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Coronavirus Disease (COVID-19): A Review of Antiviral Potential Herbal Medicines

Yıl 2022, Cilt: 9 Sayı: 2, 245 - 254, 15.08.2022
https://doi.org/10.19159/tutad.1071658

Öz

In Wuhan, China, a severe acute respiratory syndrome caused by coronavirus-2 (SARS-CoV-2) has emerged, causing serious symptoms in patients such as fever, dry cough, and exhaustion. This fatal pandemic spreads over the globe, causing significant infections in humans, mainly in the respiratory tract. To date, researchers have paid close attention to new therapeutic methods, particularly promising antiviral medicines and vaccines. Especially, existing synthetic antivirals have been used against viruses that prevent replication, entry into the cell, and transmission of the virus. These antiviral agents have been the subject of the basis of drug discovery studies that directly affect COVID 19. Since the COVID-19 outbreak, a variety of conventional herbal remedies have been employed either alone or in combination with current medications to treat infected people with encouraging results. Flavonoids, lectins, polysaccharides, alkaloids, terpenes, lectins and essential oils are some natural ingredients with demonstrated antiviral activity. These secondary metabolites have been shown to be effective against a wide range of viruses in the studies on this subject. In this review, we investigated the potential herbal medicines against various RNA, and DNA viruses, including SARS-CoV-2. We also investigated the bioactive substances from medicinal plants and their potential antiviral efficacy.

Kaynakça

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Coronavirus Disease (COVID-19): A Review of Antiviral Potential Herbal Medicines

Yıl 2022, Cilt: 9 Sayı: 2, 245 - 254, 15.08.2022
https://doi.org/10.19159/tutad.1071658

Öz

In Wuhan, China, a severe acute respiratory syndrome caused by coronavirus-2 (SARS-CoV-2) has emerged, causing serious symptoms in patients such as fever, dry cough, and exhaustion. This fatal pandemic spreads over the globe, causing significant infections in humans, mainly in the respiratory tract. To date, researchers have paid close attention to new therapeutic methods, particularly promising antiviral medicines and vaccines. Especially, existing synthetic antivirals have been used against viruses that prevent replication, entry into the cell, and transmission of the virus. These antiviral agents have been the subject of the basis of drug discovery studies that directly affect COVID 19. Since the COVID-19 outbreak, a variety of conventional herbal remedies have been employed either alone or in combination with current medications to treat infected people with encouraging results. Flavonoids, lectins, polysaccharides, alkaloids, terpenes, lectins and essential oils are some natural ingredients with demonstrated antiviral activity. These secondary metabolites have been shown to be effective against a wide range of viruses in the studies on this subject. In this review, we investigated the potential herbal medicines against various RNA, and DNA viruses, including SARS-CoV-2. We also investigated the bioactive substances from medicinal plants and their potential antiviral efficacy.

Kaynakça

  • Aanouz, I., Belhassan, A., El-Khatabi, K., Lakhlifi, T., El-ldrissi, M., Bouachrine, M., 2020. Moroccan medicinal plants as inhibitors against SARS-CoV-2 main protease: Computational investigations. Journal of Biomolecular Structure and Dynamics, 39(8): 2971-2979.
  • Abdelli, I., Hassani, F., Bekkel Brikci, S., Ghalem, S., 2020. In silico study the inhibition of angiotensin converting enzyme 2 receptor of COVID-19 by Ammoides verticillata components harvested from western Algeria. Journal of Biomolecular Structure and Dynamic, 39(9): 1-14.
  • Açıkgöz, Ö., Günay, A., 2020. The early impact of the Covid-19 pandemic on the global and Turkish economy. Turkish Journal of Medical Sciences, 50(9): 520-526.
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  • Akbudak, N., Şen, Ö., 2021. GLOBALGAP in the COVID-19 epidemic process. Turkish Journal of Agricultural Research, 8(2): 248-255. (In Turkish).
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  • Li, S., Chen, C., Zhang, H., Guo, H., Wang, H., Wang, L., Zhang, X., Hua, S., Yu, J., Xiao, P., Li, R., Tan, X., 2005. Identification of natural compounds with antiviral activities against SARS-associated coronavirus. Antiviral Research, 67(1): 18-23.
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  • Maiti, S., Banerjee, A., Nazmeen, A., Kanwar, M., Das, S., 2022. Active-site molecular docking of nigellidine with nucleocapsid- NSP2-MPro of COVID-19 and to human IL1R-IL6R and strong antioxidant role of Nigella-sativa in experimental rats. Journal of Drug Targeting, 30(5): 511-521.
  • Manganelli, R.E.U., Zaccaro, L., Tomei, P.E., 2005. Antiviral activity in vitro of Urtica dioica L. Parietaria diffusa M. et K. and Sambucus nigra L. Journal of Ethnopharmacology, 98(3): 323-327.
  • Mani, J.S., Johnson, J.B., Steel, J.C., Broszczak, A.D., Neilsen, P.M., Walsh, K.B., Naiker, M., 2020. Natural product-derived phytochemicals as potential agents against coronaviruses: a review. Virus Research, 284: 197989.
  • Mani, R.J., Sehgal, N., Dogra, N., Saxena, S., Katare, D.P., 2022. Deciphering underlying mechanism of Sars-CoV-2 infection in humans and revealing the therapeutic potential of bioactive constituents from Nigella sativa to combat COVID19: In-silico study. Journal of Biomolecular Structure and Dynamics, 40(6): 2417-2429.
  • Marchetti, M., Mastromarino, P., Rieti, S., Seganti, L., Orsi, N., 1995. Inhibition of herpes simplex, rabies and rubella viruses by lectins with different specificities. Research in Virology, 146(3): 211-215.
  • Martini, R., Esposito, F., Corona, A., Ferrarese, R., Ceresola, E.R., Visconti, L., Tintori, C., Barbieri, A., Calcaterra, A., Iovine, V., Canducci, F., Tramontano, E., Botta, M., 2017. Natural product kuwanon-L inhibits HIV-1 replication through multiple target binding. ChemBioChem, 18(4): 374-377.
  • Maryam, M., Te, K.K., Wong, F.C., Chai, T.T., Low, G.K.K., Chiew, S., Chee, H.Y., 2020. Antiviral activity of traditional Chinese medicinal plants Dryopteris crassirhizoma and Morus alba against dengue virus. Journal of Integrative Agriculture, 19(4): 1085-1096.
  • Mathai, R.V., Jindal, M.K., Mitra, J.C., Sar, S.K., 2022. COVID-19 and medicinal plants: A critical perspective. Forensic Science International: Animals and Environments, 2: 1-3.
  • Mir, S.A., Firoz, A., Alaidarous, M., Alshehri, B., Bin Dukhyil, A.A., Banawas, S., Alsagaby, S.A., Alturaiki, W., Bhat, G.A., Kashoo, F., Abdel-Hadi, A.M., 2022. Identification of SARS-CoV-2 RNA-dependent RNA polymerase inhibitors from the major phytochemicals of Nigella sativa: An in silico approach. Saudi Journal of Biological Sciences, 29(1): 394-401.
  • Mohiuddin, E., Usmanghani, K., Akram, M., Asif, M., Akhtar, N., Naveed, A., Shah, P.A., Uzair, M., 2011. Morus nigra L. Journal of Medicinal Plant Research, 5: 5197-5199.
  • Onifade, A.A., Jewell, A.P., Adedeji, W.A., 2013a. Nigella sativa concoction induced sustained seroreversion in HIV patient. African Journal of Traditional, Complementary and Alternative Medicines, 10(5): 332-335.
  • Onifade, A.A., Jewell, A.P., Ajadi, T.A., Rahamon, S.K., Ogunrin, O.O., 2013b. Effectiveness of a herbal remedy in six HIV patients in Nigeria. Journal of Herbal Medicine, 3(3): 99-103.
  • Oyero, O.G., Toyama, M., Mitsuhiro, N., Onifade, A.A., Hidaka, A., Okamoto, M., Baba, M., 2016. Selective inhibition of hepatitis c virus replication by Alpha-zam, a Nigella sativa seed formulation. African Journal of Traditional, Complementary and Alternative Medicines, 13(6): 144-148.
  • Öztoprak, F., Özyazıcı, G., 2022. Medicinal and aromatic plants in the COVID-19 process. International Conference on Global Practice of Multidisciplinary Scientific Studies, March 6-8, Cyprus, pp. 1529-1543. (In Turkish).
  • Pandey, P., Khan, F., Mazumder, A., Rana, A.K., Srivastava, Y., 2021. Inhibitory potential of dietary phytocompounds of Nigella sativa against key targets of novel coronavirus (COVID-19). Indian Journal of Pharmaceutical Education and Research, 55(1): 190-197.
  • Pereira, P.R., Winter, H.C., Verícimo, M.A., Meagher, J.L., Stuckey, J.A., Goldstein, I.J., Silva, J.T., 2015. Structural analysis and binding properties of isoforms of tarin, the GNA-related lectin from Colocasia esculenta. Biochimica et Biophysica Acta Proteins and Proteomics, 1854(1): 20-30.
  • Rahmani, A.H., Khan, A.A., Aldebasi, Y.H., 2017. Saffron (Crocus sativus) and its active ingredients: Role in the prevention and treatment of disease. Pharmacognosy Journal, 9(6): 873-879.
  • Rawat, A., Mali, R.R., 2013. Phytochemical properties and pharmcological activities of Nicotiana tabacum: A Review. Indian Journal of Pharmaceutical and Biological Research, 1(1): 74-82.
  • Reyad-ul-Ferdous, M., Arman, M.S.I., Tanvir, M.M.I., Sumi, S., Siddique, K.M.M.R., Billah, M.M., Islam, M.S., 2015. Biologically potential for pharmacologicals and phytochemicals of medicinal plants of Colocasia esculenta: A comprehensive review. American Journal of Clinical and Experimental Medicine, 3(5-1): 7-11.
  • Rizvi, S.M.D., Hussain, T., Moin, A., Dixit, S.R., Mandal, S.P., Adnan, M., Jamal, Q.M.S., Sharma, D.C., Alanazi, A.S., Unissa, R., 2021. Identifying the most potent dual-targeting compound(s) against 3CLprotease and NSP15exonuclease of SARS-CoV-2 from Nigella sativa: Virtual screening via physicochemical properties, docking and dynamic simulation analysis. Processes, 9(10): 1-15.
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  • Sampangi-Ramaiah, M.H., Vishwakarma, R., Shaanker, R.U., 2020. Molecular docking analysis of selected natural products from plants for inhibition of SARS-CoV-2 main protease. Current Science, 118(7): 1087-1092.
  • Saxena, A., 2020. Drug targets for COVID-19 therapeutics: Ongoing global efforts. Journal of Biosciences, 45(1): 1-24.
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  • Singh, B., Namrata, Kumar, L., Dwiedii, S.C., 2011. Antibacterial and antifungal activity of Colocasia esculenta aqueous extract: An edible plant. Journal of Pharmacy Research, 4(5): 1459-1460.
  • Singh, S., Shenoy, S., Nehete, P.N., Yang, P., Nehete, B., Fontenot, D., Yang, G., Newman, R. A., Sastry, K.J., 2013. Nerium oleander derived cardiac glycoside oleandrin is a novel inhibitor of HIV infectivity. Fitoterapia, 84: 32-39.
  • Song, Y.H., Kim, W.D., Curtis-Long, M.J., Yuk, J.H., Wang, Y., Zhuang, N., Lee, H.K., Jeon, S.K., Park, K.H., 2014. Papain-like protease (PLpro) inhibitory effects of cinnamic amides from Tribulus terrestris fruits. Biological and Pharmaceutical Bulletin, 37(6): 1021-1028.
  • Thuy, P.T.B., My, A.T.T., Hai, T.T.N., Hieu, L.T., Hoa, T., Loan, P.T.H., Triet, N.T., Anh, T.T. Van, Quy, P.T., Tat, P. Van, Hue, N. Van, Quang, D.T., Trung, N.T., Tung, V.T., Huynh, L.K., Nhung, A.T.N., 2020. Investigation into SARS-CoV‑2 resistance of compounds in garlic essential oil. ACS Omega, 5(14): 8312-8320.
  • Tripathi, M.K., Singh, P., Sharma, S., Singh, T.P., Ethayathulla, A.S., Kaur, P., 2021. Identification of bioactive molecule from Withania somnifera (Ashwagandha) as SARS-CoV-2 main protease inhibitor. Journal of Biomolecular Structure and Dynamics, 39(15): 5668-5681.
  • Tsang, N.Y., Zhao, L.H., Tsang, S.W., Zhang, H.J., 2017. Antiviral activity and molecular targets of plant natural products against avian influenza virus. Current Organic Chemistry, 21(18): 1777-1804.
  • Ulasli, M., Gurses, S.A., Bayraktar, R., Yumrutas, O., Oztuzcu, S., Igci, M., Igci, Y.Z., Cakmak, E.A., Arslan, A., 2014. The effects of Nigella sativa (Ns), Anthemis hyalina (Ah) and Citrus sinensis (Cs) extracts on the replication of coronavirus and the expression of TRP genes family. Molecular Biology Reports, 41(3): 1703-1711.
  • Van der Meer, F.J.U.M., De Haan, C.A.M., Schuurman, N.M.P., Haijema, B.J., Peumans, W.J., Van Damme, E.J.M., Delputte, P.L., Balzarini, J., Egberink, H.F., 2007. Antiviral activity of carbohydrate-binding agents against Nidovirales in cell culture. Antiviral Research, 76(1): 21-29.
  • Virgilio, D.N., Papazoglou, E.G., Jankauskiene, Z., Lonardo, S. Di, Praczyk, M., Wielgusz, K., 2015. The potential of stinging nettle (Urtica dioica L.) as a crop with multiple uses. Industrial Crops and Products, 68: 42-49.
  • Wang, L., Yang, R., Yuan, B., Liu, Y., Liu, C., 2015. The antiviral and antimicrobial activities of licorice , a widely-used Chinese herb. Acta Pharmaceutica Sinica B, 5(4): 310-315.
  • Xu, H., Liu, B., Xiao, Z., Zhou, M., Ge, L., Jia, F., Liu, Y., Jin, H., Zhu, X., Gao, J., Akhtar, J., Xiang, B., Tan, K., Wang, G., 2021. Computational and experimental studies reveal that thymoquinone blocks the entry of coronaviruses into in vitro cells. Infectious Diseases and Therapy, 10(1): 483-494.
Toplam 85 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Derleme / Review
Yazarlar

Tuğsen Doğru 0000-0003-0101-9742

Fatma Ayaz 0000-0003-3994-6576

Nuraniye Eruygur 0000-0002-4674-7009

Yayımlanma Tarihi 15 Ağustos 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 9 Sayı: 2

Kaynak Göster

APA Doğru, T., Ayaz, F., & Eruygur, N. (2022). Coronavirus Disease (COVID-19): A Review of Antiviral Potential Herbal Medicines. Türkiye Tarımsal Araştırmalar Dergisi, 9(2), 245-254. https://doi.org/10.19159/tutad.1071658
AMA Doğru T, Ayaz F, Eruygur N. Coronavirus Disease (COVID-19): A Review of Antiviral Potential Herbal Medicines. TÜTAD. Ağustos 2022;9(2):245-254. doi:10.19159/tutad.1071658
Chicago Doğru, Tuğsen, Fatma Ayaz, ve Nuraniye Eruygur. “Coronavirus Disease (COVID-19): A Review of Antiviral Potential Herbal Medicines”. Türkiye Tarımsal Araştırmalar Dergisi 9, sy. 2 (Ağustos 2022): 245-54. https://doi.org/10.19159/tutad.1071658.
EndNote Doğru T, Ayaz F, Eruygur N (01 Ağustos 2022) Coronavirus Disease (COVID-19): A Review of Antiviral Potential Herbal Medicines. Türkiye Tarımsal Araştırmalar Dergisi 9 2 245–254.
IEEE T. Doğru, F. Ayaz, ve N. Eruygur, “Coronavirus Disease (COVID-19): A Review of Antiviral Potential Herbal Medicines”, TÜTAD, c. 9, sy. 2, ss. 245–254, 2022, doi: 10.19159/tutad.1071658.
ISNAD Doğru, Tuğsen vd. “Coronavirus Disease (COVID-19): A Review of Antiviral Potential Herbal Medicines”. Türkiye Tarımsal Araştırmalar Dergisi 9/2 (Ağustos 2022), 245-254. https://doi.org/10.19159/tutad.1071658.
JAMA Doğru T, Ayaz F, Eruygur N. Coronavirus Disease (COVID-19): A Review of Antiviral Potential Herbal Medicines. TÜTAD. 2022;9:245–254.
MLA Doğru, Tuğsen vd. “Coronavirus Disease (COVID-19): A Review of Antiviral Potential Herbal Medicines”. Türkiye Tarımsal Araştırmalar Dergisi, c. 9, sy. 2, 2022, ss. 245-54, doi:10.19159/tutad.1071658.
Vancouver Doğru T, Ayaz F, Eruygur N. Coronavirus Disease (COVID-19): A Review of Antiviral Potential Herbal Medicines. TÜTAD. 2022;9(2):245-54.

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