyit Temel Ceyhan Cemal Akay Cem Korkmaz Mustafa Ulubay

Öz

The reproductive
health of women is currently a major worldwide public health problem. The World
Health Organization reported that more than 10 % of women are severely affected
by infertility. Environmental factors especially exposure to toxic heavy metals
may be contributed to development of unexplained infertility because toxic
heavy metals may change fertility patterns via endocrine disrupting mechanisms.
In addition to this, there are very few studies about the trace element and
toxic heavy metal levels in follicular fluid which considering as target matrix
for unexplained infertility. In this study, we aimed to evaluate the heavy
metal and trace element levels in follicular fluid undergoing in vitro
fertilization (IVF). For this purpose, follicular fluids were obtained from 19
women (age 21-38) who was treated in Department of Obstetrics and Gynecology.
Metals levels in the samples were measured using atomic absorption
spectrometric analysis (AAS). Arsenic (As) and lead (Pb) were not found in
follicular fluids. The mean levels of cadmium (Cd), aluminium (Al), copper
(Cu), zinc (Zn), chromium (Cr) and cobalt (Co) were quantified as 0.93 µg/L,
30.6 µg/dl, 46.4 µg/dl, 44.6 µg/dl, 4.15 µg/dl and 4.71µg/dl, respectively. Our
results showed that these trace and toxic heavy metals must be considered in
the etiology of unexplained infertility. Also further research should be
carried out to explain the biological effects of heavy metals in unexplained
infertility.

Anahtar Kelimeler

ASSESSMENT OF HEAVY METAL LEVELS IN FOLLICULAR FLUID OF WOMEN WITH UNEXPLAINED INFERTILITY

Kaynakça

• Eyüp ÇIRAK, Onur ERDEM, Serdar ÇETINKAYA, Seyit Temel CEYHAN, Cemal AKAY, Cem KORKMAZ, Mustafa ULUBAY
• Department of Pharmaceutical Toxicology, Gulhane Military Medical Academy, Ankara, Turkey. Department of Obstetrics and Gynecology, Gulhane Military Medical Academy, Ankara, Turkey.