Synthesis, Characterization, and Investigation of Antimicrobial Properties of Salt and Metal Complexes of 2,6-Pyridinedicarboxylic Acid and 2-Amino-4,6-dimethylpyridine

Öz

A new salt (3) of 2,6-pyridinedicarboxylic acid (1) and 2-amino-4,6-dimethylpyridine (2) and the metal complexes of the salt {(H2)x[M(1)2].nH2O, M = Fe (III), x = 1, n = 3 (4); M = Co(II), x = 2, n = 4 (5); M = Ni(II), x = 2, n = 5 (6); M = Cu(II), x = 2, n = 4 (7)} were synthesized. The structures of the compounds were suggested by AAS, IR, UV, magnetic susceptibility and molar conductivity methods. As a result of spectroscopic analysis, it was observed that all metal complexes had an ionic and octahedral structure. All substances were susceptible to Candida albicans (ATCC 14053) (yeast), Pseudomonas. aeruginosa (ATCC 27853), Staphylococcus aureus (NRRL-B 767), Listeria monocytogenes (ATCC 7644), Bacillus subtilis, Enterococcus faecalis (ATCC 29212), and Escherichia coli (ATCC 25922) bacteria were examined. Antimicrobial activity results were compared with Fluconazole, Ketoconazole, Chloramphenicol, Levofloxacin, Vancomycin and Cefepime. In the activity results, the best values were observed 3 in B. subtilis bacteria, 6 and 7 in S. aureus bacteria, 5 7 in P. aeruginoa bacteria, all compounds in L. monocytogenes bacteria, all compounds (except 4) in E. coli bacteria, 2 in E. faecalis bacteria and 4 in C. albicans yeast.

Anahtar Kelimeler

• 2,6-Pyridinedicarboxylic acid
• 2-amino-4,6-dimethylpyridine
• salt
• metal complex
• antimicrobial activity

2,6-Piridindikarboksilik Asit ile 2-Amino-4,6-dimetilpiridinin Tuzu ve Metal Komplekslerinin Sentezi, Karakterizasyonu ve Antimikrobiyal Özelliklerinin İncelenmesi

Öz

2,6-Piridindikarboksilik asit (1) ile 2-amino-4,6-dimetilpiridinin (2) yeni tuz (3) ve tuzun metal kompleksleri {(H2)x[M(1)2].nH2O, M = Fe (III), x = 1, n = 3 (4); M = Co(II), x = 2, n = 4 (5); M = Ni(II), x = 2, n = 5 (6); M = Cu(II), x = 2, n = 4 (7)} sentezlenmiştir. Bileşiklerin yapıları, AAS, IR, UV, manyetik duyarlılık ve molar iletkenlik metotları ile önerilmiştir. Spektroskopik analizler sonucunda tüm metal komplekslerinin iyonik ve oktahedral yapıya sahip olduğu gözlenmiştir Tüm maddelerin Candida albicans (ATCC 14053) mayasına, Listeria monocytogenes (ATCC 7644), Staphylococcus aureus (NRRL-B 767), Bacillus subtilis, Enterococcus faecalis (ATCC 29212), Pseudomonas aeruginosa (ATCC 27853), ve Escherichia coli (ATCC 25922) bakterilerine karşı antimikrobiyal aktiviteleri incelenmiştir. Antimikrobiyal aktivite sonuçları Flukonazol, Ketokonazol, Kloramfenikol, Levofloksasin, Vankomisin ve Sefepim ile kıyaslanmıştır. Aktivite sonuçlarında en iyi değerler B. subtilis bakterisinde 3, S. aureus bakterilerinde 6 ve 7, P. aeruginosa bakterisinde 5-7, L. monocytogenes bakterisinde tüm bileşikler, E. coli bakterisinde tüm bileşikler (2 hariç), E. faecalis bakterisinde 2 ve C. albicans mayasında 4 gözlenmiştir.

Anahtar Kelimeler

• metal kompleksi
• 2,6-Piridindikarboksilik asit
• 2-amino-4,6-dimetilpiridin
• tuz
• antimikrobiyal aktivite

Teşekkür

This study was supported within the scope of the TUBITAK 2209-A university students’ research projects support program with the application number 1919B012107912.

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