Uyku Apneli Hastalarda CPAP Tedavisi Sonrasında Serebral Metabolizmanın Değerlendirilmesi

Cilt: 37 Sayı: 1 1 Mart 2011
  • Funda Coşkun
  • Mehmet Karadağ
  • Gökhan Gökalp
  • Bahattin Hakyemez
  • Birgül Aydın
  • Şengül Cangür
  • Ahmet Ursavaş
  • Beril Erdoğan
  • Cüneyt Erdoğan
  • Selçuk Kırlı
  • Ercüment Ege
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Change in cerebral metabolism after CPAP in Obstructive Sleep Apnea Patients

Öz

Repeated apnea periods during sleep cause some changes on central nervous system in OSAS patients. MR spectroscopy is a noninvasive magnetic resonance method which can determine local metabolic changes in several situations that affect the central nervous system. In this study we aimed to determine the cerebral metabolic changes and whether there is an improvement in cerebral metabolism after continious positive positive airway pressure (CPAP) treatment in moderate-severe OSAS patients. We included 19 moderate-severe OSAS patients to the study. Polisomnography, epworth sleep scale, MR spectroscopy and neurocognitive tests were administered. CPAP treatment was given for 3 months, and MR spectroscopy, neurocognitive tests were repeated during this period. N-asetil aspartate (NAA), colin (Cho) ve creatinine (Cr) measurements was performed in frontal white matter, frontal cortex, talamus and hippocampus in MR spectroscopy. After the treatment, there was a significant reduction in frontal cortex Cr levels (p=0.046). Levels of NAA/Cho, NAA/Cr, Cho/Cr and NAA/Cho+Cr were compared and only NAA/Cr values in frontal white matter showed significant difference (p=0.01). As a result, we found that there are cerebral metabolic changes in moderate-severe OSAS patients and neurocognitive tests are associated with these changes.

Anahtar Kelimeler

Ayrıntılar

Birincil Dil

İngilizce

Konular

-

Bölüm

-

Yazarlar

Funda Coşkun Bu kişi benim

Mehmet Karadağ Bu kişi benim

Gökhan Gökalp Bu kişi benim

Bahattin Hakyemez Bu kişi benim

Birgül Aydın Bu kişi benim

Şengül Cangür Bu kişi benim

Ahmet Ursavaş Bu kişi benim

Beril Erdoğan Bu kişi benim

Cüneyt Erdoğan Bu kişi benim

Selçuk Kırlı Bu kişi benim

Ercüment Ege Bu kişi benim

Yayımlanma Tarihi

1 Mart 2011

Gönderilme Tarihi

1 Mart 2011

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2011 Cilt: 37 Sayı: 1

Kaynak Göster

APA
Coşkun, F., Karadağ, M., Gökalp, G., Hakyemez, B., Aydın, B., Cangür, Ş., Ursavaş, A., Erdoğan, B., Erdoğan, C., Kırlı, S., & Ege, E. (2011). Change in cerebral metabolism after CPAP in Obstructive Sleep Apnea Patients. Journal of Uludağ University Medical Faculty, 37(1), 27-32. https://izlik.org/JA65NB26KE
AMA
1.Coşkun F, Karadağ M, Gökalp G, vd. Change in cerebral metabolism after CPAP in Obstructive Sleep Apnea Patients. Uludağ Tıp Derg. 2011;37(1):27-32. https://izlik.org/JA65NB26KE
Chicago
Coşkun, Funda, Mehmet Karadağ, Gökhan Gökalp, vd. 2011. “Change in cerebral metabolism after CPAP in Obstructive Sleep Apnea Patients”. Journal of Uludağ University Medical Faculty 37 (1): 27-32. https://izlik.org/JA65NB26KE.
EndNote
Coşkun F, Karadağ M, Gökalp G, Hakyemez B, Aydın B, Cangür Ş, Ursavaş A, Erdoğan B, Erdoğan C, Kırlı S, Ege E (01 Mart 2011) Change in cerebral metabolism after CPAP in Obstructive Sleep Apnea Patients. Journal of Uludağ University Medical Faculty 37 1 27–32.
IEEE
[1]F. Coşkun vd., “Change in cerebral metabolism after CPAP in Obstructive Sleep Apnea Patients”, Uludağ Tıp Derg, c. 37, sy 1, ss. 27–32, Mar. 2011, [çevrimiçi]. Erişim adresi: https://izlik.org/JA65NB26KE
ISNAD
Coşkun, Funda - Karadağ, Mehmet - Gökalp, Gökhan - Hakyemez, Bahattin - Aydın, Birgül - Cangür, Şengül - Ursavaş, Ahmet v.dğr. “Change in cerebral metabolism after CPAP in Obstructive Sleep Apnea Patients”. Journal of Uludağ University Medical Faculty 37/1 (01 Mart 2011): 27-32. https://izlik.org/JA65NB26KE.
JAMA
1.Coşkun F, Karadağ M, Gökalp G, Hakyemez B, Aydın B, Cangür Ş, Ursavaş A, Erdoğan B, Erdoğan C, Kırlı S, Ege E. Change in cerebral metabolism after CPAP in Obstructive Sleep Apnea Patients. Uludağ Tıp Derg. 2011;37:27–32.
MLA
Coşkun, Funda, vd. “Change in cerebral metabolism after CPAP in Obstructive Sleep Apnea Patients”. Journal of Uludağ University Medical Faculty, c. 37, sy 1, Mart 2011, ss. 27-32, https://izlik.org/JA65NB26KE.
Vancouver
1.Funda Coşkun, Mehmet Karadağ, Gökhan Gökalp, Bahattin Hakyemez, Birgül Aydın, Şengül Cangür, Ahmet Ursavaş, Beril Erdoğan, Cüneyt Erdoğan, Selçuk Kırlı, Ercüment Ege. Change in cerebral metabolism after CPAP in Obstructive Sleep Apnea Patients. Uludağ Tıp Derg [Internet]. 01 Mart 2011;37(1):27-32. Erişim adresi: https://izlik.org/JA65NB26KE

ISSN: 1300-414X, e-ISSN: 2645-9027

Uludağ Üniversitesi Tıp Fakültesi Dergisi "Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License" ile lisanslanmaktadır.


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Journal of Uludag University Medical Faculty is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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