Araştırma Makalesi

Association Between the Neutrophil-to-Lymphocyte Ratio and Recurrence in Idiopathic Granulomatous Mastitis

Cilt: 52 3 Eylül 2026
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Association Between the Neutrophil-to-Lymphocyte Ratio and Recurrence in Idiopathic Granulomatous Mastitis

Öz

Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory breast disease with a relapsing course. The neutrophil-to-lymphocyte ratio (NLR) has been investigated as a potential inflammatory biomarker in various diseases. This study aimed to evaluate the association between NLR and recurrence in patients with IGM. This retrospective single-center study included 130 patients diagnosed with IGM and followed at the Rheumatology Outpatient Clinic of Bursa Uludağ University Faculty of Medicine between January 2019 and April 2024. Demographic characteristics, lesion features, laboratory parameters, treatments, and recurrence data were recorded. Binary Logistic Regression and Receiver operating characteristic (ROC) analyses were performed. All patients were female. The median age at diagnosis was 33 (21–64) years and the median follow-up duration was 16 (2–120) months. Recurrence developed in 63 (48.5%) patients. Multivariable analysis showed that younger age at diagnosis (OR: 0.88, p=0.022), menopause (OR: 122.87, p=0.007), lower NLR levels (OR: 0.14, p=0.003), and longer follow-up duration (OR: 1.06, p<0.001) were significantly associated with recurrence. No significant differences were observed in white blood cell count, neutrophil, platelet, erythrocyte sedimentation rate, or C-reactive protein levels. ROC analysis showed no significant predictive performance of NLR (AUC: 0.498, p=0.959). Lower NLR levels were associated with recurrence in patients with IGM; however, NLR alone did not demonstrate sufficient predictive performance and may be more useful when interpreted together with other clinical parameters.

Anahtar Kelimeler

Destekleyen Kurum

no

Etik Beyan

no

Teşekkür

no

Kaynakça

  1. 1. Kehribar DY, Duran TI, Polat AK, Ozgen M. Effectiveness of Methotrexate in Idiopathic Granulomatous Mastitis Treatment. Am J Med Sci. 2020;360(5):560-565. doi:10.1016/j.amjms.2020.05.029
  2. 2. Kessler E, Wolloch Y. Granulomatous mastitis: a lesion clinically simulating carcinoma. Am J Clin Pathol. 1972;58(6):642-646. doi:10.1093/ajcp/58.6.642
  3. 3. Hashemi Moghanjoughi P, Neshat S, Heidari A, et al. Idiopathic Granulomatous Mastitis: A Comprehensive Review of Etiology, Diagnosis, and Management. Eur J Breast Health. 2026;22(2):126-138. doi:10.4274/ejbh.galenos.2025.2025-10-7
  4. 4. Uysal E, Soran A, Sezgin E; Granulomatous Mastitis Study Group. Factors related to recurrence of idiopathic granulomatous mastitis: what do we learn from a multicentre study?. ANZ J Surg. 2018;88(6):635-639. doi:10.1111/ans.14115
  5. 5. Barreto DS, Sedgwick EL, Nagi CS, Benveniste AP. Granulomatous mastitis: etiology, imaging, pathology, treatment, and clinical findings. Breast Cancer Res Treat. 2018;171(3):527-534. doi:10.1007/s10549-018-4870-3
  6. 6. Benson JR, Dumitru D. Idiopathic granulomatous mastitis: presentation, investigation and management. Future Oncol. 2016;12(11):1381-1394. doi:10.2217/fon-2015-0038
  7. 7. Yuan QQ, Xiao SY, Farouk O, et al. Management of granulomatous lobular mastitis: an international multidisciplinary consensus (2021 edition). Mil Med Res. 2022;9(1):20. Published 2022 Apr 26. doi:10.1186/s40779-022-00380-5
  8. 8. Zhou F, Liu L, Liu L, et al. Comparison of Conservative versus Surgical Treatment Protocols in Treating Idiopathic Granulomatous Mastitis: A Meta-Analysis. Breast Care (Basel). 2020;15(4):415-420. doi:10.1159/000503602

Ayrıntılar

Birincil Dil

İngilizce

Konular

Romatoloji ve Artrit

Bölüm

Araştırma Makalesi

Yayımlanma Tarihi

3 Eylül 2026

Gönderilme Tarihi

14 Mayıs 2026

Kabul Tarihi

2 Ağustos 2026

Yayımlandığı Sayı

Yıl 2026 Cilt: 52

Kaynak Göster

APA
Lermi, N., Yağbasan, Z., Ada Tak, N. G., Yağız, B., Coskun, B. N., Pehlivan, Y., & Dalkılıç, H. E. (2026). Association Between the Neutrophil-to-Lymphocyte Ratio and Recurrence in Idiopathic Granulomatous Mastitis. Journal of Uludağ University Medical Faculty, 52. https://doi.org/10.32708/uutfd.1950919
AMA
1.Lermi N, Yağbasan Z, Ada Tak NG, vd. Association Between the Neutrophil-to-Lymphocyte Ratio and Recurrence in Idiopathic Granulomatous Mastitis. Uludağ Tıp Derg. 2026;52. doi:10.32708/uutfd.1950919
Chicago
Lermi, Nihal, Zeynep Yağbasan, N. Gul Ada Tak, vd. 2026. “Association Between the Neutrophil-to-Lymphocyte Ratio and Recurrence in Idiopathic Granulomatous Mastitis”. Journal of Uludağ University Medical Faculty 52 (Eylül). https://doi.org/10.32708/uutfd.1950919.
EndNote
Lermi N, Yağbasan Z, Ada Tak NG, Yağız B, Coskun BN, Pehlivan Y, Dalkılıç HE (01 Eylül 2026) Association Between the Neutrophil-to-Lymphocyte Ratio and Recurrence in Idiopathic Granulomatous Mastitis. Journal of Uludağ University Medical Faculty 52
IEEE
[1]N. Lermi vd., “Association Between the Neutrophil-to-Lymphocyte Ratio and Recurrence in Idiopathic Granulomatous Mastitis”, Uludağ Tıp Derg, c. 52, Eyl. 2026, doi: 10.32708/uutfd.1950919.
ISNAD
Lermi, Nihal - Yağbasan, Zeynep - Ada Tak, N. Gul - Yağız, Burcu - Coskun, Belkis Nihan - Pehlivan, Yavuz - Dalkılıç, Hüseyin Ediz. “Association Between the Neutrophil-to-Lymphocyte Ratio and Recurrence in Idiopathic Granulomatous Mastitis”. Journal of Uludağ University Medical Faculty 52 (01 Eylül 2026). https://doi.org/10.32708/uutfd.1950919.
JAMA
1.Lermi N, Yağbasan Z, Ada Tak NG, Yağız B, Coskun BN, Pehlivan Y, Dalkılıç HE. Association Between the Neutrophil-to-Lymphocyte Ratio and Recurrence in Idiopathic Granulomatous Mastitis. Uludağ Tıp Derg. 2026;52. doi:10.32708/uutfd.1950919.
MLA
Lermi, Nihal, vd. “Association Between the Neutrophil-to-Lymphocyte Ratio and Recurrence in Idiopathic Granulomatous Mastitis”. Journal of Uludağ University Medical Faculty, c. 52, Eylül 2026, doi:10.32708/uutfd.1950919.
Vancouver
1.Nihal Lermi, Zeynep Yağbasan, N. Gul Ada Tak, Burcu Yağız, Belkis Nihan Coskun, Yavuz Pehlivan, Hüseyin Ediz Dalkılıç. Association Between the Neutrophil-to-Lymphocyte Ratio and Recurrence in Idiopathic Granulomatous Mastitis. Uludağ Tıp Derg. 01 Eylül 2026;52. doi:10.32708/uutfd.1950919

ISSN: 1300-414X, e-ISSN: 2645-9027

Uludağ Üniversitesi Tıp Fakültesi Dergisi "Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License" ile lisanslanmaktadır.


Creative Commons License
Journal of Uludag University Medical Faculty is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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