EVALUATION OF THE OXIDATIVE STRESS IN SILICOSIS PATIENTS

Yıl 2018, Cilt: 3 Sayı: 1, 5 - 5, 01.02.2018

Kübranur Ünal Bağdagül Çakır Ceylan Demir Bal Ömer Hınç Yılmaz Engin Tutkun Fatma Meriç Yılmaz

Öz

ABSTRACT

Objective. Silica particles are potent inducers of cell
proliferation, cell injury, and inflammation, and oxidant release from alveolar
macrophages, thus providing a mechanistic framework for their increased
fibrogenicity. The Alveolar macrophages are viewed as a pivotal cell type in
fibrogenesis in both lung defense and elaboration of growth factors and
oxidants. In this study, we aimed to investigate serum TAS
(Total Antioxidant Status), TOS (Total Oxidant Status) and OSI (Oxidative
Stress Index) parameters in the individuals working in ceramic factory and
diagnosed as silicosis and discuss the possible effects of these parameters on
the etiopathogenesis of the disease.

Methods.
This study was performed on 33 male patients with silicosis (23-73 years)
and 30 male healthy control (18-69 years) who were admitted to Ankara
Occupational Diseases Hospital. Silicosis patients
were diagnosed depending on their chest radiograms in accordance with the ILO
2000 guidelines. TAS, TOS levels were measured in blood samples and OSI
was calculated according to formula (TOS/TAS).

Results.
Serum TOS levels of the silicosis subjects were higher than those of the
controls whereas serum TAS levels of silicosis subjects was lower than those of
the controls. But the differences between the parameters were not statistically
significant. The serum OSI levels were significantly higher (p<0.05) in the
silicosis subjects compared with the control group.

Conclusion. Our
study showed elevated OSI in patients with silicosis. Increased oxidative
stress is thougth to be related with the oxidative burst caused by alveolar
macrophage activation.

Keywords.
Silicosis, Total Antioxidant
Status, Total Oxidant Status, Oxidative Stress

Conflict
of interest: Authors do not have any conflict of interest

Anahtar Kelimeler

EVALUATION OF THE OXIDATIVE STRESS IN SILICOSIS PATIENTS

Kaynakça

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