Araştırma Makalesi
BibTex RIS Kaynak Göster

EVALUATION OF THE OXIDATIVE STRESS IN SILICOSIS PATIENTS

Yıl 2018, Cilt: 3 Sayı: 1, 5 - 5, 01.02.2018

Öz

ABSTRACT

Objective. Silica particles are potent inducers of cell
proliferation, cell injury, and inflammation, and oxidant release from alveolar
macrophages, thus providing a mechanistic framework for their increased
fibrogenicity. The Alveolar macrophages are viewed as a pivotal cell type in
fibrogenesis in both lung defense and elaboration of growth factors and
oxidants.
In this study, we aimed to investigate serum TAS
(Total Antioxidant Status), TOS (Total Oxidant Status) and OSI (Oxidative
Stress Index) parameters in the individuals working in ceramic factory and
diagnosed as silicosis and discuss the possible effects of these parameters on
the etiopathogenesis of the disease.

Methods.
This study was performed on 33 male patients with silicosis (23-73 years)
and 30 male healthy control (18-69 years) who were admitted to Ankara
Occupational Diseases Hospital. Silicosis patients
were diagnosed depending on their chest radiograms in accordance with the ILO
2000 guidelines. TAS, TOS levels were measured in blood samples and OSI
was calculated according to formula (TOS/TAS).

Results.
Serum TOS levels of the silicosis subjects were higher than those of the
controls whereas serum TAS levels of silicosis subjects was lower than those of
the controls. But the differences between the parameters were not statistically
significant. The serum OSI levels were significantly higher (p<0.05) in the
silicosis subjects compared with the control group.

Conclusion. Our
study showed elevated OSI in patients with silicosis. Increased oxidative
stress is thougth to be related with the oxidative burst caused by alveolar
macrophage activation.

Keywords.
Silicosis, Total Antioxidant
Status, Total Oxidant Status, Oxidative Stress













Conflict
of interest:
Authors do not have any conflict of interest

Kaynakça

  • 1. American Thoracic Society. 1997. Adverse effects of cyrstalline silica exposure (ATS statement). Am. J. Respir. Crit. Care Med. 155:761– 765. 2. Calhoun, W. J., et al. "Elevated immunoglobulins in the lavage fluid of healthy granite workers." Thorax 41 (1986): 766-773. 3. Green GM, Jakab GJ, Low RB, Davis GS (1977) State of the art: defense mechanisms of the respiratory membrane. Am Rev Respir Dis 115:479-514. 4. Veblen, D. R., and A. G. Wylie. 1993. Mineralogy of amphiboles and 1:1 layer silicates. In G. D. Guthrie, Jr. and B. T. Mossman, editors. Health Effects of Mineral Dusts. Reviews in Mineralogy, Vol. 28. Mineralogical Society of America, Washington, DC. 61–138. 5. Hochella, M. D., Jr. 1993. Surface chemistry, structure, and reactivity of hazardous mineral dust. In G. D. Guthrie, Jr. and B. T. Mossman, editors. Health Effects of Mineral Dusts. Reviews in Mineralogy, Vol. 28. Mineralogical Society of America, Washington, DC. 275– 308. 6. Vallyathan, V., X. Shi, N. S. Dalal, W. Irr, and V. Castranova. 1988. Generation of free radicals from freshly fractured silica dust: potential role in acute silica-induced injury. Am. Rev. Respir. Dis. 138:1213– 1219. 7. Schuyler M, Zisking M, deSalvaggio J (1977) Cell-mediated immunity silicosis. Am Rev Respir Dis 116:147-151. 8. Gibbs, A. R., and J. C. Wagner. 1988. Diseases due to silica. In A. Churg and F. H. Y. Green, editors. Pathology of Occupational Lung Diseases. Igaku-Shoin Medical Publishers, New York. 155–176.
Yıl 2018, Cilt: 3 Sayı: 1, 5 - 5, 01.02.2018

Öz

Kaynakça

  • 1. American Thoracic Society. 1997. Adverse effects of cyrstalline silica exposure (ATS statement). Am. J. Respir. Crit. Care Med. 155:761– 765. 2. Calhoun, W. J., et al. "Elevated immunoglobulins in the lavage fluid of healthy granite workers." Thorax 41 (1986): 766-773. 3. Green GM, Jakab GJ, Low RB, Davis GS (1977) State of the art: defense mechanisms of the respiratory membrane. Am Rev Respir Dis 115:479-514. 4. Veblen, D. R., and A. G. Wylie. 1993. Mineralogy of amphiboles and 1:1 layer silicates. In G. D. Guthrie, Jr. and B. T. Mossman, editors. Health Effects of Mineral Dusts. Reviews in Mineralogy, Vol. 28. Mineralogical Society of America, Washington, DC. 61–138. 5. Hochella, M. D., Jr. 1993. Surface chemistry, structure, and reactivity of hazardous mineral dust. In G. D. Guthrie, Jr. and B. T. Mossman, editors. Health Effects of Mineral Dusts. Reviews in Mineralogy, Vol. 28. Mineralogical Society of America, Washington, DC. 275– 308. 6. Vallyathan, V., X. Shi, N. S. Dalal, W. Irr, and V. Castranova. 1988. Generation of free radicals from freshly fractured silica dust: potential role in acute silica-induced injury. Am. Rev. Respir. Dis. 138:1213– 1219. 7. Schuyler M, Zisking M, deSalvaggio J (1977) Cell-mediated immunity silicosis. Am Rev Respir Dis 116:147-151. 8. Gibbs, A. R., and J. C. Wagner. 1988. Diseases due to silica. In A. Churg and F. H. Y. Green, editors. Pathology of Occupational Lung Diseases. Igaku-Shoin Medical Publishers, New York. 155–176.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular İç Hastalıkları
Bölüm Articles
Yazarlar

Kübranur Ünal Bu kişi benim

Bağdagül Çakır Bu kişi benim

Ceylan Demir Bal Bu kişi benim

Ömer Hınç Yılmaz Bu kişi benim

Engin Tutkun Bu kişi benim

Fatma Meriç Yılmaz Bu kişi benim

Yayımlanma Tarihi 1 Şubat 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 3 Sayı: 1

Kaynak Göster

APA Ünal, K., Çakır, B., Demir Bal, C., Hınç Yılmaz, Ö., vd. (2018). EVALUATION OF THE OXIDATIVE STRESS IN SILICOSIS PATIENTS. The Turkish Journal Of Occupational / Environmental Medicine and Safety, 3(1), 5-5.
AMA Ünal K, Çakır B, Demir Bal C, Hınç Yılmaz Ö, Tutkun E, Meriç Yılmaz F. EVALUATION OF THE OXIDATIVE STRESS IN SILICOSIS PATIENTS. turjoem. Şubat 2018;3(1):5-5.
Chicago Ünal, Kübranur, Bağdagül Çakır, Ceylan Demir Bal, Ömer Hınç Yılmaz, Engin Tutkun, ve Fatma Meriç Yılmaz. “EVALUATION OF THE OXIDATIVE STRESS IN SILICOSIS PATIENTS”. The Turkish Journal Of Occupational / Environmental Medicine and Safety 3, sy. 1 (Şubat 2018): 5-5.
EndNote Ünal K, Çakır B, Demir Bal C, Hınç Yılmaz Ö, Tutkun E, Meriç Yılmaz F (01 Şubat 2018) EVALUATION OF THE OXIDATIVE STRESS IN SILICOSIS PATIENTS. The Turkish Journal Of Occupational / Environmental Medicine and Safety 3 1 5–5.
IEEE K. Ünal, B. Çakır, C. Demir Bal, Ö. Hınç Yılmaz, E. Tutkun, ve F. Meriç Yılmaz, “EVALUATION OF THE OXIDATIVE STRESS IN SILICOSIS PATIENTS”, turjoem, c. 3, sy. 1, ss. 5–5, 2018.
ISNAD Ünal, Kübranur vd. “EVALUATION OF THE OXIDATIVE STRESS IN SILICOSIS PATIENTS”. The Turkish Journal Of Occupational / Environmental Medicine and Safety 3/1 (Şubat 2018), 5-5.
JAMA Ünal K, Çakır B, Demir Bal C, Hınç Yılmaz Ö, Tutkun E, Meriç Yılmaz F. EVALUATION OF THE OXIDATIVE STRESS IN SILICOSIS PATIENTS. turjoem. 2018;3:5–5.
MLA Ünal, Kübranur vd. “EVALUATION OF THE OXIDATIVE STRESS IN SILICOSIS PATIENTS”. The Turkish Journal Of Occupational / Environmental Medicine and Safety, c. 3, sy. 1, 2018, ss. 5-5.
Vancouver Ünal K, Çakır B, Demir Bal C, Hınç Yılmaz Ö, Tutkun E, Meriç Yılmaz F. EVALUATION OF THE OXIDATIVE STRESS IN SILICOSIS PATIENTS. turjoem. 2018;3(1):5-.