The Important Role of Antioxidants in The Relationship Between Oxidative Stress And Colorectal Cancer

Yıl 2024, , 119 - 124, 30.08.2024

Zeynep Bozkoyun Dusak , Yusuf Ziya Yaşar , Ayşe Şaprak

https://doi.org/10.52976/vansaglik.1443021

Öz

The body has a complex enzymatic and non-enzymatic antioxidant defense system. Antioxidant mechanisms develop a defense system against free radicals that have harmful effects on body tissues. The accumulation of free radicals in the cell causes oxidative stress and cellular damage. It is known that the increase in cell reactive oxygen species plays a role in the pathogenesis of many diseases such as colon cancer, neurodegenerative, cardiovascular, diabetes and kidney diseases. The aim of our study is to reveal the effect of oxidative stress on colorectal cancer and the opposing effects of antioxidants (such as SOD, CAT and GPx).determined that the factors in the autumn season differ proportionally according to the summer and winter months.

Anahtar Kelimeler

Antioxidants, Colon Cancer, Oxidative Stress, Free Radicals

Oksidatif Stres ve Kolorektal Kanser İlişkisinde Antioksidanların Önemli Rolü

Öz

Kolorektal kanser günümüzde en sık görülen kanserlerden biri olup, yaşam kalitesini düşüren, iş kaybına yol açan önemli bir sağlık sorunudur. Birçok kanser türünde olduğu gibi oksidatif stres ve inflamasyonun kolorektal kanserin oluşumunu ve ilerlemesini arttırdığı düşünülmektedir. Çalışmamızın amacı oksidatif stresin kolorektal kanser üzerindeki etkisini ve antioksidanların karşıt etkilerini ortaya koymaktır.

Anahtar Kelimeler

Antioksidanlar, Kolon Kanseri, Oksidatif Stres, Serbest Radikaller

Kaynakça

• Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. (2012). Oxidative stress and antioxidant defense. World Allergy Organization Journal, 5, 9-19.
• Bjelland S, Seeberg E. (2003). Mutagenicity, toxicity and repair of DNA base damage induced by oxidation. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 531(1-2), 37-80.
• Brunk UT, Terman A. (2002). The mitochondrial‐lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis. European Journal of Biochemistry, 269(8), 1996-2002.
• Cadet J, Berger M, Douki T, Ravanat JL. (2005). Oxidative damage to DNA: formation, measurement, and biological significance. Reviews of Physiology Biochemistry and Pharmacology, 1-87.
• Cejas P, Casado E, Belda-Iniesta C, De Castro J, Espinosa E, Redondo A et al. (2004). Implications of oxidative stress and cell membrane lipid peroxidation in human cancer (Spain). Cancer Causes&Control, 15, 707-719.
• Dusak A, Atasoy N, Demir H. (2022). Nutrition and colon cancer. International Journal of Academic Medicine and Pharmacy, 4(1), 80-85.
• Federico A, Morgillo F, Tuccillo C, Ciardiello F, Loguercio C. (2007). Chronic inflammation and oxidative stress in human carcinogenesis. International Journal of Cancer, 121(11), 2381-386.
• Fiaschi T, Chiarugi P. (2012). Oxidative stress, tumor microenvironment, and metabolic reprogramming: a diabolic liaison. International Journal of Cell Biology, 2012.
• Finaud J, Lac G, Filaire E. (2006). Oxidative stress: relationship with exercise and training. Sports Medicine, 36, 327-358.
• Friguet B. (2006). Oxidized protein degradation and repair in ageing and oxidative stress. FEBS etters, 580(12), 2910-6.
• Grune T, Merker K, Sandig G, Davies KJ. (2003). Selective degradation of oxidatively modified protein substrates by the proteasome. Biochemical and Biophysical Research Communications, 305(3), 709-18.
• Guz J, Foksinski M, Siomek A, Gackowski D, Rozalski R, Dziaman T et al. (2008). The relationship between 8-oxo-7, 8-dihydro-2′-deoxyguanosine level and extent of cytosine methylation in leukocytes DNA of healthy subjects and in patients with colon adenomas and carcinomas. Mutation Research/ Fundamental and Molecular Mechanisms of Mutagenesis, 640(1-2), 170-3.
• Henderson PT, Evans MD, Cooke MS. (2010). Salvage of oxidized guanine derivatives in the (2′-deoxy) ribonucleotide pool as source of mutations in DNA. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 703(1), 11-7.
• Ji LL. (2002). Exercise‐induced modulation of antioxidant defense. Annals of the New York Academy of Sciences, 959(1), 82-92.
• Ji LL. (2008). Modulation of skeletal muscle antioxidant defense by exercise: Role of redox signaling. Free Radical Biology and Medicine, 44(2), 142-152.
• Ji LL, Gomez‐Cabrera MC, Vina J. (2006). Exercise and hormesis: activation of cellular antioxidant signaling pathway. Annals of the New York Academy of Sciences, 1067(1), 425-435.
• Ji LL, Gomez-Cabrera MC, Vina J. (2007). Role of nuclear factor κ B and mitogen-activated protein kinase signaling in exercise-induced antioxidant enzyme adaptation. Applied Physiology, Nutrition, and Metabolism, 32(5), 930-935.
• Johnson IT, Lund EK. (2007). Nutrition, obesity and colorectal cancer. Alimentary Ppharmacology & Therapeutics, 26(2), 1611-81.
• Kramer HF, Goodyear LJ. (2007). Exercise, MAPK, and NF-κB signaling in skeletal muscle. Journal of Applied Physiology, 103(1), 388-395.
• Luo J, Solimini NL, Elledge SJ. (2009). Principles of cancer therapy: oncogene and non-oncogene addiction. Cell, 136(5), 823-837.
• Marnett LJ. (1999). Lipid peroxidation—DNA damage by malondialdehyde. Mutation Research/ Fundamental and Molecular Mechanisms of Mutagenesis, 424(1-2), 83-95.
• Marnett LJ. (2002). Oxy radicals, lipid peroxidation and DNA damage. Toxicology, 181, 219-222.
• Maynard S, Schurman SH, Harboe C, de Souza-Pinto NC, Bohr VA. (2009). Base excision repair of oxidative DNA damage and association with cancer and aging. Carcinogenesis, 30(1), 2-10.
• Mena S, Ortega A, Estrela JM. (2009). Oxidative stress in environmental-induced carcinogenesis. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 674(1-2), 36-44.
• Oberreuther-Moschner DL, Rechkemmer G, Pool-Zobel BL. (2005). Basal colon crypt cells are more sensitive than surface cells toward hydrogen peroxide, a factor of oxidative stress. Toxicology letters, 159(3), 212-8.
• Özer ÖF, Güler EM, Selek Ş, Çoban G, Türk HM, Koçyiğit A. (2019). Akciğer, meme ve kolon kanserli hastalarda oksidatif stres parametrelerinin değişimi. Harran Üniversitesi Tıp Fakültesi Dergisi, 16(2), 235-240.
• Pisoschi AM, Pop A. (2015). The role of antioxidants in the chemistry of oxidative stress: A review. European Journal of Medicinal Chemistry, 97, 55-74.
• Radic N, Rade I, Aleksandar Đ, Štrukelj B. (2009). Analysis of parameters significant for oxidative stress and cell injury. In The Analysis of Pharmacologically Active Compounds and Biomolecules in Real Samples.
• Shringarpure R, Davies KJ. (2002). Protein turnover by the proteasome in aging and disease. Free Radical Biology and Medicine, 32(11), 1084-9.
• Sullivan LB, Chandel NS. (2014). Mitochondrial reactive oxygen species and cancer. Cancer & Metabolism, 2, 1-12.
• Tafani M, Sansone L, Limana F, Arcangeli T, De Santis E, Polese M, Russo MA. (2016). The interplay of reactive oxygen species, hypoxia, inflammation, and sirtuins in cancer initiation and progression. Oxidative Medicine and Cellular Longevity, 2016.
• Uchida K. (2003). 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Progress in Lipid Research, 42(4), 318-343.
• Uchida K, Kumagai T. (2003). 4-hydroxy-2-nonenal as a COX-2 inducer. Molecular Aspects of Medicine, 24(4-5), 213-218.
• Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. İnternational Journal of Biochemistry & Cell Biology, 39(1), 44-84.
• Valko M, Rhodes CJB, Moncol J, Izakovic MM, Mazur M. (2006). Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico-Biological Interactions, 160(1), 1-40. Waris G, Ahsan H. (2006). Reactive oxygen species: role in the development of cancer and various chronic conditions. Journal of Carcinogenesis, 5, 14.
• Weinberg F, Chandel NS. (2009). Reactive oxygen species-dependent signaling regulates cancer. Cellular and Molecular Life Sciences, 66, 3663-3673.
• Yıldız H, Semerci B, Bişgin S. (2022). Antioksidanların insan sağlığı açısından önemi ve bitkilerdeki bazı antioksidan tayin yöntemleri. ISPEC Journal of Scıence Instıtute, 1(1), 10-16.