2-Aminopikolin Türevleri ile 4-Kloro-3-sülfamoyilbenzoik Asitin Cu(II) Komplekslerinin Sentezi, Karakterizasyonu, Antibakteriyel ve Antifungal Özelliklerinin İncelenmesi

Yıl 2025, Cilt: 9 Sayı: 2, 184 - 195, 30.12.2025

Halil İlkimen , Cengiz Yenikaya , Aysel Gülbandılar

https://doi.org/10.47137/usufedbid.1702755

https://izlik.org/JA89WB35FX

Öz

Bu çalışmada 4-kloro-3-sülfamoyilbenzoik asit (5) ile 2-amino-X-pikolin’in {X = 3 (6), 4 (7), 5 (8) ve 6 (9)} Cu(II) kompleksleri (1-4) sentezlenmiştir. Sentezlenen bileşiklerin yapıları, AAS, elementel analiz, IR, UV, molar iletkenlik ve manyetik duyarlılık metotları ile aydınlatılmıştır. Sentezlenen ve kullanılan maddelerin Candida albicans mayasına, Staphylococcus aureus, Bacillus subtilis, Enterococcus faecalis, Listeria monocytogenes, Pseudomonas aeruginosa ve Escherichia coli bakterilerine karşı antimikrobiyal aktiviteleri incelenmiştir. Antimikrobiyal aktivite sonuçları Flukonazol, Ketokonazol, Kloramfenikol, Levofloksasin, Vankomisin ve Sefepim ile kıyaslanmıştır. Bileşiklerin en iyi aktivite değerleri S. aureus bakterilerinde 1 ve 2, E. coli bakterisinde 5, P. aeruginoa bakterisinde 7, L. monocytogenes bakterisinde 2, E. faecalis bakterisinde tüm bileşikler, B. subtilis bakterisinde 8 ve C. albicans mayasında 1 gözlenmiştir.

Anahtar Kelimeler

4-Kloro-3-sülfamoyilbenzoik asit , 2-aminopikolin , Cu(II) kompleks , antimikrobiyal aktivite

Synthesis, Characterization, Investigation of Antibacterial and Antifungal Properties of Cu(II) Complexes of 2-Aminopicoline Derivatives and 4-Chloro-3-sulfamoylbenzoic Acid

https://izlik.org/JA89WB35FX

Öz

In this study, proton transfer salts (1-4) of 4-chloro-3-sulfamoylbenzoic acid (5) with 2-amino-X-picoline {X = 3 (6), 4 (7), 5 (8) ve 6 (9)} were synthesized. The structures of the synthesized compounds were elucidated by AAS, elemental analysis, IR, UV, molar conductivity and magnetic susceptibility methods. All substances used are susceptible to the yeast Candida albicans, Listeria monocytogenes, Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa. Their antimicrobial activities against bacteria were examined. Their antimicrobial activity results were comparison with Fluconazole, Ketoconazole, Chloramphenicol, Levofloxacin, Vancomycin and Cefepime. The best activity values of the compounds are 1 and 2 for S. aureus bacteria, 5 for E. coli bacteria, 7 for P. aeruginosa bacteria, 2 for L. monocytogenes bacteria, all compounds for E. faecalis bacteria, 8 for B. subtilis bacteria, and 1 for C. albicans yeast.

Anahtar Kelimeler

4-Chloro-3-sulfamoylbenzoic acid , 2-Aminopicoline , Cu(II) complex , Antimicrobial activity.

Kaynakça

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