Hipertrofik Gastropati Olmaksızın Biyopsi ile Kanıtlanmış Foveolar Hiperplazinin Klinikopatolojik Özellikleri

Öz

Foveolar hiperplazi, gastrik biyopsilerde sık karşılaşılan bir histopatolojik bulgu olmasına rağmen, özellikle belirgin hipertrofik gastropati veya Ménétrier hastalığı yokluğunda klinik önemi net değildir. Bu retrospektif çalışmada, endoskopik olarak normal veya hafif ödemli korpus mukozasından alınan biyopsilerde saptanan foveolar hiperplazisi olan hastaların klinik, laboratuvar, histopatolojik ve radyolojik özelliklerinin değerlendirilmesi amaçlandı. 2022–2025 yılları arasında üst gastrointestinal endoskopi yapılan ve gastrik korpus biyopsisi alınan hastalar çalışmaya dahil edildi. Histolojik olarak foveolar hiperplazi saptanan hastalar, yaş ve cinsiyet açısından benzer foveolar hiperplazisi olmayan kontrol grubu ile karşılaştırıldı. Klinik veriler, laboratuvar parametreleri, endoskopik bulgular ve bilgisayarlı tomografi sonuçları analiz edildi. Toplam 352 hasta çalışmaya alındı; bunların 178’inde foveolar hiperplazi mevcuttu. Foveolar hiperplazi grubunda trombosit sayısı anlamlı olarak daha yüksekken, hemoglobin, C-reaktif protein, ferritin ve albümin düzeyleri açısından gruplar arasında anlamlı fark saptanmadı. Helicobacter pylori pozitifliği ve bez atrofisi foveolar hiperplazisi olan hastalarda daha düşük orandaydı. Çok değişkenli analizde trombosit sayısı ve H. pylori negatifliği foveolar hiperplazi ile bağımsız olarak ilişkili bulundu; ancak tanısal performans sınırlıydı. Bu bulgular, foveolar hiperplazinin hipertrofik gastropati bulguları olmaksızın gastrik biyopsilerde tesadüfen saptanabilen, sistemik inflamasyon veya beslenme bozukluğu ile ilişkili olmayan benign bir değişiklik olabileceğini düşündürmektedir.

Anahtar Kelimeler

• foveolar hiperplazi
• hipertrofik gastropati
• endoskopi
• klinikopatoloji

Clinicopathological Features of Biopsy-Proven Foveolar Hyperplasia in the Absence of Hypertrophic Gastropathy

Öz

Foveolar hyperplasia is a common histopathological finding in gastric biopsies; however, its clinical relevance remains unclear, particularly in the absence of overt hypertrophic gastropathy or Ménétrier’s disease. This retrospective study aimed to evaluate the clinical, laboratory, histopathological, and radiological characteristics of patients with foveolar hyperplasia detected in gastric corpus biopsies obtained from endoscopically normal or mildly edematous mucosa. Patients who underwent upper gastrointestinal endoscopy between 2022 and 2025 and had corpus biopsies were included. Those with histologically confirmed foveolar hyperplasia were compared with age- and sex-matched controls without foveolar hyperplasia. Clinical data, laboratory parameters, endoscopic findings, and computed tomography results were reviewed and analyzed. A total of 352 patients were included, comprising 178 patients with foveolar hyperplasia and 174 controls. Platelet counts were significantly higher in the foveolar hyperplasia group, whereas hemoglobin, C-reactive protein, ferritin, and albumin levels did not differ significantly between groups. Helicobacter pylori positivity and glandular atrophy were significantly less frequent in patients with foveolar hyperplasia. Multivariate logistic regression analysis identified higher platelet count and H. pylori negativity as independent factors associated with foveolar hyperplasia, although receiver operating characteristic analysis demonstrated limited diagnostic performance. These findings suggest that foveolar hyperplasia may be encountered incidentally in gastric biopsies without clinical or endoscopic evidence of hypertrophic gastropathy and does not appear to be associated with systemic inflammation or nutritional impairment. The clinical significance of its association with platelet elevation and H. pylori negativity remains uncertain.

Anahtar Kelimeler

• Foveolar hyperplasia
• hypertrophic gastropathy
• endoscopy
• clinicopathology

Kaynakça

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