Evaluation of the Effect and Side Effect of Tyrosine Kinase Inhibitors on the Treatment of Metastatic Renal Cell Carcinomas

Öz

This study aims to retrospectively evaluate the efficacy and side effects of tyrosine kinase inhibitors (TKIs) in the treatment of metastatic renal cell carcinoma (mRCC). mRCC is a type of cancer diagnosed at advanced stages and significantly limits life expectancy. In Turkey, interferon-alpha has traditionally been used as a first-line treatment; however, targeted therapies such as TKIs have become a priority for patients showing progression. In the study, 65 patients who were diagnosed with mRCC and treated with TKI between 2010 and 2018 were examined. This retrospective analysis evaluated the demographic and clinical data of patients and their response to treatment. Key findings indicated that the survival outcomes of sunitinib and pazopanib treatments were consistent with the literature, with fatigue, hypertension, and dermatitis being prominent side effects. The average survival duration was calculated as 26 months. The results of the study support the effectiveness of TKIs in the treatment of mRCC and suggest that their impact could be better understood through prospective studies involving larger patient cohorts in the future.

Anahtar Kelimeler

• Metastatic renal cell carcinoma
• Tyrosine kinase inhibitors
• VEGF inhibitors
• Prognostic factors
• Retrospective analysis

Metastatik Renal Hücreli Kanser Tedavisinde Tirozin Kinaz İnhibitörlerinin Etki ve Yan Etkisinin Değerlendirilmesi

Öz

Bu çalışma, metastatik renal hücreli karsinom (mRHK) tedavisinde tirozin kinaz inhibitörlerinin (TKİ) etkinlik ve yan etkilerini retrospektif olarak değerlendirmeyi amaçlamaktadır. mRHK, ileri evrede tanı konulan ve yaşam süresi beklentilerini sınırlayan bir kanser türüdür. Türkiye'de interferon alfa tedavisi geleneksel olarak birinci basamak tedavi olarak uygulanmasına rağmen, progresyon gösteren hastalarda TKİ'ler gibi hedefe yönelik tedaviler öncelikli hale gelmiştir. Çalışmada, 2010-2018 yılları arasında mRHK tanısı almış ve TKİ tedavisi görmüş 65 hasta incelenmiştir. Bu retrospektif analizde, hastaların demografik ve klinik verileri ile tedaviye verilen yanıtlar değerlendirilmiştir. Ana bulgular arasında sunitinib ve pazopanib tedavilerinin sağkalım sonuçlarının literatürle uyumlu olduğu ve yan etkiler arasında halsizlik, hipertansiyon, dermatit gibi etkilerin öne çıktığı belirlenmiştir. Ortalama sağkalım süresi 26 ay olarak hesaplanmıştır. Çalışmanın sonuçları, TKİ’lerin mRHK tedavisindeki etkisini destekler nitelikte olup, gelecekte yapılacak daha geniş hasta gruplarını içeren prospektif çalışmalarla bu etkinliğin daha iyi anlaşılabileceği öne sürülmüştür.

Anahtar Kelimeler

• Metastatik renal hücreli kanser
• Tirozin kinaz inhibitörleri
• VEGF inhibitörleri
• Prognostik faktörler
• Retrospektif analiz

Kaynakça

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