İleri Evre Yaşlı Küçük Hücreli Dışı Akciğer Kanseri Hastalarının Tedavisinde Sisplatin ve Etoposid

Cilt: 29 Sayı: 1 1 Mart 2003
  • Özkan Kanat
  • Türkkan Evrensel
  • Atilla Özkan
  • Mutlu Demıray
  • İlker Ercan
  • Ender Kurt
  • Güzin Gönüllü
  • Murat Arslan
  • Hülya Demiray
  • Osman Manavoğlu
Uludağ Üniversitesi Tıp Fakültesi Dergisi Kapak
Uludağ Üniversitesi Tıp Fakültesi Dergisi
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Cisplatin and etoposide in the treatment of elderly patients with advanced non-small cell lung cancer

Öz

The aims of the present study were to test activity and tolerability of cisplatin and etoposide in advanced non-small cell lung cancer (NSCLC) patients aged 70 years or higher. Twenty-four patients were enrolled. Cisplatin was given at a dose of 60 mg/m2 on day 1 and etoposide at a dose of 120 mg/m2 on days 1-3. Total 116 courses were administered. Twelve patients (50%) completed all six cycles of treatment. Three patients (12.5%) obtained a partial response, as well as 12 (50%) stable disease and 9 (37.5%) progressive disease. The median survival was 48.5 ± 6.06 weeks, and the 1 year survival rate was 38%. Grade 3-4 neutropenia occurred in 16.6% of patients, grade 4 thrombocytopenia in %4.1, and grade 1-2 neuropathy in 25%. One patient discontinued treatment due to grade 3 nephrotoxicity. In conclusion, cisplatin and etoposide regimen is active and relatively well-tolerated in the treatment of elderly NSCLC patients. New, active and well-tolerated combination regimens could improve present results.

Anahtar Kelimeler

Ayrıntılar

Birincil Dil

İngilizce

Konular

-

Bölüm

-

Yazarlar

Özkan Kanat Bu kişi benim

Türkkan Evrensel Bu kişi benim

Atilla Özkan Bu kişi benim

Mutlu Demıray Bu kişi benim

İlker Ercan Bu kişi benim

Ender Kurt Bu kişi benim

Güzin Gönüllü Bu kişi benim

Murat Arslan Bu kişi benim

Hülya Demiray Bu kişi benim

Osman Manavoğlu Bu kişi benim

Yayımlanma Tarihi

1 Mart 2003

Gönderilme Tarihi

1 Mart 2003

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2003 Cilt: 29 Sayı: 1

IZ

https://izlik.org/JA23UY93WJ

Kaynak Göster

RIS / Bibtex
APA
Kanat, Ö., Evrensel, T., Özkan, A., Demıray, M., Ercan, İ., Kurt, E., Gönüllü, G., Arslan, M., Demiray, H., & Manavoğlu, O. (2003). Cisplatin and etoposide in the treatment of elderly patients with advanced non-small cell lung cancer. Journal of Uludağ University Medical Faculty, 29(1), 25-28. https://izlik.org/JA23UY93WJ
AMA
1.Kanat Ö, Evrensel T, Özkan A, vd. Cisplatin and etoposide in the treatment of elderly patients with advanced non-small cell lung cancer. Uludağ Tıp Derg. 2003;29(1):25-28. https://izlik.org/JA23UY93WJ
Chicago
Kanat, Özkan, Türkkan Evrensel, Atilla Özkan, vd. 2003. “Cisplatin and etoposide in the treatment of elderly patients with advanced non-small cell lung cancer”. Journal of Uludağ University Medical Faculty 29 (1): 25-28. https://izlik.org/JA23UY93WJ.
EndNote
Kanat Ö, Evrensel T, Özkan A, Demıray M, Ercan İ, Kurt E, Gönüllü G, Arslan M, Demiray H, Manavoğlu O (01 Mart 2003) Cisplatin and etoposide in the treatment of elderly patients with advanced non-small cell lung cancer. Journal of Uludağ University Medical Faculty 29 1 25–28.
IEEE
[1]Ö. Kanat vd., “Cisplatin and etoposide in the treatment of elderly patients with advanced non-small cell lung cancer”, Uludağ Tıp Derg, c. 29, sy 1, ss. 25–28, Mar. 2003, [çevrimiçi]. Erişim adresi: https://izlik.org/JA23UY93WJ
ISNAD
Kanat, Özkan - Evrensel, Türkkan - Özkan, Atilla - Demıray, Mutlu - Ercan, İlker - Kurt, Ender - Gönüllü, Güzin - Arslan, Murat - Demiray, Hülya - Manavoğlu, Osman. “Cisplatin and etoposide in the treatment of elderly patients with advanced non-small cell lung cancer”. Journal of Uludağ University Medical Faculty 29/1 (01 Mart 2003): 25-28. https://izlik.org/JA23UY93WJ.
JAMA
1.Kanat Ö, Evrensel T, Özkan A, Demıray M, Ercan İ, Kurt E, Gönüllü G, Arslan M, Demiray H, Manavoğlu O. Cisplatin and etoposide in the treatment of elderly patients with advanced non-small cell lung cancer. Uludağ Tıp Derg. 2003;29:25–28.
MLA
Kanat, Özkan, vd. “Cisplatin and etoposide in the treatment of elderly patients with advanced non-small cell lung cancer”. Journal of Uludağ University Medical Faculty, c. 29, sy 1, Mart 2003, ss. 25-28, https://izlik.org/JA23UY93WJ.
Vancouver
1.Özkan Kanat, Türkkan Evrensel, Atilla Özkan, Mutlu Demıray, İlker Ercan, Ender Kurt, Güzin Gönüllü, Murat Arslan, Hülya Demiray, Osman Manavoğlu. Cisplatin and etoposide in the treatment of elderly patients with advanced non-small cell lung cancer. Uludağ Tıp Derg [Internet]. 01 Mart 2003;29(1):25-8. Erişim adresi: https://izlik.org/JA23UY93WJ

ISSN: 1300-414X, e-ISSN: 2645-9027

Uludağ Üniversitesi Tıp Fakültesi Dergisi "Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License" ile lisanslanmaktadır.


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Journal of Uludag University Medical Faculty is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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