Hipertrofik Gastropati Olmaksızın Biyopsi ile Kanıtlanmış Foveolar Hiperplazinin Klinikopatolojik Özellikleri

Öz

Foveolar hiperplazi, gastrik biyopsilerde sık karşılaşılan bir histopatolojik bulgu olmasına rağmen, özellikle belirgin hipertrofik gastropati veya Ménétrier hastalığı yokluğunda klinik önemi net değildir. Bu retrospektif çalışmada, endoskopik olarak normal veya hafif ödemli korpus mukozasından alınan biyopsilerde saptanan foveolar hiperplazisi olan hastaların klinik, laboratuvar, histopatolojik ve radyolojik özelliklerinin değerlendirilmesi amaçlandı. 2022–2025 yılları arasında üst gastrointestinal endoskopi yapılan ve gastrik korpus biyopsisi alınan hastalar çalışmaya dahil edildi. Histolojik olarak foveolar hiperplazi saptanan hastalar, yaş ve cinsiyet açısından benzer foveolar hiperplazisi olmayan kontrol grubu ile karşılaştırıldı. Klinik veriler, laboratuvar parametreleri, endoskopik bulgular ve bilgisayarlı tomografi sonuçları analiz edildi. Toplam 352 hasta çalışmaya alındı; bunların 178’inde foveolar hiperplazi mevcuttu. Foveolar hiperplazi grubunda trombosit sayısı anlamlı olarak daha yüksekken, hemoglobin, C-reaktif protein, ferritin ve albümin düzeyleri açısından gruplar arasında anlamlı fark saptanmadı. Helicobacter pylori pozitifliği ve bez atrofisi foveolar hiperplazisi olan hastalarda daha düşük orandaydı. Çok değişkenli analizde trombosit sayısı ve H. pylori negatifliği foveolar hiperplazi ile bağımsız olarak ilişkili bulundu; ancak tanısal performans sınırlıydı. Bu bulgular, foveolar hiperplazinin hipertrofik gastropati bulguları olmaksızın gastrik biyopsilerde tesadüfen saptanabilen, sistemik inflamasyon veya beslenme bozukluğu ile ilişkili olmayan benign bir değişiklik olabileceğini düşündürmektedir.

Anahtar Kelimeler

• foveolar hiperplazi
• hipertrofik gastropati
• endoskopi
• klinikopatoloji

Destekleyen Kurum

Destekleyen kurum yoktur

Etik Beyan

Etik Beyan Bu çalışma, Helsinki Bildirgesi’nde belirtilen etik ilkelere uygun olarak yürütülmüştür. Çalışma için Ondokuz Mayıs Üniversitesi Klinik Araştırmalar Etik Kurulu’ndan etik onay alınmıştır (onay tarihi: 15.01.2026; karar no: 2025/671). Retrospektif tasarıma sahip olan çalışmada hasta verileri anonim olarak değerlendirilmiş olup, tüm katılımcılardan çalışmaya dahil edilmeden önce bilgilendirilmiş onam alınmıştır. Çalışma sürecinde ilgili kurumsal ve ulusal etik düzenlemelere tam uyum sağlanmıştır.

Clinicopathological Features of Biopsy-Proven Foveolar Hyperplasia in the Absence of Hypertrophic Gastropathy

Öz

Foveolar hyperplasia is a common histopathological finding in gastric biopsies; however, its clinical relevance remains unclear, particularly in the absence of overt hypertrophic gastropathy or Ménétrier’s disease. This retrospective study aimed to evaluate the clinical, laboratory, histopathological, and radiological characteristics of patients with foveolar hyperplasia detected in gastric corpus biopsies obtained from endoscopically normal or mildly edematous mucosa. Patients who underwent upper gastrointestinal endoscopy between 2022 and 2025 and had corpus biopsies were included. Those with histologically confirmed foveolar hyperplasia were compared with age- and sex-matched controls without foveolar hyperplasia. Clinical data, laboratory parameters, endoscopic findings, and computed tomography results were reviewed and analyzed. A total of 352 patients were included, comprising 178 patients with foveolar hyperplasia and 174 controls. Platelet counts were significantly higher in the foveolar hyperplasia group, whereas hemoglobin, C-reactive protein, ferritin, and albumin levels did not differ significantly between groups. Helicobacter pylori positivity and glandular atrophy were significantly less frequent in patients with foveolar hyperplasia. Multivariate logistic regression analysis identified higher platelet count and H. pylori negativity as independent factors associated with foveolar hyperplasia, although receiver operating characteristic analysis demonstrated limited diagnostic performance. These findings suggest that foveolar hyperplasia may be encountered incidentally in gastric biopsies without clinical or endoscopic evidence of hypertrophic gastropathy and does not appear to be associated with systemic inflammation or nutritional impairment. The clinical significance of its association with platelet elevation and H. pylori negativity remains uncertain.

Anahtar Kelimeler

• Foveolar hyperplasia
• hypertrophic gastropathy
• endoscopy
• clinicopathology

Destekleyen Kurum

No funding

Etik Beyan

Ethics Statement This study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki. Ethical approval was obtained from the Ondokuz Mayıs University Clinical Research Ethics Committee (approval date: 15 January 2026; decision number: 2025/671). Due to the retrospective design of the study, patient data were analyzed anonymously, and informed consent was obtained from all participants prior to their inclusion. The authors declare that all procedures complied with relevant institutional and national ethical guidelines.

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