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The Role of Ozone Applications in Endodontics

Yıl 2024, Cilt: 3 Sayı: 2, 390 - 397, 30.08.2024
https://doi.org/10.58711/turkishjdentres.vi.1497176

Öz

Ozone is recommended as an alternative or supportive treatment agent to current treatment methods. The prophylactic and therapeutic effects of ozone have been proven in the field of medicine. Ozone’s disinfectant, antimicrobial, and tissue healing properties have highlighted its use in dentistry. Ozone
has a very high potential for antimicrobial use in endodontics. In endodontics, ozonized water, ozonized oil, and ozone gas can be used as irrigation solutions or intracanal medicaments. Ozone can also be used for postoperative pain control in endodontics.

Kaynakça

  • 1. Bocci V. Ozone as Janus: this controversial gas can be either toxic or medically useful. Mediators Inflamm. 2004;13(1):3-11.
  • 2. Saini R. Ozone therapy in dentistry: A strategic review. J Nat Sci Biol Med. 2011;2(2):151-3.
  • 3. Di Paolo N, Bocci V, Gaggioti E. Ozone therapy. Int J Artif Organs. 2004;27(3):168-75.
  • 4. Bocci VA. Scientific and medical aspects of ozone therapy. State of the art. Arch Med Res. 2006;37(4):425-35.
  • 5. Sen S, Sen S. Ozone therapy a new vista in dentistry: integrated review. Medical Gas Research. 2020;10(4),189– 192.
  • 6. Sujatha B, Kumar M, Pratap G, Vardhan R. Ozone therapy–A paradigm shift in dentistry. Health Sci. 2013;2(3):1-10.
  • 7. Azarpazhooh A, Limeback H. The application of ozone in dentistry: a systematic review of literature. J Dent. 2008;36(2), 104–116.
  • 8. McKenna DF, Borzabadi-Farahani A, Lynch E. The effect of subgingival ozone and/or hydrogen peroxide on the development of peri-implant mucositis: a double- blind randomized controlled trial. Int J Oral Maxillofac Implants. 2013;28(6):1483-9.
  • 9. Baumgartner JC, Cuenin PR. Efficacy of several concentrations of sodium hypochlorite for root canal irrigation. J Endod. 1992;18(12):605-12.
  • 10. Brugnera A, Zanin F, Barbin EL, Spano JC, Santana R, Pécora JD. Effects of Er: YAG and Nd: YAG laser irradiation on radicular dentine permeability using different irrigating solutions. Lasers Surg Med. 2003;33(4):256-9.
  • 11. Song M, Zeng Q, Xiang Y, Gao L, Huang J, Huang J, Wu K, Lu J. The antibacterial effect of topical ozone on the treatment of MRSA skin infection. Mol Med Rep. 2018;17(2):2449–2455.
  • 12. Tiwari S, Avinash A, Katiyar S, Aarthi Iyer A, Jain S. Dental applications of ozone therapy: A review of literature. The Saudi J Dent Res. 2017; 8(1-2):105- 111.
  • 13. Silva EJNL, Prado MC, Soares DN, Hecksher F, Martins JNR, Fidalgo TKS. The effect of ozone therapy in root canal disinfection: a systematic review. Int Endod J. 2020;53(3):317-332.
  • 14. Kaptan F, Güven EP, Topcuoglu N, Yazici M, Külekçi G. In vitro assessment of the recurrent doses of topical gaseous ozone in the removal of Enterococcus faecalis biofilms in root canals. Niger J Clin Pract. 2014;17(5):573–578.
  • 15. Polydorou O, Pelz K, Hahn P. Antibacterial effect of an ozone device and its comparison with two dentin‐ bonding systems. Eur J Oral Sci. 2006;114(4):349-53.
  • 16. Sousa SIV, Alvim‐Ferraz MCM, Martins FG, Pereira MC. Ozone exposure and its influence on the worsening of childhood asthma. Allergy. 2009;64(7):1046-55.
  • 17. Halbauer K, Prskalo K, Jankovic B, Tarle Z, Panduric V, Kalenic S. Efficacy of ozone on microorganisms in the tooth root canal. Coll Antropol. 2013;37(1):101-7.
  • 18. Hems RS, Gulabivala K, Ng YL, Ready D, Spratt DA. An in vitro evaluation of the ability of ozone to kill a strain of Enterococcus faecalis. Int Endod J. 2005;38(1):22-9.
  • 19. Nagayoshi M, Fukuizumi T, Kitamura C, Yano J, Terashita M, Nishihara T. Efficacy of ozone on survival and permeability of oral microorganisms. Oral Microbiol
  • 20. Thanomsub B, Anupunpisit V, Chanphetch S, Watcharachaipong T, Poonkhum R, Srisukonth C. Effects of ozone treatment on cell growth and ultrastructural changes in bacteria. J Gen Appl Microbiol. 2002;48(4):193-9.
  • 21. Baysan A, Whiley RA, Lynch E. Antimicrobial effect of a novel ozone-Immunol. generating device on microorganisms associated with primary root carious lesions in vitro. Caries Res. 2000;34(6):498-501.
  • 22. Huth KC, Jakob FM, Saugel B, Cappello C, Paschos E, Hollweck R, Hickel R, Brand K. Effect of ozone on oral cells compared with established antimicrobials. Eur J Oral Sci. 2006;114(5):435-40.
  • 23. Bal FA, Ozkocak I, Cadirci BH, Karaarslan ES, Cakdinleyen M, Agaccioglu M. Effects of photodynamic therapy with indocyanine green on Streptococcus mutans biofilm. Photodiagnosis Photodyn Ther. 2019;26:229-234.
  • 24. Kapdan A, Öztaş N, Sümer Z. Comparing the antibacterial activity of gaseous ozone and chlorhexidine solution on a tooth cavity model. J Clin Exp Dent. 2013;5(3):e133-e137.
  • 25. Pinheiro SL, da Silva CC, da Silva LA, Cicotti MP, da Silveira Bueno CE, Fontana CE et al. Antimicrobial efficacy of 2.5% sodium hypochlorite, 2% chlorhexidine, and ozonated water as irrigants in mesiobuccal root canals with severe curvature of mandibular molars. Eur J Dent. 2018;12(1):94–99.
  • 26. Agarwal S, Tyagi P, Deshpande A, Yadav S, Jain V, Rana KS. Comparison of antimicrobial efficacy of aqueous ozone, green tea, and normal saline as irrigants in pulpectomy procedures of primary teeth. J Indian Soc Pedod Prev Dent. 2020;38(2):164-170.
  • 27. Mehta N, Gupta A, Mahesh S, Abraham D, Singh A, Jala S, Chauhan N, Sreen D. Comparative evaluation of antibacterial efficacy of Allium sativum extract, aqueous ozone, diode laser, and 3% sodium hypochlorite in root canal disinfection: An in vivo study. J Conserv Dent. 2020; 23(6): 577–582.
  • 28. Hubbezoglu I, Zan R, Tunc T, Sumer Z. Antibacterial Efficacy of Aqueous Ozone in Root Canals Infected by Enterococcus faecalis. Jundishapur J Microbiol. 2014;7(7):e11411.
  • 29. Estrela C, Estrela CRA, Decurcio DA, Hollanda ACB, Silva JA. Antimicrobial efficacy of ozonated water, gaseous ozone, sodium hypochlorite and chlorhexidine in infected human root canals. Int Endod J. 2007;40(2):85-93.
  • 30. Moraes MM, Coelho MS, Nascimento WM, Nogales CG, de Campos FUF, Soares AJ, Frozoni M. The antimicrobial effect of different ozone protocols applied in severe curved canals contaminated with Enterococcus faecalis: ex vivo study. Odontology. 2021;109(3):696–700.
  • 31. Boch T, Tennert C, Vach K, Al-Ahmad A, Hellwig E, Polydorou O. Effect of gaseous ozone on Enterococcus faecalis biofilm– an in vitro study. Clin Oral Investig. 2016;20(7):1733-39.
  • 32. Küçük F, Yıldırım S, Çetiner S. Cytotoxicity assessment of different doses of ozonated water on dental pulp cells. BMC Oral Health. 2021;19;21(1):32.
  • 33. Reddy KS, Prasad SD, Sirisha PD, Prashanth V. Evaluation of Antimicrobial Efficacy of Ozonated Sesame Oil, Calcium Hydroxide and their Combination as Intracanal Medicament against Candida Albicans: An in-vitro study. Adv Hum Biol. 2015;5(2):78-87.
  • 34. Silveira AMV, Lopes HP, Siqueira Jr JF, Macedo SB, Consolaro A. Periradicular repair after two-visit endodontic treatment using two different intracanal medications compared to single- visit endodontic treatment. Braz Dent J. 2007;18(4):299-304.
  • 35. Kriplani S, Sedani S, Mishra A, Umre U. Non-surgical Management of Periapical Lesions With the Use of Newer Modalities in Adjunct to the Conventional: A Case Series. Cureus. 2024;16(3): e57314.
  • 36. Vasavada K, Kapoor S. Evaluation of ozonized calcium hydroxide as an effective intracanal medicament during root canal procedures: an in vitro observational study. Med Gas Res. 2020;10(3):122-124.
  • 37. Khalilov R. Semptomatik Apikal Periodontitisli Molar Dişlere Sahip Hastalarda Kanal İçi Ozon Uygulamasının Postoperatif Ağrıya Etkisi: Randomize, Plasebo Kontrollü Klinik Çalışma (Uzmanlık Tezi) Erzurum: Atatürk Üniversitesi Diş Hekimliği Fakültesi, Endodonti Anabilim Dalı;2017.
  • 38. Sağlam H, Aladağ H. Comparison of ıntracanal ozone and low‐level laser therapy on postoperative pain in vital teeth with symptomatic apical periodontitis:placebo‐controlled randomize trial. Lasers Med Sci. 2023; 38(1):227.
  • 39. Sinha N, Asthana G, Parmar G, Langaliya A, Shah J, Kumbhar A, Singh B. Evaluation of Ozone Therapy in Endodontic Treatment of Teeth with Necrotic Pulp and Apical Periodontitis: A Randomized Clinical Trial. J Endod. 2021;47(12):1820–1828.
  • 40. Ahmed N, Suzuki S, Mosallam R. Effect of Oleozon on Healing of Exposed Pulp Tissues. J Am Sci. 2011;7(5):38– 44.
  • 41. Chandra SP, Chandrasekhar R, Uloopi KS, Vinay C, Kumar NM. Success of root fillings with zinc oxide-ozonated oil in primary molars: preliminary results. Eur Arch Paediatr Dent. 2014;15(3):191-5.
  • 42. El-Desouky SS, Omer SMM, Ghouraba RF, Ali Abdel Latif RM, Kabbash IA, Hadwa SM. Zinc oxide-ozonated olive oil as a new root canal filling material in primary molars: a clinical randomized controlled trial. Clin Oral Investig. 2023;27(12):7395-7405.
  • 43. Maiya A. Applications of ozone in dentistry. Int J Clin Den Sci. 2011;2:23-7.
  • 44. Menzel DB. Ozone: an overview of its toxicity in man and animals. J Toxicol Environ Health. 1984;13(2- 3):181-204.
  • 45. Pattanaik B, Jetwa D, Pattanaik S, Manglekar S, Naitam DN, Dani A. Ozone therapy in dentistry: a literature review. J Interdisciplinary Dent. 2011;1(2):87.

Endodontide Ozon Uygulamalarının Yeri

Yıl 2024, Cilt: 3 Sayı: 2, 390 - 397, 30.08.2024
https://doi.org/10.58711/turkishjdentres.vi.1497176

Öz

Ozon, mevcut tedavi yöntemlerine bir alternatif veya yardımcı tedavi ajanı olarak tavsiye edilmektedir. Ozonun profilaktik ve tedavi edici etkisi tıp alanında kanıtlanmıştır. Ozonun sahip olduğu dezenfektan, antimikrobiyal ve doku iyileştirici özellikleri, onu diş hekimliğinde kullanım için öne çıkarmıştır. Ozonun endodontide antimikrobiyal olarak kullanım potansiyeli çok yüksektir. Endodontide ozonlanmış
su, ozonlanmış yağ ve ozon gazı formlarında irrigasyon solüsyonu ya da kanal içi medikament olarak kullanılabilir. Ozon endodontide postoperatif ağrı kontrolünde de kullanılabilir.

Kaynakça

  • 1. Bocci V. Ozone as Janus: this controversial gas can be either toxic or medically useful. Mediators Inflamm. 2004;13(1):3-11.
  • 2. Saini R. Ozone therapy in dentistry: A strategic review. J Nat Sci Biol Med. 2011;2(2):151-3.
  • 3. Di Paolo N, Bocci V, Gaggioti E. Ozone therapy. Int J Artif Organs. 2004;27(3):168-75.
  • 4. Bocci VA. Scientific and medical aspects of ozone therapy. State of the art. Arch Med Res. 2006;37(4):425-35.
  • 5. Sen S, Sen S. Ozone therapy a new vista in dentistry: integrated review. Medical Gas Research. 2020;10(4),189– 192.
  • 6. Sujatha B, Kumar M, Pratap G, Vardhan R. Ozone therapy–A paradigm shift in dentistry. Health Sci. 2013;2(3):1-10.
  • 7. Azarpazhooh A, Limeback H. The application of ozone in dentistry: a systematic review of literature. J Dent. 2008;36(2), 104–116.
  • 8. McKenna DF, Borzabadi-Farahani A, Lynch E. The effect of subgingival ozone and/or hydrogen peroxide on the development of peri-implant mucositis: a double- blind randomized controlled trial. Int J Oral Maxillofac Implants. 2013;28(6):1483-9.
  • 9. Baumgartner JC, Cuenin PR. Efficacy of several concentrations of sodium hypochlorite for root canal irrigation. J Endod. 1992;18(12):605-12.
  • 10. Brugnera A, Zanin F, Barbin EL, Spano JC, Santana R, Pécora JD. Effects of Er: YAG and Nd: YAG laser irradiation on radicular dentine permeability using different irrigating solutions. Lasers Surg Med. 2003;33(4):256-9.
  • 11. Song M, Zeng Q, Xiang Y, Gao L, Huang J, Huang J, Wu K, Lu J. The antibacterial effect of topical ozone on the treatment of MRSA skin infection. Mol Med Rep. 2018;17(2):2449–2455.
  • 12. Tiwari S, Avinash A, Katiyar S, Aarthi Iyer A, Jain S. Dental applications of ozone therapy: A review of literature. The Saudi J Dent Res. 2017; 8(1-2):105- 111.
  • 13. Silva EJNL, Prado MC, Soares DN, Hecksher F, Martins JNR, Fidalgo TKS. The effect of ozone therapy in root canal disinfection: a systematic review. Int Endod J. 2020;53(3):317-332.
  • 14. Kaptan F, Güven EP, Topcuoglu N, Yazici M, Külekçi G. In vitro assessment of the recurrent doses of topical gaseous ozone in the removal of Enterococcus faecalis biofilms in root canals. Niger J Clin Pract. 2014;17(5):573–578.
  • 15. Polydorou O, Pelz K, Hahn P. Antibacterial effect of an ozone device and its comparison with two dentin‐ bonding systems. Eur J Oral Sci. 2006;114(4):349-53.
  • 16. Sousa SIV, Alvim‐Ferraz MCM, Martins FG, Pereira MC. Ozone exposure and its influence on the worsening of childhood asthma. Allergy. 2009;64(7):1046-55.
  • 17. Halbauer K, Prskalo K, Jankovic B, Tarle Z, Panduric V, Kalenic S. Efficacy of ozone on microorganisms in the tooth root canal. Coll Antropol. 2013;37(1):101-7.
  • 18. Hems RS, Gulabivala K, Ng YL, Ready D, Spratt DA. An in vitro evaluation of the ability of ozone to kill a strain of Enterococcus faecalis. Int Endod J. 2005;38(1):22-9.
  • 19. Nagayoshi M, Fukuizumi T, Kitamura C, Yano J, Terashita M, Nishihara T. Efficacy of ozone on survival and permeability of oral microorganisms. Oral Microbiol
  • 20. Thanomsub B, Anupunpisit V, Chanphetch S, Watcharachaipong T, Poonkhum R, Srisukonth C. Effects of ozone treatment on cell growth and ultrastructural changes in bacteria. J Gen Appl Microbiol. 2002;48(4):193-9.
  • 21. Baysan A, Whiley RA, Lynch E. Antimicrobial effect of a novel ozone-Immunol. generating device on microorganisms associated with primary root carious lesions in vitro. Caries Res. 2000;34(6):498-501.
  • 22. Huth KC, Jakob FM, Saugel B, Cappello C, Paschos E, Hollweck R, Hickel R, Brand K. Effect of ozone on oral cells compared with established antimicrobials. Eur J Oral Sci. 2006;114(5):435-40.
  • 23. Bal FA, Ozkocak I, Cadirci BH, Karaarslan ES, Cakdinleyen M, Agaccioglu M. Effects of photodynamic therapy with indocyanine green on Streptococcus mutans biofilm. Photodiagnosis Photodyn Ther. 2019;26:229-234.
  • 24. Kapdan A, Öztaş N, Sümer Z. Comparing the antibacterial activity of gaseous ozone and chlorhexidine solution on a tooth cavity model. J Clin Exp Dent. 2013;5(3):e133-e137.
  • 25. Pinheiro SL, da Silva CC, da Silva LA, Cicotti MP, da Silveira Bueno CE, Fontana CE et al. Antimicrobial efficacy of 2.5% sodium hypochlorite, 2% chlorhexidine, and ozonated water as irrigants in mesiobuccal root canals with severe curvature of mandibular molars. Eur J Dent. 2018;12(1):94–99.
  • 26. Agarwal S, Tyagi P, Deshpande A, Yadav S, Jain V, Rana KS. Comparison of antimicrobial efficacy of aqueous ozone, green tea, and normal saline as irrigants in pulpectomy procedures of primary teeth. J Indian Soc Pedod Prev Dent. 2020;38(2):164-170.
  • 27. Mehta N, Gupta A, Mahesh S, Abraham D, Singh A, Jala S, Chauhan N, Sreen D. Comparative evaluation of antibacterial efficacy of Allium sativum extract, aqueous ozone, diode laser, and 3% sodium hypochlorite in root canal disinfection: An in vivo study. J Conserv Dent. 2020; 23(6): 577–582.
  • 28. Hubbezoglu I, Zan R, Tunc T, Sumer Z. Antibacterial Efficacy of Aqueous Ozone in Root Canals Infected by Enterococcus faecalis. Jundishapur J Microbiol. 2014;7(7):e11411.
  • 29. Estrela C, Estrela CRA, Decurcio DA, Hollanda ACB, Silva JA. Antimicrobial efficacy of ozonated water, gaseous ozone, sodium hypochlorite and chlorhexidine in infected human root canals. Int Endod J. 2007;40(2):85-93.
  • 30. Moraes MM, Coelho MS, Nascimento WM, Nogales CG, de Campos FUF, Soares AJ, Frozoni M. The antimicrobial effect of different ozone protocols applied in severe curved canals contaminated with Enterococcus faecalis: ex vivo study. Odontology. 2021;109(3):696–700.
  • 31. Boch T, Tennert C, Vach K, Al-Ahmad A, Hellwig E, Polydorou O. Effect of gaseous ozone on Enterococcus faecalis biofilm– an in vitro study. Clin Oral Investig. 2016;20(7):1733-39.
  • 32. Küçük F, Yıldırım S, Çetiner S. Cytotoxicity assessment of different doses of ozonated water on dental pulp cells. BMC Oral Health. 2021;19;21(1):32.
  • 33. Reddy KS, Prasad SD, Sirisha PD, Prashanth V. Evaluation of Antimicrobial Efficacy of Ozonated Sesame Oil, Calcium Hydroxide and their Combination as Intracanal Medicament against Candida Albicans: An in-vitro study. Adv Hum Biol. 2015;5(2):78-87.
  • 34. Silveira AMV, Lopes HP, Siqueira Jr JF, Macedo SB, Consolaro A. Periradicular repair after two-visit endodontic treatment using two different intracanal medications compared to single- visit endodontic treatment. Braz Dent J. 2007;18(4):299-304.
  • 35. Kriplani S, Sedani S, Mishra A, Umre U. Non-surgical Management of Periapical Lesions With the Use of Newer Modalities in Adjunct to the Conventional: A Case Series. Cureus. 2024;16(3): e57314.
  • 36. Vasavada K, Kapoor S. Evaluation of ozonized calcium hydroxide as an effective intracanal medicament during root canal procedures: an in vitro observational study. Med Gas Res. 2020;10(3):122-124.
  • 37. Khalilov R. Semptomatik Apikal Periodontitisli Molar Dişlere Sahip Hastalarda Kanal İçi Ozon Uygulamasının Postoperatif Ağrıya Etkisi: Randomize, Plasebo Kontrollü Klinik Çalışma (Uzmanlık Tezi) Erzurum: Atatürk Üniversitesi Diş Hekimliği Fakültesi, Endodonti Anabilim Dalı;2017.
  • 38. Sağlam H, Aladağ H. Comparison of ıntracanal ozone and low‐level laser therapy on postoperative pain in vital teeth with symptomatic apical periodontitis:placebo‐controlled randomize trial. Lasers Med Sci. 2023; 38(1):227.
  • 39. Sinha N, Asthana G, Parmar G, Langaliya A, Shah J, Kumbhar A, Singh B. Evaluation of Ozone Therapy in Endodontic Treatment of Teeth with Necrotic Pulp and Apical Periodontitis: A Randomized Clinical Trial. J Endod. 2021;47(12):1820–1828.
  • 40. Ahmed N, Suzuki S, Mosallam R. Effect of Oleozon on Healing of Exposed Pulp Tissues. J Am Sci. 2011;7(5):38– 44.
  • 41. Chandra SP, Chandrasekhar R, Uloopi KS, Vinay C, Kumar NM. Success of root fillings with zinc oxide-ozonated oil in primary molars: preliminary results. Eur Arch Paediatr Dent. 2014;15(3):191-5.
  • 42. El-Desouky SS, Omer SMM, Ghouraba RF, Ali Abdel Latif RM, Kabbash IA, Hadwa SM. Zinc oxide-ozonated olive oil as a new root canal filling material in primary molars: a clinical randomized controlled trial. Clin Oral Investig. 2023;27(12):7395-7405.
  • 43. Maiya A. Applications of ozone in dentistry. Int J Clin Den Sci. 2011;2:23-7.
  • 44. Menzel DB. Ozone: an overview of its toxicity in man and animals. J Toxicol Environ Health. 1984;13(2- 3):181-204.
  • 45. Pattanaik B, Jetwa D, Pattanaik S, Manglekar S, Naitam DN, Dani A. Ozone therapy in dentistry: a literature review. J Interdisciplinary Dent. 2011;1(2):87.
Toplam 45 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Endodonti
Bölüm Derlemeler
Yazarlar

Merve Gökyar 0000-0002-2735-156X

İdil Özden 0000-0003-0838-4355

Hesna Sazak Öveçoğlu 0000-0003-4709-422X

Yayımlanma Tarihi 30 Ağustos 2024
Gönderilme Tarihi 7 Haziran 2024
Kabul Tarihi 31 Temmuz 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 3 Sayı: 2

Kaynak Göster

Vancouver Gökyar M, Özden İ, Sazak Öveçoğlu H. Endodontide Ozon Uygulamalarının Yeri. J Turkish Dent Res. 2024;3(2):390-7.

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