Tip 1 Diyabet (T1D)'li Türk Hastalarda Glutatyon-S-Transferaz (GSTT1 ve GSTM1) Gen Polimorfizmlerinin Araştırılması

Cilt: 38 Sayı: 2 1 Haziran 2012
  • Mutlu Karkucak
  • Soner Cander
  • Adem Deligönül
  • Gökhan Ocakoğlu
  • Tuna Gülten
  • Özen Öz Gül
  • Orhan Görükmez
  • Mustafa Ferhat Öksüz
  • Tahsin Yakut
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Investigation of Glutathione-S-Transferases (GSTT1 and GSTM1) Gene Polymorphisms in Turkish Patients with Type 1 Diabetes(T1D)

Öz

Oxidative stress plays an important role in the development of type 1 diabetes(T1D) and its complications. Glutathione-S-Transferases (GST) is one of the defense systems against the harmful effects of oxidative stress. In our study, we aimed to investigate the relationship between GSTT1 and GSTM1 gene polymorphisms and Turkish patients with T1D. In our study, 71 patients were diagnosed with T1D and 62 control subjects were included. GSTM1 and GSTT1 gene polymorphisms were used to evaluate the multiplex PCR method.In statistical analysis, the level of significance was set at p0.05). These results show that GSTT1 and GSTM1-negative (null) genotypes may not contribute to the development of T1D and its complications but more studies with larger sample size are needed.

Anahtar Kelimeler

Ayrıntılar

Birincil Dil

İngilizce

Konular

-

Bölüm

-

Yazarlar

Mutlu Karkucak Bu kişi benim

Soner Cander Bu kişi benim

Adem Deligönül Bu kişi benim

Gökhan Ocakoğlu Bu kişi benim

Tuna Gülten Bu kişi benim

Özen Öz Gül Bu kişi benim

Orhan Görükmez Bu kişi benim

Mustafa Ferhat Öksüz Bu kişi benim

Tahsin Yakut Bu kişi benim

Yayımlanma Tarihi

1 Haziran 2012

Gönderilme Tarihi

1 Haziran 2012

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2012 Cilt: 38 Sayı: 2

IZ

https://izlik.org/JA42JR58LT

Kaynak Göster

RIS / Bibtex
APA
Karkucak, M., Cander, S., Deligönül, A., Ocakoğlu, G., Gülten, T., Gül, Ö. Ö., Görükmez, O., Öksüz, M. F., & Yakut, T. (2012). Investigation of Glutathione-S-Transferases (GSTT1 and GSTM1) Gene Polymorphisms in Turkish Patients with Type 1 Diabetes(T1D). Journal of Uludağ University Medical Faculty, 38(2), 75-78. https://izlik.org/JA42JR58LT
AMA
1.Karkucak M, Cander S, Deligönül A, vd. Investigation of Glutathione-S-Transferases (GSTT1 and GSTM1) Gene Polymorphisms in Turkish Patients with Type 1 Diabetes(T1D). Uludağ Tıp Derg. 2012;38(2):75-78. https://izlik.org/JA42JR58LT
Chicago
Karkucak, Mutlu, Soner Cander, Adem Deligönül, vd. 2012. “Investigation of Glutathione-S-Transferases (GSTT1 and GSTM1) Gene Polymorphisms in Turkish Patients with Type 1 Diabetes(T1D)”. Journal of Uludağ University Medical Faculty 38 (2): 75-78. https://izlik.org/JA42JR58LT.
EndNote
Karkucak M, Cander S, Deligönül A, Ocakoğlu G, Gülten T, Gül ÖÖ, Görükmez O, Öksüz MF, Yakut T (01 Haziran 2012) Investigation of Glutathione-S-Transferases (GSTT1 and GSTM1) Gene Polymorphisms in Turkish Patients with Type 1 Diabetes(T1D). Journal of Uludağ University Medical Faculty 38 2 75–78.
IEEE
[1]M. Karkucak vd., “Investigation of Glutathione-S-Transferases (GSTT1 and GSTM1) Gene Polymorphisms in Turkish Patients with Type 1 Diabetes(T1D)”, Uludağ Tıp Derg, c. 38, sy 2, ss. 75–78, Haz. 2012, [çevrimiçi]. Erişim adresi: https://izlik.org/JA42JR58LT
ISNAD
Karkucak, Mutlu - Cander, Soner - Deligönül, Adem - Ocakoğlu, Gökhan - Gülten, Tuna - Gül, Özen Öz - Görükmez, Orhan - Öksüz, Mustafa Ferhat - Yakut, Tahsin. “Investigation of Glutathione-S-Transferases (GSTT1 and GSTM1) Gene Polymorphisms in Turkish Patients with Type 1 Diabetes(T1D)”. Journal of Uludağ University Medical Faculty 38/2 (01 Haziran 2012): 75-78. https://izlik.org/JA42JR58LT.
JAMA
1.Karkucak M, Cander S, Deligönül A, Ocakoğlu G, Gülten T, Gül ÖÖ, Görükmez O, Öksüz MF, Yakut T. Investigation of Glutathione-S-Transferases (GSTT1 and GSTM1) Gene Polymorphisms in Turkish Patients with Type 1 Diabetes(T1D). Uludağ Tıp Derg. 2012;38:75–78.
MLA
Karkucak, Mutlu, vd. “Investigation of Glutathione-S-Transferases (GSTT1 and GSTM1) Gene Polymorphisms in Turkish Patients with Type 1 Diabetes(T1D)”. Journal of Uludağ University Medical Faculty, c. 38, sy 2, Haziran 2012, ss. 75-78, https://izlik.org/JA42JR58LT.
Vancouver
1.Mutlu Karkucak, Soner Cander, Adem Deligönül, Gökhan Ocakoğlu, Tuna Gülten, Özen Öz Gül, Orhan Görükmez, Mustafa Ferhat Öksüz, Tahsin Yakut. Investigation of Glutathione-S-Transferases (GSTT1 and GSTM1) Gene Polymorphisms in Turkish Patients with Type 1 Diabetes(T1D). Uludağ Tıp Derg [Internet]. 01 Haziran 2012;38(2):75-8. Erişim adresi: https://izlik.org/JA42JR58LT

ISSN: 1300-414X, e-ISSN: 2645-9027

Uludağ Üniversitesi Tıp Fakültesi Dergisi "Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License" ile lisanslanmaktadır.


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Journal of Uludag University Medical Faculty is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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