Eksozomların IVF’deki Kullanımları

Yıl 2024, Cilt: 8 Sayı: 2, 158 - 165, 30.12.2024

Rabia Tuana Lekesiz , Hilal Körükcü , Murat Ihlamur

https://doi.org/10.47137/usufedbid.1520798

Öz

Günümüzde, kısırlık vb. üreme sistemi kaynaklı çeşitli fonksiyonel bozuklukların tedavisi in vitro fertilizasyon (IVF) ile mümkün olsa da başarı düzeyleri henüz istenilen orana ulaşamamıştır. Hücre tipi farketmeksizin hemen hemen her hücre tarafından salgılanabilen ekstrasellüler vezikül ailesinin en küçük üyesi olan eksozomlar her ne kadar maliyet, karakterizasyon ve izolasyon gibi sorunları barındırsa da IVF’te kullanılan geleneksel yöntemlere kıyasla; hem düşük invazyonla izolasyonunun gerçekleştirilebilmesi hem de zengin biyoaktif molekül içeriğiyle endometriyum-embriyo etkileşiminin yanı sıra embriyonel gelişimi de modüle edebilmektedir. Eksozomlar sağlık alanındaki birçok çalışmanın yanı sıra reprodüktif çalışmalarda da son yıllarda ilgi görmektedir. Yumurta, sperm, blastosit ve endometriyumdan salgılanan eksozomlar IVF’nin kalitesini etkilemektedir. Bu doku ve hücrelerle yapılan çalışmalarda eksozomların yardımcı üreme tekniklerinde diagnostik ve terapötik olarak kullanılabileceği düşünülmektedir.

Anahtar Kelimeler

Eksozom, IVF, Ekstrasellüler veziküller, Tedavi

Uses of Exosomes in IVF

Öz

Nowadays, infertility etc. Although the treatment of various functional disorders originating from the reproductive system is possible with in vitro fertilization (IVF), the success levels have not yet reached the desired rate. Although exosomes, the smallest member of the extracellular vesicle family that can be secreted by almost every cell regardless of cell type, have problems such as cost, characterization and isolation, compared to the traditional methods used in IVF; It can be isolated with low invasion and can modulate embryonal development as well as endometrium-embryo interaction with its rich bioactive molecule content. Exosomes have attracted interest in reproductive studies as well as many studies in the field of health in recent years. Exosomes secreted from eggs, sperm, blastocytes and endometrium affect the quality of in vitro fertilisation (IVF). Studies with these tissues and cells suggest that exosomes can be used diagnostically and therapeutically in assisted reproductive techniques.

Anahtar Kelimeler

Exosome, IVF, Extracellular vesicles, Treatment

Kaynakça

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