Veteriner Hekimlikte Apiterapi ve Uygulamaları

Yıl 2024, , 442 - 458, 18.11.2024

Ayşe Ebru Borum

https://doi.org/10.31467/uluaricilik.1537629

Öz

Arı ve arı ürünlerinin insan ve veteriner hekimliğinde tedavi amaçlı kullanımına apiterapi denir. Doğal ürünler, insanlık tarihi boyunca hastalıklara karşı korunmak ve tedavi etmek için kullanılmıştır. Son yıllarda ilaç direncinin ortaya çıkması ve farmakolojik ajanların gelişigüzel ve düzensiz kullanımıyla ilişkili olumsuz etkilerin ortaya çıkması, insanlığı alternatif çözümler aramaya yöneltmiştir. En önemli çözümlerden biri de arı ürünlerinin uygulanmasıdır. Arı ürünlerinin apiterapi uygulamalarında kullanımı bal, arı zehri, polen, propolis, balmumu, arı sütü, perga ve apilarnil (arı larvaları) içerir. Genel olarak, çok çeşitli endikasyonlara sahip apiterapi ürünleri çeşitli sistem hastalıklarında ve bazı dermatolojik problemlerde yaygın olarak kullanılmaktadır ve bu ürünlerin antibakteriyel, antifungal, antiviral, antioksidan, antikarsinojenik, antiinflamatuar, antidiyabetik ve in vitro ve in vivo immünomodülatör etkileri gibi çeşitli etkileri birçok farklı çalışmada araştırılmıştır. Apiterapi, veteriner hekimliğinde insan hekimliğine göre daha az yaygındır. Ayrıca, arı ürünleri gastrointestinal bozukluklar, otitis, sinüzitis, oftalmik durumlar, dermatolojik bozukluklar ve cilt bakımı dahil olmak üzere diğer hayvan hastalıklarının tedavisinde kullanılır. Ayrıca, arı ürünleri hayvanlar için gıda takviyesi olarak kullanılır. Hayvansal gıdalardaki en yaygın katkı maddesi arı polenidir. Büyümeyi teşvik ettiği, ölüm oranını azalttığı ve morbiditeyi önlediği gösterilmiştir. Apiterapi, özellikle gıda olarak tüketilen hayvanların tedavisinde hem insan sağlığını hem de ekonomik kayıpları önlemek amacıyla son yıllarda veterinerlik alanında önem kazanmıştır.

Anahtar Kelimeler

Apiterapi, Arı Ürünü, Veteriner Hekimlik

Etik Beyan

Ethics committee approval is not required.

Destekleyen Kurum

Not applicable

APITHERAPY AND APPLICATIONS IN VETERINARY MEDICINE

Öz

The use of bees and bee products for therapeutic purposes in human and veterinary medicine is called apitherapy. Natural products have been used throughout human history to protect against and treat diseases. In recent years, the emergence of drug resistance and the occurrence of adverse effects associated with the indiscriminate and irregular use of pharmacological agents have prompted humanity to pursue alternative solutions. One of the most significant solutions is the administration of bee products. The use of bee products in apitherapy applications includes honey, bee venom, pollen, propolis, beeswax, royal jelly, perga and apilarnil (bee larvae). In general, apitherapy products with a wide range of indications are widely used in various system diseases and some dermatologic problems and various effects of these products such as antibacterial, antifungal, antiviral, antioxidant, anticarcinogenic, anti-inflammatory, antidiabetic and immunomodulatory effects in vitro and in vivo have been investigated in many different studies. Apitherapy is less common in veterinary practice than in human medicine. Additionally, bee products are employed in the treatment of other animal diseases, including gastrointestinal disorders, otitis, sinusitis, ophthalmic conditions, dermatological disorders, and skin care. Additionally, bee products are employed as food supplements for animals. The most prevalent additive in animal food is bee pollen. It has been demonstrated to promote growth, reduce mortality and prevent morbidity. Apitherapy has gained importance in the field of veterinary medicine in recent years in order to prevent both human health and economic losses, especially in the treatment of animals consumed as food.

Anahtar Kelimeler

Apitherapy, Bee Products, Veterinary Medicine

Kaynakça

• Abdul-Hafeez MM.Testimony for veterinary apitherapy. Alt Med Chiropractic OA J, 2019; 2(1), 180009.
• Abu-Seida, Ashraf M. Potential Benefits of Propolis in Large and Small Animal Practices: A Narrative Review of the Literature. World J. Vet. Sci., 2023; 3: 441-451.
• Aguiar SC, Cottica SM, Boeing JS, Samensari RB, Santos GT, Visentainer JV, Zeoula LM. Effect of feeding phenolic compounds from propolis extracts to dairy cows on milk production, milk fatty acid composition, and the antioxidant capacity of milk." Anim Feed Sci Technol. 2014; 193: 148-154.
• Ahuja V, Ahuja A. Apitherapy-A sweet approach to dental diseases. Part II: Propolis. J. Adv. Oral Res, 2011; 2(2): 1-8.
• Almuhayawi MS. Propolis as a novel antibacterial agent. Saudi J Biol Sci. 2020;27(11):3079-3086. doi:10.1016/j.sjbs.2020.09.016.
• Altan O, Yücel B, Açikgöz Z, Seremet C, Kösoğlu M, Turgan N, Ozgonul AM. Apilarnil reduces fear and advances sexual development in male broilers but has no effect on growth. Br Poult Sci. 2013;54(3):355-361. doi:10.1080/00071668.2013.791382.
• Alvarez-Suarez JM, Gasparrini M, Forbes-Hernández TY, Mazzoni L, Giampieri F. The Composition and Biological Activity of Honey: A Focus on Manuka Honey. Foods. 2014;3(3):420-432. doi:10.3390/foods3030420.
• Atabay NÖ. Effect of Royal Jelly on Fetility in Akkaraman Ewes. Erciyes University Doktora Tezi, Kayseri, 2012.
• Aydın Y, Tekeoğlu İ. Tamamlayici Tip Ve Güncel Apiterapi Uygulamaları. Journal of Biotechnology and Strategic Health Research, 2018; 2(2): 64-73.
• Betancourt NT, García-Contreras L, Sánchez TAC. Propolis in dogs: Clinical experiences and perspectives (A Brief Review). Open J. Vet. 2015; 5(1); 11-17.
• Bischofberger AS, Dart CM, Perkins NR, Dart AJ. A preliminary study on the effect of manuka honey on second-intention healing of contaminated wounds on the distal aspect of the forelimbs of horses. Vet Surg. 2011;40(7):898-902. doi:10.1111/j.1532-950X.2011.00886.x
• Bogdanov S. Propolis: Biological properties and medical applications. The Propolis Book, Chapter 2. Bee Product Science, www.bee-hexagon.net, retrieved on March 30, 2011.
• Bolatovna KS, Omirzak T, Akhanov UK, Rustenov A, Eleuqalieva N. Improving reproductive qualities of pigs using the drone brood homogenate. Biol. and Med., 2015; 7(2): BM-091.
• Bonomi A, Marletto F, Bianchi M. Use of propolis in the food of laying hens. Rev. di. Avicul. 1976; 45: 43-55.
• Bonomi A, Bonomi BM, Formaggioni P, Quarantelli A. The use of royal jelly in the laying hens feeding. Riv. Sci. Aliment. (Italy), 2000; 29(3): 339-352.
• Boukraa L. Additive activity of royal jelly and honey against Pseudomonas aeruginosa. Altern Med Rev. 2008;13(4):330-333.
• Boukraâ, L. Honey in traditional and modern medicine. 2023, CRC Press.
• Calli C, Tugyan K, Oncel S, Pinar E, Demirtaşoglu F, Calli AO, Tolon B, Yilmaz O, Kiray A.. Effectiveness of royal jelly on tympanic membrane perforations: an experimental study. J Otolaryngol Head Neck Surg. 2008;37(2):179-184.
• Cengiz MM, Tosun M, Topal M. Determination of the physicochemical properties and 13C/12C isotope ratios of some honeys from the northeast Anatolia region of Turkey. J Food Compos Anal. 2018; 69, 39-44.
• Chatzimisios K, Tsioli V, Brellou GD, Apostolopoulou EP, Angelou V, Pratsinakis ED, Cremers NAJ, Papazoglou LG. Evaluation of the Effectiveness of Medical-Grade Honey and Hypericum Perforatum Ointment on Second-Intention Healing of Full-Thickness Skin Wounds in Cats. Animals (Basel). 2023;14(1):36. doi: 10.3390/ani14010036.
• Crane E. Bees and beekeeping: science, practice and world resources, 1st edition, 1990; 614 pp.
• Cetin E, Silici S, Cetin N, Güçlü BK. Effects of diets containing different concentrations of propolis on hematological and immunological variables in laying hens. Poult Sci. 2010;89(8):1703-8. doi: 10.3382/ps.2009-00546.
• das Neves Ferreİra L, Finger PF, de Castro CC, Sica B, Hübner O. Effect of the ethanolic extract from green propolis on production of antibodies after immunization against canine parvovirus (CPV) and canine coronavirus (CCoV). Braz J Vet Res Anim Sci. 2012; 49(2): 116-121.
• De Oliveira MC, Da Silva DM, Loch FC, Martins PC, Dias DMB, Simon GA.. Effect of bee pollen on the immunity and tibia characteristics in broilers. Braz. J. Poult. Sci. 2013; 15: 323-327.
• Efanova NV, Osina LM, Batalova SV. Influence of drone homogenate on the elemental and metabolic status of dogs. Innovations and Food Security, 2019; (2): 24.
• Erdem B, Özkök A. Can Food Supplement Produced from Apilarnil be an Alternative to Testosterone Replacement Therapy? Hacettepe J. Biol. Chem. 2018; 45(4): 635-638.
• Ettle T, Roth FX, Lin Z, Eder K, Windisch W. Prebiotic action of Chinese pine pollen (Pinus massoniana) as a model substance of undigestible crude fibre in the pig, 9. Tagung Schweine- und Geflügelernährung, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany, 28-30 November 2006, 185-187 ref. 4
• Fujii A, Kobayashi S, Kuboyama N, Furukawa Y, Kaneko Y, Ishihama S, Yamamoto H, Tamura T. Augmentation of wound healing by royal jelly (RJ) in streptozotocin-diabetic rats. Jpn J Pharmacol. 1990;53(3):331-7. doi: 10.1254/jjp.53.331.
• Ghisalberti EL. Propolis: a review. Bee World, 1979; 60(2): 59-84.
• Giral T, Hugues B, Soto CJ. Suspensión oftálmica de propóleos-R: Una alternativa en el tratamiento de las oftalmopatias en animales afectivos. REDVET. Revista Electrónica de Veterinaria, 2007; 8(9): 1-6.
• Glenn P. Apimedica, 2006; Athens, Greece.
• Han SM, Lee KG, Yeo JH, Oh BY, Kim BS, Lee W, Baek HJ, Kim ST, Hwang SJ, Pak SC. Effects of honeybee venom supplementation in drinking water on growth performance of broiler chickens. Poult Sci. 2010;89(11):2396-400. doi: 10.3382/ps.2010-00915.
• NM, Abd El-Hady A, Hassan O. Effect of vitamin E or propolis supplementation on semen quality, oxidative status and hemato-biochemical changes of rabbit bucks during hot season. Livest. Sci., 2013; 157(2-3): 520-526.
• Ilewicz L, Luciak M, Skrobidurska D, Scheller S, Stojko A. Działanie etanolowych ekstraktów propolisu na miazge zebowa u psów [The effect of ethanol propolis extracts on the dental pulp in dogs]. Czas Stomatol. 1979;32(4):321-329.
• Jalali FSS, Saifzadeh S, Tajik H, and Farshid AA. 2007. Experimental of repair process of burn-wounds treated with natural honey. J Anim Vet Adv, 6(2): 179–184
• Jung BG, Lee JA, Park SB, Hyun PM, Park JK, Suh GH, Lee BJ. Immunoprophylactic effects of administering honeybee (Apis melifera) venom spray against Salmonella gallinarum in broiler chicks. J Vet Med Sci. 2013;75(10):1287-95. doi: 10.1292/jvms.13-0045.
• Kasote D, Bankova V, Viljoen AM. Propolis: chemical diversity and challenges in quality control. Phytochem Rev. 2022;21(6):1887-1911. doi: 10.1007/s11101-022-09816-1.
• Khalil A, Elesawy BH, Ali TM, Ahmed OM. Bee Venom: From Venom to Drug. Molecules. 2021;26(16):4941. doi: 10.3390/molecules26164941.
• Kridli RT, Al-Khetib SS. Reproductive responses in ewes treated with eCG or increasing doses of royal jelly. Anim Reprod Sci. 2006;92(1-2):75-85. doi: 10.1016/j.anireprosci.2005.05.021.
• Krylov NV, Bardahchieva LV, The use of ungapiven in veterinary surgery. 1997, The. XXXVth. Apimondia Congres
• Kurtdede E., Alçığır, M. E., Alperen, A. M., Baran, B., Karaca, O. K., & Gülendağ, E. Evaluation of the combined effects of Turkish mad honey and 5-Fluorouracil in colon cancer model in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 2023; 70(4): 427-435. DOI: 10.33988/auvfd.1113279
• Liu S, Wang, D, Cao Y, Lu T, Liu H, Li S. Effects of propolis on the immune enhancement of the formalin‐inactivated Aeromonas salmonicida vaccine.Aquac.Res., 2020; 51(11): 4759-4770.
• Lukanc B, Potokar T, Erjavec V. Complete skin regeneration with medical honey after skin loss on the entire circumference of a leg in a cat. J Tissue Viability. 2020;29(2):148-152. doi: 10.1016/j.jtv.2020.03.007.
• Ma X, Guo Z, Shen Z, Wang J, Hu Y, Wang D. The immune enhancement of propolis adjuvant on inactivated porcine parvovirus vaccine in guinea pig. Cell Immunol. 2011;270(1):13-8. doi: 10.1016/j.cellimm.2011.03.020.
• Mărgăoan R, Stranț M, Varadi A, Topal E, Yücel B, Cornea-Cipcigan M, Campos MG, Vodnar DC. Bee Collected Pollen and Bee Bread: Bioactive Constituents and Health Benefits. Antioxidants (Basel). 2019;8(12):568. doi: 10.3390/antiox8120568.
• Molan PC. Honey as an Antimicrobial Agent. 2002; Waikato Honey Research Unit, University of Waikato, New Zealand, http://honey.bio.waikato.ac.nz/selection.shtml.
• Morsy AS, Abdalla AL, Soltan YA, Sallam SM, El-Azrak Kel-D, Louvandini H, Alencar SM. Effect of Brazilian red propolis administration on hematological, biochemical variables and parasitic response of Santa Inês ewes during and after flushing period. Trop Anim Health Prod. 2013;45(7):1609-18. doi: 10.1007/s11250-013-0406-3.
• Nakajin S, Okiyama K, Yamashita S, Akiyama Y, Shinoda M. Effect of royal jelly on experimental hypercholesterolemia in rabbits. Shoyakugaku Zasshi, 1982; 36 (1): 65-69.
• Onbaşlı D. Apiterapi ve insan sağlığı üzerine etkileri. Erciyes Üniv Vet Fak Derg 2019;16(1): 49-56.
• Öner AC, Usta, A. Sağlık Bilimlerinde Güncel Başlıklar III, Bölüm II Apiterapi ve Veteriner Hekimlikte Kullanımı İksad Yayınevi, 2022, Ankara, pp.33-48.
• Parlakpınar H, Polat S. Apiterapi ürünlerinin biyokimyasal içeriği. J Tradit Complem Med, 2021; 2(2): 38-48.
• Prabhakar AR, Balehosur DV, Basappa N. Comparative Evaluation of Shear Bond Strength and Fluoride Release of Conventional Glass Ionomer with 1% Ethanolic Extract of Propolis Incorporated Glass Ionomer Cement -Invitro Study. J Clin Diagn Res. 2016;10(5):ZC88-91. doi: 10.7860/JCDR/2016/17056.7818.
• Rahimjanova S, Dinç H, Günaydın S. Obstetride ve Jinekolojide Apiterapinin Kullanımı. Sağlık Akademisyenleri Dergisi, 2022; 9(4): 359-364.
• Rodrigues RB, Pucci LEA, Uczay J, Molinari M, Lazzari R, Uczay M. Pollen as additives in diets for broilers. Nativa: Pesquisas Agrárias e Ambientais, 2018; 6 (5): 551-556.
• Rooster HD, Declercq J. (2008). Honey in wound management: myth or science? Part 2: clinical cases in dogs. Vlaams Diergeneeskundig Tijdschrift, 2008; 77(2): 75-80.
• Sánchez TAC, García PAE, Zamora CIL, Martínez MA, Valencia VP, Orozco AL. Use of propolis for topical treatment of dermatophytosis in dog. Open J. Vet. 2014;4(10): 239-245.
• Santana HF, Barbosa AA, Ferreira SO, Mantovani HC. Bactericidal activity of ethanolic extracts of propolis against Staphylococcus aureus isolated from mastitic cows. World J Microbiol Biotechnol. 2012 Feb;28(2):485-91. doi: 10.1007/s11274-011-0839-7.
• Sawczuk R, Karpinska J, Filipowska D, Bajguz A, Hryniewicka M. Evaluation of total phenols content, anti-DPPH activity and the content of selected antioxidants in the honeybee drone brood homogenate. Food Chem. 2022;368:130745. doi: 10.1016/j.foodchem.2021.130745.
• Schmidt JO, Buchmann SL. Other products of the hive. The Hive and the Honey Bee. Dadant & Sons, Hamilton, Illinois, USA, 1992; 927-988.
• Seven I, Aksu T, Seven PT. The effects of propolis on biochemical parameters and activity of antioxidant enzymes in broilers exposed to lead-induced oxidative stress. Asian-Australas J Anim Sci, 2010; 23(11): 1482-1489.
• Shoinbayeva KB. Biologically active preparation and reproductive function of stud rams. Asian J. Pharm. 2017; 11(03): 184-191.
• Sidor E, Dżugan M. Drone Brood Homogenate as Natural Remedy for Treating Health Care Problem: A Scientific and Practical Approach. Molecules. 2020 Dec 3;25(23):5699. doi: 10.3390/molecules25235699.
• Sorucu A. Arı Ürünleri ve Apiterapi. Vet Farm Toks Dern Bult. 2019; 10(1): 1-15.
• Sönmez E, Kekeçoğlu M, Bozdeveci A, Alpay Karaoğlu Ş. In Vitro Reserch on Antimicrobial Activity of Native Anatolian Honey Bee Products Against Paenibacillus larvae Strains. J. Agric. Sci. Technol. 2023.
• Stevanović J, Glavinić U, Ristanić M, Erjavec V, Denk B, Dolašević S, Stanimirović Z. Bee-Inspired Healing: Apitherapy in Veterinary Medicine for Maintenance and Improvement Animal Health and Well-Being. Pharmaceuticals, 2024; 17(8): 1050.
• Tamura T, Fujii A, Kuboyama N. Antitumor effects of royal jelly (RJ). Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1987; 89(2): 73-80.
• Temamoğulları F, Aral F, Demirkol R. Erkek farelerde arı sütünün uzun süreli uygulanmasının bazı spermatolojik özellikler üzerine etkisi. FÜ Sağ. Bil. Derg, 2006; 20(5): 341-344.
• Tolon B, Önenç A, Kaya A, Altan Ö. Effects of propolis on growth of calves. In 1st German Congress for Bee Products and Apitherapy 2002; pp. 23-24.
• Toutiaee S, Mojgani N, Harzandi N, Moharrami M, Mokhberalsafa L. Anti-Bacterial Activity of Four Distinct Propolis Extracts against P. Larvae and M. plutonius; Etiological Agent of American and European Foulbrood Disease of Honeybees. Arch Razi Inst. 2023 Jun 30;78(3):899-905. doi: 10.22092/ARI.2022.360019.2531.
• Urcan A, Criste A, Dezmirean D, Bobiş O, Mărghitaş L, Mărgăoan R, Hrinca A. Antimicrobial Activity of Bee Bread Extracts Against Different Bacterial Strains. Bulletin of the University of Agricultural Sciences & Veterinary Medicine Cluj-Napoca. Animal Science & Biotechnologies, 2018; 75(2); 85-91.
• Vick JA, Brooks RJ. Pharmacological studies of the major fractions of bee venom. Am. Bee J., 1972; 12 (8): 288-289.
• Vogt NA, Vriezen E, Nwosu A, Sargeant JM. A Scoping Review of the Evidence for the Medicinal Use of Natural Honey in Animals. Front Vet Sci. 2021;7:618301. doi: 10.3389/fvets.2020.618301.
• Yucel B, Acikgoz Z, Bayraktar H, Seremet C. The effects of apilarnil (drone bee larvae) administration on growth performance and secondary sex characteristics of male broilers. J Anim Vet Adv.2011; 10(17): 2263-2266.