Two Acute Coronary Syndrome Cases Induced By Panax Usage; The Secret and Big Danger?

Abstract

Atherosclerotic cardiovascular diseases have become epidemic. They are the most common causes of morbidity and mortality. In recent years, herbal combination called Panax which has ingredient Tribulus terrestris (TT), Avena sativa (AS), and Panax Ginseng (PG), often used by patients with coronary artery disease. In this article, two cases that have coronary artery disease developed acute coronary syndrome due to leaving the drugs were presented.

Keywords

• Acute coronary syndrome, herbal combination

Panax Kullanımına Bağlı Gelişen İki Akut Koroner Sendrom Olgusu; Gizli ve Büyük Tehlike

Öz

Aterosklerotik kardiyovasküler hastalıklar günümüzde epidemik hale gelmiştir. Morbidite ve mortalitenin en sık nedenleridir. Son yıllarda, Tribulus terrestris (TT), Avena sativa (AS) ve Panax Ginseng (PG) içeren bitkisel karışımlar koroner arter hastaları tarafından sık olarak kullanılmaktadır. Bu yazıda, bilinen koroner arter hastalığı olmasına rağmen, ilaçlarını bırakıp bitkisel karışım kullanan ve akut koroner sendrom gelişen iki olgu sunuldu.

Anahtar Kelimeler

• Akut koroner sendrom, bitkisel karışımlar

Kaynakça

1. 1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensivemechanism of Tribulus terrestris in 2K1C hypertensive rats:role of tissue ACE activity. Life Sci 2003;73:2963-71. 2. Phillips OA, Mathew KT, Oriowo MA. Antihypertensiveand vasodilator effects of methanolic and aqueous extracts of Tribulus terrestris in rats. J Ethnopharmacol 2006;104:351-5.
2. 3. Wang B, Ma L, Liu T. 406 cases of angina pectoris in coronary heart disease treated with saponin of Tribulus terrestris. Zhong Xi Yi Jie He Za Zhi 1990;10:85-7, 68.
3. 4. Andersson KE, Svedberg KA, Lindholm MW, Oste R, Hellstrand P. Oats (Avena sativa) reduce atherogenesis in LDL-receptor-deficient mice. Atherosclerosis 2010;212:93-9.
4. 5. Kiefer D, Pantuso T. Panax ginseng. Am Fam Physician 2003;68:1539-42.
5. 6. Zhang YG, Zhang HG, Zhang GY, Fan JS, Li XH, Liu YH, et al. Panax notoginseng saponins attenuate atherosclerosis in rats by regulating the blood lipid profile and an anti-inflammatory action. Clin Exp Pharmacol Physiol 2008;35:1238-44.
6. 7. Gillis CN. Panax ginseng pharmacology: a nitric oxide link? Biochem Pharmacol 1997;54:1-8
7. 8. Brinker FJ. Herb contraindications and drug interactions: with extensive appendices addressing specific conditions, herb effects, critical medications, and nutritional supplements. 3d ed. Sandy, Ore: Eclectic Medical Publications; 2001.
8. 9. Vogler BK, Pittler MH, Ernst E. The efficacy of ginseng. A systematic review of randomised clinical trials. Eur J Clin Pharmacol 1999;55:567-75.

9. 10. Ding DZ, Shen TK, Cui YZ. Effects of red ginseng on the congestive heart failure and its mechanism. [Article in Chinese] Zhongguo Zhong Xi Yi Jie He Za Zhi 1995;15:325-7.
10. 11. Atar Aİ, Er O, Güven A, Eryonucu B. Two cases of acute coronary syndrome after intake of clavis panax. Turk Kardiyol Dern Ars 2012;40:269-75
11. 12. Güneş H, Küçükdurmaz Z, Karapınar H, Gül İ. Acute anterior myocardial infarction presented with cardiogenic shock in a patient on herbal medication. Turk Kardiyol Dern Ars 2012;40:262-4
12. 13. Vatankulu MA, Tasal A, Erdoğan E, Göktekin Ö. Three case reports of the use of herbal combinations resulted in stent thrombosis: herbal combinations; friend or foe? Turk Kardiyol Dern Ars 2012;40:265-8
13. 14. Yüksel İA, Arslan Ş, Çağrıcı G, Yılmaz A, Acute massive pulmonary embolism in a patient using clavis panax, Türk Kardiyol Dern Arş -2013;41(4):351-353