Akut Lösemili Hastalarda Kantitatif İn Situ Hibridizasyon Yapılarak Akım Sitometri ile Telomer Uzunluğu Ölçümü ve Prognozla İlişkisi

Cilt: 30 Sayı: 3 1 Eylül 2004
  • Vildan Özkocaman
  • Fahir Özkalemkaş
  • Ferah Budak
  • Gülderen Yanikkaya Demirel
  • Rıdvan Ali
  • H.barbaros Oral
  • Tülay Özçelik
  • Ülkü Ozan
  • Ahmet Tunalı
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Measurement of Telomere Length in Patients with Acute Leukaemia Using Quantitative In situ Hybridization and Flow Cytometry and It's Relationship with Prognosis

Öz

We examined and compared the telomere length at the initial diagnosis and during the remission periods in patients with acute leukaemia and evaluated whether it has a prognostic value or not. This study included 21 patients (13 being female and 8 being male) with acute leukaemia. Their median age was 37 years (range 17-66) and 15 patients had AML and 6 patients had ALL. Relative telomere length (RTL) level was determined in bone marrow blood mononuclear cells by flow-FISH method. At the initial diagnosis short telomere length was observed in 3 patients, long telomere length in 18 patients. During the remission period short telomere length was observed in 11 patients, long telomere length in 10 patients. No statistically significant relation could be found between telomere length and laboratory parameters. When survival and remission times were concerned, no statistically significant difference was observed between the groups of lengthened and shortened relative telomere length. In conclusion, our findings on the analysis of relative telomer length parameters suggest that our population is heterogeneous. For this reason it is critical to evaluate both telomerase activity and telomer length in acute leukaemia patients.

Anahtar Kelimeler

Ayrıntılar

Birincil Dil

İngilizce

Konular

-

Bölüm

-

Yazarlar

Vildan Özkocaman Bu kişi benim

Fahir Özkalemkaş Bu kişi benim

Ferah Budak Bu kişi benim

Gülderen Yanikkaya Demirel Bu kişi benim

Rıdvan Ali Bu kişi benim

H.barbaros Oral Bu kişi benim

Tülay Özçelik Bu kişi benim

Ülkü Ozan Bu kişi benim

Ahmet Tunalı Bu kişi benim

Yayımlanma Tarihi

1 Eylül 2004

Gönderilme Tarihi

1 Eylül 2004

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2004 Cilt: 30 Sayı: 3

IZ

https://izlik.org/JA58KA59HJ

Kaynak Göster

RIS / Bibtex
APA
Özkocaman, V., Özkalemkaş, F., Budak, F., Demirel, G. Y., Ali, R., Oral, H., Özçelik, T., Ozan, Ü., & Tunalı, A. (2004). Measurement of Telomere Length in Patients with Acute Leukaemia Using Quantitative In situ Hybridization and Flow Cytometry and It’s Relationship with Prognosis. Journal of Uludağ University Medical Faculty, 30(3), 189-194. https://izlik.org/JA58KA59HJ
AMA
1.Özkocaman V, Özkalemkaş F, Budak F, vd. Measurement of Telomere Length in Patients with Acute Leukaemia Using Quantitative In situ Hybridization and Flow Cytometry and It’s Relationship with Prognosis. Uludağ Tıp Derg. 2004;30(3):189-194. https://izlik.org/JA58KA59HJ
Chicago
Özkocaman, Vildan, Fahir Özkalemkaş, Ferah Budak, vd. 2004. “Measurement of Telomere Length in Patients with Acute Leukaemia Using Quantitative In situ Hybridization and Flow Cytometry and It’s Relationship with Prognosis”. Journal of Uludağ University Medical Faculty 30 (3): 189-94. https://izlik.org/JA58KA59HJ.
EndNote
Özkocaman V, Özkalemkaş F, Budak F, Demirel GY, Ali R, Oral H, Özçelik T, Ozan Ü, Tunalı A (01 Eylül 2004) Measurement of Telomere Length in Patients with Acute Leukaemia Using Quantitative In situ Hybridization and Flow Cytometry and It’s Relationship with Prognosis. Journal of Uludağ University Medical Faculty 30 3 189–194.
IEEE
[1]V. Özkocaman vd., “Measurement of Telomere Length in Patients with Acute Leukaemia Using Quantitative In situ Hybridization and Flow Cytometry and It’s Relationship with Prognosis”, Uludağ Tıp Derg, c. 30, sy 3, ss. 189–194, Eyl. 2004, [çevrimiçi]. Erişim adresi: https://izlik.org/JA58KA59HJ
ISNAD
Özkocaman, Vildan - Özkalemkaş, Fahir - Budak, Ferah - Demirel, Gülderen Yanikkaya - Ali, Rıdvan - Oral, H.barbaros - Özçelik, Tülay - Ozan, Ülkü - Tunalı, Ahmet. “Measurement of Telomere Length in Patients with Acute Leukaemia Using Quantitative In situ Hybridization and Flow Cytometry and It’s Relationship with Prognosis”. Journal of Uludağ University Medical Faculty 30/3 (01 Eylül 2004): 189-194. https://izlik.org/JA58KA59HJ.
JAMA
1.Özkocaman V, Özkalemkaş F, Budak F, Demirel GY, Ali R, Oral H, Özçelik T, Ozan Ü, Tunalı A. Measurement of Telomere Length in Patients with Acute Leukaemia Using Quantitative In situ Hybridization and Flow Cytometry and It’s Relationship with Prognosis. Uludağ Tıp Derg. 2004;30:189–194.
MLA
Özkocaman, Vildan, vd. “Measurement of Telomere Length in Patients with Acute Leukaemia Using Quantitative In situ Hybridization and Flow Cytometry and It’s Relationship with Prognosis”. Journal of Uludağ University Medical Faculty, c. 30, sy 3, Eylül 2004, ss. 189-94, https://izlik.org/JA58KA59HJ.
Vancouver
1.Vildan Özkocaman, Fahir Özkalemkaş, Ferah Budak, Gülderen Yanikkaya Demirel, Rıdvan Ali, H.barbaros Oral, Tülay Özçelik, Ülkü Ozan, Ahmet Tunalı. Measurement of Telomere Length in Patients with Acute Leukaemia Using Quantitative In situ Hybridization and Flow Cytometry and It’s Relationship with Prognosis. Uludağ Tıp Derg [Internet]. 01 Eylül 2004;30(3):189-94. Erişim adresi: https://izlik.org/JA58KA59HJ

ISSN: 1300-414X, e-ISSN: 2645-9027

Uludağ Üniversitesi Tıp Fakültesi Dergisi "Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License" ile lisanslanmaktadır.


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Journal of Uludag University Medical Faculty is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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