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Fiziksel Aktivitenin Kısıtlanması: Yetişkin ve Yaşlı Yetişkin Bireyler Arasındaki Farklılıklar

Yıl 2021, Cilt: 47 Sayı: 1, 127 - 132, 01.04.2021
https://doi.org/10.32708/uutfd.833931

Öz

Fiziksel hareketsizlik, vücut yapılarının ve işlevlerinin genelde azalma eğilimi gösterdiği ve kardiyovasküler hastalıklar, hipertansiyon, tip 2 diyabet, dislipidemi gibi hastalıkların oluşumu açısından risk artışına neden olan bir süreçtir. Koronavirüs (Covid-19) pandemisi ileri yaşlı kişilerde fiziksel aktivite düzeylerinin azalmasına, fiziksel hareketsizliğin artmasına neden olmuştur. Fiziksel aktivite düzeyinin azalmasına neden olan bu pandemi döneminde ileri yaştaki bireylerin fiziksel hareketsizlik durumundan etkilenme riskleri genç yaşlardaki bireylere göre daha fazladır. Bu derlemede, fiziksel aktivite azlığının yaşlıların kas iskelet sisteminde ve performansında yaratacağı değişimler ile kronobiyolojik değişimler incelenmektedir. Ayrıca yetişkinler (18-64 yaş) ile yaşlı yetişkinler (≥65 yaş) arasında metabolik süreçler, kardiyak ve bağışıklık sistemi açısından görülen farklılıklar üzerinde durulmaktadır.

Kaynakça

  • World Health Organization (WHO). Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV). Available at: https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov). [accessed 30.01.2020].
  • Chen P, Mao L, Nassis GP et al. Wuhan coronavirus (2019-nCoV): The need to maintain regular physical activity while taking precautions. J Sport Health Sci 2020;9(2):103-104.
  • Booth FW, Roberts CK, Laye MJ. Lack of exercise is a major cause of chronic diseases. Compr Physiol 2012;2(2):1143-1211.
  • Tremblay MS, Warburton DE, Janssen I et al. New Canadian physical activity guidelines. Appl Physiol Nutr Metab 2011;36(1):36-46.
  • Aagaard P, Magnusson PS, Larsson B, Kjær M, Krustrup P. Mechanical muscle function, morphology, and fiber type in lifelong trained elderly. Med Sci Sports Exerc 2007;39(11):1989-96.
  • Mosole S, Carraro U, Kern H et al. Long-term high-level exercise promotes muscle reinnervation with age. J Neuropathol Exp Neurol 2014;73(4):284-94.
  • Nishimune H, Stanford JA, Mori Y. Role of exercise in maintaining the integrity of the neuromuscular junction. Muscle Nerve 2014;49(3):315-24.
  • Wilkinson DJ, Piasecki M, Atherton PJ. The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans. Ageing Res Rev 2018;47:123-32.
  • Marzetti E, Privitera G, Simili V et al. Multiple pathways to the same end: mechanisms of myonuclear apoptosis in sarcopenia of aging. ScientificWorldJournal 2010;10:340-349.
  • Marzetti E, Groban L, Wohlgemuth SE et al. Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats. Am J Physiol Regul Integr Comp Physiol 2008;294(2):R558-R67.
  • Mckendry J, Breen L, Shad BJ, Greig CA. Muscle morphology and performance in master athletes: A systematic review and meta-analyses. Ageing Res Rev 2018;45:62-82.
  • Paddon-Jones D, Sheffield-Moore M, Cree MG et al. Atrophy and impaired muscle protein synthesis during prolonged inactivity and stress. J Clin Endocrinol Metab 2006;91(12):4836-41.
  • Guadalupe-Grau A, Fuentes T, Guerra B, Calbet JA. Exercise and bone mass in adults. Sports Med 2009;39(6):439-68.
  • Hemmatian H, Bakker AD, Klein-Nulend J, van Lenthe GH. Aging, osteocytes, and mechanotransduction. Curr Osteoporos Rep 2017;15(5):401-11.
  • WHO, Geneva: Switzerland; 2010. [accessed 12/11/2013]. World Health Organization. Definition of an older or elderly person. http://www.who.int/healthinfo/survey/ageingdefnolder/en/index.html .
  • Astrand I. Aerobic capacity in men and women with special reference to age. Acta physiol scand 1960;49(169):1-89.
  • Hawkins SA, Wiswell RA. Rate and mechanism of maximal oxygen consumption decline with aging. Sports Med 2003;33(12):877-88.
  • Robinson S. Experimental studies of physical fitness in relation to age. Arbeitsphysiologie 1938;10(3):251-323.
  • Pišot R, Marusic U, Biolo G et al. Greater loss in muscle mass and function but smaller metabolic alterations in older compared with younger men following 2 wk of bed rest and recovery. J Appl Physiol (1985) 2016;120(8):922-9.
  • Dupont Rocher S, Bessot N, Sesboüé B, Bulla J, Davenne D. Circadian characteristics of older adults and aerobic capacity. J Gerontol A Biol Sci Med Sci 2016;71(6):817-22.
  • Vardar E, Vardar SA, Molla T, Kaynak C, Ersoz E. Psychological symptoms and sleep quality in young subjects with different circadian preferences. Biological Rhythm Research 2008;39(6):493-500.
  • Acet O, Girit Ç, Kaya Ş, Süt N, Vardar SA. The relationship between chronotypes and physical activity in healthy young medical students. Turkish Med Stud J 2018;5(2):24-7.
  • Dupont Rocher S, Bessot N, Sesboüé B, Bulla J, Davenne D. Circadian Characteristics of Older Adults and Aerobic Capacity. J Gerontol A Biol Sci Med Sci 2016;71(6):817-22.
  • Hower IM, Harper SA, Buford TW. Circadian Rhythms, Exercise, and Cardiovascular Health. J Circadian Rhythms 2018;16:7.
  • Wolff G, Esser KA. Scheduled exercise phase shifts the circadian clock in skeletal muscle. Med Sci Sports Exerc 2012;44(9):1663.
  • Gabriel BM, Zierath JR. Circadian rhythms and exercise—re-setting the clock in metabolic disease. Nat Rev Endocrinol 2019;15(4):197-206.
  • US Department of Health and Human Services et al. Physical activity guidelines advisory committee report, 2008. (2008): 1923-1929.
  • Knudsen SH, Hansen LS, Pedersen M et al. Changes in insulin sensitivity precede changes in body composition during 14 days of step reduction combined with overfeeding in healthy young men. J Appl Physiol (1985) 2012;113(1):7-15.
  • Giridharan N. Glucose & energy homeostasis: Lessons from animal studies. Indian J Med Res 2018;148(5):659.
  • Braden A, Musher-Eizenman D, Watford T, Emley E. Eating when depressed, anxious, bored, or happy: Are emotional eating types associated with unique psychological and physical health correlates? Appetite 2018;125:410-7.
  • Narici M, De Vito G, Franchi M et al. Impact of sedentarism due to the COVID-19 home confinement on neuromuscular, cardiovascular and metabolic health: Physiological and pathophysiological implications and recommendations for physical and nutritional countermeasures. Eur J Sport Sci 2020:1-22.
  • Sierra F, Kohanski R, (eds). Advances in geroscience. Switzerland: Springer International Publishing; 2016.
  • Frasca D, Blomberg BB, Paganelli R. Aging, obesity, and inflammatory age-related diseases. Front Immunol 2017;8:1745.
  • Palmer AK, Kirkland JL. Aging and adipose tissue: potential interventions for diabetes and regenerative medicine. Exp Gerontol 2016;86:97-105.
  • Hodes RJ, Sierra F, Austad SN et al. Disease drivers of aging. Ann N Y Acad Sci 2016;1386(1):45.
  • Petersen KF, Morino K, Alves TC et al. Effect of aging on muscle mitochondrial substrate utilization in humans. Proc Natl Acad Sci U S A 2015;112(36):11330-4.
  • Evans EM, Racette SB, Peterson LR et al. Aerobic power and insulin action improve in response to endurance exercise training in healthy 77–87 yr olds. J Appl Physiol (1985) 2005;98(1):40-5.
  • Cartee GD, Hepple RT, Bamman MM, Zierath JR. Exercise promotes healthy aging of skeletal muscle. Cell Metab 2016;23(6):1034-47.
  • Ballin M, Nordström P, Niklasson J, Alamäki A, Condell J, Tedesco S, Nordström A. Daily step count and incident diabetes in community-dwelling 70-year-olds: a prospective cohort study. BMC Public Health 2020;20(1):1830.
  • Biensø RS, Olesen J, Gliemann L et al. Effects of exercise training on regulation of skeletal muscle glucose metabolism in elderly men. J Gerontol A Biol Sci Med Sci 2015;70(7):866-72.
  • Prior SJ, Goldberg AP, Ortmeyer HK et al. Increased skeletal muscle capillarization independently enhances insulin sensitivity in older adults after exercise training and detraining. Diabetes 2015;64(10):3386-95.
  • Benjamin EJ, Blaha MJ, Chiuve SE et al. Heart disease and stroke statistics—2017 update. Circulation 2017;135(10):e146-e603.
  • Gounder SS, Kannan S, Devadoss D et al. Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training. PloS One 2012;7(9):e45697.
  • Narasimhan M, Rajasekaran NS. Exercise, Nrf2 and antioxidant signaling in cardiac aging. Front Physiol 2016;7:241.
  • Ribeiro F, Alves AJ, Duarte JA, Oliveira J. Is exercise training an effective therapy targeting endothelial dysfunction and vascular wall inflammation? Int J Cardiol 2010;141(3):214-21.
  • Ciolac EG, da Silva JMR, Vieira RP. Physical Exercise as an Immunomodulator of Chronic Diseases in Aging. J Phys Act Health 2020;17(6):662-72.
  • Fletcher GF, Landolfo C, Niebauer J et al. Promoting physical activity and exercise: JACC health promotion series. J Am Coll Cardiol 2018;72(14):1622-39.
  • Luan X, Tian X, Zhang H et al. Exercise as a prescription for patients with various diseases. J Sport Health Sci 2019;8(5):422-41.
  • Vardar SA. Egzersiz ve bağışıklık sistemi. In: Ünal M, (ed). Egzersiz Fizyolojsi. İstanbul: İstanbul Tıp Kitapevleri; 2019:295-307.
  • Nieman DC, Wentz LM. The compelling link between physical activity and the body's defense system. J Sport Health Sci 2019;8(3):201-17.
  • Wright C, Simone NL. Obesity and tumor growth: inflammation, immunity, and the role of a ketogenic diet. Curr Opin Clin Nutr Metab Care 2016;19(4):294-9.
  • Kakanis M, Peake J, Hooper S, Gray B, Marshall-Gradisnik S. The open window of susceptibility to infection after acute exercise in healthy young male elite athletes. J Sci Med Sport 2010;13:e85-e6.
  • Cerqueira É, Marinho DA, Neiva HP, Lourenço O. Inflammatory effects of high and moderate intensity exercise—A systematic review. Front Physiol 2020;10:1550.
  • Campbell JP, Turner JE. Debunking the myth of exercise-induced immune suppression: redefining the impact of exercise on immunological health across the lifespan. Front Immunol 2018;9:648.
  • Davison G, Kehaya C, Wyn Jones A. Nutritional and physical activity interventions to improve immunity. Am J Lifestyle Med 2016;10(3):152-69.
  • Fondell E, Lagerros YT, Sundberg CJ et al. Physical activity, stress, and self-reported upper respiratory tract infection. Med Sci Sports Exerc 2011;43(2):272-9.
  • Siu E, Campitelli MA, Kwong JC. Physical activity and influenza-coded outpatient visits, a population-based cohort study. PloS One 2012;7(6):e39518.
  • Fallon, K. Exercise in the time of COVID-19. Aust J Gen Pract 2020; 49 Suppl 13. doi: 10.31128. AJGP-COVID-13.[ePub ahead of print].
  • Franceschi C, Bonafè M, Valensin S et al. Inflamm‐aging: an evolutionary perspective on immunosenescence. Ann N Y Acad Sci 2000;908(1):244-54.
  • Goronzy JJ, Weyand CM. Understanding immunosenescence to improve responses to vaccines. Nat Immunol 2013;14(5):428.
  • Gómez-Rubio P, Trapero I. The beneficial effect of physical exercise on inflammatory makers in older individuals. Endocr Metab Immune Disord Drug Targets. 2020 Jun 6. doi: 10.2174/1871530320666200606225357. Epub ahead of print. PMID: 32504508.
  • Daskalopoulou C, Stubbs B, Kralj C et al. Physical activity and healthy ageing: A systematic review and meta-analysis of longitudinal cohort studies. Ageing Res Rev 2017;38:6-17.
  • Bangsbo J, Blackwell J, Boraxbekk C-J et al. Copenhagen Consensus statement 2019: physical activity and ageing. Br J Sports Med 2019;53(14):856-8.
  • Peçanha T, Goessler KF, Roschel H, Gualano B. Social isolation during the COVID-19 pandemic can increase physical inactivity and the global burden of cardiovascular disease. Am J Physiol Heart Circ Physiol 2020;318(6):H1441-H6.
  • WHO. Coronavirus disease 2019 (COVID-19): Situation report – 63, 2020. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200323-sitrep-63-covid-19.pdf?sfvrsn=b617302d_4
  • Durstine JL, Gordon B, Wang Z, Luo X. Chronic disease and the link to physical activity. J Sport Health Sci 2013;2(1):3-11.
  • Ekelund U, Tarp J, Steene-Johannessen J et al. Dose-response associations between accelerometry measured physical activity and sedentary time and all cause mortality: systematic review and harmonised meta-analysis. BMJ 2019; 366:l4570.

Restriction of Physical Activity: Differences Between Adults and Older Adult Individuals

Yıl 2021, Cilt: 47 Sayı: 1, 127 - 132, 01.04.2021
https://doi.org/10.32708/uutfd.833931

Öz

Physical inactivity is a process in which body structures and functions generally tend to decrease and increase the risk of diseases such as cardiovascular diseases, hypertension, type 2 diabetes and dyslipidemia. The coronavirus (Covid-19) pandemic caused a decrease in physical activity levels and increased physical inactivity in elderly subjects. In this pandemic period, which causes a decrease in the level of physical activity, elderly individuals more affected by physical inactivity than younger individuals. In this review, the changes caused by lack of physical activity in the musculoskeletal system and performance of the elderly and the chronobiological changes are examined. In addition the differences in metabolic processes, cardiac and immune systems between adults (18-64 years) and older adults (≥65 years) are emphasized.

Kaynakça

  • World Health Organization (WHO). Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV). Available at: https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov). [accessed 30.01.2020].
  • Chen P, Mao L, Nassis GP et al. Wuhan coronavirus (2019-nCoV): The need to maintain regular physical activity while taking precautions. J Sport Health Sci 2020;9(2):103-104.
  • Booth FW, Roberts CK, Laye MJ. Lack of exercise is a major cause of chronic diseases. Compr Physiol 2012;2(2):1143-1211.
  • Tremblay MS, Warburton DE, Janssen I et al. New Canadian physical activity guidelines. Appl Physiol Nutr Metab 2011;36(1):36-46.
  • Aagaard P, Magnusson PS, Larsson B, Kjær M, Krustrup P. Mechanical muscle function, morphology, and fiber type in lifelong trained elderly. Med Sci Sports Exerc 2007;39(11):1989-96.
  • Mosole S, Carraro U, Kern H et al. Long-term high-level exercise promotes muscle reinnervation with age. J Neuropathol Exp Neurol 2014;73(4):284-94.
  • Nishimune H, Stanford JA, Mori Y. Role of exercise in maintaining the integrity of the neuromuscular junction. Muscle Nerve 2014;49(3):315-24.
  • Wilkinson DJ, Piasecki M, Atherton PJ. The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans. Ageing Res Rev 2018;47:123-32.
  • Marzetti E, Privitera G, Simili V et al. Multiple pathways to the same end: mechanisms of myonuclear apoptosis in sarcopenia of aging. ScientificWorldJournal 2010;10:340-349.
  • Marzetti E, Groban L, Wohlgemuth SE et al. Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats. Am J Physiol Regul Integr Comp Physiol 2008;294(2):R558-R67.
  • Mckendry J, Breen L, Shad BJ, Greig CA. Muscle morphology and performance in master athletes: A systematic review and meta-analyses. Ageing Res Rev 2018;45:62-82.
  • Paddon-Jones D, Sheffield-Moore M, Cree MG et al. Atrophy and impaired muscle protein synthesis during prolonged inactivity and stress. J Clin Endocrinol Metab 2006;91(12):4836-41.
  • Guadalupe-Grau A, Fuentes T, Guerra B, Calbet JA. Exercise and bone mass in adults. Sports Med 2009;39(6):439-68.
  • Hemmatian H, Bakker AD, Klein-Nulend J, van Lenthe GH. Aging, osteocytes, and mechanotransduction. Curr Osteoporos Rep 2017;15(5):401-11.
  • WHO, Geneva: Switzerland; 2010. [accessed 12/11/2013]. World Health Organization. Definition of an older or elderly person. http://www.who.int/healthinfo/survey/ageingdefnolder/en/index.html .
  • Astrand I. Aerobic capacity in men and women with special reference to age. Acta physiol scand 1960;49(169):1-89.
  • Hawkins SA, Wiswell RA. Rate and mechanism of maximal oxygen consumption decline with aging. Sports Med 2003;33(12):877-88.
  • Robinson S. Experimental studies of physical fitness in relation to age. Arbeitsphysiologie 1938;10(3):251-323.
  • Pišot R, Marusic U, Biolo G et al. Greater loss in muscle mass and function but smaller metabolic alterations in older compared with younger men following 2 wk of bed rest and recovery. J Appl Physiol (1985) 2016;120(8):922-9.
  • Dupont Rocher S, Bessot N, Sesboüé B, Bulla J, Davenne D. Circadian characteristics of older adults and aerobic capacity. J Gerontol A Biol Sci Med Sci 2016;71(6):817-22.
  • Vardar E, Vardar SA, Molla T, Kaynak C, Ersoz E. Psychological symptoms and sleep quality in young subjects with different circadian preferences. Biological Rhythm Research 2008;39(6):493-500.
  • Acet O, Girit Ç, Kaya Ş, Süt N, Vardar SA. The relationship between chronotypes and physical activity in healthy young medical students. Turkish Med Stud J 2018;5(2):24-7.
  • Dupont Rocher S, Bessot N, Sesboüé B, Bulla J, Davenne D. Circadian Characteristics of Older Adults and Aerobic Capacity. J Gerontol A Biol Sci Med Sci 2016;71(6):817-22.
  • Hower IM, Harper SA, Buford TW. Circadian Rhythms, Exercise, and Cardiovascular Health. J Circadian Rhythms 2018;16:7.
  • Wolff G, Esser KA. Scheduled exercise phase shifts the circadian clock in skeletal muscle. Med Sci Sports Exerc 2012;44(9):1663.
  • Gabriel BM, Zierath JR. Circadian rhythms and exercise—re-setting the clock in metabolic disease. Nat Rev Endocrinol 2019;15(4):197-206.
  • US Department of Health and Human Services et al. Physical activity guidelines advisory committee report, 2008. (2008): 1923-1929.
  • Knudsen SH, Hansen LS, Pedersen M et al. Changes in insulin sensitivity precede changes in body composition during 14 days of step reduction combined with overfeeding in healthy young men. J Appl Physiol (1985) 2012;113(1):7-15.
  • Giridharan N. Glucose & energy homeostasis: Lessons from animal studies. Indian J Med Res 2018;148(5):659.
  • Braden A, Musher-Eizenman D, Watford T, Emley E. Eating when depressed, anxious, bored, or happy: Are emotional eating types associated with unique psychological and physical health correlates? Appetite 2018;125:410-7.
  • Narici M, De Vito G, Franchi M et al. Impact of sedentarism due to the COVID-19 home confinement on neuromuscular, cardiovascular and metabolic health: Physiological and pathophysiological implications and recommendations for physical and nutritional countermeasures. Eur J Sport Sci 2020:1-22.
  • Sierra F, Kohanski R, (eds). Advances in geroscience. Switzerland: Springer International Publishing; 2016.
  • Frasca D, Blomberg BB, Paganelli R. Aging, obesity, and inflammatory age-related diseases. Front Immunol 2017;8:1745.
  • Palmer AK, Kirkland JL. Aging and adipose tissue: potential interventions for diabetes and regenerative medicine. Exp Gerontol 2016;86:97-105.
  • Hodes RJ, Sierra F, Austad SN et al. Disease drivers of aging. Ann N Y Acad Sci 2016;1386(1):45.
  • Petersen KF, Morino K, Alves TC et al. Effect of aging on muscle mitochondrial substrate utilization in humans. Proc Natl Acad Sci U S A 2015;112(36):11330-4.
  • Evans EM, Racette SB, Peterson LR et al. Aerobic power and insulin action improve in response to endurance exercise training in healthy 77–87 yr olds. J Appl Physiol (1985) 2005;98(1):40-5.
  • Cartee GD, Hepple RT, Bamman MM, Zierath JR. Exercise promotes healthy aging of skeletal muscle. Cell Metab 2016;23(6):1034-47.
  • Ballin M, Nordström P, Niklasson J, Alamäki A, Condell J, Tedesco S, Nordström A. Daily step count and incident diabetes in community-dwelling 70-year-olds: a prospective cohort study. BMC Public Health 2020;20(1):1830.
  • Biensø RS, Olesen J, Gliemann L et al. Effects of exercise training on regulation of skeletal muscle glucose metabolism in elderly men. J Gerontol A Biol Sci Med Sci 2015;70(7):866-72.
  • Prior SJ, Goldberg AP, Ortmeyer HK et al. Increased skeletal muscle capillarization independently enhances insulin sensitivity in older adults after exercise training and detraining. Diabetes 2015;64(10):3386-95.
  • Benjamin EJ, Blaha MJ, Chiuve SE et al. Heart disease and stroke statistics—2017 update. Circulation 2017;135(10):e146-e603.
  • Gounder SS, Kannan S, Devadoss D et al. Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training. PloS One 2012;7(9):e45697.
  • Narasimhan M, Rajasekaran NS. Exercise, Nrf2 and antioxidant signaling in cardiac aging. Front Physiol 2016;7:241.
  • Ribeiro F, Alves AJ, Duarte JA, Oliveira J. Is exercise training an effective therapy targeting endothelial dysfunction and vascular wall inflammation? Int J Cardiol 2010;141(3):214-21.
  • Ciolac EG, da Silva JMR, Vieira RP. Physical Exercise as an Immunomodulator of Chronic Diseases in Aging. J Phys Act Health 2020;17(6):662-72.
  • Fletcher GF, Landolfo C, Niebauer J et al. Promoting physical activity and exercise: JACC health promotion series. J Am Coll Cardiol 2018;72(14):1622-39.
  • Luan X, Tian X, Zhang H et al. Exercise as a prescription for patients with various diseases. J Sport Health Sci 2019;8(5):422-41.
  • Vardar SA. Egzersiz ve bağışıklık sistemi. In: Ünal M, (ed). Egzersiz Fizyolojsi. İstanbul: İstanbul Tıp Kitapevleri; 2019:295-307.
  • Nieman DC, Wentz LM. The compelling link between physical activity and the body's defense system. J Sport Health Sci 2019;8(3):201-17.
  • Wright C, Simone NL. Obesity and tumor growth: inflammation, immunity, and the role of a ketogenic diet. Curr Opin Clin Nutr Metab Care 2016;19(4):294-9.
  • Kakanis M, Peake J, Hooper S, Gray B, Marshall-Gradisnik S. The open window of susceptibility to infection after acute exercise in healthy young male elite athletes. J Sci Med Sport 2010;13:e85-e6.
  • Cerqueira É, Marinho DA, Neiva HP, Lourenço O. Inflammatory effects of high and moderate intensity exercise—A systematic review. Front Physiol 2020;10:1550.
  • Campbell JP, Turner JE. Debunking the myth of exercise-induced immune suppression: redefining the impact of exercise on immunological health across the lifespan. Front Immunol 2018;9:648.
  • Davison G, Kehaya C, Wyn Jones A. Nutritional and physical activity interventions to improve immunity. Am J Lifestyle Med 2016;10(3):152-69.
  • Fondell E, Lagerros YT, Sundberg CJ et al. Physical activity, stress, and self-reported upper respiratory tract infection. Med Sci Sports Exerc 2011;43(2):272-9.
  • Siu E, Campitelli MA, Kwong JC. Physical activity and influenza-coded outpatient visits, a population-based cohort study. PloS One 2012;7(6):e39518.
  • Fallon, K. Exercise in the time of COVID-19. Aust J Gen Pract 2020; 49 Suppl 13. doi: 10.31128. AJGP-COVID-13.[ePub ahead of print].
  • Franceschi C, Bonafè M, Valensin S et al. Inflamm‐aging: an evolutionary perspective on immunosenescence. Ann N Y Acad Sci 2000;908(1):244-54.
  • Goronzy JJ, Weyand CM. Understanding immunosenescence to improve responses to vaccines. Nat Immunol 2013;14(5):428.
  • Gómez-Rubio P, Trapero I. The beneficial effect of physical exercise on inflammatory makers in older individuals. Endocr Metab Immune Disord Drug Targets. 2020 Jun 6. doi: 10.2174/1871530320666200606225357. Epub ahead of print. PMID: 32504508.
  • Daskalopoulou C, Stubbs B, Kralj C et al. Physical activity and healthy ageing: A systematic review and meta-analysis of longitudinal cohort studies. Ageing Res Rev 2017;38:6-17.
  • Bangsbo J, Blackwell J, Boraxbekk C-J et al. Copenhagen Consensus statement 2019: physical activity and ageing. Br J Sports Med 2019;53(14):856-8.
  • Peçanha T, Goessler KF, Roschel H, Gualano B. Social isolation during the COVID-19 pandemic can increase physical inactivity and the global burden of cardiovascular disease. Am J Physiol Heart Circ Physiol 2020;318(6):H1441-H6.
  • WHO. Coronavirus disease 2019 (COVID-19): Situation report – 63, 2020. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200323-sitrep-63-covid-19.pdf?sfvrsn=b617302d_4
  • Durstine JL, Gordon B, Wang Z, Luo X. Chronic disease and the link to physical activity. J Sport Health Sci 2013;2(1):3-11.
  • Ekelund U, Tarp J, Steene-Johannessen J et al. Dose-response associations between accelerometry measured physical activity and sedentary time and all cause mortality: systematic review and harmonised meta-analysis. BMJ 2019; 366:l4570.
Toplam 67 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Tıbbi Fizyoloji
Bölüm Derleme Makaleler
Yazarlar

Ecem Büşra Değer 0000-0003-0272-8727

Selma Arzu Vardar 0000-0002-1073-1718

Yayımlanma Tarihi 1 Nisan 2021
Kabul Tarihi 23 Mart 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 47 Sayı: 1

Kaynak Göster

APA Değer, E. B., & Vardar, S. A. (2021). Fiziksel Aktivitenin Kısıtlanması: Yetişkin ve Yaşlı Yetişkin Bireyler Arasındaki Farklılıklar. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 47(1), 127-132. https://doi.org/10.32708/uutfd.833931
AMA Değer EB, Vardar SA. Fiziksel Aktivitenin Kısıtlanması: Yetişkin ve Yaşlı Yetişkin Bireyler Arasındaki Farklılıklar. Uludağ Tıp Derg. Nisan 2021;47(1):127-132. doi:10.32708/uutfd.833931
Chicago Değer, Ecem Büşra, ve Selma Arzu Vardar. “Fiziksel Aktivitenin Kısıtlanması: Yetişkin Ve Yaşlı Yetişkin Bireyler Arasındaki Farklılıklar”. Uludağ Üniversitesi Tıp Fakültesi Dergisi 47, sy. 1 (Nisan 2021): 127-32. https://doi.org/10.32708/uutfd.833931.
EndNote Değer EB, Vardar SA (01 Nisan 2021) Fiziksel Aktivitenin Kısıtlanması: Yetişkin ve Yaşlı Yetişkin Bireyler Arasındaki Farklılıklar. Uludağ Üniversitesi Tıp Fakültesi Dergisi 47 1 127–132.
IEEE E. B. Değer ve S. A. Vardar, “Fiziksel Aktivitenin Kısıtlanması: Yetişkin ve Yaşlı Yetişkin Bireyler Arasındaki Farklılıklar”, Uludağ Tıp Derg, c. 47, sy. 1, ss. 127–132, 2021, doi: 10.32708/uutfd.833931.
ISNAD Değer, Ecem Büşra - Vardar, Selma Arzu. “Fiziksel Aktivitenin Kısıtlanması: Yetişkin Ve Yaşlı Yetişkin Bireyler Arasındaki Farklılıklar”. Uludağ Üniversitesi Tıp Fakültesi Dergisi 47/1 (Nisan 2021), 127-132. https://doi.org/10.32708/uutfd.833931.
JAMA Değer EB, Vardar SA. Fiziksel Aktivitenin Kısıtlanması: Yetişkin ve Yaşlı Yetişkin Bireyler Arasındaki Farklılıklar. Uludağ Tıp Derg. 2021;47:127–132.
MLA Değer, Ecem Büşra ve Selma Arzu Vardar. “Fiziksel Aktivitenin Kısıtlanması: Yetişkin Ve Yaşlı Yetişkin Bireyler Arasındaki Farklılıklar”. Uludağ Üniversitesi Tıp Fakültesi Dergisi, c. 47, sy. 1, 2021, ss. 127-32, doi:10.32708/uutfd.833931.
Vancouver Değer EB, Vardar SA. Fiziksel Aktivitenin Kısıtlanması: Yetişkin ve Yaşlı Yetişkin Bireyler Arasındaki Farklılıklar. Uludağ Tıp Derg. 2021;47(1):127-32.

ISSN: 1300-414X, e-ISSN: 2645-9027

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