Effect of Aloe Vera on the Nasal Mucosa in Rhinitis Medicamentosa: Experimental Study

Öz

In the study, we aimed to show the effects of Aloe vera on nasal mucosa in rhinitis medicamentosa (RM). 30 healthy 6-month-old Wistar albino rats weighing approximately 250-300 g were used. For one week all animals were examined, no pathology was detected. The rats were divided into five groups. In group 1, 50 μl of 0.05% oxymetazoline was applied to each nostril every day for 60 days. In Group 2, 50 μl of saline was administered every day for 60 days as the control group of Group 1. Third, fourth and fifth groups were given 50 μl of 0.05% oxymetazoline three times a day for 60 days. Group 3 used only Aloe vera solution for the following 15 days at the end of the 60th day. At the end of day 60 in Group 4, only mometasone furoate was used for the following 15 days. In group 5, saline was used for the following 15 days at the end of the 60th day as the treatment control group. Nasal mucosa was evaluated histopathologically. In Group 3, the epithelium and connective tissue forming the tunica mucosa showed a strong similarity to Group 2, and the level of edema and infiltration in the connective tissue was observed to be decreased. Histological features of tunica mucosa were close to normal in Group 4,. As a result, we found that the healing effect of Aloe vera on RM was as effective as mometasone furoate. As a result of our literature research, our study is the first to reveal the effect of Aloe vera on the nasal mucosa in RM.

Anahtar Kelimeler

• Aloe
• Oxymetazoline
• Rhinitis
• Mometasone Furoate
• Nasal mucosa

Proje Numarası

2019009

Aloe Vera’nın Rinitis Medikamentoza’da Nazal Mukoza Üzerine Etkisi: Deneysel Çalışma

Öz

Bu çalışmamızda Aloe veranın rinitis medikamentoza (RM)‘da mukoza üzerindeki etkilerini göstermeyi amaçladık. Yaklaşık 250-300 g ağırlığında 30 adet sağlıklı 6 aylık Wistar albino sıçan kullanıldı. Bir hafta boyunca tüm hayvanlar muayene edildi, herhangi bir patoloji saptanmadı. Sıçanlar beş gruba ayrıldı. Grup 1'de 60 gün boyunca her bir burun deliğine 50 μl %0,05 oksimetazolin uygulandı. Grup 2'de, Grup 1'in kontrol grubu olarak 60 gün boyunca her gün 50 μl serum fizyolojik uygulandı. Üçüncü, dördüncü ve beşinci gruplara 60 gün boyunca günde üç kez 50 μl %0,05 oksimetazolin verildi. Grup 3, 60. günün sonunda takip eden 15 gün boyunca sadece Aloe vera solüsyonu kullandı. Grup 4'te 60. günün sonunda takip eden 15 gün boyunca sadece mometazon furoat kullanıldı. Grup 5'te tedavi kontrol grubu olarak 60. günün sonunda takip eden 15 gün serum fizyolojik kullanıldı. Nazal mukoza histopatolojik olarak değerlendirildi. Grup 3'te tunika mukozayı oluşturan epitel ve bağ dokusu Grup 2'ye güçlü bir benzerlik göstermiş ve bağ dokusunda ödem ve infiltrasyon düzeyi azalmış izlenmiştir. Grup 4'te tunika mukozanın histolojik özellikleri normale yakındı. Aloe vera yan etkisi olmayan, hem in vitro hem de in vivo antiinflamatuvar etkili bir ajandır. Sonuç olarak Aloe vera'nın RM üzerindeki iyileştirici etkisinin mometazon furoat kadar etkili olduğunu bulduk. Yaptığımız literatür araştırmaları sonucunda, bizim çalışmamız RM’de nazal mukoza üzerine Aloe veranın etkisini ortaya koyan ilk çalışmadır.

Anahtar Kelimeler

• Aloe
• Rinit
• Mometazon Furoat
• Nazal mukoza
• Oksimetazolin

Destekleyen Kurum

İSTANBUL RUMELİ ÜNİVERSİTESİ REKTÖRLÜĞÜ, BİLİMSEL ARAŞTIRMA PROJELERİ KOORDİNASYON BİRİMİ

Proje Numarası

2019009

Teşekkür

Katkılarından dolayı Dilara Baban'a çok teşekkür ederiz.

Kaynakça

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