EN
TR
Discoidin Domain Receptors (DDRs) as Novel Collagen Receptors and Their Importance
Öz
Extracellular matrix (ECM) provide scaffolding for cells and tissue compartments and also regulate communication between cells and tissues via cell surface receptors which are activated by components of the extracellular matrix. Collagen is one of the the major components of the extracellular matrix (ECM). Discoidin Domain Receptors (DDRs) is a novel family of tyrosine kinase collagen receptors that are activated by several types of collagens. The two members of these cell surface receptors, discoidin domain receptor 1 and 2, are widely expressed in different cell types and organs. DDRs play essential role in regulation of cell adhesion, proliferation and differentiation by binding to collagen and mediating metalloproteinase production. This review article summarizes current knowledge about these new collagen receptors and highlights their relations with crucial diseases such as tumor progression, atherosclerosis, inflammation and tissue fibrosis. We hope, this review may contribute to understanding of their complex roles in the pathogenesis of the wide range of diseases and may draw atraction to new researches on DDRs and lead to establishment of new therapeutical targets for the treatment of these diseases.
Anahtar Kelimeler
Ayrıntılar
Birincil Dil
İngilizce
Konular
-
Bölüm
-
Yayımlanma Tarihi
1 Eylül 2010
Gönderilme Tarihi
1 Eylül 2010
Kabul Tarihi
-
Yayımlandığı Sayı
Yıl 2010 Cilt: 36 Sayı: 3
APA
Reel, B., Cilaker Mıcılı, S., & Ergür, B. U. (2010). Discoidin Domain Receptors (DDRs) as Novel Collagen Receptors and Their Importance. Journal of Uludağ University Medical Faculty, 36(3), 121-126. https://izlik.org/JA25AW44CR
AMA
1.Reel B, Cilaker Mıcılı S, Ergür BU. Discoidin Domain Receptors (DDRs) as Novel Collagen Receptors and Their Importance. Uludağ Tıp Derg. 2010;36(3):121-126. https://izlik.org/JA25AW44CR
Chicago
Reel, Buket, Serap Cilaker Mıcılı, ve Bekir Uğur Ergür. 2010. “Discoidin Domain Receptors (DDRs) as Novel Collagen Receptors and Their Importance”. Journal of Uludağ University Medical Faculty 36 (3): 121-26. https://izlik.org/JA25AW44CR.
EndNote
Reel B, Cilaker Mıcılı S, Ergür BU (01 Eylül 2010) Discoidin Domain Receptors (DDRs) as Novel Collagen Receptors and Their Importance. Journal of Uludağ University Medical Faculty 36 3 121–126.
IEEE
[1]B. Reel, S. Cilaker Mıcılı, ve B. U. Ergür, “Discoidin Domain Receptors (DDRs) as Novel Collagen Receptors and Their Importance”, Uludağ Tıp Derg, c. 36, sy 3, ss. 121–126, Eyl. 2010, [çevrimiçi]. Erişim adresi: https://izlik.org/JA25AW44CR
ISNAD
Reel, Buket - Cilaker Mıcılı, Serap - Ergür, Bekir Uğur. “Discoidin Domain Receptors (DDRs) as Novel Collagen Receptors and Their Importance”. Journal of Uludağ University Medical Faculty 36/3 (01 Eylül 2010): 121-126. https://izlik.org/JA25AW44CR.
JAMA
1.Reel B, Cilaker Mıcılı S, Ergür BU. Discoidin Domain Receptors (DDRs) as Novel Collagen Receptors and Their Importance. Uludağ Tıp Derg. 2010;36:121–126.
MLA
Reel, Buket, vd. “Discoidin Domain Receptors (DDRs) as Novel Collagen Receptors and Their Importance”. Journal of Uludağ University Medical Faculty, c. 36, sy 3, Eylül 2010, ss. 121-6, https://izlik.org/JA25AW44CR.
Vancouver
1.Buket Reel, Serap Cilaker Mıcılı, Bekir Uğur Ergür. Discoidin Domain Receptors (DDRs) as Novel Collagen Receptors and Their Importance. Uludağ Tıp Derg [Internet]. 01 Eylül 2010;36(3):121-6. Erişim adresi: https://izlik.org/JA25AW44CR
